ATE218581T1 - Cyclosporinderivat, dessen herstellung und pharmazeutische zusammensetzung - Google Patents

Cyclosporinderivat, dessen herstellung und pharmazeutische zusammensetzung

Info

Publication number
ATE218581T1
ATE218581T1 AT97952997T AT97952997T ATE218581T1 AT E218581 T1 ATE218581 T1 AT E218581T1 AT 97952997 T AT97952997 T AT 97952997T AT 97952997 T AT97952997 T AT 97952997T AT E218581 T1 ATE218581 T1 AT E218581T1
Authority
AT
Austria
Prior art keywords
production
pharmaceutical composition
cyclosporine derivative
cyclosporine
derivative
Prior art date
Application number
AT97952997T
Other languages
English (en)
Inventor
Jean-Claude Barriere
Georges Bashiardes
Jean-Christophe Carry
Michel Evers
Bruno Filoche
Serge Mignani
Original Assignee
Aventis Pharma Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma Sa filed Critical Aventis Pharma Sa
Application granted granted Critical
Publication of ATE218581T1 publication Critical patent/ATE218581T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links
    • C07K7/645—Cyclosporins; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Virology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
AT97952997T 1996-12-24 1997-12-23 Cyclosporinderivat, dessen herstellung und pharmazeutische zusammensetzung ATE218581T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9615954A FR2757520B1 (fr) 1996-12-24 1996-12-24 Derive de cyclosporine, sa preparation et les compositions pharmaceutiques qui le contiennent
PCT/FR1997/002404 WO1998028328A1 (fr) 1996-12-24 1997-12-23 Derive de cyclosporine, sa preparation et les compositions pharmaceutiques qui le contiennent

Publications (1)

Publication Number Publication Date
ATE218581T1 true ATE218581T1 (de) 2002-06-15

Family

ID=9499087

Family Applications (1)

Application Number Title Priority Date Filing Date
AT97952997T ATE218581T1 (de) 1996-12-24 1997-12-23 Cyclosporinderivat, dessen herstellung und pharmazeutische zusammensetzung

Country Status (11)

