ATE217526T1 - Trockene zusammensetzungen zur herstellung von emulsionen im submikron-bereich - Google Patents

Trockene zusammensetzungen zur herstellung von emulsionen im submikron-bereich

Info

Publication number
ATE217526T1
ATE217526T1 AT93906024T AT93906024T ATE217526T1 AT E217526 T1 ATE217526 T1 AT E217526T1 AT 93906024 T AT93906024 T AT 93906024T AT 93906024 T AT93906024 T AT 93906024T AT E217526 T1 ATE217526 T1 AT E217526T1
Authority
AT
Austria
Prior art keywords
weight percent
component
emulsifier
compositions
dry
Prior art date
Application number
AT93906024T
Other languages
English (en)
Inventor
Doron Friedman
Yanir Aldouby
Original Assignee
Pharmos Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from IL10100792A external-priority patent/IL101007A/xx
Application filed by Pharmos Corp filed Critical Pharmos Corp
Application granted granted Critical
Publication of ATE217526T1 publication Critical patent/ATE217526T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/04—Dispersions; Emulsions
    • A61K8/06—Emulsions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/04—Dispersions; Emulsions
    • A61K8/06—Emulsions
    • A61K8/062—Oil-in-water emulsions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
    • A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/20—Chemical, physico-chemical or functional or structural properties of the composition as a whole
    • A61K2800/21—Emulsions characterized by droplet sizes below 1 micron
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
    • A61K2800/84—Products or compounds obtained by lyophilisation, freeze-drying

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • Birds (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Dermatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Medicinal Preparation (AREA)
  • Colloid Chemistry (AREA)
  • Cosmetics (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
AT93906024T 1992-02-18 1993-02-17 Trockene zusammensetzungen zur herstellung von emulsionen im submikron-bereich ATE217526T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IL10100792A IL101007A (en) 1992-02-18 1992-02-18 Dry stable compositions prepared by lyophilization
US08/016,913 US5472706A (en) 1992-02-18 1993-02-12 Dry compositions for preparing submicron emulsions
PCT/US1993/001415 WO1993015736A1 (en) 1992-02-18 1993-02-17 Dry compositions for preparing submicron emulsions

Publications (1)

Publication Number Publication Date
ATE217526T1 true ATE217526T1 (de) 2002-06-15

Family

ID=26322400

Family Applications (1)

Application Number Title Priority Date Filing Date
AT93906024T ATE217526T1 (de) 1992-02-18 1993-02-17 Trockene zusammensetzungen zur herstellung von emulsionen im submikron-bereich

Country Status (6)

Country Link
EP (1) EP0626850B1 (de)
AT (1) ATE217526T1 (de)
AU (1) AU675930B2 (de)
CA (1) CA2130357A1 (de)
DE (1) DE69331930T2 (de)
WO (1) WO1993015736A1 (de)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL101387A (en) * 1992-03-26 1999-11-30 Pharmos Ltd Emulsion with enhanced topical and/or transdermal systemic effect utilizing submicron oil droplets
US6113921A (en) * 1993-03-23 2000-09-05 Pharmos Corp. Topical and transdermal delivery system utilizing submicron oil spheres
US5576016A (en) * 1993-05-18 1996-11-19 Pharmos Corporation Solid fat nanoemulsions as drug delivery vehicles
IL107471A (en) * 1993-11-02 1997-09-30 Yissum Res Dev Co Pharmaceutical preparation comprising a self- emulsifying formulation and process for its production
IT1271031B (it) * 1994-10-21 1997-05-26 Poli Ind Chimica Spa Composizioni farmaceutiche miorilassanti
EP0711556A1 (de) * 1994-11-09 1996-05-15 Ciba-Geigy Ag Intravenöse Lösungen für ein Staurosporinderivat
JPH11504028A (ja) * 1995-04-24 1999-04-06 イースム リサーチ ディベロップメント カンパニー オブ ザ ヒーブル ユニバーシティ オブ エルサレム 油／水エマルジョンを作り出す自己乳化性配合物
FR2733914B1 (fr) 1995-05-11 1997-08-01 Sanofi Sa Composition de liquide stable contenant de l'urate oxydase et composition lyophilisee pour sa preparation
WO1996037192A1 (en) * 1995-05-26 1996-11-28 Vesifact Ag Pharmaceutical and cosmetic compositions containing sphingo- and glycolipids
WO1997037636A1 (en) * 1996-04-03 1997-10-16 Elias Hakalehto Therapeutic and preventive method against harmful microbes
ATE229282T1 (de) * 1996-09-16 2002-12-15 Nestle Sa Essbare mikroemulsion zum beschichten von nahrungsmitteln, und verwendung zum bräunen und knusprig machen durch mikrowellen
AU6733898A (en) * 1997-04-03 1998-10-22 Elias Hakalehto A method for producing jelly sweets which contain antibodies
US6281244B1 (en) 1997-06-05 2001-08-28 Novartis Nutrition Ag Therapeutic use for glycine
US6281175B1 (en) * 1997-09-23 2001-08-28 Scimed Life Systems, Inc. Medical emulsion for lubrication and delivery of drugs
US6054421A (en) * 1997-09-23 2000-04-25 Scimed Life Systems, Inc. Medical emulsion lubricant
WO1999016471A1 (en) 1997-10-01 1999-04-08 Wakamoto Pharmaceutical Co., Ltd. O/w emulsion compositions
WO2000015763A1 (de) * 1998-09-14 2000-03-23 Vesifact Ag Verwendung von nanocells in kulturmedien-endprodukten
IL143604A0 (en) 1998-12-30 2002-04-21 Dexcel Ltd Dispersable concentrate for the delivery of cyclosporin
EP1175205B1 (de) 1999-11-12 2006-06-14 Abbott Laboratories Feste dispersion mit ritonavir, fenofibrat oder griseofulvin
DE10026698A1 (de) 2000-05-30 2001-12-06 Basf Ag Selbstemulgierende Wirkstoffformulierung und Verwendung dieser Formulierung
RU2541809C2 (ru) 2003-04-04 2015-02-20 Зоетис Пи ЛЛК Микрофлюидизированные эмульсии "масло в воде" и композиции вакцины
US8025899B2 (en) 2003-08-28 2011-09-27 Abbott Laboratories Solid pharmaceutical dosage form
US8377952B2 (en) 2003-08-28 2013-02-19 Abbott Laboratories Solid pharmaceutical dosage formulation
CA2575216A1 (en) * 2004-07-28 2006-02-09 Sd Pharmaceuticals, Inc. Stable injectable composition of alpha tocopheryl succinate, analogues and salts thereof
BR112014009866A2 (pt) 2011-10-25 2018-09-04 Onclave Therapeutics Limited formulações de anticorpos e métodos

