ATE216699T1 - Ein itraconazol mit einer verbesserten löslichkeit, ein verfahren zu seiner herstellung und eine pharmazeutische zusammensetzung zur oralen verabreichung, die dieses enthält - Google Patents

Ein itraconazol mit einer verbesserten löslichkeit, ein verfahren zu seiner herstellung und eine pharmazeutische zusammensetzung zur oralen verabreichung, die dieses enthält

Info

Publication number
ATE216699T1
ATE216699T1 AT98929878T AT98929878T ATE216699T1 AT E216699 T1 ATE216699 T1 AT E216699T1 AT 98929878 T AT98929878 T AT 98929878T AT 98929878 T AT98929878 T AT 98929878T AT E216699 T1 ATE216699 T1 AT E216699T1
Authority
AT
Austria
Prior art keywords
itraconazole
production
pharmaceutical composition
same
oral administration
Prior art date
Application number
AT98929878T
Other languages
English (en)
Inventor
Bong-Jin Cha
Jun-Gyo Oh
Su-Eon Kim
Original Assignee
Dong A Pharm Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dong A Pharm Co Ltd filed Critical Dong A Pharm Co Ltd
Application granted granted Critical
Publication of ATE216699T1 publication Critical patent/ATE216699T1/de

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10Antimycotics

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Plural Heterocyclic Compounds (AREA)
AT98929878T 1997-06-16 1998-06-16 Ein itraconazol mit einer verbesserten löslichkeit, ein verfahren zu seiner herstellung und eine pharmazeutische zusammensetzung zur oralen verabreichung, die dieses enthält ATE216699T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR1019970024938A KR19990001564A (ko) 1997-06-16 1997-06-16 용해도를 개선한 아졸계 항진균제 및 이를 함유하는 제제
PCT/KR1998/000164 WO1998057967A1 (en) 1997-06-16 1998-06-16 An itraconazole exhibiting an improved solubility, a method of preparing the same and a pharmaceutical composition for oral administration comprising the same

Publications (1)

Publication Number Publication Date
ATE216699T1 true ATE216699T1 (de) 2002-05-15

Family

ID=19509733

Family Applications (1)

Application Number Title Priority Date Filing Date
AT98929878T ATE216699T1 (de) 1997-06-16 1998-06-16 Ein itraconazol mit einer verbesserten löslichkeit, ein verfahren zu seiner herstellung und eine pharmazeutische zusammensetzung zur oralen verabreichung, die dieses enthält

Country Status (17)

Country Link
US (1) US6346533B1 (de)
EP (1) EP0991646B1 (de)
JP (1) JP2002504930A (de)
KR (1) KR19990001564A (de)
CN (1) CN1129598C (de)
AT (1) ATE216699T1 (de)
AU (1) AU7939298A (de)
BR (1) BR9810124A (de)
CA (1) CA2294398A1 (de)
DE (1) DE69805070T2 (de)
DK (1) DK0991646T3 (de)
ES (1) ES2177022T3 (de)
HU (1) HUP0004050A3 (de)
PL (1) PL338631A1 (de)
PT (1) PT991646E (de)
WO (1) WO1998057967A1 (de)
YU (1) YU66799A (de)