Country Link
US (1) US5948755A (de)
EP (1) EP0951473B1 (de)
JP (1) JP4104666B2 (de)
AT (1) ATE218581T1 (de)
AU (1) AU5669198A (de)
DE (1) DE69713151D1 (de)
DK (1) DK0951473T3 (de)
ES (1) ES2178036T3 (de)
FR (1) FR2757520B1 (de)
PT (1) PT951473E (de)
WO (1) WO1998028328A1 (de)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030220234A1 (en) 1998-11-02 2003-11-27 Selvaraj Naicker Deuterated cyclosporine analogs and their use as immunodulating agents
ES2212583T3 (es) * 1998-06-12 2004-07-16 C-Chem Ag Nuevas ciclosporinas.
PT1091975E (pt) 1998-07-01 2006-05-31 Debiopharm Sa Nova ciclosporina com um perfil de actividade melhorado
US6254860B1 (en) 1999-04-13 2001-07-03 Allergan Sales, Inc. Ocular treatment using cyclosporin-A derivatives
WO2003033526A2 (en) 2001-10-19 2003-04-24 Isotechnika Inc. Synthesis of cyclosporin analogs
EP2116228A1 (de) * 2001-10-19 2009-11-11 Isotechnika Inc. Neuartige Cyclosporinanalog-Mikroemulsionspräkonzentrate
KR100512019B1 (ko) * 2002-07-25 2005-09-02 신득용 사이클로스포린 ａ 또는 이의 유도체를 이용한 세포의노화를 억제하는 방법 및 배양배지
JP2006524232A (ja) 2003-03-17 2006-10-26 アルバニー モレキュラー リサーチ インコーポレーティッド 新規サイクロスポリン
GB0320638D0 (en) 2003-09-03 2003-10-01 Novartis Ag Organic compounds
JP2007513154A (ja) * 2003-12-08 2007-05-24 サイトキネティクス・インコーポレーテッド 化合物、組成物及び方法
JP2008514701A (ja) 2004-09-29 2008-05-08 エーエムアール テクノロジー インコーポレイテッド シクロスポリンアルキン類似体およびそれらの薬学的使用
EP1804823A4 (de) 2004-09-29 2010-06-09 Amr Technology Inc Neue cyclosporin-analoga und ihre pharmazeutischen anwendungen
JP5139065B2 (ja) * 2004-10-01 2013-02-06 スシネキス インク Ｃ型肝炎感染の治療及び予防のための３−エーテル及び３−チオエーテル置換シクロスポリン誘導体
US7196161B2 (en) * 2004-10-01 2007-03-27 Scynexis Inc. 3-ether and 3-thioether substituted cyclosporin derivatives for the treatment and prevention of hepatitis C infection
UA88484C2 (ru) 2004-10-01 2009-10-26 Дебиофарм Са ПРИМЕНЕНИЕ [D-MeAla]3-[EtVal]4-ЦИКЛОСПОРИНА ДЛЯ ЛЕЧЕНИЯ ИНФЕКЦИИ ГЕПАТИТА С И ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ, КОТОРАЯ ВКЛЮЧАЕТ [D-MeAla]3-[EtVal]4-ЦИКЛОСПОРИН
US7361636B2 (en) 2004-10-06 2008-04-22 Amr Technology, Inc. Cyclosporin alkynes and their utility as pharmaceutical agents
US8329658B2 (en) 2005-09-30 2012-12-11 Scynexis, Inc. Arylalkyl and heteroarylalkyl derivatives of cyclosporine A for the treatment and prevention of viral infection
BRPI0616476A2 (pt) 2005-09-30 2011-06-21 Scynexis Inc uso de uma quantidade terapeuticamente eficaz de um derivado de ciclosporina, e, composição farmacêutica
US7696166B2 (en) 2006-03-28 2010-04-13 Albany Molecular Research, Inc. Use of cyclosporin alkyne/alkene analogues for preventing or treating viral-induced disorders
US7696165B2 (en) 2006-03-28 2010-04-13 Albany Molecular Research, Inc. Use of cyclosporin alkyne analogues for preventing or treating viral-induced disorders
ATE502633T1 (de) 2006-05-19 2011-04-15 Scynexis Inc Cyclosporins zur behandlung und vorbeugung von augenerkrankungen
EP2027761A1 (de) * 2006-06-02 2009-02-25 Claude Annie Perrichon Verwaltung von aktieven elektronen
US7576057B2 (en) 2006-11-20 2009-08-18 Scynexis, Inc. Cyclic peptides
US20080255038A1 (en) * 2007-04-11 2008-10-16 Samuel Earl Hopkins Pharmaceutical compositions
WO2009042892A1 (en) 2007-09-26 2009-04-02 Oregon Health & Science University Cyclic undecapeptides and derivatives as multiple sclerosis therapies
US9090671B2 (en) 2008-06-06 2015-07-28 Scynexis, Inc. Macrocyclic peptides
US20090306033A1 (en) * 2008-06-06 2009-12-10 Keqiang Li Novel cyclic peptides
AU2009268549B2 (en) * 2008-07-10 2015-07-16 Allergan, Inc. Cyclosporin derivatives for treating ocular and dermal diseases and conditions
EP2376524B1 (de) * 2008-12-31 2017-03-15 Cypralis Limited Derivate von cyclosporin a
AU2010254316A1 (en) 2009-05-27 2011-12-22 Allergan, Inc. Cyclosporin derivatives for treating inflammatory diseases and conditions
KR101149529B1 (ko) 2009-09-11 2012-05-25 한국화학연구원 인덴온 유도체 및 이를 포함하는 약학적 조성물
AU2010339460A1 (en) 2009-12-30 2012-07-19 Scynexis Inc. Cyclosporine analogues
JP6144627B2 (ja) 2010-12-15 2017-06-07 コントラヴィア ファーマシューティカルズ、インク． アミノ酸１および３で修飾されたシクロスポリン類似体分子
US9395551B2 (en) 2013-04-24 2016-07-19 Kamakura Koki Co., Ltd. Optical image stabilizer
AR111464A1 (es) * 2017-04-14 2019-07-17 Contravir Pharmaceuticals Inc Terapia combinada para el tratamiento de infecciones virales

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0194972B1 (de) * 1985-03-11 1992-07-29 Sandoz Ag Cyclosporine
US4814323A (en) * 1986-03-25 1989-03-21 Andrieu J M Process for the treatment and the prevention of AIDS and other disorders induced by the LAV/HTLV III virus
ATE148469T1 (de) * 1990-11-02 1997-02-15 Sandoz Ag Zyklosporine
PL324531A1 (en) * 1995-07-17 1998-06-08 Chem Ag C Derivatives of cyclosporin effective against hiv virus

Also Published As

Publication number Publication date
WO1998028328A1 (fr) 1998-07-02
PT951473E (pt) 2002-11-29
EP0951473A1 (de) 1999-10-27
JP2001507016A (ja) 2001-05-29
ES2178036T3 (es) 2002-12-16
US5948755A (en) 1999-09-07
FR2757520B1 (fr) 1999-01-29
AU5669198A (en) 1998-07-17
JP4104666B2 (ja) 2008-06-18
DK0951473T3 (da) 2002-09-16
EP0951473B1 (de) 2002-06-05
FR2757520A1 (fr) 1998-06-26
DE69713151D1 (de) 2002-07-11

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