ATE218548T1 - 4-aminoethoxy-indolon-derivate - Google Patents

4-aminoethoxy-indolon-derivate

Info

Publication number: ATE218548T1
Authority: AT; Austria
Prior art keywords: hydrogen; addiction; dihydro; integers; aryl
Prior art date: 1996-08-27

Application number

AT97938596T

Other languages

English (en)

Inventor

Richard Eric Mewshaw

Original Assignee

American Home Prod

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-08-27

Filing date

1997-08-26

Publication date

2002-06-15

1997-08-26 Application filed by American Home Prod filed Critical American Home Prod

2002-06-15 Application granted granted Critical

2002-06-15 Publication of ATE218548T1 publication Critical patent/ATE218548T1/de

Links

LYHRMERCJMBWDE-UHFFFAOYSA-N 4-(2-aminoethoxy)indol-2-one Chemical class NCCOC1=CC=CC2=NC(=O)C=C12 LYHRMERCJMBWDE-UHFFFAOYSA-N 0.000 title 1
-1 2-oxobenzimidazolyl Chemical group 0.000 abstract 4
125000000217 alkyl group Chemical group 0.000 abstract 3
239000001257 hydrogen Substances 0.000 abstract 3
229910052739 hydrogen Inorganic materials 0.000 abstract 3
150000002431 hydrogen Chemical group 0.000 abstract 3
125000003118 aryl group Chemical group 0.000 abstract 2
VYFYYTLLBUKUHU-UHFFFAOYSA-N dopamine Chemical compound NCCC1=CC=C(O)C(O)=C1 VYFYYTLLBUKUHU-UHFFFAOYSA-N 0.000 abstract 2
208000007848 Alcoholism Diseases 0.000 abstract 1
208000022497 Cocaine-Related disease Diseases 0.000 abstract 1
206010012335 Dependence Diseases 0.000 abstract 1
208000018737 Parkinson disease Diseases 0.000 abstract 1
208000000323 Tourette Syndrome Diseases 0.000 abstract 1
208000016620 Tourette disease Diseases 0.000 abstract 1
125000003545 alkoxy group Chemical group 0.000 abstract 1
125000005418 aryl aryl group Chemical group 0.000 abstract 1
QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
125000003785 benzimidazolyl group Chemical group N1=C(NC2=C1C=CC=C2)* 0.000 abstract 1
230000015572 biosynthetic process Effects 0.000 abstract 1
125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 abstract 1
201000006145 cocaine dependence Diseases 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
125000000753 cycloalkyl group Chemical group 0.000 abstract 1
229960003638 dopamine Drugs 0.000 abstract 1
229940079593 drug Drugs 0.000 abstract 1
239000003814 drug Substances 0.000 abstract 1
206010013663 drug dependence Diseases 0.000 abstract 1
229910052736 halogen Inorganic materials 0.000 abstract 1
150000002367 halogens Chemical group 0.000 abstract 1
125000001041 indolyl group Chemical group 0.000 abstract 1
239000003112 inhibitor Substances 0.000 abstract 1
229910052757 nitrogen Inorganic materials 0.000 abstract 1
125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
125000004095 oxindolyl group Chemical group N1(C(CC2=CC=CC=C12)=O)* 0.000 abstract 1
239000001301 oxygen Substances 0.000 abstract 1
229910052760 oxygen Inorganic materials 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
201000000980 schizophrenia Diseases 0.000 abstract 1
238000003786 synthesis reaction Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/32—Oxygen atoms
- C07D209/34—Oxygen atoms in position 2
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Psychiatry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Indole Compounds (AREA)
Plural Heterocyclic Compounds (AREA)

AT97938596T 1996-08-27 1997-08-26 4-aminoethoxy-indolon-derivate ATE218548T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US70361096A	1996-08-27	1996-08-27
PCT/US1997/014950 WO1998008819A1 (en)	1996-08-27	1997-08-26	4-aminoethoxy indolone derivatives

Publications (1)

Publication Number	Publication Date
ATE218548T1 true ATE218548T1 (de)	2002-06-15

Family

ID=24826069

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT97938596T ATE218548T1 (de)	1996-08-27	1997-08-26	4-aminoethoxy-indolon-derivate

Country Status (12)

Country	Link
EP (1)	EP0923551B1 (de)
JP (1)	JP2000516959A (de)
KR (1)	KR20000035818A (de)
CN (1)	CN1234024A (de)
AT (1)	ATE218548T1 (de)
AU (1)	AU4088897A (de)
CA (1)	CA2264078A1 (de)
DE (1)	DE69713110T2 (de)
DK (1)	DK0923551T3 (de)
ES (1)	ES2179362T3 (de)
PT (1)	PT923551E (de)
WO (1)	WO1998008819A1 (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
BR9807703A (pt) *	1997-02-18	2000-05-02	American Home Prod	Derivados de 4-aminoalcóxi-1,3-diidrobenzoimidazol-2-ona, suas preparações e seus usos como agonistas (d2) auto-receptores da dopamina
US5990144A (en) *	1997-02-18	1999-11-23	American Home Products Corporation	4-aminoalkoxy-1,3-dihydrobenzoimidazol-2-one dopamine autoreceptor agonists
US6150533A (en) *	1998-04-08	2000-11-21	American Home Products Corp.	N-aryloxyethyl-indoly-alkylamines for the treatment of depression
US6110956A (en) *	1998-04-08	2000-08-29	American Home Products Corp.	N-aryloxyethylamine derivatives for the treatment of depression
CN1160332C (zh) *	1998-04-08	2004-08-04	惠氏公司	用于治疗抑郁症的n-芳氧基乙基胺衍生物
DK1068199T3 (da) *	1998-04-08	2003-03-03	Wyeth Corp	N-Aryloxyethyl-indolyl-alkylaminer til behandling af depression
ZA992670B (en) *	1998-04-13	2000-10-12	American Home Prod	4-amino-(ethylamino)-oxindole dopamine autoreceptor agonists.
FR2845992B1 (fr) *	2002-10-16	2005-02-04	Pf Medicament	Derives de 3-(cyclopenten-1yl)-benzyl-ou3-(cyclopenten-1yl)- heteroarylmethyl-amines et leur utilisation a titre de medicaments pour le traitement de la schizophrenie
CN113004233B (zh) *	2019-12-18	2022-12-20	南京优氟医药科技有限公司	一种用于制备prc2抑制剂的化合物、其制备方法和用途
CN114507162A (zh) *	2020-11-16	2022-05-17	尚科生物医药（上海）有限公司	一种制备2-氟-5-甲氧基苯磺酰氯的方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2210397A2 (en) *	1972-12-20	1974-07-12	Sandoz Sa	Aminoalkoxyoxindole derivs - as beta-adren ergic blockers
US4314944A (en) *	1980-08-22	1982-02-09	Smithkline Corporation	4-Aminoalkyl-7-hydroxy-2(3H)-indolones
FR2510112A1 (fr) *	1981-07-24	1983-01-28	Roussel Uclaf	Nouveaux derives du 2-oxo-pyrid-3-yl ou piperidin-3-yl indole, leurs sels, procede de preparation, application a titre de medicaments et compositions les renfermant
US4452808A (en) *	1982-12-07	1984-06-05	Smithkline Beckman Corporation	4-Aminoalkyl-2(3H)-indolones
GB8712073D0 (en) *	1987-05-21	1987-06-24	Smith Kline French Lab	Medicament
JPH07506823A (ja) *	1992-05-18	1995-07-27	スミスクライン・ビーチャム・パブリック・リミテッド・カンパニー	記憶障害，性的機能不全およびパーキンソン氏病の治療のためのインドロン誘導体の使用
AU4787593A (en) *	1992-07-31	1994-03-03	Syntex (U.S.A.) Inc.	Heterocyclic derivatives useful in the treatment of cardiovascular diseases

1997
- 1997-08-26 AT AT97938596T patent/ATE218548T1/de not_active IP Right Cessation
- 1997-08-26 KR KR1019997001466A patent/KR20000035818A/ko not_active Withdrawn
- 1997-08-26 ES ES97938596T patent/ES2179362T3/es not_active Expired - Lifetime
- 1997-08-26 CN CN97198979A patent/CN1234024A/zh active Pending
- 1997-08-26 PT PT97938596T patent/PT923551E/pt unknown
- 1997-08-26 CA CA002264078A patent/CA2264078A1/en not_active Abandoned
- 1997-08-26 DE DE69713110T patent/DE69713110T2/de not_active Expired - Fee Related
- 1997-08-26 DK DK97938596T patent/DK0923551T3/da active
- 1997-08-26 JP JP10511803A patent/JP2000516959A/ja active Pending
- 1997-08-26 EP EP97938596A patent/EP0923551B1/de not_active Expired - Lifetime
- 1997-08-26 WO PCT/US1997/014950 patent/WO1998008819A1/en not_active Ceased
- 1997-08-26 AU AU40888/97A patent/AU4088897A/en not_active Abandoned

Also Published As

Publication number	Publication date
ES2179362T3 (es)	2003-01-16
PT923551E (pt)	2002-09-30
DK0923551T3 (da)	2002-09-16
KR20000035818A (ko)	2000-06-26
WO1998008819A1 (en)	1998-03-05
JP2000516959A (ja)	2000-12-19
EP0923551A1 (de)	1999-06-23
DE69713110D1 (de)	2002-07-11
AU4088897A (en)	1998-03-19
EP0923551B1 (de)	2002-06-05
CN1234024A (zh)	1999-11-03
DE69713110T2 (de)	2002-12-19
CA2264078A1 (en)	1998-03-05

Legal Events

Date

Code

Title

Description

2003-03-15

UEP

Publication of translation of european patent specification

Ref document number: 0923551

Country of ref document: EP

2005-05-15

REN

Ceased due to non-payment of the annual fee

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