ATE216989T1 - Trennung von octahydroisochinoline enantiomeren - Google Patents

Trennung von octahydroisochinoline enantiomeren

Info

Publication number: ATE216989T1
Authority: AT; Austria
Prior art keywords: octahydroisocinoline; enantiomers; separation; racemic; octahydroisoquinoline
Prior art date: 1997-09-17

Application number

AT98944648T

Other languages

English (en)

Inventor

Iulia Demian

Kenneth D Stanley

Original Assignee

B I Chemicals Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-09-17

Filing date

1998-09-02

Publication date

2002-05-15

1998-09-02 Application filed by B I Chemicals Inc filed Critical B I Chemicals Inc

2002-05-15 Application granted granted Critical

2002-05-15 Publication of ATE216989T1 publication Critical patent/ATE216989T1/de

Links

HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical compound C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 title 1
238000000926 separation method Methods 0.000 title 1
BDAGIHXWWSANSR-UHFFFAOYSA-N methanoic acid Natural products OC=O BDAGIHXWWSANSR-UHFFFAOYSA-N 0.000 abstract 2
239000000203 mixture Substances 0.000 abstract 2
NPEVCJZMQGZNET-UHFFFAOYSA-N 1-[(4-methoxyphenyl)methyl]-1,2,3,4,5,6,7,8-octahydroisoquinoline Chemical compound C1=CC(OC)=CC=C1CC1C(CCCC2)=C2CCN1 NPEVCJZMQGZNET-UHFFFAOYSA-N 0.000 abstract 1
OSWFIVFLDKOXQC-UHFFFAOYSA-N 4-(3-methoxyphenyl)aniline Chemical compound COC1=CC=CC(C=2C=CC(N)=CC=2)=C1 OSWFIVFLDKOXQC-UHFFFAOYSA-N 0.000 abstract 1
235000019253 formic acid Nutrition 0.000 abstract 1
238000002955 isolation Methods 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
- C07D217/18—Aralkyl radicals
- C07D217/20—Aralkyl radicals with oxygen atoms directly attached to the aromatic ring of said aralkyl radical, e.g. papaverine

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Epoxy Compounds (AREA)
Other In-Based Heterocyclic Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

AT98944648T 1997-09-17 1998-09-02 Trennung von octahydroisochinoline enantiomeren ATE216989T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US5919397P	1997-09-17	1997-09-17
PCT/US1998/018134 WO1999014198A1 (en)	1997-09-17	1998-09-02	Separation of enantiomers of octahydroisoquinoline

Publications (1)

Publication Number	Publication Date
ATE216989T1 true ATE216989T1 (de)	2002-05-15

Family

ID=22021401

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT98944648T ATE216989T1 (de)	1997-09-17	1998-09-02	Trennung von octahydroisochinoline enantiomeren

Country Status (10)

Country	Link
US (1)	US6063925A (de)
EP (1)	EP1015432B1 (de)
JP (1)	JP2001516746A (de)
AT (1)	ATE216989T1 (de)
CA (1)	CA2303972A1 (de)
DE (1)	DE69805193T2 (de)
DK (1)	DK1015432T3 (de)
ES (1)	ES2173615T3 (de)
PT (1)	PT1015432E (de)
WO (1)	WO1999014198A1 (de)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP1023269A4 (de) *	1997-09-30	2001-06-27	Molecular Design Int	Beta3-adrenoreceptor-agonisten, agonist-zubereitungen und verfahren zu ihrer verwendung
US6593341B2 (en)	2001-03-29	2003-07-15	Molecular Design International, Inc.	β3-adrenoreceptor agonists, agonist compositions and methods of making and using the same
US6596734B1 (en)	2002-10-11	2003-07-22	Molecular Design International, Inc.	Tetrahydroisoquinoline compounds for use as β3-adrenoreceptor agonists

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3436179A1 (de) *	1984-10-03	1986-04-10	Merck Patent Gmbh, 6100 Darmstadt	Verfahren zur herstellung optisch aktiver amine
JPH11508903A (ja) *	1995-07-11	1999-08-03	ロンザアーゲー	光学活性１−（ｐ−メトキシベンジル）−１，２，３，４，５，６，７，８−オクタヒドロイソキノリンの製造方法

1998
- 1998-09-02 PT PT98944648T patent/PT1015432E/pt unknown
- 1998-09-02 DE DE69805193T patent/DE69805193T2/de not_active Expired - Fee Related
- 1998-09-02 WO PCT/US1998/018134 patent/WO1999014198A1/en not_active Ceased
- 1998-09-02 JP JP2000511749A patent/JP2001516746A/ja active Pending
- 1998-09-02 EP EP98944648A patent/EP1015432B1/de not_active Expired - Lifetime
- 1998-09-02 DK DK98944648T patent/DK1015432T3/da active
- 1998-09-02 ES ES98944648T patent/ES2173615T3/es not_active Expired - Lifetime
- 1998-09-02 AT AT98944648T patent/ATE216989T1/de not_active IP Right Cessation
- 1998-09-02 US US09/146,124 patent/US6063925A/en not_active Expired - Fee Related
- 1998-09-02 CA CA002303972A patent/CA2303972A1/en not_active Abandoned

Also Published As

Publication number	Publication date
JP2001516746A (ja)	2001-10-02
US6063925A (en)	2000-05-16
PT1015432E (pt)	2002-09-30
DE69805193D1 (de)	2002-06-06
DE69805193T2 (de)	2003-05-15
EP1015432A1 (de)	2000-07-05
CA2303972A1 (en)	1999-03-25
EP1015432B1 (de)	2002-05-02
WO1999014198A1 (en)	1999-03-25
ES2173615T3 (es)	2002-10-16
DK1015432T3 (da)	2002-07-08

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Legal Events

Date	Code	Title	Description
2004-06-15	REN	Ceased due to non-payment of the annual fee