ATE215988T1 - Vitamin-k-abhängige carboxylase - Google Patents

Vitamin-k-abhängige carboxylase

Info

Publication number
ATE215988T1
ATE215988T1 AT92913019T AT92913019T ATE215988T1 AT E215988 T1 ATE215988 T1 AT E215988T1 AT 92913019 T AT92913019 T AT 92913019T AT 92913019 T AT92913019 T AT 92913019T AT E215988 T1 ATE215988 T1 AT E215988T1
Authority
AT
Austria
Prior art keywords
vitamin
dependent carboxylase
carboxylase
isolated dna
dna
Prior art date
Application number
AT92913019T
Other languages
English (en)
Inventor
Darrell E Stafford
Sheue-Mei Wu
Original Assignee
Univ North Carolina
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ North Carolina filed Critical Univ North Carolina
Application granted granted Critical
Publication of ATE215988T1 publication Critical patent/ATE215988T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/88—Lyases (4.)

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
AT92913019T 1991-05-08 1992-05-08 Vitamin-k-abhängige carboxylase ATE215988T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US69742791A 1991-05-08 1991-05-08
US07/756,250 US5268275A (en) 1991-05-08 1991-09-09 Vitamin K-dependent carboxylase
PCT/US1992/003853 WO1992019636A1 (en) 1991-05-08 1992-05-08 Vitamin k-dependent carboxylase

Publications (1)

Publication Number Publication Date
ATE215988T1 true ATE215988T1 (de) 2002-04-15

Family

ID=27106020

Family Applications (1)

Application Number Title Priority Date Filing Date
AT92913019T ATE215988T1 (de) 1991-05-08 1992-05-08 Vitamin-k-abhängige carboxylase

Country Status (9)

Country Link
US (1) US5268275A (de)
EP (1) EP0587742B1 (de)
AT (1) ATE215988T1 (de)
AU (1) AU665199B2 (de)
CA (1) CA2102702C (de)
DE (1) DE69232544T2 (de)
DK (1) DK0587742T3 (de)
ES (1) ES2174835T3 (de)
WO (1) WO1992019636A1 (de)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19725796A1 (de) * 1997-06-18 1998-12-24 Basf Ag Herstellung optisch aktiver Phospholane, deren Metallkomplexe und Anwendung in der asymmetrischen Synthese
DE19824121A1 (de) 1998-05-29 1999-12-02 Basf Ag Herstellung optisch aktiver Phospholane, deren Metallkomplexe und Anwendung in der asymmetrischen Synthese
EP1325127B1 (de) 2000-10-02 2009-03-11 Novo Nordisk Health Care AG Verfahren zur herstellung vitamin-k-abhängiger proteine
WO2003014374A2 (en) * 2001-08-08 2003-02-20 University Of Utah Research Foundation CONUS η-CARBOXYLASE
PT2380985E (pt) 2003-09-23 2014-03-26 Univ North Carolina Células que expressam a vitamina k epóxido reductase e sua utilização
DK2189523T3 (da) 2003-10-14 2012-03-12 Baxter Int VKORC1 (vitamin K-epoxid-tilbageføringspolypeptid), et terapeutisk mål for coumarin og dets derivater
GB0324044D0 (en) 2003-10-14 2003-11-19 Astrazeneca Ab Protein
EP1831363A1 (de) * 2004-12-21 2007-09-12 Novo Nordisk Health Care AG Expression von gamma-carboxylierten polypeptiden in wirtssystemen mit gamma-carboxylierungsmangel
PT1853700E (pt) 2005-02-28 2013-01-14 Baxter Int Co-expressão recombinante da subunidade 1 da vitamina k epóxido redutase para melhorar a expressão de proteína dependente de vitamina
CA2601574C (en) 2005-03-15 2014-12-02 University Of North Carolina At Chapel Hill Methods and compositions for producing active vitamin k-dependent proteins
WO2006110083A1 (en) 2005-04-13 2006-10-19 Astrazeneca Ab A host cell comprising a vector for production of proteins requiring gamma-carboxylation
PL1969127T5 (pl) * 2005-12-21 2018-02-28 Cnj Holdings, Inc Metoda wytwarzania biologicznie czynnych białek zależnych od witaminy K metodami rekombinacji
CA3061952C (en) * 2006-03-09 2022-07-19 Aethlon Medical, Inc. Extracorporeal removal of microvesicular particles
CA2683423C (en) 2007-04-26 2020-10-27 Inspiration Biopharmaceuticals, Inc. Recombinant vitamin k dependent proteins with high sialic acid content and methods of preparing same
US8206967B2 (en) 2007-07-06 2012-06-26 Medimmune Limited Method for production of recombinant human thrombin
WO2009130602A2 (en) 2008-04-24 2009-10-29 Celtic Pharma Peg Ltd. Factor ix conjugates with extended half-lives
ES2475718T3 (es) 2009-07-10 2014-07-11 Csl Limited Método para incrementar el rendimiento de la expresión de proteínas dependientes de vitamina K
EP2655607A4 (de) 2010-12-21 2014-05-14 Univ North Carolina Verfahren und zusammensetzungen zur herstellung aktiver vitamin-k-abhängiger proteine
EP3617316A4 (de) 2017-04-27 2020-12-23 Chugai Seiyaku Kabushiki Kaisha Koagulationsfaktor ix mit verbesserter pharmakokinetik
CN109207462B (zh) * 2018-08-01 2021-05-11 深圳市新产业生物医学工程股份有限公司 异常凝血酶原及其制备方法和包含其的检测剂、试剂盒及应用

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4912038A (en) * 1984-12-11 1990-03-27 California Biotechnology Inc. Recombinant DNA sequence encoding alveolar surfactant protein
SE447863B (sv) * 1985-07-09 1986-12-22 Per Ostemar Anordning for formning och pressning av ostmassa
NL8600206A (nl) * 1986-01-29 1987-08-17 Univ Limburg Werkwijze voor het winnen van een vitamine k afhankelijk carboxylase-complex, werkwijze voor het bereiden van antilichamen ten aanzien van het vitamine k afhankelijke carboxylase/niet-gecarboxyleerde bloedstollingsfactoren-complex, dragermaterialen met dergelijke antilichamen, waaraan een carboxylase-complex is gebonden, werkwijze voor het carboxyleren van glutaminezuur bevattende exogene produkten met deze dragermaterialen alsmede de op met deze laatstgenoemde werkwijze verkregen produkten gebaseerde farmaceutische preparaten.
JPH01502080A (ja) * 1986-11-17 1989-07-27 ニュー・イングランド・メディカル・センター 組み換えビタミンｋ依存性蛋白質のガンマカルボキシル化の増強
WO1991001372A1 (en) * 1989-07-17 1991-02-07 New England Medical Center Hospitals, Inc. VITAMIN K-DEPENDENT η-CARBOXYLASE
EP0540650A1 (de) * 1990-07-23 1993-05-12 Zymogenetics, Inc. Gamma-carboxylase und methoden der anwendung

Also Published As

Publication number Publication date
EP0587742A1 (de) 1994-03-23
AU2006292A (en) 1992-12-21
EP0587742A4 (de) 1995-05-24
EP0587742B1 (de) 2002-04-10
AU665199B2 (en) 1995-12-21
DE69232544T2 (de) 2002-11-21
ES2174835T3 (es) 2002-11-16
CA2102702A1 (en) 1992-11-09
US5268275A (en) 1993-12-07
CA2102702C (en) 2000-09-26
DE69232544D1 (de) 2002-05-16
WO1992019636A1 (en) 1992-11-12
DK0587742T3 (da) 2002-08-05

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