ATE290015T1 - Cyclosporinderivate, deren herstellung und pharmazeutische zubereitungen - Google Patents

Cyclosporinderivate, deren herstellung und pharmazeutische zubereitungen

Info

Publication number: ATE290015T1
Authority: AT; Austria
Prior art keywords: production; pharmaceutical preparations; cyclosporine derivatives; radical; derivatives
Prior art date: 1997-04-30

Application number

AT98922872T

Other languages

English (en)

Inventor

Michel Evers

Serge Mignani

Jean-Christophe Carry

Bruno Filoche

Georges Bashiardes

Claude Bensoussan

Jean-Christophe Gueguen

Jean-Claude Barriere

Original Assignee

Aventis Pharma Sa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-04-30

Filing date

1998-04-27

Publication date

2005-03-15

1998-04-27 Application filed by Aventis Pharma Sa filed Critical Aventis Pharma Sa

2005-03-15 Application granted granted Critical

2005-03-15 Publication of ATE290015T1 publication Critical patent/ATE290015T1/de

Links

PMATZTZNYRCHOR-CGLBZJNRSA-N Cyclosporin A Chemical class CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O PMATZTZNYRCHOR-CGLBZJNRSA-N 0.000 title abstract 2
238000004519 manufacturing process Methods 0.000 title 1
239000000825 pharmaceutical preparation Substances 0.000 title 1
208000005074 Retroviridae Infections Diseases 0.000 abstract 1
238000011321 prophylaxis Methods 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
238000011282 treatment Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/64—Cyclic peptides containing only normal peptide links
- C07K7/645—Cyclosporins; Related peptides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Virology (AREA)
Molecular Biology (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Immunology (AREA)
Biophysics (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Biochemistry (AREA)
Genetics & Genomics (AREA)
AIDS & HIV (AREA)
Tropical Medicine & Parasitology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)

AT98922872T 1997-04-30 1998-04-27 Cyclosporinderivate, deren herstellung und pharmazeutische zubereitungen ATE290015T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
FR9705351A FR2762843B1 (fr)	1997-04-30	1997-04-30	Nouveaux derives de cyclosporine, leur preparation et les compositions pharmaceutiques qui les contiennent
PCT/FR1998/000838 WO1998049193A1 (fr)	1997-04-30	1998-04-27	Nouveaux derives de cyclosporine, leur preparation et les compositions pharmaceutiques qui les contiennent

Publications (1)

Publication Number	Publication Date
ATE290015T1 true ATE290015T1 (de)	2005-03-15

Family

ID=9506467

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT98922872T ATE290015T1 (de)	1997-04-30	1998-04-27	Cyclosporinderivate, deren herstellung und pharmazeutische zubereitungen

Country Status (13)