Families Citing this family (55)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2251985T3 (es) 1999-03-24 2006-05-16 R.P. Scherer Technologies, Inc. Particula granulada para mejorar la solubilidad acuosa de farmacos, y su procedimiento de preparacion.
IT1312115B1 (it) * 1999-06-24 2002-04-04 Nicox Sa Composti amorfi e relative composizioni farmaceutiche
KR100694667B1 (ko) * 1999-12-08 2007-03-14 동아제약주식회사 생체내이용률 향상과 개인간 및 개인내 흡수 편차를감소시킨 이트라코나졸 함유 항진균성 제제
KR20010097244A (ko) * 2000-04-21 2001-11-08 유충식 위산도 비의존성 고용해도를 갖는 이트라코나졸 함유약학적 조성물 및 그 제조방법
KR100432949B1 (ko) * 2000-06-13 2004-05-31 코오롱제약주식회사 생체이용율이 향상된 이트라코나졸의 분립체 조성물과이를 이용한 이트라코나졸 제제 및 그 제조방법
US9700866B2 (en) * 2000-12-22 2017-07-11 Baxter International Inc. Surfactant systems for delivery of organic compounds
NZ526608A (en) * 2000-12-22 2006-06-30 Baxter Int Method for preparing submicron particle suspensions
US7193084B2 (en) * 2000-12-22 2007-03-20 Baxter International Inc. Polymorphic form of itraconazole
US7037528B2 (en) 2000-12-22 2006-05-02 Baxter International Inc. Microprecipitation method for preparing submicron suspensions
US6951656B2 (en) 2000-12-22 2005-10-04 Baxter International Inc. Microprecipitation method for preparing submicron suspensions
US6884436B2 (en) * 2000-12-22 2005-04-26 Baxter International Inc. Method for preparing submicron particle suspensions
US20050048126A1 (en) * 2000-12-22 2005-03-03 Barrett Rabinow Formulation to render an antimicrobial drug potent against organisms normally considered to be resistant to the drug
US20030096013A1 (en) * 2000-12-22 2003-05-22 Jane Werling Preparation of submicron sized particles with polymorph control
US8067032B2 (en) 2000-12-22 2011-11-29 Baxter International Inc. Method for preparing submicron particles of antineoplastic agents
US20040256749A1 (en) * 2000-12-22 2004-12-23 Mahesh Chaubal Process for production of essentially solvent-free small particles
US6977085B2 (en) 2000-12-22 2005-12-20 Baxter International Inc. Method for preparing submicron suspensions with polymorph control
US20040173147A1 (en) * 2001-06-07 2004-09-09 Figueroa Iddys D. Application of a bioactive agent to a delivery substrate
US6962715B2 (en) * 2001-10-24 2005-11-08 Hewlett-Packard Development Company, L.P. Method and dosage form for dispensing a bioactive substance
US20040173146A1 (en) * 2001-06-07 2004-09-09 Figueroa Iddys D. Application of a bioactive agent to a delivery substrate
WO2002100407A1 (en) * 2001-06-12 2002-12-19 Smartrix Technologies Inc. Itraconazole granulations: pharmaceutical formulations for oral administration and method of preparing same
US7163700B2 (en) 2001-07-31 2007-01-16 Capricorn Pharma, Inc. Amorphous drug beads
KR100438485B1 (ko) * 2001-08-13 2004-07-09 한국디디에스제약 주식회사 아졸류 항진균제의 약제학적 조성물
BR0212833A (pt) * 2001-09-26 2004-10-13 Baxter Int Preparação de nanopartìculas de tamanho submìcron através de dispersão e de remoção de solvente ou de fase lìquida
US20060003012A9 (en) 2001-09-26 2006-01-05 Sean Brynjelsen Preparation of submicron solid particle suspensions by sonication of multiphase systems
US7112340B2 (en) 2001-10-19 2006-09-26 Baxter International Inc. Compositions of and method for preparing stable particles in a frozen aqueous matrix
CA2363376A1 (en) * 2001-11-16 2003-05-16 Bernard Charles Sherman Solid pharmaceutical compositions for oral administration comprising itraconazole
