ATE216236T1 - Metronidazolpräparate mit modifizierter freisetzung und verfahren für ihre herstellung und verwendung - Google Patents

Metronidazolpräparate mit modifizierter freisetzung und verfahren für ihre herstellung und verwendung

Info

Publication number: ATE216236T1
Authority: AT; Austria
Prior art keywords: metronidazole; aqueous; methods; aqueous soluble; compositions
Prior art date: 1994-01-27

Application number

AT95907963T

Other languages

English (en)

Inventor

Subhash Desai

Alan Mark Mancini

Steven Charles Schumann

Original Assignee

Searle & Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-01-27

Filing date

1995-01-04

Publication date

2002-05-15

1995-01-04 Application filed by Searle & Co filed Critical Searle & Co

2002-05-15 Application granted granted Critical

2002-05-15 Publication of ATE216236T1 publication Critical patent/ATE216236T1/de

Links

VAOCPAMSLUNLGC-UHFFFAOYSA-N metronidazole Chemical compound CC1=NC=C([N+]([O-])=O)N1CCO VAOCPAMSLUNLGC-UHFFFAOYSA-N 0.000 title abstract 8
229960000282 metronidazole Drugs 0.000 title abstract 8
238000000034 method Methods 0.000 title abstract 3
238000004519 manufacturing process Methods 0.000 title 1
238000002360 preparation method Methods 0.000 title 1
239000003085 diluting agent Substances 0.000 abstract 4
239000000203 mixture Substances 0.000 abstract 3
239000008194 pharmaceutical composition Substances 0.000 abstract 3
239000008187 granular material Substances 0.000 abstract 2
229920002845 Poly(methacrylic acid) Polymers 0.000 abstract 1
229920001577 copolymer Polymers 0.000 abstract 1
239000012729 immediate-release (IR) formulation Substances 0.000 abstract 1
208000015181 infectious disease Diseases 0.000 abstract 1
239000000314 lubricant Substances 0.000 abstract 1
230000000813 microbial effect Effects 0.000 abstract 1
239000008024 pharmaceutical diluent Substances 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Epidemiology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Communicable Diseases (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
Oncology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicinal Preparation (AREA)

AT95907963T 1994-01-27 1995-01-04 Metronidazolpräparate mit modifizierter freisetzung und verfahren für ihre herstellung und verwendung ATE216236T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US08/187,568 US6103262A (en)	1994-01-27	1994-01-27	Modified-release metronidazole compositions and methods for making and using same
PCT/US1995/000005 WO1995020383A1 (en)	1994-01-27	1995-01-04	Modified-release metronidazole compositions and methods for making and using same

Publications (1)

Publication Number	Publication Date
ATE216236T1 true ATE216236T1 (de)	2002-05-15

Family

ID=22689500

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT95907963T ATE216236T1 (de)	1994-01-27	1995-01-04	Metronidazolpräparate mit modifizierter freisetzung und verfahren für ihre herstellung und verwendung

Country Status (16)