Country	Link
US (1)	US5977067A (de)
EP (1)	EP0979244B1 (de)
JP (1)	JP2001524105A (de)
AT (1)	ATE290015T1 (de)
AU (1)	AU7535798A (de)
DE (1)	DE69829175T2 (de)
ES (1)	ES2236902T3 (de)
FR (1)	FR2762843B1 (de)
MA (1)	MA26488A1 (de)
PT (1)	PT979244E (de)
TN (1)	TNSN98057A1 (de)
WO (1)	WO1998049193A1 (de)
ZA (1)	ZA983618B (de)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US20030220234A1 (en)	1998-11-02	2003-11-27	Selvaraj Naicker	Deuterated cyclosporine analogs and their use as immunodulating agents
EP2116228A1 (de) *	2001-10-19	2009-11-11	Isotechnika Inc.	Neuartige Cyclosporinanalog-Mikroemulsionspräkonzentrate
WO2003033526A2 (en)	2001-10-19	2003-04-24	Isotechnika Inc.	Synthesis of cyclosporin analogs
KR20040039622A (ko) *	2002-11-04	2004-05-12	주식회사 엘지생활건강	모발 성장 효과를 갖는 사이클로스포린 3 위치 유도체를유효성분으로 하는 모발 성장 촉진제
US20060130158A1 (en) *	2002-08-30	2006-06-15	Turner Andrew J	Modified transferrin fusion proteins comprising duplicate transferrin amino or carboxy terminal domains
JP2006524232A (ja)	2003-03-17	2006-10-26	アルバニーモレキュラーリサーチインコーポレーティッド	新規サイクロスポリン
ATE488252T1 (de) *	2003-05-05	2010-12-15	Virxsys Corp	Erhöhte transduktion mit abc- transportersubstratenhemmern
JP2008514701A (ja)	2004-09-29	2008-05-08	エーエムアールテクノロジーインコーポレイテッド	シクロスポリンアルキン類似体およびそれらの薬学的使用
EP1804823A4 (de)	2004-09-29	2010-06-09	Amr Technology Inc	Neue cyclosporin-analoga und ihre pharmazeutischen anwendungen
JP5139065B2 (ja) *	2004-10-01	2013-02-06	スシネキスインク	Ｃ型肝炎感染の治療及び予防のための３−エーテル及び３−チオエーテル置換シクロスポリン誘導体
US7196161B2 (en) *	2004-10-01	2007-03-27	Scynexis Inc.	3-ether and 3-thioether substituted cyclosporin derivatives for the treatment and prevention of hepatitis C infection
US7361636B2 (en)	2004-10-06	2008-04-22	Amr Technology, Inc.	Cyclosporin alkynes and their utility as pharmaceutical agents
US8329658B2 (en) *	2005-09-30	2012-12-11	Scynexis, Inc.	Arylalkyl and heteroarylalkyl derivatives of cyclosporine A for the treatment and prevention of viral infection
BRPI0616476A2 (pt) *	2005-09-30	2011-06-21	Scynexis Inc	uso de uma quantidade terapeuticamente eficaz de um derivado de ciclosporina, e, composição farmacêutica
US9839667B2 (en)	2005-10-14	2017-12-12	Allergan, Inc.	Prevention and treatment of ocular side effects with a cyclosporin
EP3103468B1 (de) *	2005-10-14	2020-07-15	Allergan, Inc.	Prävention von mit arzneimitteln in zusammenhang stehenden keratokonjunctivitis mit cyclosporin
US7745400B2 (en) *	2005-10-14	2010-06-29	Gregg Feinerman	Prevention and treatment of ocular side effects with a cyclosporin
ATE502633T1 (de)	2006-05-19	2011-04-15	Scynexis Inc	Cyclosporins zur behandlung und vorbeugung von augenerkrankungen
EP2027761A1 (de) *	2006-06-02	2009-02-25	Claude Annie Perrichon	Verwaltung von aktieven elektronen
US7576057B2 (en)	2006-11-20	2009-08-18	Scynexis, Inc.	Cyclic peptides
US20080255038A1 (en) *	2007-04-11	2008-10-16	Samuel Earl Hopkins	Pharmaceutical compositions
US20090306033A1 (en) *	2008-06-06	2009-12-10	Keqiang Li	Novel cyclic peptides
US9090671B2 (en)	2008-06-06	2015-07-28	Scynexis, Inc.	Macrocyclic peptides
BRPI0911709A2 (pt) *	2008-07-30	2017-06-20	Isotechnika Labs Inc	composto, processo para a produção de um composto, composição farmacêutica e método de tratar uma doença mediada a ciclofilina em um mamífero
DE102008060549A1 (de)	2008-12-04	2010-06-10	MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V.	Wirkstoff-Peptid-Konstrukt zur extrazellulären Anreicherung
EP2376524B1 (de) *	2008-12-31	2017-03-15	Cypralis Limited	Derivate von cyclosporin a
SG173180A1 (en)	2009-01-30	2011-09-29	Enanta Pharm Inc	Cyclosporin analogues for preventing or treating hepatitis c infection
US8481483B2 (en) *	2009-02-19	2013-07-09	Enanta Pharmaceuticals, Inc.	Cyclosporin analogues
WO2010138422A1 (en) *	2009-05-27	2010-12-02	Allergan, Inc.	Cyclosporin derivatives for enhancing the growth of hair
AU2010254316A1 (en) *	2009-05-27	2011-12-22	Allergan, Inc.	Cyclosporin derivatives for treating inflammatory diseases and conditions
US8685917B2 (en) *	2009-07-09	2014-04-01	Enanta Pharmaceuticals, Inc.	Cyclosporin analogues
AU2010339460A1 (en)	2009-12-30	2012-07-19	Scynexis Inc.	Cyclosporine analogues
US9175042B2 (en) *	2010-10-12	2015-11-03	Allergan, Inc.	Cyclosporin analogs
RU2013119869A (ru)	2010-10-12	2014-11-20	Аллерган, Инк.	Аналоги циклоспорина
JP6144627B2 (ja)	2010-12-15	2017-06-07	コントラヴィアファーマシューティカルズ、インク．	アミノ酸１および３で修飾されたシクロスポリン類似体分子
DE102011111991A1 (de) *	2011-08-30	2013-02-28	Lead Discovery Center Gmbh	Neue Cyclosporin-Derivate
EP2705856A1 (de)	2012-09-07	2014-03-12	Deutsches Zentrum für Neurodegenerative Erkrankungen e.V.	Verbindungen zur Behandlung von neurodegenerativen Erkrankungen
WO2014049540A2 (en)	2012-09-29	2014-04-03	Novartis Ag	Cyclic peptides and use as medicines

