ATE218581T1 - Cyclosporinderivat, dessen herstellung und pharmazeutische zusammensetzung - Google Patents

Cyclosporinderivat, dessen herstellung und pharmazeutische zusammensetzung

Info

Publication number
ATE218581T1
ATE218581T1 AT97952997T AT97952997T ATE218581T1 AT E218581 T1 ATE218581 T1 AT E218581T1 AT 97952997 T AT97952997 T AT 97952997T AT 97952997 T AT97952997 T AT 97952997T AT E218581 T1 ATE218581 T1 AT E218581T1
Authority
AT
Austria
Prior art keywords
production
pharmaceutical composition
cyclosporine derivative
cyclosporine
derivative
Prior art date
Application number
AT97952997T
Other languages
English (en)
Inventor
Jean-Claude Barriere
Georges Bashiardes
Jean-Christophe Carry
Michel Evers
Bruno Filoche
Serge Mignani
Original Assignee
Aventis Pharma Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma Sa filed Critical Aventis Pharma Sa
Application granted granted Critical
Publication of ATE218581T1 publication Critical patent/ATE218581T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links
    • C07K7/645—Cyclosporins; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
AT97952997T 1996-12-24 1997-12-23 Cyclosporinderivat, dessen herstellung und pharmazeutische zusammensetzung ATE218581T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9615954A FR2757520B1 (fr) 1996-12-24 1996-12-24 Derive de cyclosporine, sa preparation et les compositions pharmaceutiques qui le contiennent
PCT/FR1997/002404 WO1998028328A1 (fr) 1996-12-24 1997-12-23 Derive de cyclosporine, sa preparation et les compositions pharmaceutiques qui le contiennent

Publications (1)

Publication Number Publication Date
ATE218581T1 true ATE218581T1 (de) 2002-06-15

Family

ID=9499087

Family Applications (1)

Application Number Title Priority Date Filing Date
AT97952997T ATE218581T1 (de) 1996-12-24 1997-12-23 Cyclosporinderivat, dessen herstellung und pharmazeutische zusammensetzung

Country Status (11)