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0647533B2 (ja) * 1984-08-10 1994-06-22 裕 水島 ４−ビフエニリル酢酸系化合物含有脂肪乳剤
IL78930A0 (en) * 1985-07-29 1986-09-30 Abbott Lab Lyophilized emulsion compositions for parenteral administration
DD295765A5 (de) * 1988-07-18 1991-11-14 Arzneimittelwerk Dresden Gmbh,De Verfahren zur herstellung galenischer formulierungen fuer hydrophobe bzw. lipophile peptidwirkstoffe
JP2847783B2 (ja) * 1988-08-11 1999-01-20 日清製粉株式会社 抗癌活性増強剤

Also Published As

Publication number Publication date
CA2130357A1 (en) 1993-08-19
DE69331930D1 (de) 2002-06-20
EP0626850A4 (de) 1995-07-26
EP0626850B1 (de) 2002-05-15
DE69331930T2 (de) 2003-01-09
EP0626850A1 (de) 1994-12-07
AU3721593A (en) 1993-09-03
AU675930B2 (en) 1997-02-27
WO1993015736A1 (en) 1993-08-19

Similar Documents

Publication Publication Date Title
DE69331930D1 (de) Trockene zusammensetzungen zur herstellung von emulsionen im submikron-bereich
KR950005324A (ko) 인슐린 제제
DE69531179D1 (de) Nanoemulsion von dem Öl-in-Wasser Typ, gebrauchbar als ein ophthalmischen Vehikel und Verfahren zur seiner Herstellung
AU626298B2 (en) Cosmetic products containing milk constituents
CA2230097A1 (fr) Emulsion huile-dans-eau stable, son procede de fabrication et son utilisation dans les domaines cosmetique et dermatologique
ES2098738T3 (es) Producto parcialmente desnaturalizado de proteinas de suero lacteo.
DK0797432T3 (da) Olie-i-vand-emulsioner
FI972431A7 (fi) Sytotoksisten T-lymfosyyttivasteiden induktio
WO2003041651A3 (en) Allatoin-containing skin cream
IE870283L (en) Micro emulsions
WO1999006010A3 (de) Dekorative kosmetische o/w- emulsion ohne emulgator
DK0680699T3 (da) Varmestabile olie-i-vand-emulsioner stabiliseret medhydrolysater
ATE202277T1 (de) Verfahren zur stabilisierung von vesikeln aus amphiphilen lipiden und diese stabilisierte vesikeln enthaltende zusammensetzung für die topische anwendung
MX9201632A (es) Emulsiones multiples, estables, para composiciones topicas medicinales y cosmetologia y procedimiento para su preparacion.
KR920007571A (ko) 영양학적 조성물 및 이의 제조방법
FR2706298B1 (fr) Composition cosmétique ou dermatologique sous forme d'une émulsion huile-dans-l'eau stable contenant au moins une huile végétale constituée d'au moins 40% de triglycérides d'acide linoléique.
US4963656A (en) Emulsified compositions containing elastin hydrolysate
NO169189C (no) Blanding paa basis av biopolymerer, fremgangsmaate for deres fremstilling og anvendelse av blandingen
DE50210700D1 (de) Gelemulsionen in form von o/w-emulsionen mit einem gehalt an hydrokolloiden
KR20010006776A (ko) Ｌ-2-옥소티아졸리딘-4-카르복실산을 함유하는, 연속수성상을 갖는 조성물
BR9712605A (pt) Composição alimeticia sólida, barra alimentìcia, processo de preparação de uma composição alimentìcia, composição cremosa, e, utilização de um emulsificante hidrossolúvel.
KR930012023A (ko) 환원된 형태의 비글리코실화 재조합 인체 il2의 안정화된 제약 조성물 및 그의 제조방법
JPS5998727A (ja) 乳化組成物
JPH0435212B2 (de)
JPS5920212A (ja) 乳化組成物

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties