ATE216382T1 - Verfahren zur herstellung von 5-methoxy-2-((4- methoxy-3,5-dimethyl-2-pyrydyl)methyl)sulfinyl- h-benzimidazol - Google Patents

Verfahren zur herstellung von 5-methoxy-2-((4- methoxy-3,5-dimethyl-2-pyrydyl)methyl)sulfinyl- h-benzimidazol

Info

Publication number: ATE216382T1
Authority: AT; Austria
Prior art keywords: methoxy; benzimidazole; dimethyl; methyl; sulfinyl
Prior art date: 1998-07-13

Application number

AT99930107T

Other languages

English (en)

Inventor

Milac Natasa Hafner

Darja Jereb

Original Assignee

Lek Tovarna Farmacevtskih

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-07-13

Filing date

1999-07-12

Publication date

2002-05-15

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=20432301&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE216382(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1999-07-12 Application filed by Lek Tovarna Farmacevtskih filed Critical Lek Tovarna Farmacevtskih

2002-05-15 Application granted granted Critical

2002-05-15 Publication of ATE216382T1 publication Critical patent/ATE216382T1/de

Links

238000004519 manufacturing process Methods 0.000 title 1
WCYWZMWISLQXQU-UHFFFAOYSA-N methyl Chemical class [CH3] WCYWZMWISLQXQU-UHFFFAOYSA-N 0.000 title 1
SUBDBMMJDZJVOS-UHFFFAOYSA-N 5-methoxy-2-{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl}-1H-benzimidazole Chemical compound N=1C2=CC(OC)=CC=C2NC=1S(=O)CC1=NC=C(C)C(OC)=C1C SUBDBMMJDZJVOS-UHFFFAOYSA-N 0.000 abstract 3
XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 abstract 3
229960000381 omeprazole Drugs 0.000 abstract 2
NHQDETIJWKXCTC-UHFFFAOYSA-N 3-chloroperbenzoic acid Chemical compound OOC(=O)C1=CC=CC(Cl)=C1 NHQDETIJWKXCTC-UHFFFAOYSA-N 0.000 abstract 1
XURCIPRUUASYLR-UHFFFAOYSA-N Omeprazole sulfide Chemical compound N=1C2=CC(OC)=CC=C2NC=1SCC1=NC=C(C)C(OC)=C1C XURCIPRUUASYLR-UHFFFAOYSA-N 0.000 abstract 1
230000015572 biosynthetic process Effects 0.000 abstract 1
239000012043 crude product Substances 0.000 abstract 1
238000004090 dissolution Methods 0.000 abstract 1
239000012467 final product Substances 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
230000003647 oxidation Effects 0.000 abstract 1
238000007254 oxidation reaction Methods 0.000 abstract 1
238000000746 purification Methods 0.000 abstract 1
238000001226 reprecipitation Methods 0.000 abstract 1
238000003786 synthesis reaction Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B41/00—Formation or introduction of functional groups containing oxygen
- C07B41/06—Formation or introduction of functional groups containing oxygen of carbonyl groups

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Engineering & Computer Science (AREA)
Pharmacology & Pharmacy (AREA)
Bioinformatics & Cheminformatics (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Plural Heterocyclic Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

AT99930107T 1998-07-13 1999-07-12 Verfahren zur herstellung von 5-methoxy-2-((4- methoxy-3,5-dimethyl-2-pyrydyl)methyl)sulfinyl- h-benzimidazol ATE216382T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
SI9800196A SI20019A (sl)	1998-07-13	1998-07-13	Izboljšan postopek sinteze 5-metoksi -2-/(4-metoksi-3,5-dimetil-2-piridil)metil/ sulfinil-1H-benzimidazola
PCT/SI1999/000020 WO2000002876A1 (en)	1998-07-13	1999-07-12	Improved process of synthesis of 5-methoxy- 2-[(4-methoxy- 3,5-dimethyl- 2-pyridyl)methyl]sulfinyl-1h-benzimidazole

Publications (1)

Publication Number	Publication Date
ATE216382T1 true ATE216382T1 (de)	2002-05-15

Family

ID=20432301

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT99930107T ATE216382T1 (de)	1998-07-13	1999-07-12	Verfahren zur herstellung von 5-methoxy-2-((4- methoxy-3,5-dimethyl-2-pyrydyl)methyl)sulfinyl- h-benzimidazol

Country Status (13)

