ATE215965T1 - Derivate von amiden glycopeptidischer antibiotica - Google Patents

Derivate von amiden glycopeptidischer antibiotica

Info

Publication number: ATE215965T1
Authority: AT; Austria
Prior art keywords: derivatives; amids; glycopeptide antibiotics; control; resistant
Prior art date: 1996-06-28

Application number

AT97304495T

Other languages

English (en)

Inventor

Robin David Grey Cooper

Michael John Rodriguez

Nancy June Snyder

Mark James Zweifel

Original Assignee

Lilly Co Eli

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-06-28

Filing date

1997-06-25

Publication date

2002-04-15

1997-06-25 Application filed by Lilly Co Eli filed Critical Lilly Co Eli

2002-04-15 Application granted granted Critical

2002-04-15 Publication of ATE215965T1 publication Critical patent/ATE215965T1/de

Links

239000003910 polypeptide antibiotic agent Substances 0.000 title 1
241000192125 Firmicutes Species 0.000 abstract 1
108010059993 Vancomycin Proteins 0.000 abstract 1
-1 amide compounds Chemical class 0.000 abstract 1
150000001408 amides Chemical class 0.000 abstract 1
230000000844 anti-bacterial effect Effects 0.000 abstract 1
229940088710 antibiotic agent Drugs 0.000 abstract 1
230000001580 bacterial effect Effects 0.000 abstract 1
230000003115 biocidal effect Effects 0.000 abstract 1
XJHXLMVKYIVZTE-LOALFDMRSA-N chloroeremomycin Chemical compound O([C@@H]1C2=CC=C(C(=C2)Cl)OC=2C=C3C=C(C=2O[C@H]2[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O2)O[C@@H]2O[C@@H](C)[C@H](O)[C@@](C)(N)C2)OC2=CC=C(C=C2Cl)[C@@H](O)[C@H](C(N[C@@H](CC(N)=O)C(=O)N[C@H]3C(=O)N[C@H]2C(=O)N[C@@H]1C(N[C@@H](C1=CC(O)=CC(O)=C1C=1C(O)=CC=C2C=1)C(O)=O)=O)=O)NC(=O)[C@@H](CC(C)C)NC)[C@H]1C[C@](C)(N)[C@@H](O)[C@H](C)O1 XJHXLMVKYIVZTE-LOALFDMRSA-N 0.000 abstract 1
108700026803 chloroorienticin A Proteins 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
229960003165 vancomycin Drugs 0.000 abstract 1
MYPYJXKWCTUITO-LYRMYLQWSA-N vancomycin Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1=C2C=C3C=C1OC1=CC=C(C=C1Cl)[C@@H](O)[C@H](C(N[C@@H](CC(N)=O)C(=O)N[C@H]3C(=O)N[C@H]1C(=O)N[C@H](C(N[C@@H](C3=CC(O)=CC(O)=C3C=3C(O)=CC=C1C=3)C(O)=O)=O)[C@H](O)C1=CC=C(C(=C1)Cl)O2)=O)NC(=O)[C@@H](CC(C)C)NC)[C@H]1C[C@](C)(N)[C@H](O)[C@H](C)O1 MYPYJXKWCTUITO-LYRMYLQWSA-N 0.000 abstract 1
MYPYJXKWCTUITO-UHFFFAOYSA-N vancomycin Natural products O1C(C(=C2)Cl)=CC=C2C(O)C(C(NC(C2=CC(O)=CC(O)=C2C=2C(O)=CC=C3C=2)C(O)=O)=O)NC(=O)C3NC(=O)C2NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(CC(C)C)NC)C(O)C(C=C3Cl)=CC=C3OC3=CC2=CC1=C3OC1OC(CO)C(O)C(O)C1OC1CC(C)(N)C(O)C(C)O1 MYPYJXKWCTUITO-UHFFFAOYSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
- C07K9/006—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence being part of a ring structure
- C07K9/008—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence being part of a ring structure directly attached to a hetero atom of the saccharide radical, e.g. actaplanin, avoparcin, ristomycin, vancomycin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Biochemistry (AREA)
Biophysics (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
General Chemical & Material Sciences (AREA)
Oncology (AREA)
Chemical Kinetics & Catalysis (AREA)
Communicable Diseases (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Compounds Of Unknown Constitution (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Investigating Or Analysing Biological Materials (AREA)

AT97304495T 1996-06-28 1997-06-25 Derivate von amiden glycopeptidischer antibiotica ATE215965T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US2077496P	1996-06-28	1996-06-28
US08/847,069 US5919756A (en)	1996-06-28	1997-05-01	Amides

Publications (1)

Publication Number	Publication Date
ATE215965T1 true ATE215965T1 (de)	2002-04-15

Family

ID=26693848

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT97304495T ATE215965T1 (de)	1996-06-28	1997-06-25	Derivate von amiden glycopeptidischer antibiotica

Country Status (11)

Country	Link
US (1)	US5919756A (de)
EP (1)	EP0816378B1 (de)
JP (1)	JP4086318B2 (de)
AT (1)	ATE215965T1 (de)
AU (1)	AU3411197A (de)
CA (1)	CA2258906C (de)
DE (1)	DE69711766T2 (de)
DK (1)	DK0816378T3 (de)
ES (1)	ES2172749T3 (de)
PT (1)	PT816378E (de)
WO (1)	WO1998000153A1 (de)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5840684A (en) *	1994-01-28	1998-11-24	Eli Lilly And Company	Glycopeptide antibiotic derivatives
US8022095B2 (en) *	1996-08-16	2011-09-20	Pozen, Inc.	Methods of treating headaches using 5-HT agonists in combination with long-acting NSAIDs
US5952310A (en) *	1997-05-20	1999-09-14	Eli Lilly And Company	Glycopeptide hexapeptides
US5919771A (en) *	1997-05-20	1999-07-06	Eli Lilly And Company	Urea and thiourea derivatives of glycopeptides
PT1140993E (pt) *	1998-12-23	2003-10-31	Theravance Inc	Derivados de glicopeptidos e composicoes farmaceuticas contendo os mesmos
SG87877A1 (en) *	1998-12-23	2002-04-16	Advanced Medicine Inc	Glycopeptide derivatives and pharmaceutical compositions containing the same
EP1147118A4 (de) *	1999-01-12	2004-01-28	Univ Princeton	Substituierte alpha-verknüpfte disaccharide
US6699836B2 (en)	1999-04-02	2004-03-02	The Trustees Of Princeton University	Vancomycin analogs
CA2726789A1 (en)	2000-02-05	2001-11-08	Theravance, Inc.	Cyclodextrin containing glycopeptide antibiotic compositions
JP4713810B2 (ja)	2000-05-02	2011-06-29	セラヴァンス，インコーポレーテッド	グリコペプチドに対する還元的アルキル化プロセス
AU2001259298A1 (en) *	2000-05-02	2001-11-12	Advanced Medicine, Inc.	Polyacid glycopeptide derivatives
ES2302733T3 (es)	2000-06-22	2008-08-01	Theravance, Inc.	Derivados carboxi-sacaridos de glucopeptido.
UA75083C2 (uk)	2000-06-22	2006-03-15	Тераванс, Інк.	Похідні глікопептидфосфонатів
WO2001098329A1 (en)	2000-06-22	2001-12-27	Theravance, Inc.	Polyhydroxy glycopeptide derivatives
US6872804B2 (en)	2000-06-22	2005-03-29	Theravance, Inc.	Glycopeptide disulfide and thioester derivatives
GB0026924D0 (en) *	2000-11-03	2000-12-20	Univ Cambridge Tech	Antibacterial agents
TWI312785B (en)	2001-08-24	2009-08-01	Theravance Inc	Process for preparing vancomycin derivatives
TWI275594B (en)	2001-08-24	2007-03-11	Theravance Inc	Process for preparing vancomycin phosphonate derivatives
AU2003267962A1 (en) *	2002-05-31	2003-12-19	The Trustees Of The University Of Pennsylvania	Antibacterial compounds and methods for treating gram positive bacterial infections
US20070185015A1 (en) *	2005-02-28	2007-08-09	Chiron Corporation and North China Pharmaceutical Corporation	Semi-synthetic desmethyl-vancomycin-based glycopeptides with antibiotic activity
US7632918B2 (en) *	2005-02-28	2009-12-15	Novartis Vaccines And Diagnostics, Inc.	Semi-synthetic glycopeptides with antibiotic activity
US7368422B2 (en) *	2005-02-28	2008-05-06	Novartis Vaccines And Diagnostics Inc.	Semi-synthetic rearranged vancomycin/desmethyl-vancomycin-based glycopeptides with antibiotic activity
JP5178520B2 (ja)	2005-09-22	2013-04-10	メディバスエルエルシー	固体ポリマー送達組成物およびその使用法
CA2623198C (en)	2005-09-22	2014-08-05	Medivas, Llc	Bis-(a-amino)-diol-diester-containing poly(ester amide) and poly(ester urethane) compositions and methods of use
EP2260060A4 (de)	2008-04-01	2013-01-16	Univ Cornell	Organisch lösliche chitosansalze und daraus hergestellte chitosan-abgeleitete biomaterialien
CN102250221A (zh) *	2010-05-19	2011-11-23	复旦大学	万古霉素类衍生物及其制备方法和用途
CN102838661A (zh) *	2011-06-21	2012-12-26	复旦大学	万古霉素或去甲万古霉素类似物及其药用用途
US10294275B2 (en) *	2013-03-13	2019-05-21	Yale University	Site-selective functionalization of glycopeptide antibiotics
AU2014322817A1 (en)	2013-09-23	2016-04-21	Jawaharlal Nehru Centre for Advanced Scientific Research (JNCASR)	Vancomycin-sugar conjugates and uses thereof
AU2017348434B2 (en) *	2016-10-31	2021-10-07	The Scripps Research Institute	Peripheral modifications on pocket-redesigned vancomycin analogs synergistically improve antimicrobial potency and durability

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EG18377A (en) *	1986-09-19	1993-04-30	Lilly Co Eli	Process for preparing glycopeptide antibiotics
US4845194A (en) *	1987-02-27	1989-07-04	Eli Lilly And Company	Glycopeptide recovery process
US5071749A (en) *	1987-04-16	1991-12-10	Shionogi & Co., Ltd.	Glycopetide antibiotic pa-45052-b
US5534420A (en) *	1988-07-28	1996-07-09	Eli Lilly And Company	Biotransformation of glycopeptide antibiotics
CA1339808C (en) *	1988-10-19	1998-04-07	Manuel Debono	Glycopeptide antibiotics
US5194424A (en) *	1988-12-27	1993-03-16	Gruppo Lepetit Spa	C63 -amide derivatives of 34-de(acetylglucosaminyl)-34-deoxy-teicoplanin and their use as medicaments against bacteria resistant to glycopeptide antibiotics
ZA909847B (en) *	1989-12-13	1992-08-26	Lilly Co Eli	Glycopeptide derivatives
US5840684A (en) *	1994-01-28	1998-11-24	Eli Lilly And Company	Glycopeptide antibiotic derivatives
TW457248B (en) *	1994-01-28	2001-10-01	Lilly Co Eli	Glycopeptide antibiotic derivatives

1997
- 1997-05-01 US US08/847,069 patent/US5919756A/en not_active Expired - Fee Related
- 1997-06-25 EP EP97304495A patent/EP0816378B1/de not_active Expired - Lifetime
- 1997-06-25 AT AT97304495T patent/ATE215965T1/de not_active IP Right Cessation
- 1997-06-25 ES ES97304495T patent/ES2172749T3/es not_active Expired - Lifetime
- 1997-06-25 CA CA002258906A patent/CA2258906C/en not_active Expired - Fee Related
- 1997-06-25 DK DK97304495T patent/DK0816378T3/da active
- 1997-06-25 AU AU34111/97A patent/AU3411197A/en not_active Abandoned
- 1997-06-25 PT PT97304495T patent/PT816378E/pt unknown
- 1997-06-25 JP JP50427698A patent/JP4086318B2/ja not_active Expired - Fee Related
- 1997-06-25 DE DE69711766T patent/DE69711766T2/de not_active Expired - Fee Related
- 1997-06-25 WO PCT/US1997/011094 patent/WO1998000153A1/en not_active Ceased

Also Published As

Publication number	Publication date
CA2258906C (en)	2003-01-28
WO1998000153A1 (en)	1998-01-08
AU3411197A (en)	1998-01-21
DK0816378T3 (da)	2002-06-17
DE69711766T2 (de)	2002-11-07
JP4086318B2 (ja)	2008-05-14
EP0816378A1 (de)	1998-01-07
CA2258906A1 (en)	1998-01-08
US5919756A (en)	1999-07-06
HK1007884A1 (en)	1999-04-30
ES2172749T3 (es)	2002-10-01
EP0816378B1 (de)	2002-04-10
DE69711766D1 (de)	2002-05-16
PT816378E (pt)	2002-08-30
JP2001524929A (ja)	2001-12-04

Legal Events

Date	Code	Title	Description
2002-07-15	UEP	Publication of translation of european patent specification
2011-03-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
ATE215965T1 (de)	2002-04-15	Derivate von amiden glycopeptidischer antibiotica
NZ217555A (en)	1989-10-27	Amides of teicoplanin compounds and pharmaceutical compositions
FI932944A0 (fi)	1993-06-24	Amider av antibiot GE 2270 faktorer
AU4461193A (en)	1994-02-17	9-{substituted glycyl)amido}-6-demethyl-6-deoxyte tracyclines
NO951198D0 (no)	1995-03-29	Lipopeptidderivater, fremgangsmåte for fremstilling derav og anvendelse av derivatene
DE69816180D1 (de)	2003-08-14	Antibiotisch wirksame, alkylierte Hexapeptide
ES2136457T3 (es)	1999-11-16	Dimeros unidos covalentemente de antibioticos glucopeptidicos.
ES2140184T3 (es)	2000-02-16	Dimeros unidos covalentemente de antibioticos glicopeptidicos.
ES8705893A1 (es)	1987-05-16	Un procedimiento para preparar derivados monoamidicos basicos de actagardina
DE69818144D1 (de)	2003-10-23	Derivate des Antibiotikums A82846B (Chloroorienticin A)
MX9605773A (es)	1998-02-28	Compuestos de cefalosporina y procesos para la preparacion de los mismos.