ATE216994T1 - Derivate von benzo(1,2-c)pyrrol als inhibitoren der serotonin wideraufnahme - Google Patents

Derivate von benzo(1,2-c)pyrrol als inhibitoren der serotonin wideraufnahme

Info

Publication number: ATE216994T1
Authority: AT; Austria
Prior art keywords: alkyl; aryl; cycloalkyl; benzo; alkenyl
Prior art date: 1999-03-26

Application number

AT00400812T

Other languages

English (en)

Inventor

Jean-Louis Peglion

Bertrand Goument

Aimee Dessinges

Mark Millan

Jean-Michel Rivet

Anne Dekeyne

Original Assignee

Servier Lab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-03-26

Filing date

2000-03-24

Publication date

2002-05-15

2000-03-24 Application filed by Servier Lab filed Critical Servier Lab

2002-05-15 Application granted granted Critical

2002-05-15 Publication of ATE216994T1 publication Critical patent/ATE216994T1/de

Links

VHMICKWLTGFITH-UHFFFAOYSA-N 2H-isoindole Chemical class C1=CC=CC2=CNC=C21 VHMICKWLTGFITH-UHFFFAOYSA-N 0.000 title 1
239000003772 serotonin uptake inhibitor Substances 0.000 title 1
125000000217 alkyl group Chemical group 0.000 abstract 15
125000003118 aryl group Chemical group 0.000 abstract 13
125000000753 cycloalkyl group Chemical group 0.000 abstract 10
125000003342 alkenyl group Chemical group 0.000 abstract 4
125000003545 alkoxy group Chemical group 0.000 abstract 4
125000001072 heteroaryl group Chemical group 0.000 abstract 4
125000000304 alkynyl group Chemical group 0.000 abstract 3
229910052736 halogen Inorganic materials 0.000 abstract 3
125000000592 heterocycloalkyl group Chemical group 0.000 abstract 3
229910052757 nitrogen Inorganic materials 0.000 abstract 3
229910052760 oxygen Inorganic materials 0.000 abstract 3
125000004104 aryloxy group Chemical group 0.000 abstract 2
125000004122 cyclic group Chemical group 0.000 abstract 2
125000005843 halogen group Chemical group 0.000 abstract 2
125000005842 heteroatom Chemical group 0.000 abstract 2
150000003233 pyrroles Chemical class 0.000 abstract 2
229910052717 sulfur Inorganic materials 0.000 abstract 2
125000002827 triflate group Chemical group FC(S(=O)(=O)O*)(F)F 0.000 abstract 2
125000004385 trihaloalkyl group Chemical group 0.000 abstract 2
YBYIRNPNPLQARY-UHFFFAOYSA-N 1H-indene Natural products C1=CC=C2CC=CC2=C1 YBYIRNPNPLQARY-UHFFFAOYSA-N 0.000 abstract 1
125000005073 adamantyl group Chemical group C12(CC3CC(CC(C1)C3)C2)* 0.000 abstract 1
125000002619 bicyclic group Chemical group 0.000 abstract 1
125000004432 carbon atom Chemical group C* 0.000 abstract 1
125000005046 dihydronaphthyl group Chemical group 0.000 abstract 1
150000002367 halogens Chemical class 0.000 abstract 1
125000003392 indanyl group Chemical group C1(CCC2=CC=CC=C12)* 0.000 abstract 1
125000003454 indenyl group Chemical group C1(C=CC2=CC=CC=C12)* 0.000 abstract 1
238000004519 manufacturing process Methods 0.000 abstract 1
125000002950 monocyclic group Chemical group 0.000 abstract 1
125000001624 naphthyl group Chemical group 0.000 abstract 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
229920006395 saturated elastomer Polymers 0.000 abstract 1
125000001712 tetrahydronaphthyl group Chemical group C1(CCCC2=CC=CC=C12)* 0.000 abstract 1
125000004952 trihaloalkoxy group Chemical group 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/58—[b]- or [c]-condensed
- C07D209/70—[b]- or [c]-condensed containing carbocyclic rings other than six-membered
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Engineering & Computer Science (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Psychiatry (AREA)
Addiction (AREA)
Pain & Pain Management (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Pyrrole Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Indole Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

AT00400812T 1999-03-26 2000-03-24 Derivate von benzo(1,2-c)pyrrol als inhibitoren der serotonin wideraufnahme ATE216994T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
FR9903811A FR2791345B1 (fr)	1999-03-26	1999-03-26	Nouveaux derives du benzo[3,4]cyclobuta[1,2-c]pyrrole, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Publications (1)

Publication Number	Publication Date
ATE216994T1 true ATE216994T1 (de)	2002-05-15

Family

ID=9543685

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT00400812T ATE216994T1 (de)	1999-03-26	2000-03-24	Derivate von benzo(1,2-c)pyrrol als inhibitoren der serotonin wideraufnahme

Country Status (21)

Country	Link
US (1)	US6153640A (de)
EP (1)	EP1038873B1 (de)
JP (1)	JP3256788B2 (de)
KR (1)	KR100427127B1 (de)
CN (1)	CN1166638C (de)
AT (1)	ATE216994T1 (de)
AU (1)	AU762990B2 (de)
BR (1)	BR0001420A (de)
CA (1)	CA2301787C (de)
DE (1)	DE60000142T2 (de)
DK (1)	DK1038873T3 (de)
EA (1)	EA003302B1 (de)
ES (1)	ES2176156T3 (de)
FR (1)	FR2791345B1 (de)
HU (1)	HUP0001246A3 (de)
NO (1)	NO315513B1 (de)
NZ (1)	NZ503588A (de)
PL (1)	PL339203A1 (de)
PT (1)	PT1038873E (de)
SI (1)	SI1038873T1 (de)
ZA (1)	ZA200001501B (de)

