HUP0001246A2 - Benzo[3,4]ciklobuta[1,2-c]pirrol-származékok, eljárás azok előállítására és ilyen származékokat tartalmazó gyógyszerkészítmények - Google Patents

Benzo[3,4]ciklobuta[1,2-c]pirrol-származékok, eljárás azok előállítására és ilyen származékokat tartalmazó gyógyszerkészítmények

Info

Publication number
HUP0001246A2
HUP0001246A2 HU0001246A HUP0001246A HUP0001246A2 HU P0001246 A2 HUP0001246 A2 HU P0001246A2 HU 0001246 A HU0001246 A HU 0001246A HU P0001246 A HUP0001246 A HU P0001246A HU P0001246 A2 HUP0001246 A2 HU P0001246A2
Authority
HU
Hungary
Prior art keywords
group
alkyl group
compounds
general formula
cyclobuta
Prior art date
Application number
HU0001246A
Other languages
English (en)
Inventor
Anne Dekeyne
Aimée Dessinges
Bertrand Goument
Mark Millan
Jean-Louis Peglion
Jean-Michel Rivet
Original Assignee
Adir Et Compagnie
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Adir Et Compagnie filed Critical Adir Et Compagnie
Publication of HU0001246D0 publication Critical patent/HU0001246D0/hu
Publication of HUP0001246A2 publication Critical patent/HUP0001246A2/hu
Publication of HUP0001246A3 publication Critical patent/HUP0001246A3/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/58—[b]- or [c]-condensed
    • C07D209/70—[b]- or [c]-condensed containing carbocyclic rings other than six-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Addiction (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Atalálmány új benzo[3,4]ciklobuta[1,2-c]pirrol-származékokra, azokelőállítására alkalmas eljárásra és ilyen származékokat tartalmazógyógyszerkészítményekre vonatkozik. Atalálmány szerinti vegyületek (I)általános képletében - R1, R2 és R3 jelentése egymástól függetlenül aleírásban részletesen megadott; - R4 jelentése hidrogénatom,alkilcsoport, alkenilcsoport, alkinilcsoport, cikloalkilcsoport,cikloalkil-alkil-csoport, arilcsoport, aril-alkil-csoport,heterociklusos alkilcsoport, heterociklusos alkil-alkil-csoport,heteroarilcsoport vagy heteroaril-alkil-csoport; - R5 jelentése adottesetben szubsztituált aril- vagy heteroarilcsoport; és - n jelentése -a határértékeket is beleértve - 1és 3közötti egész szám. A találmányvonatkozik az (I) általános képletű vegyületek izomereire ésfarmakológiai szempontból elfogadható savakkal vagy bázisokkalalkotott sóira is. Atalálmány tárgyát képezik az (I) általános képletűvegyületeket, azok izomereit vagy farmakológiai szempontbólelfogadható savakkal vagy bázisokkal alkotott sóit tartalmazógyógyszerkészítmények is. Avegyületek gátolják a szerotoninújrafelvételét. Ó
HU0001246A 1999-03-26 2000-03-24 Benzo[3,4]cyclobuta[1,2-c]pyrrole derivatives, process for their production and medicaments containing them HUP0001246A3 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9903811A FR2791345B1 (fr) 1999-03-26 1999-03-26 Nouveaux derives du benzo[3,4]cyclobuta[1,2-c]pyrrole, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Publications (3)

Publication Number Publication Date
HU0001246D0 HU0001246D0 (en) 2000-06-28
HUP0001246A2 true HUP0001246A2 (hu) 2001-01-29
HUP0001246A3 HUP0001246A3 (en) 2002-02-28

Family

ID=9543685

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0001246A HUP0001246A3 (en) 1999-03-26 2000-03-24 Benzo[3,4]cyclobuta[1,2-c]pyrrole derivatives, process for their production and medicaments containing them

Country Status (21)

