ATE217905T1 - Zellinien, die einen biologisch aktiven faktor-ix exprimieren - Google Patents

Zellinien, die einen biologisch aktiven faktor-ix exprimieren

Info

Publication number: ATE217905T1
Authority: AT; Austria
Prior art keywords: promoter region; cell lines; gene; biologically active; hepatic cells
Prior art date: 1989-08-09

Application number

AT90913241T

Other languages

English (en)

Inventor

Sophie Jallat

Pierre Meulien

Andrea Pavirani

Frederic Perraud

Original Assignee

Transgene Sa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-08-09

Filing date

1990-08-09

Publication date

2002-06-15

1990-08-09 Application filed by Transgene Sa filed Critical Transgene Sa

2002-06-15 Application granted granted Critical

2002-06-15 Publication of ATE217905T1 publication Critical patent/ATE217905T1/de

Links

229960004222 factor ix Drugs 0.000 title 1
108700039691 Genetic Promoter Regions Proteins 0.000 abstract 5
210000003494 hepatocyte Anatomy 0.000 abstract 3
108091029865 Exogenous DNA Proteins 0.000 abstract 2
229960000027 human factor ix Drugs 0.000 abstract 2
108010076282 Factor IX Proteins 0.000 abstract 1
241000699660 Mus musculus Species 0.000 abstract 1
101100293199 Mus musculus Myc gene Proteins 0.000 abstract 1
XDMCWZFLLGVIID-SXPRBRBTSA-N O-(3-O-D-galactosyl-N-acetyl-beta-D-galactosaminyl)-L-serine Chemical compound CC(=O)N[C@H]1[C@H](OC[C@H]([NH3+])C([O-])=O)O[C@H](CO)[C@H](O)[C@@H]1OC1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 XDMCWZFLLGVIID-SXPRBRBTSA-N 0.000 abstract 1
108700020796 Oncogene Proteins 0.000 abstract 1
108010050122 alpha 1-Antitrypsin Proteins 0.000 abstract 1
210000004027 cell Anatomy 0.000 abstract 1
210000004748 cultured cell Anatomy 0.000 abstract 1
239000001963 growth medium Substances 0.000 abstract 1
108090000623 proteins and genes Proteins 0.000 abstract 1
238000011830 transgenic mouse model Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/027—New or modified breeds of vertebrates
- A01K67/0275—Genetically modified vertebrates, e.g. transgenic
- A01K67/0278—Knock-in vertebrates, e.g. humanised vertebrates
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
- C12N9/644—Coagulation factor IXa (3.4.21.22)
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21022—Coagulation factor IXa (3.4.21.22)
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2207/00—Modified animals
- A01K2207/15—Humanized animals
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/10—Mammal
- A01K2227/105—Murine
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/01—Animal expressing industrially exogenous proteins
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/008—Vector systems having a special element relevant for transcription cell type or tissue specific enhancer/promoter combination

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Chemical & Material Sciences (AREA)
Genetics & Genomics (AREA)
Zoology (AREA)
Organic Chemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Wood Science & Technology (AREA)
Biotechnology (AREA)
General Engineering & Computer Science (AREA)
Biomedical Technology (AREA)
General Health & Medical Sciences (AREA)
Biochemistry (AREA)
Molecular Biology (AREA)
Microbiology (AREA)
Environmental Sciences (AREA)
Veterinary Medicine (AREA)
Biophysics (AREA)
Plant Pathology (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Animal Husbandry (AREA)
Biodiversity & Conservation Biology (AREA)
Physics & Mathematics (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Enzymes And Modification Thereof (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

AT90913241T 1989-08-09 1990-08-09 Zellinien, die einen biologisch aktiven faktor-ix exprimieren ATE217905T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
FR8910720A FR2650838A1 (fr)	1989-08-09	1989-08-09	Vecteurs d'expression du facteur ix dans une cellule eucaryote superieure, procede de preparation de facteur ix par des animaux transgeniques et facteur ix obtenu
PCT/FR1990/000606 WO1991002056A1 (fr)	1989-08-09	1990-08-09	Lignees cellulaires exprimant un facteur ix biologiquement actif

Publications (1)

Publication Number	Publication Date
ATE217905T1 true ATE217905T1 (de)	2002-06-15

Family

ID=9384606

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT90913241T ATE217905T1 (de)	1989-08-09	1990-08-09	Zellinien, die einen biologisch aktiven faktor-ix exprimieren

Country Status (8)

Country	Link
US (1)	US5814716A (de)
EP (1)	EP0437599B1 (de)
JP (1)	JPH04501209A (de)
AT (1)	ATE217905T1 (de)
CA (1)	CA2039153A1 (de)
DE (1)	DE69033961T2 (de)
FR (1)	FR2650838A1 (de)
WO (1)	WO1991002056A1 (de)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IT1265794B1 (it) *	1992-09-07	1996-12-03	Angeletti P Ist Richerche Bio	Mammiferi transgenici non umani con un oncogene sotto il controllo di un promotore inducibile fegato-specifico
DE4407859C1 (de) *	1994-03-04	1995-03-02	Max Planck Gesellschaft	Vektor für die leberspezifische Gentherapie
US20040038898A1 (en) *	1996-05-16	2004-02-26	The Trustees Of Columbia University	Method for inhibiting thrombosis in a patient whose blood is subjected to extracorporeal circulation
US6740519B1 (en) *	1997-11-03	2004-05-25	Mount Sinai School Of Medicine	Immortalized, homozygous stat1-deficient mammalian cell lines and their uses
US6610906B1 (en) *	1999-06-09	2003-08-26	The Regents Of The University Of Michigan	Nucleotide sequences for gene regulation and methods of use thereof
WO2002040544A2 (en) *	2000-11-14	2002-05-23	Board Of Regents, University Of Texas Systems	Mutant human factor ix with an increased resistance to inhibition by heparin
ES2356154T3 (es)	2003-07-21	2011-04-05	Transgene S.A.	Citoquinas multifuncionales.
WO2006076288A2 (en) *	2005-01-11	2006-07-20	Five Prime Therapeutics, Inc.	Dna constructs for long-term expression of intravascularly injected naked dna
CA2770075C (en)	2009-08-07	2021-08-24	Perrine Martin	Composition for treating hbv infection
TWI575070B (zh)	2011-07-12	2017-03-21	傳斯堅公司	Ｈｂｖ聚合酶突變體
TW201318637A (zh)	2011-09-29	2013-05-16	Transgene Sa	免疫療法組成物及用於治療ｃ型肝炎病毒感染之療程（一）
WO2013045668A2 (en)	2011-09-29	2013-04-04	Transgene Sa	Immunotherapy composition and regimen for treating hepatitis c virus infection
JP6430949B2 (ja)	2012-10-23	2018-11-28	エモリーユニバーシティ	Ｇｍ−ｃｓｆとｉｌ−４のコンジュゲート、組成物、ならびにそれに関連する方法
EP3626832B1 (de)	2014-11-25	2024-06-12	The Brigham and Women's Hospital, Inc.	Verfahren zur identifizierung einer person mit einer prädisposition für eine kardiometabolische krankheit oder eine davon betroffene person
US10683552B2 (en)	2014-11-25	2020-06-16	Presidents And Fellows Of Harvard College	Clonal haematopoiesis
JP7119009B2 (ja) *	2017-05-31	2022-08-16	ザユニバーシティオブノースカロライナアットチャペルヒル	最適化されたヒト凝固第ｉｘ因子遺伝子発現カセットおよびそれらの使用

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB223755A (en) *	1923-11-12	1924-10-30	Underwood Typewriter Company L	Improvements relating to ink-ribbon mechanism for combined typewriting and computingmachines
WO1984000560A1 (en) *	1982-08-04	1984-02-16	Nat Res Dev	Molecular cloning of the gene for human anti-haemophilic factor ix
FR2564106B1 (fr) *	1984-05-09	1988-04-22	Transgene Sa	Vecteurs d'expression du facteur ix, cellules transformees par ces vecteurs et procede de preparation du facteur ix.
DE3545126A1 (de) *	1985-12-19	1987-06-25	Boehringer Mannheim Gmbh	Verfahren zur verbesserung der expression von eukaryontenprotein
FR2637613B1 (fr) *	1987-06-19	1991-09-27	Transgene Sa	Procede de preparation de lignees cellulaires stables pour la production de proteines determinees, a partir d'animaux transgeniques; lignees cellulaires tumorales et proteines obtenues
AU612404B2 (en) *	1987-09-11	1991-07-11	Genentech Inc.	Method for increasing the expression of polypeptides in recombinant cell culture
GB2223755A (en) *	1988-09-21	1990-04-18	Cambridge Animal Biotech	Tissue modification

1989
- 1989-08-09 FR FR8910720A patent/FR2650838A1/fr not_active Withdrawn
1990
- 1990-08-09 JP JP2512388A patent/JPH04501209A/ja active Pending
- 1990-08-09 WO PCT/FR1990/000606 patent/WO1991002056A1/fr not_active Ceased
- 1990-08-09 EP EP90913241A patent/EP0437599B1/de not_active Expired - Lifetime
- 1990-08-09 DE DE69033961T patent/DE69033961T2/de not_active Expired - Fee Related
- 1990-08-09 CA CA002039153A patent/CA2039153A1/fr not_active Abandoned
- 1990-08-09 AT AT90913241T patent/ATE217905T1/de not_active IP Right Cessation
1995
- 1995-02-24 US US08/394,210 patent/US5814716A/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
JPH04501209A (ja)	1992-03-05
FR2650838A1 (fr)	1991-02-15
DE69033961T2 (de)	2002-11-07
WO1991002056A1 (fr)	1991-02-21
DE69033961D1 (de)	2002-06-27
EP0437599A1 (de)	1991-07-24
US5814716A (en)	1998-09-29
CA2039153A1 (fr)	1991-02-10
EP0437599B1 (de)	2002-05-22

Legal Events

Date	Code	Title	Description
2002-10-15	UEP	Publication of translation of european patent specification
2003-11-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
AU560340B2 (en)	1987-04-02	Rennin from recombinant dna
DE69033961D1 (de)	2002-06-27	Zellinien, die einen biologisch aktiven faktor-ix exprimieren
AU2126688A (en)	1989-03-01	Serum free media for the growth of insect cells and expression of products thereby
ZA942719B (en)	1995-01-09	Expression of heterologous genes
DK0770136T3 (da)	2007-06-11	Fremgangsmåde til at selektere höjtudtrykkende værtsceller
FI883722A0 (fi)	1988-08-10	Alfa-amiderande enzymkompositioner och foerfaranden foer deras framstaellning och anvaendning.
ES2121803T3 (es)	1998-12-16	Plantas de zea mays y plantas transgenicas de zea mays generadas a partir de protoplastos o celulas derivadas de protoplastos.
CA2193094A1 (en)	1995-12-21	The cytoplasmic inhibition of gene expression
ATE163046T1 (de)	1998-02-15	Genetische veränderung von endothelzellen
DK0843961T3 (da)	2007-05-21	Kimærisk mus og fremgangsmåde til at producere samme
DK309387D0 (da)	1987-06-17	Humant erythropoietin-gen samt expression deraf i transficerede celler
ATE92530T1 (de)	1993-08-15	Transformation und expression eines fremden gens in -i(brassica) spezies.
ATE414782T1 (de)	2008-12-15	Verfahren zur herstellung von polypeptiden in mutierten aspergillus zellen
JP2008086326A (ja)	2008-04-17	ゲノム性要素を使用する遺伝子の操作および発現
DE3853474D1 (de)	1995-05-04	Vektor zur integrationsstellenunabhängigen genexpression in säugetier-wirtszellen.
EP0758681A3 (de)	1997-06-04	Hemmung der Transformation der Zellen mit erhöhter Purin-metabolischer Enzymaktivität
ATE15693T1 (de)	1985-10-15	Zellkultur-verfahren.
CA2298412A1 (en)	1999-02-04	Identification of human cell lines for the production of human proteins by endogenous gene activation
EP0837931A4 (de)	1999-06-02	Methode zur expression in und isolation von biologisch aktiven molekülen aus urin
ATE243741T1 (de)	2003-07-15	Zufuhr von genprodukten mittels mesangium-zellen
DE69130704D1 (de)	1999-02-11	Polypeptide beteiligt an der kobalamin- und/oder kobamid-biosynthese, für diese kodierende dns-sequencen, und ihre herstellung und vewendung.
RU94043769A (ru)	1997-03-27	Способ повышения продукции протеина с, способ повышения уровня его модификации
AU2209988A (en)	1989-04-20	Method for increasing the expression of polypeptides in recombinant cell culture
ES2003462A6 (es)	1988-11-01	Un metodo de obtencion de un alto nivel de expresion de una proteina.
AU581819B2 (en)	1989-03-02	Process for the immortalization of human and animal cells