Country Link
US (1) US5948755A (de)
EP (1) EP0951473B1 (de)
JP (1) JP4104666B2 (de)
AT (1) ATE218581T1 (de)
AU (1) AU5669198A (de)
DE (1) DE69713151D1 (de)
DK (1) DK0951473T3 (de)
ES (1) ES2178036T3 (de)
FR (1) FR2757520B1 (de)
PT (1) PT951473E (de)
WO (1) WO1998028328A1 (de)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030220234A1 (en) 1998-11-02 2003-11-27 Selvaraj Naicker Deuterated cyclosporine analogs and their use as immunodulating agents
WO1999065933A1 (en) * 1998-06-12 1999-12-23 C-Chem Ag Novel cyclosporins
USRE40987E1 (en) 1998-07-01 2009-11-17 Debiopharm S.A. Cyclosporin with improved activity profile
US6254860B1 (en) * 1999-04-13 2001-07-03 Allergan Sales, Inc. Ocular treatment using cyclosporin-A derivatives
PT1435910E (pt) * 2001-10-19 2009-09-07 Isotechnika Inc Novos pré-concentrados de microemulsão de análogos da ciclosporina
DE60231570D1 (de) 2001-10-19 2009-04-23 Isotechnika Inc Synthese von Cyclosporinanalogen
KR100512019B1 (ko) * 2002-07-25 2005-09-02 신득용 사이클로스포린 ａ 또는 이의 유도체를 이용한 세포의노화를 억제하는 방법 및 배양배지
AU2004222306A1 (en) 2003-03-17 2004-09-30 Albany Molecular Research, Inc. Novel cyclosporins
GB0320638D0 (en) 2003-09-03 2003-10-01 Novartis Ag Organic compounds
JP2007513154A (ja) * 2003-12-08 2007-05-24 サイトキネティクス・インコーポレーテッド 化合物、組成物及び方法
JP2008514702A (ja) 2004-09-29 2008-05-08 エーエムアール テクノロジー インコーポレイテッド 新規シクロスポリン類似体およびそれらの薬学的使用
WO2006039163A2 (en) 2004-09-29 2006-04-13 Amr Technology, Inc. Cyclosporin alkyne analogues and their pharmaceutical uses
SI1802650T1 (sl) * 2004-10-01 2012-03-30 Scynexis Inc Eter in tioeter substituirani ciklosporinski derivati za zdravljenje in preventivo pred infekcijami s hepatitisom c
PT1793844E (pt) 2004-10-01 2011-03-10 Debiopharm Sa Utilização de [d-meala]3-[etval]4-csa para o tratamento de infecção causada pelo vírus da hepatite c
US7196161B2 (en) 2004-10-01 2007-03-27 Scynexis Inc. 3-ether and 3-thioether substituted cyclosporin derivatives for the treatment and prevention of hepatitis C infection
WO2006041631A2 (en) 2004-10-06 2006-04-20 Amr Technology, Inc. Novel cyclosporin alkynes and their utility as pharmaceutical agents
CN105169369B (zh) 2005-09-30 2019-10-18 中美华世通生物医药科技（武汉）有限公司 治疗和预防丙型肝炎感染的方法和药物组合物
CA2623864C (en) * 2005-09-30 2014-12-16 Scynexis, Inc. Arylalkyl and heteroarylalkyl derivatives of cyclosporine a for the treatment and prevention of viral infection
US7696165B2 (en) 2006-03-28 2010-04-13 Albany Molecular Research, Inc. Use of cyclosporin alkyne analogues for preventing or treating viral-induced disorders
US7696166B2 (en) 2006-03-28 2010-04-13 Albany Molecular Research, Inc. Use of cyclosporin alkyne/alkene analogues for preventing or treating viral-induced disorders
EP2023918B1 (de) 2006-05-19 2011-03-23 Scynexis, Inc. Cyclosporins zur behandlung und vorbeugung von augenerkrankungen
KR101089112B1 (ko) * 2006-06-02 2011-12-06 피씨 제스띠옹 에스.아.에스. 활성 전자 관리
US7576057B2 (en) 2006-11-20 2009-08-18 Scynexis, Inc. Cyclic peptides
WO2008127613A1 (en) * 2007-04-11 2008-10-23 Scynexis, Inc. New pharmaceutical compositions
WO2009042892A1 (en) 2007-09-26 2009-04-02 Oregon Health & Science University Cyclic undecapeptides and derivatives as multiple sclerosis therapies
JP5820722B2 (ja) 2008-06-06 2015-11-24 スシネキス インク シクロスポリン類似体及びｈｃｖ感染の治療におけるその使用
WO2009148615A1 (en) * 2008-06-06 2009-12-10 Scynexis, Inc. Cyclosporin analogs and their use in the treatment of hcv infections
JP5661035B2 (ja) * 2008-07-10 2015-01-28 アラーガン、インコーポレイテッドＡｌｌｅｒｇａｎ，Ｉｎｃｏｒｐｏｒａｔｅｄ 眼および皮膚の疾患および症状の治療用のシクロスポリン誘導体
CA2748389A1 (en) 2008-12-31 2010-07-08 Scynexis, Inc. Derivatives of cyclosporin a
CA2763207A1 (en) 2009-05-27 2010-12-02 Allergan, Inc. Cyclosporin derivatives for treating inflammatory diseases and conditions
KR101149529B1 (ko) 2009-09-11 2012-05-25 한국화학연구원 인덴온 유도체 및 이를 포함하는 약학적 조성물
KR20120125610A (ko) 2009-12-30 2012-11-16 싸이넥시스, 인크. 시클로스포린 유사체
LT2651965T (lt) 2010-12-15 2019-01-10 Contravir Pharmaceuticals, Inc. Ciklosporino analogo molekulės su modifikuotomis 1 ir 3 aminorūgštimis
US9395551B2 (en) 2013-04-24 2016-07-19 Kamakura Koki Co., Ltd. Optical image stabilizer
AR111464A1 (es) * 2017-04-14 2019-07-17 Contravir Pharmaceuticals Inc Terapia combinada para el tratamiento de infecciones virales

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0194972B1 (de) * 1985-03-11 1992-07-29 Sandoz Ag Cyclosporine
US4814323A (en) * 1986-03-25 1989-03-21 Andrieu J M Process for the treatment and the prevention of AIDS and other disorders induced by the LAV/HTLV III virus
DE69124459T3 (de) * 1990-11-02 2001-05-31 Novartis Ag, Basel Zyklosporine
NZ315324A (en) * 1995-07-17 1999-10-28 Chem Ag C Cyclosporin derivatives with anti-hiv effect

Also Published As

Publication number Publication date
ES2178036T3 (es) 2002-12-16
EP0951473B1 (de) 2002-06-05
PT951473E (pt) 2002-11-29
FR2757520A1 (fr) 1998-06-26
DE69713151D1 (de) 2002-07-11
WO1998028328A1 (fr) 1998-07-02
US5948755A (en) 1999-09-07
AU5669198A (en) 1998-07-17
JP2001507016A (ja) 2001-05-29
DK0951473T3 (da) 2002-09-16
FR2757520B1 (fr) 1999-01-29
EP0951473A1 (de) 1999-10-27
JP4104666B2 (ja) 2008-06-18

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