US7927613B2 (en) 2002-02-15 2011-04-19 University Of South Florida Pharmaceutical co-crystal compositions
US7446107B2 (en) 2002-02-15 2008-11-04 Transform Pharmaceuticals, Inc. Crystalline forms of conazoles and methods of making and using the same
US7790905B2 (en) 2002-02-15 2010-09-07 Mcneil-Ppc, Inc. Pharmaceutical propylene glycol solvate compositions
AU2003213719A1 (en) 2002-03-01 2003-09-16 Regents Of The University Of Michigan Multiple-component solid phases containing at least one active pharmaceutical ingredient
KR20040098023A (ko) * 2002-03-26 2004-11-18 테바 파마슈티컬 인더스트리즈 리미티드 약물 미세입자
EP1511490A4 (de) 2002-05-31 2009-03-11 Transform Pharmaceuticals Inc Neue kristalline conazol-formen und verwandte prozesse, pharmazeutische zusammensetzungen und verfahren
IL165383A0 (en) 2002-06-21 2006-01-15 Transform Pharmaceuticals Inc Pharmaceutical compositions with improved dissolution
KR100557680B1 (ko) * 2002-11-23 2006-03-07 한국유나이티드제약 주식회사 이트라코나졸의 용해도 개선을 위한 펠렛제제 및 그제조방법
US8183290B2 (en) 2002-12-30 2012-05-22 Mcneil-Ppc, Inc. Pharmaceutically acceptable propylene glycol solvate of naproxen
DE60312635T3 (de) * 2003-01-14 2013-05-08 Cimex Pharma Ag Zusammensetzung in Form eines festen Dispersion enthaltend Itraconazol und ein hydrophilisches Polymer mit einer verbesserten Bioverfügbarkeit
GB0319797D0 (en) * 2003-08-26 2003-09-24 Leuven K U Res & Dev Particle size reduction of poorly soluble drugs
AU2004275764B2 (en) * 2003-09-22 2010-01-14 Baxter Healthcare S.A. High-pressure sterilization to terminally sterilize pharmaceutical preparations and medical products
US20050118265A1 (en) * 2003-11-28 2005-06-02 Anandi Krishnan Antifungal oral dosage forms and the methods for preparation
SK50782006A3 (sk) 2004-02-26 2007-03-01 Zentiva, A. S. Amorfné formy risedronátu monosodného
CN1294912C (zh) * 2004-03-01 2007-01-17 上海医药工业研究院 伊曲康唑盐酸盐组合物及其冻干粉针
US20050202051A1 (en) * 2004-03-15 2005-09-15 Chinea Vanessa I. Pharmaceutical vehicle
US20050203482A1 (en) * 2004-03-15 2005-09-15 Chinea Vanessa I. Pharmaceutical dispensing apparatus and method
CA2598204C (en) 2004-11-09 2015-01-13 Board Of Regents, The University Of Texas System Stabilized hme composition with small drug particles
US20060182777A1 (en) * 2005-02-15 2006-08-17 Steve Kangas Method of modulating drug release from a coated substrate
WO2006138202A2 (en) * 2005-06-14 2006-12-28 Baxter International Inc. Pharmaceutical formulations for minimizing drug-drug interactions
US20070134341A1 (en) * 2005-11-15 2007-06-14 Kipp James E Compositions of lipoxygenase inhibitors
WO2008080047A2 (en) * 2006-12-23 2008-07-03 Baxter International Inc. Magnetic separation of fine particles from compositions
US20080293814A1 (en) * 2007-05-22 2008-11-27 Deepak Tiwari Concentrate esmolol
US8426467B2 (en) * 2007-05-22 2013-04-23 Baxter International Inc. Colored esmolol concentrate
US8722736B2 (en) * 2007-05-22 2014-05-13 Baxter International Inc. Multi-dose concentrate esmolol with benzyl alcohol
GB0818403D0 (en) * 2008-10-08 2008-11-12 Univ Leuven Kath Aqueous electrophoretic deposition
WO2010040648A2 (en) * 2008-10-06 2010-04-15 Katholieke Universiteit Leuven, K.U.Leuven R&D Functional layers of biomolecules and living cells, and a novel system to produce such
CN104224687A (zh) * 2014-09-28 2014-12-24 武汉药谷生物工程有限公司 硝酸异康唑阴道栓及其制备方法
PL447909A1 (pl) * 2024-03-01 2025-09-08 Uniwersytet Śląski W Katowicach Sposób otrzymywania itrakonazolu w stabilnej fazie nematycznej