Country	Link
US (2)	US6103262A (de)
EP (1)	EP0744947B1 (de)
JP (1)	JPH09508381A (de)
KR (1)	KR100368769B1 (de)
CN (1)	CN1095665C (de)
AT (1)	ATE216236T1 (de)
AU (1)	AU682248B2 (de)
BR (1)	BR9506662A (de)
CA (1)	CA2181985C (de)
DE (1)	DE69526434T2 (de)
DK (1)	DK0744947T3 (de)
ES (1)	ES2174930T3 (de)
MX (1)	MX9602951A (de)
NZ (1)	NZ279368A (de)
PT (1)	PT744947E (de)
WO (1)	WO1995020383A1 (de)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU8588898A (en)	1997-07-28	1999-02-16	Mary L. Redmond	Composition and process for the treatment of epidermal traumas such as decubitusulcers
US6322819B1 (en) *	1998-10-21	2001-11-27	Shire Laboratories, Inc.	Oral pulsed dose drug delivery system
DE19850445A1 (de) *	1998-11-02	2000-05-04	Falk Pharma Gmbh	Arzneimittel zur topischen Behandlung entzündlicher Darmerkrankungen
ECSP003851A (es) *	1999-12-22	2002-05-23	Pharmacia Corp	Composicon de liberacion doble de un inhibidor ciclooxigenasa-2
US6423707B1 (en)	2000-08-28	2002-07-23	California Pacific Medical Center	Nitroimidazole ester analogues and therapeutic applications
US8846100B2 (en) *	2006-05-12	2014-09-30	Shire Llc	Controlled dose drug delivery system
WO2012075015A2 (en)	2010-11-29	2012-06-07	Dr. Reddy's Laboratories Ltd.	Oral metronidazole pharmaceutical compositions
EP2806861A1 (de) *	2012-01-23	2014-12-03	Ranbaxy Laboratories Limited	In-situ-mehrschichttablettentechnologie
JP6487534B2 (ja)	2014-09-05	2019-03-20	シンビオミックスセラピューティクス、エルエルシー	細菌性膣炎の治療に使用するためのセクニダゾール
US11253501B2 (en)	2015-06-01	2022-02-22	Lupin Inc.	Secnidazole formulations and use in treating bacterial vaginosis
US11547675B2 (en) *	2015-08-10	2023-01-10	Purdue Research Foundation	Methods and systems for depositing active ingredients on substrates
GR1008992B (el)	2015-12-17	2017-03-23	Verisfield (Uk) Ltd, Υποκαταστημα Ελλαδας, Εμπορια Φαρμακων	Φαρμακευτικη συνθεση σε μορφη κοκκιων για χορηγηση απο το στομα που περιεχει μετρονιδαζολη ή παραγωγα αυτης και εναν παραγοντα καλυψης της γευσης
CN112007002B (zh) *	2020-08-05	2022-08-12	河北君临药业有限公司	一种质量稳定的甲硝唑片剂组合物及其制备方法
US12280037B2 (en)	2020-09-22	2025-04-22	Evofem Biosciences, Inc.	Method and pharmaceutical composition for treating or preventing trichomoniasis and uses thereof
US11826477B1 (en) *	2022-06-17	2023-11-28	Imam Abdulrahman Bin Faisal University	Metal organic framework/porous silicate and/or aluminosilicate nanocarrier for blastocystosis treatment

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US2944061A (en) *	1957-09-20	1960-07-05		Acyl derivatives and process
FI63335B (fi) *	1979-02-02	1983-02-28	Orion Yhtymae Oy	Foerfarande foer framstaellning av tabletter med foerdroejd loslighet av effektaemne
JPS6056122B2 (ja) *	1980-05-21	1985-12-09	塩野義製薬株式会社	徐放性製剤
GB8707416D0 (en) *	1987-03-27	1987-04-29	Wellcome Found	Pharmaceutical formulations
US4927639A (en) *	1989-02-02	1990-05-22	Warner-Lambert Company	Modified release gemfibrozil composition
DE4125048A1 (de) *	1991-07-29	1993-02-04	Peggy Albrecht	Arzneimittel mit verzoegerter freisetzung zur behandlung von periodontitis
CA2093282C (en) *	1992-05-04	1999-01-12	Tibor Sipos	Intraoral medicament-releasing device

1994
- 1994-01-27 US US08/187,568 patent/US6103262A/en not_active Expired - Fee Related
1995
- 1995-01-04 CA CA002181985A patent/CA2181985C/en not_active Expired - Fee Related
- 1995-01-04 WO PCT/US1995/000005 patent/WO1995020383A1/en not_active Ceased
- 1995-01-04 KR KR1019960703863A patent/KR100368769B1/ko not_active Expired - Fee Related
- 1995-01-04 NZ NZ279368A patent/NZ279368A/en unknown
- 1995-01-04 DK DK95907963T patent/DK0744947T3/da active
- 1995-01-04 BR BR9506662A patent/BR9506662A/pt not_active IP Right Cessation
- 1995-01-04 JP JP7520048A patent/JPH09508381A/ja not_active Ceased
- 1995-01-04 MX MX9602951A patent/MX9602951A/es not_active IP Right Cessation
- 1995-01-04 ES ES95907963T patent/ES2174930T3/es not_active Expired - Lifetime
- 1995-01-04 DE DE69526434T patent/DE69526434T2/de not_active Expired - Fee Related
- 1995-01-04 CN CN95191364A patent/CN1095665C/zh not_active Expired - Fee Related
- 1995-01-04 PT PT95907963T patent/PT744947E/pt unknown
- 1995-01-04 AT AT95907963T patent/ATE216236T1/de not_active IP Right Cessation
- 1995-01-04 EP EP95907963A patent/EP0744947B1/de not_active Expired - Lifetime
- 1995-01-04 AU AU15967/95A patent/AU682248B2/en not_active Ceased
- 1995-05-19 US US08/445,309 patent/US5618559A/en not_active Expired - Lifetime

