ES2185985T3 - Derivados de 4-aminoetoxiindolona como agonistas del receptor d2 de dopamina. - Google Patents
Derivados de 4-aminoetoxiindolona como agonistas del receptor d2 de dopamina.Info
- Publication number
- ES2185985T3 ES2185985T3 ES97938630T ES97938630T ES2185985T3 ES 2185985 T3 ES2185985 T3 ES 2185985T3 ES 97938630 T ES97938630 T ES 97938630T ES 97938630 T ES97938630 T ES 97938630T ES 2185985 T3 ES2185985 T3 ES 2185985T3
- Authority
- ES
- Spain
- Prior art keywords
- hydrogen
- dopamine
- aminoetoxiindolone
- agenists
- receptor
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 102000004980 Dopamine D2 Receptors Human genes 0.000 title 1
- 108090001111 Dopamine D2 Receptors Proteins 0.000 title 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 4
- 239000001257 hydrogen Substances 0.000 abstract 4
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- VYFYYTLLBUKUHU-UHFFFAOYSA-N dopamine Chemical compound NCCC1=CC=C(O)C(O)=C1 VYFYYTLLBUKUHU-UHFFFAOYSA-N 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 150000002367 halogens Chemical group 0.000 abstract 2
- 150000002431 hydrogen Chemical group 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 208000007848 Alcoholism Diseases 0.000 abstract 1
- 208000022497 Cocaine-Related disease Diseases 0.000 abstract 1
- 206010012335 Dependence Diseases 0.000 abstract 1
- 208000018737 Parkinson disease Diseases 0.000 abstract 1
- 208000000323 Tourette Syndrome Diseases 0.000 abstract 1
- 208000016620 Tourette disease Diseases 0.000 abstract 1
- 125000004414 alkyl thio group Chemical group 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 201000006145 cocaine dependence Diseases 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 229960003638 dopamine Drugs 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 206010013663 drug dependence Diseases 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Addiction (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Psychiatry (AREA)
- Epidemiology (AREA)
- Psychology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Abstract
LA INVENCION SE REFIERE A UN COMPUESTO DE FORMULA (I), DONDE Y ES HIDROGENO, HALOGENO O ALCOXI; R ES HIDROGENO O ALQUILTIO; R 1 ES HIDROGENO O ALQUILO; X ES HIDROGENO, HALOGENO, ALCOXI, ALQUILO O FENILO; N ES UNO DE LOS ENTEROS 1, 2, 3 O 4; O UNA SAL FARMACEUTICAMENTE ACEPTABLE DEL MISMO. DICHOS COMPUESTOS SON INHIBIDORES DE LA SINTESIS Y LIBERACION DE DOPAMINA, UTILES PARA EL TRATAMIENTO DE LA ESQUIZOFRENIA, LA ENFERMEDAD DE PARKINSON, EL SINDROME DE GILLES DE LA TOURETTE, LA ADICCION AL ALCOHOL, A LA COCAINA Y A DROGAS ANALOGAS.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US70360696A | 1996-08-27 | 1996-08-27 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2185985T3 true ES2185985T3 (es) | 2003-05-01 |
Family
ID=24826054
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES97938630T Expired - Lifetime ES2185985T3 (es) | 1996-08-27 | 1997-08-26 | Derivados de 4-aminoetoxiindolona como agonistas del receptor d2 de dopamina. |
Country Status (12)
| Country | Link |
|---|---|
| EP (1) | EP0923576B1 (es) |
| JP (1) | JP2000517318A (es) |
| KR (1) | KR20000035822A (es) |
| CN (1) | CN1077890C (es) |
| AT (1) | ATE227284T1 (es) |
| AU (1) | AU4091797A (es) |
| CA (1) | CA2264072A1 (es) |
| DE (1) | DE69716932T2 (es) |
| DK (1) | DK0923576T3 (es) |
| ES (1) | ES2185985T3 (es) |
| PT (1) | PT923576E (es) |
| WO (1) | WO1998008843A1 (es) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR9807703A (pt) * | 1997-02-18 | 2000-05-02 | American Home Prod | Derivados de 4-aminoalcóxi-1,3-diidrobenzoimidazol-2-ona, suas preparações e seus usos como agonistas (d2) auto-receptores da dopamina |
| US5990144A (en) * | 1997-02-18 | 1999-11-23 | American Home Products Corporation | 4-aminoalkoxy-1,3-dihydrobenzoimidazol-2-one dopamine autoreceptor agonists |
| CN114507162A (zh) * | 2020-11-16 | 2022-05-17 | 尚科生物医药（上海）有限公司 | 一种制备2-氟-5-甲氧基苯磺酰氯的方法 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5541199A (en) * | 1995-06-02 | 1996-07-30 | American Home Products Corporation | Chroman-2-ylmethylamino derivatives |
| AR004523A1 (es) * | 1995-11-06 | 1998-12-16 | American Home Prod | 2-(AMINOMETIL)-3,4,7,9-TETRAHIDRO-2H-PIRANO-[2,3e] INDOL-8-ONAS Y COMPOSICIONES FARMACEUTICAS QUE LAS COMPRENDEN |
-
1997
- 1997-08-26 PT PT97938630T patent/PT923576E/pt unknown
- 1997-08-26 DK DK97938630T patent/DK0923576T3/da active
- 1997-08-26 DE DE69716932T patent/DE69716932T2/de not_active Expired - Fee Related
- 1997-08-26 CA CA002264072A patent/CA2264072A1/en not_active Abandoned
- 1997-08-26 ES ES97938630T patent/ES2185985T3/es not_active Expired - Lifetime
- 1997-08-26 AT AT97938630T patent/ATE227284T1/de not_active IP Right Cessation
- 1997-08-26 EP EP97938630A patent/EP0923576B1/en not_active Expired - Lifetime
- 1997-08-26 WO PCT/US1997/015027 patent/WO1998008843A1/en not_active Ceased
- 1997-08-26 CN CN97198975A patent/CN1077890C/zh not_active Expired - Fee Related
- 1997-08-26 JP JP10511857A patent/JP2000517318A/ja active Pending
- 1997-08-26 KR KR1019997001478A patent/KR20000035822A/ko not_active Withdrawn
- 1997-08-26 AU AU40917/97A patent/AU4091797A/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| KR20000035822A (ko) | 2000-06-26 |
| EP0923576B1 (en) | 2002-11-06 |
| DE69716932D1 (de) | 2002-12-12 |
| ATE227284T1 (de) | 2002-11-15 |
| CA2264072A1 (en) | 1998-03-05 |
| CN1234033A (zh) | 1999-11-03 |
| CN1077890C (zh) | 2002-01-16 |
| AU4091797A (en) | 1998-03-19 |
| EP0923576A1 (en) | 1999-06-23 |
| DE69716932T2 (de) | 2003-03-27 |
| DK0923576T3 (da) | 2003-03-03 |
| PT923576E (pt) | 2003-02-28 |
| JP2000517318A (ja) | 2000-12-26 |
| WO1998008843A1 (en) | 1998-03-05 |
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