ATE215955T1 - Verfahren zur herstellung von narcotischen analgetika - Google Patents

Verfahren zur herstellung von narcotischen analgetika

Info

Publication number: ATE215955T1
Authority: AT; Austria
Prior art keywords: producing; narcotic analgesics; analgesics; hydromorphone; hydrocodone
Prior art date: 1996-08-01

Application number

AT97932926T

Other languages

English (en)

Inventor

Bogdan Mudryk

Joydeep Kant

Chester Sapino

Original Assignee

Johnson Matthey Plc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-08-01

Filing date

1997-07-18

Publication date

2002-04-15

1997-07-18 Application filed by Johnson Matthey Plc filed Critical Johnson Matthey Plc

2002-04-15 Application granted granted Critical

2002-04-15 Publication of ATE215955T1 publication Critical patent/ATE215955T1/de

Links

229940035676 analgesics Drugs 0.000 title abstract 2
239000000730 antalgic agent Substances 0.000 title abstract 2
238000004519 manufacturing process Methods 0.000 title abstract 2
230000003533 narcotic effect Effects 0.000 title abstract 2
230000003197 catalytic effect Effects 0.000 abstract 1
XYYVYLMBEZUESM-UHFFFAOYSA-N dihydrocodeine Natural products C1C(N(CCC234)C)C2C=CC(=O)C3OC2=C4C1=CC=C2OC XYYVYLMBEZUESM-UHFFFAOYSA-N 0.000 abstract 1
LLPOLZWFYMWNKH-CMKMFDCUSA-N hydrocodone Chemical compound C([C@H]1[C@H](N(CC[C@@]112)C)C3)CC(=O)[C@@H]1OC1=C2C3=CC=C1OC LLPOLZWFYMWNKH-CMKMFDCUSA-N 0.000 abstract 1
229960000240 hydrocodone Drugs 0.000 abstract 1
OROGSEYTTFOCAN-UHFFFAOYSA-N hydrocodone Natural products C1C(N(CCC234)C)C2C=CC(O)C3OC2=C4C1=CC=C2OC OROGSEYTTFOCAN-UHFFFAOYSA-N 0.000 abstract 1
WVLOADHCBXTIJK-YNHQPCIGSA-N hydromorphone Chemical compound O([C@H]1C(CC[C@H]23)=O)C4=C5[C@@]12CCN(C)[C@@H]3CC5=CC=C4O WVLOADHCBXTIJK-YNHQPCIGSA-N 0.000 abstract 1
229960001410 hydromorphone Drugs 0.000 abstract 1
125000002524 organometallic group Chemical group 0.000 abstract 1
LLPOLZWFYMWNKH-UHFFFAOYSA-N trans-dihydrocodeinone Natural products C1C(N(CCC234)C)C2CCC(=O)C3OC2=C4C1=CC=C2OC LLPOLZWFYMWNKH-UHFFFAOYSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
- C07D489/02—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with oxygen atoms attached in positions 3 and 6, e.g. morphine, morphinone
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
- C07D489/06—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with a hetero atom directly attached in position 14
- C07D489/08—Oxygen atom
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Other In-Based Heterocyclic Compounds (AREA)
Steroid Compounds (AREA)
Medicines Containing Plant Substances (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

AT97932926T 1996-08-01 1997-07-18 Verfahren zur herstellung von narcotischen analgetika ATE215955T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GBGB9616253.2A GB9616253D0 (en)	1996-08-01	1996-08-01	Preparation of narcotic analgesics
PCT/GB1997/001977 WO1998005667A1 (en)	1996-08-01	1997-07-18	Preparation of narcotic analgesics

Publications (1)

Publication Number	Publication Date
ATE215955T1 true ATE215955T1 (de)	2002-04-15

Family

ID=10797912

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT97932926T ATE215955T1 (de)	1996-08-01	1997-07-18	Verfahren zur herstellung von narcotischen analgetika

Country Status (15)

Country	Link
US (1)	US5847142A (de)
EP (1)	EP0915884B1 (de)
JP (2)	JP4316674B2 (de)
CN (1)	CN1105721C (de)
AT (1)	ATE215955T1 (de)
AU (1)	AU3629197A (de)
DE (1)	DE69711883T2 (de)
DK (1)	DK0915884T3 (de)
ES (1)	ES2175438T3 (de)
GB (1)	GB9616253D0 (de)
MY (1)	MY117858A (de)
PL (1)	PL186307B1 (de)
TW (1)	TW396157B (de)
WO (1)	WO1998005667A1 (de)
ZA (1)	ZA976853B (de)

Families Citing this family (47)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB9616253D0 (en) *	1996-08-01	1996-09-11	Johnson Matthey Plc	Preparation of narcotic analgesics
MXPA02004678A (es) *	1999-11-09	2005-10-05	Abbott Laboratoires	Composiciones de hidrocodeinona e hdromorfinona y metodos para su sintesis.
US7501433B2 (en)	2002-05-17	2009-03-10	Jenken Biosciences, Inc.	Opioid and opioid-like compounds and uses thereof
CA2486157C (en) *	2002-05-17	2013-04-16	Jenken Biosciences, Inc.	Opioid and opioid-like compounds and uses thereof
US7923454B2 (en)	2002-05-17	2011-04-12	Jenken Biosciences, Inc.	Opioid and opioid-like compounds and uses thereof
RU2215741C1 (ru) *	2002-11-05	2003-11-10	Открытое Акционерное Общество "Международная Научно-Технологическая Корпорация"	Сложные эфиры n-замещенных 14-гидроксиморфинанов и способ их получения
RU2215742C1 (ru) *	2002-11-05	2003-11-10	Открытое Акционерное Общество "Международная Научно-Технологическая Корпорация"	Способ получения сложных эфиров n-замещенных 14-гидроксиморфинанов
CA2545052C (en) *	2002-11-11	2011-01-11	Mallinckrodt, Inc.	Method for the catalytic production of hydrocodone and hydromorphone
US7321038B2 (en) *	2002-11-11	2008-01-22	Mallinckrodt Inc.	Method for the catalytic production of hydrocodone and hydromorphone
US7323565B2 (en) *	2002-11-11	2008-01-29	Mallinckrodt Inc.	Method for the catalytic production of hydrocodone and hydromorphone
US7399858B2 (en) *	2002-11-11	2008-07-15	Mallinckrodt Inc.	Method for the catalytic production of hydrocodone, hydromorphone, and derivatives thereof
US8017622B2 (en)	2003-05-16	2011-09-13	Jenken Biosciences, Inc.	Opioid and opioid-like compounds and uses thereof
SK286047B6 (sk) *	2004-04-13	2008-01-07	Zentiva, A. S.	Spôsob prípravy derivátov 4,5alfa-epoxy-6-oxomorfínanu
CN1914210A (zh) *	2004-05-13	2007-02-14	马林克罗特公司	用于催化生产氢可酮和氢吗啡酮的方法
US6946556B1 (en)	2004-05-21	2005-09-20	Acura Pharmaceuticals, Inc.	Preparation of opioid analgesics by a one-pot process
US7348430B2 (en) *	2005-01-21	2008-03-25	Acura Pharmaceuticals, Inc.	Production of opioid analgesics
EP1871774A1 (de)	2005-03-28	2008-01-02	Mallinckrodt, Inc.	Verfahren zur katalytischen herstellung von hydrocodon, hydromorphon und derivaten davon
ES2357216T3 (es) *	2005-06-16	2011-04-20	Mallinckrodt, Inc.	Una ruta de síntesis de 14-hidroxil-opiáceos a través de 1-halo-tebaína o análogos.
US7399859B1 (en)	2007-02-06	2008-07-15	Cody Laboratories Inc.	Method for catalytic preparation of hydromorphone and hydrocodone
ES2407033T3 (es)	2007-05-04	2013-06-11	Mallinckrodt Llc	Procedimientos mejorados para la preparación de opiáceos 6-alfa-hidroxi-n-alquilados
US7999104B2 (en)	2007-06-29	2011-08-16	Brock University	Methods for one-pot N-demethylation/N-acylation of morphine and tropane alkaloids
US8962841B2 (en)	2007-06-29	2015-02-24	Brock University	Methods for one-pot N-demethylation/N-functionalization of morphine and tropane alkaloids