Also Published As

Publication number	Publication date
DE69526434T2 (de)	2002-10-31
CN1095665C (zh)	2002-12-11
CN1139382A (zh)	1997-01-01
AU1596795A (en)	1995-08-15
NZ279368A (en)	1998-04-27
WO1995020383A1 (en)	1995-08-03
MX9602951A (es)	1997-06-28
JPH09508381A (ja)	1997-08-26
EP0744947A1 (de)	1996-12-04
ES2174930T3 (es)	2002-11-16
US5618559A (en)	1997-04-08
CA2181985C (en)	2000-12-05
US6103262A (en)	2000-08-15
DE69526434D1 (de)	2002-05-23
KR100368769B1 (ko)	2003-05-16
AU682248B2 (en)	1997-09-25
DK0744947T3 (da)	2002-07-29
CA2181985A1 (en)	1995-08-03
EP0744947B1 (de)	2002-04-17
PT744947E (pt)	2002-08-30
BR9506662A (pt)	1997-11-18

Legal Events

Date	Code	Title	Description
2002-07-15	UEP	Publication of translation of european patent specification
2006-10-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
DE69526434D1 (de)	2002-05-23	Metronidazolpräparate mit modifizierter freisetzung und verfahren für ihre herstellung und verwendung
IL111647A0 (en)	1995-01-24	Microencapsulated 3-piperidinyl-substituted 1,2-benzisoxazoles and 1,2-benzisothiazoles, their preparation and pharmaceutical compositions containing them
KR950702409A (ko)	1995-07-29	방출 조절 모르핀 제제(controlled release morphine preparation)
DE69104991D1 (de)	1994-12-08	Mometason-furoate-monohydrat, verfahren zu seiner herstellung und das enthaltende pharmazeutische zusammensetzungen.
CA2268097A1 (en)	1999-04-15	Sulfinic acid derivatives and their preparation and use
ATE219499T1 (de)	2002-07-15	Lipopeptid-derivate, verfahren zu ihrer herstellung und ihre verwendung
DE59409794D1 (de)	2001-08-02	Benzoylguanidine, ihre herstellung und ihre verwendung in arzneimitteln
MXPA04011914A (es)	2005-03-31	Formulacion farmaceutica de liberacion modificada.
MY139606A (en)	2009-10-30	Sustained-release composition and process for producing the same
DE60202958D1 (de)	2005-03-17	Stabiles polymorph von flibanserin, industrielles verfahren zu dessen herstellung und dessen verwendung zur herstellung von medikamenten
DE69726457D1 (de)	2004-01-08	Pharmazeutische zusammensetzungen mit antimikrobieller wirkung
BR0007589A (pt)	2002-10-15	Inibidores da proliferação de células
WO2002062767A1 (en)	2002-08-15	Novel quinazoline derivatives
ATE164578T1 (de)	1998-04-15	Verzweigte aminothiazole-derivate, verfahren zu ihrer herstellung und pharmazeutische zusammenstellungen die sie enthalten
IL112020A0 (en)	1995-03-15	Arylacetic acid derivatives, their preparation and their use as fungicides
RU95111308A (ru)	1996-12-27	Производные 2-амино-4-фенил-4-оксомасляной кислоты, способы получения, фармацевтическая композиция
MX9708696A (es)	1998-08-30	Cefalosporinas antibacterianas.
ATE237610T1 (de)	2003-05-15	Substituierte dimere carboxamid-derivate, verfahren zu ihrer herstellung und sie enthaltende pharmazeutische zubereitungen
DE69410614D1 (de)	1998-07-02	Bis-naphthalimide für die behandlung von krebs
PT1534352E (pt)	2008-11-13	Implante para transporte e libertação de agentes farmacologicamente activos e processo para a sua produção
WO2001017955A3 (en)	2001-06-21	Hydroxyacetamidobenzenesulphonamide derivatives
FI954786A0 (fi)	1995-10-06	Menetelmä aminometaanifosfonihapon valmistamiseksi
EP0173950A3 (de)	1987-10-28	Neuer alpha-Glukosidase Inhibitor, Verfahren zur seiner Herstellung, seine Verwendung und pharmazeutische Präparate
ATE100102T1 (de)	1994-01-15	Substituierte derivate von 20,21dinoreburnamenin, verfahren zur herstellung und so hergestellte zwischenprodukte, ihre verwendung als arzneimittel und diese enthaltende pharmazeutische zusammenstellungen.
ATE112276T1 (de)	1994-10-15	Aryl-chinolyl-substituierte 1,4-dihydropyridin- dicarbonsäurederivate, verfahren zu ihrer herstellung und ihre verwendung in arzneimitteln.