ATE215988T1 - Vitamin-k-abhängige carboxylase - Google Patents

Vitamin-k-abhängige carboxylase

Info

Publication number
ATE215988T1
ATE215988T1 AT92913019T AT92913019T ATE215988T1 AT E215988 T1 ATE215988 T1 AT E215988T1 AT 92913019 T AT92913019 T AT 92913019T AT 92913019 T AT92913019 T AT 92913019T AT E215988 T1 ATE215988 T1 AT E215988T1
Authority
AT
Austria
Prior art keywords
vitamin
dependent carboxylase
carboxylase
isolated dna
dna
Prior art date
Application number
AT92913019T
Other languages
English (en)
Inventor
Darrell E Stafford
Sheue-Mei Wu
Original Assignee
Univ North Carolina
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ North Carolina filed Critical Univ North Carolina
Application granted granted Critical
Publication of ATE215988T1 publication Critical patent/ATE215988T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/88—Lyases (4.)

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
AT92913019T 1991-05-08 1992-05-08 Vitamin-k-abhängige carboxylase ATE215988T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US69742791A 1991-05-08 1991-05-08
US07/756,250 US5268275A (en) 1991-05-08 1991-09-09 Vitamin K-dependent carboxylase
PCT/US1992/003853 WO1992019636A1 (en) 1991-05-08 1992-05-08 Vitamin k-dependent carboxylase

Publications (1)

Publication Number Publication Date
ATE215988T1 true ATE215988T1 (de) 2002-04-15

Family

ID=27106020

Family Applications (1)

Application Number Title Priority Date Filing Date
AT92913019T ATE215988T1 (de) 1991-05-08 1992-05-08 Vitamin-k-abhängige carboxylase

Country Status (9)

Country Link
US (1) US5268275A (de)
EP (1) EP0587742B1 (de)
AT (1) ATE215988T1 (de)
AU (1) AU665199B2 (de)
CA (1) CA2102702C (de)
DE (1) DE69232544T2 (de)
DK (1) DK0587742T3 (de)
ES (1) ES2174835T3 (de)
WO (1) WO1992019636A1 (de)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19725796A1 (de) * 1997-06-18 1998-12-24 Basf Ag Herstellung optisch aktiver Phospholane, deren Metallkomplexe und Anwendung in der asymmetrischen Synthese
DE19824121A1 (de) 1998-05-29 1999-12-02 Basf Ag Herstellung optisch aktiver Phospholane, deren Metallkomplexe und Anwendung in der asymmetrischen Synthese
BR0114373A (pt) 2000-10-02 2004-02-17 Novo Nordisk As Célula hospedeira eucariótica, métodos para a produção de fvii e de fviia ou de suas variantes, de uma proteìna dependente de vitamina k e de uma célula hospedeira eucariótica produtora de fvii ou de seu análogo, vetor recombinante, fvii e fviia recombinante ou suas variantes, e, proteìna dependente de vitamina k recombinante
US20030096361A1 (en) * 2001-08-08 2003-05-22 Cognetix, Inc. Conus gamma-carboxylase
DE602004025157D1 (de) 2003-09-23 2010-03-04 Univ North Carolina Zellen, die Vitamin-K-Reduktase und Vitamin-K-abhängiges Protein coexprimieren und deren Anwendung zur Verbesserung der Produktivität von diesem Vitamin-K-abhängigen Protein
GB0324044D0 (en) 2003-10-14 2003-11-19 Astrazeneca Ab Protein
DE602004026897D1 (de) 2003-10-14 2010-06-10 Baxter Healthcare Sa Vkorc1 (vitamin k epoxide recycling polypeptide), ein therapeutisches ziel für coumarin und deren derivate
US20090100533A1 (en) * 2004-12-21 2009-04-16 Novo Nordisk Health Care Ag Expression of gamma-carboxylated polypeptides in gamma-carboxylation deficient host sytems
PL1853700T3 (pl) 2005-02-28 2013-05-31 Baxalta Inc Koekspresja przez rekombinowanie podjednostki 1 reduktazy epoksydu witaminy K w celu poprawy ekspresji białka zależnego od witaminy K
CA2601574C (en) 2005-03-15 2014-12-02 University Of North Carolina At Chapel Hill Methods and compositions for producing active vitamin k-dependent proteins
CN101198696B (zh) 2005-04-13 2014-02-26 阿斯利康(瑞典)有限公司 包含产生需要γ-羧化的蛋白质用的载体的宿主细胞
AU2006331501B2 (en) * 2005-12-21 2013-09-05 Aptevo Biotherapeutics Llc Method of producing biologically active vitamin K dependent proteins by recombinant methods
DK3517151T3 (da) * 2006-03-09 2021-07-12 Aethlon Medical Inc Ekstrakorporal fjernelse af mikrovesikulære partikler
JP6050927B2 (ja) 2007-04-26 2016-12-21 シーエヌジェイ ホールディングス，インコーポレイテッド 高シアル酸含量を有する組換えビタミンｋ依存性タンパク質およびその調製方法
US8206967B2 (en) 2007-07-06 2012-06-26 Medimmune Limited Method for production of recombinant human thrombin
DK2280734T3 (da) 2008-04-24 2014-05-26 Cantab Biopharmaceuticals Patents Ltd Faktor-ix-konjugater med forlængede halveringstider
EP2451963B1 (de) 2009-07-10 2014-04-30 CSL Limited Verfahren zur erhöhung des expressionsertrags von vitamin-k-abhängigen proteinen
US9631002B2 (en) 2010-12-21 2017-04-25 The University Of North Carolina At Chapel Hill Methods and compositions for producing active vitamin K-dependent proteins
EP3617316A4 (de) 2017-04-27 2020-12-23 Chugai Seiyaku Kabushiki Kaisha Koagulationsfaktor ix mit verbesserter pharmakokinetik
CN109207462B (zh) * 2018-08-01 2021-05-11 深圳市新产业生物医学工程股份有限公司 异常凝血酶原及其制备方法和包含其的检测剂、试剂盒及应用