Country Link
US (1) US6153640A (hu)
EP (1) EP1038873B1 (hu)
JP (1) JP3256788B2 (hu)
KR (1) KR100427127B1 (hu)
CN (1) CN1166638C (hu)
AT (1) ATE216994T1 (hu)
AU (1) AU762990B2 (hu)
BR (1) BR0001420A (hu)
CA (1) CA2301787C (hu)
DE (1) DE60000142T2 (hu)
DK (1) DK1038873T3 (hu)
EA (1) EA003302B1 (hu)
ES (1) ES2176156T3 (hu)
FR (1) FR2791345B1 (hu)
HU (1) HUP0001246A3 (hu)
NO (1) NO315513B1 (hu)
NZ (1) NZ503588A (hu)
PL (1) PL339203A1 (hu)
PT (1) PT1038873E (hu)
SI (1) SI1038873T1 (hu)
ZA (1) ZA200001501B (hu)

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK136420B (da) * 1972-09-29 1977-10-10 Sandoz Ag Analogifremgangsmåde til fremstilling af isoindolinforbindelser.
US4171369A (en) * 1972-09-29 1979-10-16 Sandoz Ltd. Hydro-4-phenyl-benz[f]isoindoline compounds
US4314081A (en) * 1974-01-10 1982-02-02 Eli Lilly And Company Arloxyphenylpropylamines
EP0170093B1 (en) * 1984-07-25 1990-03-07 Abbott Laboratories 1,2,3,3a,8,8a-hexahydro-indeno-(1,2-c)pyrrdes
US4622405A (en) * 1984-07-25 1986-11-11 Abbott Laboratories 1,2,3,3a,8,8a-hexahydro-indeno[1,2-c]pyrroles useful in the treatment of hypertension
EP0223403B1 (en) * 1985-10-25 1993-08-04 Beecham Group Plc Piperidine derivative, its preparation, and its use as medicament
US5049564A (en) * 1989-11-17 1991-09-17 Abbott Laboratories 5-HT selective agents
GB9012469D0 (en) * 1990-06-05 1990-07-25 Glaxo Group Ltd Medicaments
US5574060A (en) * 1993-08-12 1996-11-12 The United States Of America As Represented By The Department Of Health And Human Services Selective inhibitors of biogenic amine transporters
DE4341402A1 (de) * 1993-12-04 1995-06-08 Basf Ag N-substituierte Azabicycloheptan-Derivate, ihre Herstellung und Verwendung

Also Published As

Publication number Publication date
NO315513B1 (no) 2003-09-15
EA003302B1 (ru) 2003-04-24
JP2000290253A (ja) 2000-10-17
ATE216994T1 (de) 2002-05-15
AU762990B2 (en) 2003-07-10
ZA200001501B (en) 2000-10-24
FR2791345B1 (fr) 2001-05-04
PT1038873E (pt) 2002-09-30
DE60000142D1 (de) 2002-06-06
DK1038873T3 (da) 2002-08-19
BR0001420A (pt) 2000-10-10
HU0001246D0 (en) 2000-06-28
SI1038873T1 (en) 2002-08-31
PL339203A1 (en) 2000-10-09
HK1031380A1 (en) 2001-06-15
CN1274718A (zh) 2000-11-29
EP1038873A2 (fr) 2000-09-27
EP1038873A3 (fr) 2000-10-04
HUP0001246A3 (en) 2002-02-28
NO20001542L (no) 2000-09-27
NZ503588A (en) 2000-12-22
US6153640A (en) 2000-11-28
NO20001542D0 (no) 2000-03-24
KR20010006863A (ko) 2001-01-26
DE60000142T2 (de) 2002-12-12
KR100427127B1 (ko) 2004-04-17
JP3256788B2 (ja) 2002-02-12
AU2257900A (en) 2000-09-28
EA200000260A2 (ru) 2000-12-25
CA2301787A1 (fr) 2000-09-26
ES2176156T3 (es) 2002-12-01
CN1166638C (zh) 2004-09-15
FR2791345A1 (fr) 2000-09-29
EP1038873B1 (fr) 2002-05-02
CA2301787C (fr) 2004-11-02

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HUP0001246A2 (hu) Benzo[3,4]ciklobuta[1,2-c]pirrol-származékok, eljárás azok előállítására és ilyen származékokat tartalmazó gyógyszerkészítmények

Legal Events

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FD9A Lapse of provisional protection due to non-payment of fees