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4218458A (en) 1978-06-23 1980-08-19 Janssen Pharmaceutica, N.V. Heterocyclic derivatives of (4-aryloxy-methyl-1,3-dioxolan-2-yl)methyl-1H-imidazoles and 1H-1,2,4-triazoles
US4368200A (en) 1978-06-23 1983-01-11 Janssen Pharmaceutica N.V. Heterocyclic derivatives of (4-phenyl-piperazine-1-yl-aryloxymethyl-1,3-dioxolan-2-yl)-methyl-1H-imidazoles and 1H-1,2,4-triazoles
US4490530A (en) 1981-01-14 1984-12-25 Janssen Pharmaceutica N.V. Heterocyclic derivatives of (4-phenylpiperazin-1-yl-aryloxymethyl-1,3-dioxolan-2-yl)-methyl-1H-imidazoles and 1H-1,2,4-triazoles
JPS60139688A (ja) * 1983-12-28 1985-07-24 Tokyo Tanabe Co Ltd 無定形ジヒドロピリジン粉末製剤
GB8506792D0 (en) 1985-03-15 1985-04-17 Janssen Pharmaceutica Nv Derivatives of y-cyclodextrin
US4870060A (en) 1985-03-15 1989-09-26 Janssen Pharmaceutica Derivatives of γ-cylodextrin
PH30929A (en) * 1992-09-03 1997-12-23 Janssen Pharmaceutica Nv Beads having a core coated with an antifungal and a polymer.
CA2154777A1 (en) 1993-01-27 1994-08-04 Nancy M. Gray Method and composition employing (2r,4s) itraconazole
IT1263831B (it) * 1993-01-29 1996-09-04 Paolo Chiesi Complessi di inclusione multicomponente ad elevata solubilita' costituiti da un farmaco di tipo basico, un acido ed una ciclodestrina
TW438601B (en) * 1994-05-18 2001-06-07 Janssen Pharmaceutica Nv New mucoadhesive emulsion compositions and a process for the preparation thereof
FR2722984B1 (fr) * 1994-07-26 1996-10-18 Effik Lab Procede de preparation de formes pharmaceutiques seches et les compositions pharmaceutiques ainsi realisees
US5750147A (en) * 1995-06-07 1998-05-12 Emisphere Technologies, Inc. Method of solubilizing and encapsulating itraconazole
BR9611562A (pt) * 1995-11-23 1999-03-02 Janssen Pharmaceutica Nv Misturas sólidas de ciclodextrinas preparadas via extrusão sob fusão
US5686133A (en) * 1996-01-31 1997-11-11 Port Systems, L.L.C. Water soluble pharmaceutical coating and method for producing coated pharmaceuticals
WO1997044014A1 (en) * 1996-05-20 1997-11-27 Janssen Pharmaceutica N.V. Antifungal compositions with improved bioavailability

Also Published As

Publication number Publication date
JP2002504930A (ja) 2002-02-12
ES2177022T3 (es) 2002-12-01
DE69805070D1 (de) 2002-05-29
HUP0004050A3 (en) 2003-03-28
PT991646E (pt) 2002-08-30
KR19990001564A (ko) 1999-01-15
CA2294398A1 (en) 1998-12-23
CN1129598C (zh) 2003-12-03
EP0991646A1 (de) 2000-04-12
DK0991646T3 (da) 2002-06-10
DE69805070T2 (de) 2002-11-07
YU66799A (sh) 2002-06-19
CN1262682A (zh) 2000-08-09
EP0991646B1 (de) 2002-04-24
HUP0004050A2 (hu) 2001-06-28
PL338631A1 (en) 2000-11-06
AU7939298A (en) 1999-01-04
WO1998057967A1 (en) 1998-12-23
BR9810124A (pt) 2000-08-08
US6346533B1 (en) 2002-02-12

Similar Documents

Publication Publication Date Title
ATE216699T1 (de) Ein itraconazol mit einer verbesserten löslichkeit, ein verfahren zu seiner herstellung und eine pharmazeutische zusammensetzung zur oralen verabreichung, die dieses enthält
DE3880762D1 (de) Orale, acetaminophen enthaltende zusammensetzung mit gesteuerter arzneistoff-freisetzung und verfahren zu ihrer herstellung.
ATE231882T1 (de) 7alpha-(epsilon-aminoalkyl)-estratriene, verfahren zu deren herstellung, pharmazeutische präparate, die diese 7alpha-(epsilon-aminoalkyl)- estratriene enthalten sowie deren verwendung zur herstellung von arzneimitteln
HU9701416D0 (en) Phenyl-substituted guanidides of alkenyl-carboxylic acids, process for producing them, their use as medicine or diagnostics, and pharmaceutical compositions containing them
ATE235507T1 (de) Neue aminosäurederivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende pharmazeutische zusammensetzungen
ATE197801T1 (de) Benzazepin-, benzoxazepin- und benzothiazepin-n- essigsäure-derivate sowie verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
ATE252562T1 (de) Pyrazolcarbonsäurederivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische zusammensetzungen
AU2323897A (en) Cyclopropyl alkanoic acid derivatives
DE60100186D1 (de) Orale pharmazeutische formulierungen von benzimidazolderivaten und verfahren zu ihrer herstellung
ATE220898T1 (de) Nifedipinzubereitung mit langanhaltender freisetzung
DE59710629D1 (de) Stabile arzneiform mit benzimidazolderivaten als wirkstoff zur oralen verabreichung und verfahren zu ihrer herstellung
ATE249435T1 (de) Neue kristalline form gamma des tert-butylamin salzes von perindopril, verfahren zu deren herstellung und dieses enthaltende arzneimittel
ATE198152T1 (de) Oral anzuwendende arzneizubereitung mit verzögerter wirkstoffabgabe
DE59608169D1 (de) Verfahren zur Herstellung einer liposomalen, in Wasser dispergierbaren, oral zu verabreichenden, festen, trockenen therapeutischen Formulierung
ATE429903T1 (de) Pharmazeutische zubereitung mit verzögerter wirkstoff-freisetzung enthaltend milchsäure- glycolsäure copolymer, und verfahren zu deren herstellung
ATE189888T1 (de) Vitamin d-derivate mit substituenten an c-25, verfahren zu ihrer herstellung, zwischenprodukte und die verwendung zur herstellung von arzneimitteln
ATA90122000A (de) Stabilisierte orale pharmazeutische zusammensetzung, die jodid und jodat enthält und verfahren zu deren herstellung
DE3874358D1 (de) 4-(3h)-chinazolinon-derivate, verfahren zu ihrer herstellung und pharmazeutische zusammensetzungen.
DE68909412D1 (de) Salze von glykosaminoglykanen, verfahren zu ihrer herstellung und diese salze enthaltende pharmazeutische zusammensetzungen.
SK1452000A3 (en) Pyrrolidine-3-carboxylic acid derivatives and their use as endothelin antagonists
DE59608606D1 (de) Cyclosprorin(e) enthaltende pharmazeutische zubereitung zur oralen applikation und verfahren zu ihrer herstellung
ATE23266T1 (de) Pharmazeutische produkte in formen mit verzoegerter abgabe und verfahren an deren herstellung.
LV10256B (en) Novel acylale of imidazole-5-carboxylic acid derivatives, process for producing thereof and using same
DE69114721D1 (de) Verfahren zur herstellung einer festen dosierungseinheit zur verzögerten freigabe.
EP0329008A3 (de) Cephalosporinderivative und Verfahren zu ihrer Herstellung

Legal Events

Date Code Title Description
REN Ceased due to non-payment of the annual fee