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DK136420B (da) *	1972-09-29	1977-10-10	Sandoz Ag	Analogifremgangsmåde til fremstilling af isoindolinforbindelser.
US4171369A (en) *	1972-09-29	1979-10-16	Sandoz Ltd.	Hydro-4-phenyl-benz[f]isoindoline compounds
US4314081A (en) *	1974-01-10	1982-02-02	Eli Lilly And Company	Arloxyphenylpropylamines
EP0170093B1 (de) *	1984-07-25	1990-03-07	Abbott Laboratories	1,2,3,3a,8,8a-Hexahydro-Indeno-(1,2-c)Pyrrde
US4622405A (en) *	1984-07-25	1986-11-11	Abbott Laboratories	1,2,3,3a,8,8a-hexahydro-indeno[1,2-c]pyrroles useful in the treatment of hypertension
EP0223403B1 (de) *	1985-10-25	1993-08-04	Beecham Group Plc	Piperidinderivat, seine Herstellung und seine Verwendung als Arzneimittel
US5049564A (en) *	1989-11-17	1991-09-17	Abbott Laboratories	5-HT selective agents
GB9012469D0 (en) *	1990-06-05	1990-07-25	Glaxo Group Ltd	Medicaments
US5574060A (en) *	1993-08-12	1996-11-12	The United States Of America As Represented By The Department Of Health And Human Services	Selective inhibitors of biogenic amine transporters
DE4341402A1 (de) *	1993-12-04	1995-06-08	Basf Ag	N-substituierte Azabicycloheptan-Derivate, ihre Herstellung und Verwendung

1999
- 1999-03-26 FR FR9903811A patent/FR2791345B1/fr not_active Expired - Fee Related
2000
- 2000-03-23 US US09/533,684 patent/US6153640A/en not_active Expired - Fee Related
- 2000-03-24 BR BR0001420-6A patent/BR0001420A/pt not_active Application Discontinuation
- 2000-03-24 SI SI200030008T patent/SI1038873T1/xx unknown
- 2000-03-24 DE DE60000142T patent/DE60000142T2/de not_active Expired - Fee Related
- 2000-03-24 CA CA002301787A patent/CA2301787C/fr not_active Expired - Fee Related
- 2000-03-24 PL PL00339203A patent/PL339203A1/xx not_active Application Discontinuation
- 2000-03-24 ES ES00400812T patent/ES2176156T3/es not_active Expired - Lifetime
- 2000-03-24 AT AT00400812T patent/ATE216994T1/de not_active IP Right Cessation
- 2000-03-24 HU HU0001246A patent/HUP0001246A3/hu unknown
- 2000-03-24 EA EA200000260A patent/EA003302B1/ru not_active IP Right Cessation
- 2000-03-24 NO NO20001542A patent/NO315513B1/no unknown
- 2000-03-24 DK DK00400812T patent/DK1038873T3/da active
- 2000-03-24 KR KR10-2000-0015002A patent/KR100427127B1/ko not_active Expired - Fee Related
- 2000-03-24 JP JP2000083880A patent/JP3256788B2/ja not_active Expired - Fee Related
- 2000-03-24 PT PT00400812T patent/PT1038873E/pt unknown
- 2000-03-24 ZA ZA200001501A patent/ZA200001501B/xx unknown
- 2000-03-24 AU AU22579/00A patent/AU762990B2/en not_active Ceased
- 2000-03-24 EP EP00400812A patent/EP1038873B1/de not_active Expired - Lifetime
- 2000-03-24 CN CNB001083325A patent/CN1166638C/zh not_active Expired - Fee Related
- 2000-03-24 NZ NZ503588A patent/NZ503588A/xx unknown

Also Published As

Publication number	Publication date
NO315513B1 (no)	2003-09-15
EA003302B1 (ru)	2003-04-24
JP2000290253A (ja)	2000-10-17
AU762990B2 (en)	2003-07-10
ZA200001501B (en)	2000-10-24
FR2791345B1 (fr)	2001-05-04
PT1038873E (pt)	2002-09-30
DE60000142D1 (de)	2002-06-06
DK1038873T3 (da)	2002-08-19
BR0001420A (pt)	2000-10-10
HU0001246D0 (en)	2000-06-28
SI1038873T1 (en)	2002-08-31
PL339203A1 (en)	2000-10-09
HK1031380A1 (en)	2001-06-15
CN1274718A (zh)	2000-11-29
EP1038873A2 (de)	2000-09-27
EP1038873A3 (de)	2000-10-04
HUP0001246A3 (en)	2002-02-28
NO20001542L (no)	2000-09-27
NZ503588A (en)	2000-12-22
US6153640A (en)	2000-11-28
NO20001542D0 (no)	2000-03-24
KR20010006863A (ko)	2001-01-26
DE60000142T2 (de)	2002-12-12
KR100427127B1 (ko)	2004-04-17
JP3256788B2 (ja)	2002-02-12
HUP0001246A2 (hu)	2001-01-29
AU2257900A (en)	2000-09-28
EA200000260A2 (ru)	2000-12-25
CA2301787A1 (fr)	2000-09-26
ES2176156T3 (es)	2002-12-01
CN1166638C (zh)	2004-09-15
FR2791345A1 (fr)	2000-09-29
EP1038873B1 (de)	2002-05-02
CA2301787C (fr)	2004-11-02

Legal Events

Date	Code	Title	Description
2002-10-15	UEP	Publication of translation of european patent specification
2009-12-15	REN	Ceased due to non-payment of the annual fee

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ES443519A1 (es)	1977-08-16	Procedimiento para la obtencion de derivados de benz (f) i- soindolina.