JP2010533719A (ja) *	2007-07-17	2010-10-28	マリンクロッド・インコーポレイテッド	還元的アミノ化によるｎ−アルキル化オピエートの調製
NZ607842A (en)	2008-09-30	2013-12-20	Mallinckrodt Llc	Processes for the selective amination of ketomorphinans
US8946419B2 (en)	2009-02-23	2015-02-03	Mallinckrodt Llc	(+)-6-hydroxy-morphinan or (+)-6-amino-morphinan derivatives
US20100261906A1 (en) *	2009-04-09	2010-10-14	Mallinckrodt Inc.	Preparation of 6-Keto, 3-Alkoxy Morphinans
US8293907B2 (en) *	2009-04-09	2012-10-23	Mallinckrodt Inc.	Preparation of saturated ketone morphinan compounds by catalytic isomerization
WO2010118275A1 (en) *	2009-04-09	2010-10-14	Mallinckrodt Inc.	Preparation of saturated ketone morphinan compounds
US8519133B2 (en) *	2009-06-11	2013-08-27	Mallinckrodt Llc	Preparation of 6-alpha-amino N-substituted morphinans by catalytic hydrogen transfer
US8471023B2 (en) *	2009-06-11	2013-06-25	Mallinckrodt Llc	Reductive amination of 6-keto normorphinans by catalytic hydrogen transfer
US9119848B2 (en)	2009-12-04	2015-09-01	Alkermes Pharma Ireland Limited	Morphinan derivatives for the treatment of drug overdose
EP2580201B1 (de)	2010-06-11	2017-08-02	Rhodes Technologies	Übergangsmetallkatalysierte verfahren zur herstellung von n-allyl-verbindungen und ihre verwendung
CA2802294C (en)	2010-06-11	2016-05-10	Rhodes Technologies	Process for n-dealkylation of tertiary amines
PL2588481T3 (pl)	2010-07-02	2018-05-30	Johnson Matthey Public Limited Company	Sposób syntezy i oczyszczania oksykodonu
JP5728084B2 (ja) *	2010-07-08	2015-06-03	アルカーメスファーマアイルランドリミテッド	置換モルフィナンの合成のための方法
HUE065427T2 (hu)	2010-08-23	2024-05-28	Alkermes Pharma Ireland Ltd	Eljárások antipszichotikum által indukált súlygyarapodás kezelésére
CN103619847A (zh)	2011-05-06	2014-03-05	布鲁克大学	通过金属催化n-脱甲基化/官能化以及分子内基团转移制备吗啡类似物的方法
KR20140036215A (ko)	2011-06-09	2014-03-25	말린크로트 엘엘씨	촉매 수소 전달에 의한 6-케토 모르피난의 환원 아미노화
MX2014002630A (es)	2011-09-08	2014-04-14	Mallinckrodt Llc	Produccion de alcaloides sin el aislamiento de compuestos intermediarios.
US9211293B2 (en)	2011-12-15	2015-12-15	Alkermes Pharma Ireland Limited	Opioid agonist antagonist combinations
EP3003311A2 (de)	2013-05-24	2016-04-13	Alkermes Pharma Ireland Limited	Verfahren zur behandlung von symptomen für depression
CA2911231C (en)	2013-05-24	2021-12-07	Alkermes Pharma Ireland Limited	Morphan and morphinan analogues, and methods of use
GB201313211D0 (en) *	2013-07-24	2013-09-04	Cambrex Karlskoga Ab	New process
EP3255051A1 (de)	2016-06-09	2017-12-13	Siegfried AG	Trägerbasierter metallkatalysator für die herstellung von hydrocodon und hydromorphon
US10081636B2 (en)	2016-07-08	2018-09-25	Cody Laboratories, Inc.	Method for catalytic preparation of hydromorphone, hydrocodone, and other opiates
WO2022101444A1 (en)	2020-11-12	2022-05-19	Alkermes Pharma Ireland Limited	Immediate release multilayer tablet
WO2022101408A1 (en)	2020-11-13	2022-05-19	Ferrer Internacional, S.A.	Synthesis of hydromorphone base