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4912038A (en) * 1984-12-11 1990-03-27 California Biotechnology Inc. Recombinant DNA sequence encoding alveolar surfactant protein
SE447863B (sv) * 1985-07-09 1986-12-22 Per Ostemar Anordning for formning och pressning av ostmassa
NL8600206A (nl) * 1986-01-29 1987-08-17 Univ Limburg Werkwijze voor het winnen van een vitamine k afhankelijk carboxylase-complex, werkwijze voor het bereiden van antilichamen ten aanzien van het vitamine k afhankelijke carboxylase/niet-gecarboxyleerde bloedstollingsfactoren-complex, dragermaterialen met dergelijke antilichamen, waaraan een carboxylase-complex is gebonden, werkwijze voor het carboxyleren van glutaminezuur bevattende exogene produkten met deze dragermaterialen alsmede de op met deze laatstgenoemde werkwijze verkregen produkten gebaseerde farmaceutische preparaten.
AU8339187A (en) * 1986-11-17 1988-06-16 New England Medical Center Hospitals, Inc., The Enhancing gamma-carboxylation of recombinant vitamin k-dependent proteins
WO1991001372A1 (en) * 1989-07-17 1991-02-07 New England Medical Center Hospitals, Inc. VITAMIN K-DEPENDENT η-CARBOXYLASE
AU8427091A (en) * 1990-07-23 1992-02-18 Zymogenetics Inc. Gamma-carboxylase and methods of use

Also Published As

Publication number Publication date
EP0587742B1 (de) 2002-04-10
AU2006292A (en) 1992-12-21
ES2174835T3 (es) 2002-11-16
AU665199B2 (en) 1995-12-21
DK0587742T3 (da) 2002-08-05
CA2102702A1 (en) 1992-11-09
DE69232544T2 (de) 2002-11-21
US5268275A (en) 1993-12-07
EP0587742A4 (de) 1995-05-24
EP0587742A1 (de) 1994-03-23
DE69232544D1 (de) 2002-05-16
WO1992019636A1 (en) 1992-11-12
CA2102702C (en) 2000-09-26

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