Country	Link
US (2)	US6268502B1 (de)
EP (1)	EP1095037B2 (de)
AT (1)	ATE216382T1 (de)
AU (1)	AU4671499A (de)
CZ (1)	CZ293653B6 (de)
DE (1)	DE69901307D1 (de)
HU (1)	HUP0102523A2 (de)
NZ (1)	NZ509000A (de)
PL (1)	PL202167B1 (de)
RU (1)	RU2197486C2 (de)
SI (2)	SI20019A (de)
SK (1)	SK286432B6 (de)
WO (1)	WO2000002876A1 (de)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE19951960C2 (de) *	1999-10-28	2002-06-27	Gruenenthal Gmbh	Verfahren zur Herstellung als Ulkustherapeutika geeigneter Benzimidazol-Derivate
CZ20032351A3 (cs) *	2001-02-02	2004-08-18	Tevaápharmaceuticaláindustriesáltd	Způsob výroby substituovaných @@}@@pyridylmethylB sulfinyl @�H@benzimidazolů
SI20875A (sl) *	2001-04-25	2002-10-31	LEK, tovarna farmacevtskih in kemi�nih izdelkov, d.d.	Kristalna oblika omeprazola
HU230155B1 (hu) *	2001-07-16	2015-09-28	Janssen Pharmaceutica N.V.	Javított eljárás benzimidazol típusú vegyületek előállítására
KR100873419B1 (ko) *	2002-06-18	2008-12-11	페어차일드코리아반도체 주식회사	높은 항복 전압, 낮은 온 저항 및 작은 스위칭 손실을갖는 전력용 반도체 소자
EP1764364A1 (de) *	2002-08-21	2007-03-21	Teva Pharmaceutical Industries Ltd	Eine Methode zur Reinigung von Lansoprazol
EP1501824B1 (de) *	2002-08-21	2007-10-10	Teva Pharmaceutical Industries Ltd	Verfahren zur aufreinigung von lanzoprazol
SE0203092D0 (en)	2002-10-18	2002-10-18	Astrazeneca Ab	Method for the synthesis of a benzimidazole compound
EP1743893A1 (de) *	2002-11-18	2007-01-17	Teva Pharmaceutical Industries Ltd.	Stabiles Lansoprazol, enthaltend mehr als 500 ppm bis zu 3000 ppm Wasser und mehr als 200 ppm bis zu 5000 ppm Alkohol
AU2003294405A1 (en) *	2002-11-18	2004-06-15	Teva Pharmaceutical Industries Ltd.	Stable lansoprazole containing more than 500 ppm, up to about 3,000 ppm water and more than 200 ppm, up to about 5,000 ppm alcohol
CA2515130A1 (en) *	2003-02-05	2004-08-26	Teva Pharmaceutical Industries Ltd.	Method of stabilizing lansoprazole
WO2006040635A1 (en) *	2004-10-11	2006-04-20	Ranbaxy Laboratories Limited	Processes for the preparation of substituted sulfoxides
EP1801110A1 (de)	2005-12-22	2007-06-27	KRKA, tovarna zdravil, d.d., Novo mesto	Argininsalz des Esomeprazols
RU2339631C1 (ru) *	2007-04-12	2008-11-27	Новосибирский институт органической химии им. Н.Н. Ворожцова СО РАН (НИОХ СО РАН)	Способ получения эзомепразола

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
SE7804231L (sv) *	1978-04-14	1979-10-15	Haessle Ab	Magsyrasekretionsmedel
US4472409A (en) *	1981-11-05	1984-09-18	Byk Gulden Lomberg Chemische Fabrik Gesellschaft Mit Beschrankter Haftung	2-Pyridylmethyl thio(sulfinyl)benzimidazoles with gastric acid secretion inhibiting effects
JPS6150978A (ja) *	1984-08-16	1986-03-13	Takeda Chem Ind Ltd	ピリジン誘導体およびその製造法
SE9002043D0 (sv) *	1990-06-07	1990-06-07	Astra Ab	Improved method for synthesis
SE521100C2 (sv) *	1995-12-15	2003-09-30	Astra Ab	Förfarande för framställning av en bensimidazolförening
SE510666C2 (sv) *	1996-12-20	1999-06-14	Astra Ab	Nya Kristallmodifikationer
UA72748C2 (en) *	1998-11-10	2005-04-15	Astrazeneca Ab	A novel crystalline form of omeprazole

1998
- 1998-07-13 SI SI9800196A patent/SI20019A/sl not_active IP Right Cessation
1999
- 1999-07-12 AT AT99930107T patent/ATE216382T1/de active
- 1999-07-12 HU HU0102523A patent/HUP0102523A2/hu unknown
- 1999-07-12 SI SI9930057T patent/SI1095037T2/sl unknown
- 1999-07-12 RU RU2001103900/04A patent/RU2197486C2/ru not_active IP Right Cessation
- 1999-07-12 CZ CZ2001123A patent/CZ293653B6/cs not_active IP Right Cessation
- 1999-07-12 DE DE69901307T patent/DE69901307D1/de not_active Expired - Lifetime
- 1999-07-12 PL PL345543A patent/PL202167B1/pl not_active IP Right Cessation
- 1999-07-12 NZ NZ509000A patent/NZ509000A/en not_active IP Right Cessation
- 1999-07-12 SK SK25-2001A patent/SK286432B6/sk not_active IP Right Cessation
- 1999-07-12 EP EP99930107A patent/EP1095037B2/de not_active Expired - Lifetime
- 1999-07-12 AU AU46714/99A patent/AU4671499A/en not_active Abandoned
- 1999-07-12 WO PCT/SI1999/000020 patent/WO2000002876A1/en not_active Ceased
- 1999-07-12 US US09/463,651 patent/US6268502B1/en not_active Expired - Lifetime
2001
- 2001-07-30 US US09/919,068 patent/US20020007069A1/en not_active Abandoned

Also Published As

Publication number	Publication date
PL202167B1 (pl)	2009-06-30
PL345543A1 (en)	2001-12-17
CZ2001123A3 (en)	2001-05-16
EP1095037A1 (de)	2001-05-02
EP1095037B2 (de)	2007-08-08
SI1095037T2 (sl)	2007-10-31
SK252001A3 (en)	2001-07-10
EP1095037B1 (de)	2002-04-17
US20020007069A1 (en)	2002-01-17
SI20019A (sl)	2000-02-29
SK286432B6 (sk)	2008-10-07
DE69901307D1 (de)	2002-05-23
WO2000002876A1 (en)	2000-01-20
RU2197486C2 (ru)	2003-01-27
CZ293653B6 (cs)	2004-06-16
NZ509000A (en)	2001-12-21
US6268502B1 (en)	2001-07-31
AU4671499A (en)	2000-02-01
HUP0102523A2 (hu)	2001-11-28
SI1095037T1 (en)	2002-08-31

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