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US2628962A (en) *	1949-10-20	1953-02-17	Mallinckrodt Chemical Works	Method for preparing dihydrocodeinone, dihydromorphinone, and codeinone
US2654756A (en) *	1949-10-20	1953-10-06	Mallinckrodt Chemical Works	Process of preparing codeinone, dihydrocodeinone, and dihydromorphinone
US2715626A (en) *	1950-07-05	1955-08-16	Merck & Co Inc	Process of preparing dihydrocodeinone
FR1290174A (fr) *	1961-01-25	1962-04-13	S E M P A Chemie	Préparation de la codéïnone à partir de la thébaïne
GB9616253D0 (en) *	1996-08-01	1996-09-11	Johnson Matthey Plc	Preparation of narcotic analgesics

1996
- 1996-08-01 GB GBGB9616253.2A patent/GB9616253D0/en active Pending
1997
- 1997-04-03 US US08/825,744 patent/US5847142A/en not_active Expired - Lifetime
- 1997-07-18 CN CN97198338A patent/CN1105721C/zh not_active Expired - Lifetime
- 1997-07-18 JP JP50769898A patent/JP4316674B2/ja not_active Expired - Lifetime
- 1997-07-18 AT AT97932926T patent/ATE215955T1/de active
- 1997-07-18 DK DK97932926T patent/DK0915884T3/da active
- 1997-07-18 ES ES97932926T patent/ES2175438T3/es not_active Expired - Lifetime
- 1997-07-18 PL PL97331525A patent/PL186307B1/pl unknown
- 1997-07-18 DE DE69711883T patent/DE69711883T2/de not_active Expired - Lifetime
- 1997-07-18 AU AU36291/97A patent/AU3629197A/en not_active Abandoned
- 1997-07-18 EP EP97932926A patent/EP0915884B1/de not_active Expired - Lifetime
- 1997-07-18 WO PCT/GB1997/001977 patent/WO1998005667A1/en not_active Ceased
- 1997-07-24 TW TW086110548A patent/TW396157B/zh active
- 1997-07-28 MY MYPI97003431A patent/MY117858A/en unknown
- 1997-07-31 ZA ZA9706853A patent/ZA976853B/xx unknown
2009
- 2009-03-12 JP JP2009059906A patent/JP2009161557A/ja active Pending

Also Published As

Publication number	Publication date
DE69711883T2 (de)	2002-10-31
JP4316674B2 (ja)	2009-08-19
AU3629197A (en)	1998-02-25
CN1105721C (zh)	2003-04-16
JP2001500846A (ja)	2001-01-23
ES2175438T3 (es)	2002-11-16
DE69711883D1 (de)	2002-05-16
PL331525A1 (en)	1999-07-19
MY117858A (en)	2004-08-30
DK0915884T3 (da)	2002-07-01
GB9616253D0 (en)	1996-09-11
CN1231667A (zh)	1999-10-13
EP0915884B1 (de)	2002-04-10
EP0915884A1 (de)	1999-05-19
WO1998005667A1 (en)	1998-02-12
JP2009161557A (ja)	2009-07-23
ZA976853B (en)	1998-02-11
US5847142A (en)	1998-12-08
TW396157B (en)	2000-07-01
PL186307B1 (pl)	2003-12-31

Legal Events

Date	Code	Title	Description
2002-08-15	UEP	Publication of translation of european patent specification

Publication	Publication Date	Title
DE69711883D1 (de)	2002-05-16	Verfahren zur herstellung von narcotischen analgetika
ATA100687A (de)	1996-08-15	Verfahren zur herstellung von eisen
DE69618485D1 (de)	2002-02-14	Verfahren zur herstellung von epoxidierungskatalysatoren
DE69119587D1 (de)	1996-06-20	Verfahren zur herstellung von tagatose
DE69623460D1 (de)	2002-10-10	Verfahren zur herstellung von 3-haloalkyl-1h-pyrazole
DE69722210D1 (de)	2003-06-26	Verfahren zur herstellung einer mischung von sterin-estern
DE59509924D1 (de)	2002-01-24	Verfahren zur Herstellung von verbrückten Halbsandwichkomplexen
DE3878153D1 (de)	1993-03-18	Verfahren zur herstellung eines alkylenamins unter verwendung eines katalysators von gemischten oxiden.
DE3675239D1 (de)	1990-12-06	Verfahren zur herstellung von aminopropylalkoxysilanen.
ATE271070T1 (de)	2004-07-15	Verfahren zur herstellung eines metallocen- katalysatorsystems
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AT399722B (de)	1995-07-25	Verfahren zur herstellung von mevinolin
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ATA95587A (de)	1990-09-15	Verfahren zur herstellung von glucosylmoranolin
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