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0194972B1 (de) *	1985-03-11	1992-07-29	Sandoz Ag	Cyclosporine
US4814323A (en) *	1986-03-25	1989-03-21	Andrieu J M	Process for the treatment and the prevention of AIDS and other disorders induced by the LAV/HTLV III virus
US4798823A (en) *	1987-06-03	1989-01-17	Merck & Co., Inc.	New cyclosporin analogs with modified "C-9 amino acids"
US4885276A (en) *	1987-06-03	1989-12-05	Merck & Co., Inc.	Cyclosporin analogs with modified "C-9 amino acids"
ATE148469T1 (de) *	1990-11-02	1997-02-15	Sandoz Ag	Zyklosporine
US5512555A (en) *	1994-07-21	1996-04-30	Merck & Co., Inc.	Method of treating sweat-related conditions using finasteride, epristeride and a cholestan-3-one
PL324531A1 (en) *	1995-07-17	1998-06-08	Chem Ag C	Derivatives of cyclosporin effective against hiv virus

1997
- 1997-04-30 FR FR9705351A patent/FR2762843B1/fr not_active Expired - Fee Related
1998
- 1998-04-27 MA MA25048A patent/MA26488A1/fr unknown
- 1998-04-27 EP EP98922872A patent/EP0979244B1/de not_active Expired - Lifetime
- 1998-04-27 ES ES98922872T patent/ES2236902T3/es not_active Expired - Lifetime
- 1998-04-27 AT AT98922872T patent/ATE290015T1/de active
- 1998-04-27 PT PT98922872T patent/PT979244E/pt unknown
- 1998-04-27 AU AU75357/98A patent/AU7535798A/en not_active Abandoned
- 1998-04-27 WO PCT/FR1998/000838 patent/WO1998049193A1/fr not_active Ceased
- 1998-04-27 DE DE69829175T patent/DE69829175T2/de not_active Expired - Lifetime
- 1998-04-27 JP JP54666498A patent/JP2001524105A/ja active Pending
- 1998-04-29 ZA ZA983618A patent/ZA983618B/xx unknown
- 1998-04-29 TN TNTNSN98057A patent/TNSN98057A1/fr unknown
- 1998-04-30 US US09/069,959 patent/US5977067A/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
EP0979244A1 (de)	2000-02-16
DE69829175T2 (de)	2006-02-16
ES2236902T3 (es)	2005-07-16
WO1998049193A1 (fr)	1998-11-05
MA26488A1 (fr)	2004-12-20
FR2762843A1 (fr)	1998-11-06
PT979244E (pt)	2005-06-30
DE69829175D1 (de)	2005-04-07
TNSN98057A1 (fr)	2005-03-15
AU7535798A (en)	1998-11-24
ZA983618B (en)	1998-11-04
US5977067A (en)	1999-11-02
FR2762843B1 (fr)	1999-12-10
EP0979244B1 (de)	2005-03-02
JP2001524105A (ja)	2001-11-27

Legal Events

Date

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2006-10-15

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