ATE217619T1 - Endothelin-rezeptor-antagonisten - Google Patents

Endothelin-rezeptor-antagonisten

Info

Publication number
ATE217619T1
ATE217619T1 AT95930974T AT95930974T ATE217619T1 AT E217619 T1 ATE217619 T1 AT E217619T1 AT 95930974 T AT95930974 T AT 95930974T AT 95930974 T AT95930974 T AT 95930974T AT E217619 T1 ATE217619 T1 AT E217619T1
Authority
AT
Austria
Prior art keywords
receptor antagonists
endothelin receptor
novel
compounds
pharmaceutical compositions
Prior art date
Application number
AT95930974T
Other languages
English (en)
Inventor
John Duncan Elliott
Joseph Weinstock
Jia-Ning Xiang
Original Assignee
Smithkline Beecham Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham Corp filed Critical Smithkline Beecham Corp
Application granted granted Critical
Publication of ATE217619T1 publication Critical patent/ATE217619T1/de

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D233/00Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/02Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/12Antihypertensives
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D409/00Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Endocrinology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Urology & Nephrology (AREA)
  • Pain & Pain Management (AREA)
  • Reproductive Health (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
AT95930974T 1994-09-02 1995-08-28 Endothelin-rezeptor-antagonisten ATE217619T1 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US30082994A 1994-09-02 1994-09-02
US37531895A 1995-01-18 1995-01-18
US47699295A 1995-06-07 1995-06-07
PCT/US1995/010885 WO1996007653A1 (en) 1994-09-02 1995-08-28 Endothelin receptor antagonists

Publications (1)

Publication Number Publication Date
ATE217619T1 true ATE217619T1 (de) 2002-06-15

Family

ID=27404770

Family Applications (1)

Application Number Title Priority Date Filing Date
AT95930974T ATE217619T1 (de) 1994-09-02 1995-08-28 Endothelin-rezeptor-antagonisten

Country Status (6)

Country Link
EP (1) EP0778833B1 (de)
JP (1) JPH10505085A (de)
AT (1) ATE217619T1 (de)
AU (1) AU3416995A (de)
DE (1) DE69526738T2 (de)
WO (1) WO1996007653A1 (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6030970A (en) * 1995-08-02 2000-02-29 Smithkline Beecham Corporation Endothelin receptor antagonists
MX9800975A (es) * 1995-08-02 1998-04-30 Smithkline Beecham Corp Antagonistas de receptor de endotelina.
EP0841926B1 (de) * 1995-08-02 2003-03-26 Smithkline Beecham Corporation Endothelinrezeptorantagonist
EP0868180A4 (de) * 1995-12-21 1999-08-04 Smithkline Beecham Corp Endothelinm rezeptor antogonisten
JP2000504013A (ja) * 1996-02-01 2000-04-04 スミスクライン・ビーチャム・コーポレイション エンドセリンレセプターアンタゴニスト
EP0983265A4 (de) * 1996-02-01 2001-10-17 Smithkline Beecham Corp Endothelinrezeptor-antagonisten

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4006137A (en) * 1975-08-21 1977-02-01 E. R. Squibb & Sons, Inc. 2-Ethenyl imidazolium derivatives
JPH0680057B2 (ja) * 1986-04-28 1994-10-12 保土谷化学工業株式会社 トリフエニルイミダゾ−ル及びその二量体
DK0403159T3 (da) * 1989-06-14 2000-08-14 Smithkline Beecham Corp Imidazolylalkensyrer
EP0403158A3 (de) * 1989-06-14 1991-12-18 Smithkline Beecham Corporation Imidazolyl-Alkensäuren
JP3214856B2 (ja) * 1990-12-14 2001-10-02 スミスクライン・ビーチャム・コーポレイション イミダゾリル−アルケン酸
WO1994002474A1 (en) * 1992-07-17 1994-02-03 Smithkline Beecham Corporation Endothelin receptor antagonists

Also Published As

Publication number Publication date
AU3416995A (en) 1996-03-27
DE69526738T2 (de) 2003-02-06
WO1996007653A1 (en) 1996-03-14
EP0778833B1 (de) 2002-05-15
EP0778833A1 (de) 1997-06-18
JPH10505085A (ja) 1998-05-19
DE69526738D1 (de) 2002-06-20
EP0778833A4 (de) 1998-12-16

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Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties