ATE229944T1 - Benzooxazine als antimikrobielle mittel - Google Patents

Benzooxazine als antimikrobielle mittel

Info

Publication number: ATE229944T1
Authority: AT; Austria
Prior art keywords: benzooxazine; antimicrobial agents; antimicrobial; agents
Prior art date: 1995-11-07

Application number

AT96936648T

Other languages

English (en)

Inventor

Roger Frechette

Michele A Weidner-Wells

Original Assignee

Ortho Mcneil Pharm Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-11-07

Filing date

1996-10-17

Publication date

2003-01-15

1996-10-17 Application filed by Ortho Mcneil Pharm Inc filed Critical Ortho Mcneil Pharm Inc

2003-01-15 Application granted granted Critical

2003-01-15 Publication of ATE229944T1 publication Critical patent/ATE229944T1/de

Links

CMLFRMDBDNHMRA-UHFFFAOYSA-N 2h-1,2-benzoxazine Chemical compound C1=CC=C2C=CNOC2=C1 CMLFRMDBDNHMRA-UHFFFAOYSA-N 0.000 title 1
239000004599 antimicrobial Substances 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
- C07D265/34—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings
- C07D265/36—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings condensed with one six-membered ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/26—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D307/30—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/32—Oxygen atoms
- C07D307/33—Oxygen atoms in position 2, the oxygen atom being in its keto or unsubstituted enol form
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Furan Compounds (AREA)
Plural Heterocyclic Compounds (AREA)

AT96936648T 1995-11-07 1996-10-17 Benzooxazine als antimikrobielle mittel ATE229944T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US08/553,188 US5696117A (en)	1995-11-07	1995-11-07	Benzoxazine antimicrobial agents
PCT/US1996/016669 WO1997017333A1 (en)	1995-11-07	1996-10-17	Benzoxazine antimicrobial agents

Publications (1)

Publication Number	Publication Date
ATE229944T1 true ATE229944T1 (de)	2003-01-15

Family

ID=24208465

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT96936648T ATE229944T1 (de)	1995-11-07	1996-10-17	Benzooxazine als antimikrobielle mittel

Country Status (24)

Country	Link
US (2)	US5696117A (de)
EP (1)	EP0869949B1 (de)
JP (1)	JP2000500134A (de)
KR (1)	KR100503910B1 (de)
AR (1)	AR004706A1 (de)
AT (1)	ATE229944T1 (de)
AU (1)	AU720743B2 (de)
BR (1)	BR9611400A (de)
CZ (1)	CZ137998A3 (de)
DE (1)	DE69625515T2 (de)
DK (1)	DK0869949T3 (de)
ES (1)	ES2188795T3 (de)
HU (1)	HUP9901184A3 (de)
IL (1)	IL124337A (de)
MX (1)	MX9803650A (de)
MY (1)	MY128650A (de)
NO (1)	NO311026B1 (de)
NZ (1)	NZ321251A (de)
PL (1)	PL189987B1 (de)
RU (1)	RU2191179C2 (de)
SK (2)	SK283888B6 (de)
TW (1)	TW536537B (de)
WO (1)	WO1997017333A1 (de)
ZA (1)	ZA969326B (de)

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CA2307068C (en)	1997-10-27	2007-04-10	Dr. Reddy's Laboratories Limited	Bicyclic compounds, process for their preparation and pharmaceutical compositions containing them
US6265401B1 (en) *	1997-10-27	2001-07-24	Reddy-Cheminor, Inc.	Bicyclic compounds and their use in medicine, process for their preparation and pharmaceutical compositions containing them
AU3406599A (en) *	1998-04-09	1999-11-01	Institut Fur Diagnostikforschung Gmbh An Der Freien Universitat Berlin	Novel benzyl guanidine derivatives for therapy and (in-vivo) and (in-vitro) diagnosis
US6667299B1 (en) *	2000-03-16	2003-12-23	Hollis-Eden Pharmaceuticals, Inc.	Pharmaceutical compositions and treatment methods
WO2001012600A1 (en) *	1999-08-12	2001-02-22	Cor Therapeutics, Inc.	INHIBITORS OF FACTOR Xa
WO2001087861A2 (en) *	2000-05-12	2001-11-22	Ortho-Mcneil Pharmaceutical, Inc.	Methods of treatment using benzoxazinones as peroxisome proliferator activated receptor gamma modulators
WO2001087860A2 (en) *	2000-05-12	2001-11-22	Ortho-Mcneil Pharmaceutical, Inc.	Novel benzoxazinones as peroxisome proliferator activated receptor gamma modulators and method of treatment
US6908908B2 (en) *	2000-05-12	2005-06-21	Ortho-Mcneil Pharmaceutical, Inc.	Biologically active 4H-benzo [1,4] oxazin-3-ones
AU2001263083A1 (en)	2000-05-12	2001-11-26	Ortho-Mcneil Pharmaceutical, Inc.	Biologically active 4h-benzo(1,4)oxazin-3-ones
CA2450073C (en)	2001-07-25	2017-08-29	Biomarin Pharmaceutical Inc.	Compositions and methods for modulating blood-brain barrier transport
AU2004268865B8 (en) *	2003-09-01	2011-01-06	Ono Pharmaceutical Co., Ltd.	Condensed ring compound and use thereof
KR20060080197A (ko) *	2003-09-17	2006-07-07	오노 야꾸힝 고교 가부시키가이샤	카르복실산 화합물 및 이들을 유효 성분으로서 함유하는의약 조성물
US20050266575A1 (en) *	2004-05-27	2005-12-01	Mayo Kevin H	Pharmacophores for nociceptin, methods of obtaining and using in screening for nociceptin mimics
GB0423405D0 (en) *	2004-10-21	2004-11-24	Novartis Ag	Organic compounds
WO2006082495A1 (en) *	2005-02-02	2006-08-10	Ranbaxy Laboratories Limited	Peroxisome proliferator activated receptor modulators
EP2671508B1 (de)	2005-04-28	2020-09-16	Proteus Digital Health, Inc.	Pharma-Informatiksystem
TWI386207B (zh) *	2005-11-24	2013-02-21	Eisai R&D Man Co Ltd	味啉類型之肉桂醯胺化合物
WO2007086504A1 (ja) *	2006-01-27	2007-08-02	Japan Tobacco Inc.	カルボン酸化合物及びその用途
US20070197512A1 (en) *	2006-01-27	2007-08-23	Japan Tobacco Inc.	Carboxylic Acid Compounds and Use Thereof
JP5099814B2 (ja) *	2006-02-02	2012-12-19	田辺三菱製薬株式会社	含窒素複素二環式化合物
TWI385161B (zh)	2006-02-02	2013-02-11	Mitsubishi Tanabe Pharma Corp	含氮雜雙環化合物
KR20080103090A (ko) *	2006-03-10	2008-11-26	유조 츠치다	항미생물제 및 항미생물성 조성물
JP2010503710A (ja)	2006-09-18	2010-02-04	ラプトールファーマシューティカルインコーポレイテッド	受容体関連タンパク質（ｒａｐ）結合体の投与による肝障害の処置
TWI410410B (zh) *	2007-08-10	2013-10-01	Ono Pharmaceutical Co	Phenylacetic acid compounds
ES2919563T3 (es)	2009-02-20	2022-07-27	Enhanx Biopharm Inc	Sistema de administración de medicamentos a base de glutatión
AU2010237801A1 (en) *	2009-04-14	2011-10-20	Syngenta Participations Ag	Haloalkylsulfonanilide derivative
KR20180114970A (ko)	2009-05-06	2018-10-19	라보라토리 스킨 케어, 인크.	활성제-칼슘 포스페이트 입자 복합체를 포함하는 피부 전달 조성물 및 이들을 이용하는 방법
US20120077778A1 (en)	2010-09-29	2012-03-29	Andrea Bourdelais	Ladder-Frame Polyether Conjugates
US9493452B2 (en)	2011-03-24	2016-11-15	Southern Methodist University	Compounds and derivatives of 2H-pyrido (3,2-b)(1, 4) oxazin 3)4H)-ones as raf kinase and LRRK2 inhibitors
US8669363B2 (en)	2011-03-24	2014-03-11	Southern Methodist University	Quinoxaline compounds and derivatives
WO2013142831A1 (en)	2012-03-23	2013-09-26	Southern Methodist University	Methods of making and using thioxothiazolidine and rhodanine derivatives as hiv-1 and jsp-1 inhibitors
GB2533925A (en) *	2014-12-31	2016-07-13	Univ Bath	Antimicrobial compounds, compositions and methods
JP7397491B2 (ja)	2018-10-23	2023-12-13	国立研究開発法人科学技術振興機構	ＰＰＡＲδ活性化剤

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3635956A (en) *	1968-03-01	1972-01-18	Squibb & Sons Inc	Benzothiazines related compounds derivatives and salts thereof
US3725403A (en) *	1970-10-20	1973-04-03	Squibb & Sons Inc	Benzothiazine derivatives
JPS5547006B2 (de) *	1973-04-04	1980-11-27
FR2588868B1 (fr) *	1985-10-21	1988-11-10	Negma Laboratoires	Acyl-7 benzoxazinones et leurs derives, procede pour les obtenir et compositions pharmaceutiques les contenant
EP0233728A1 (de) *	1986-02-11	1987-08-26	Takeda Chemical Industries, Ltd.	1,4-Benzoxazin-Derivate, ihre Herstellung und Verwendung
DE3705621C2 (de) *	1986-02-25	1997-01-09	Otsuka Pharma Co Ltd	Heterocyclisch substituierte Chinoloncarbonsäurederivate
AU5404790A (en) *	1989-04-26	1990-11-16	Upjohn Company, The	Antibacterial pyrido(1,2,3-de)-1,4-benzoxazinone agents
NO179912C (no) *	1990-11-28	1997-01-08	Daiichi Seiyaku Co	Analogifremgangsmåte for fremstilling av et terapeutisk virksomt optisk aktivt pyridobenzoksazinderivat
DE4304806A1 (de) *	1993-02-17	1994-08-18	Kali Chemie Pharma Gmbh	5-Phenyl-pyrrolo-1,4-benzoxazin- und -thiazin-Derivate sowie Verfahren und Zwischenprodukte zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel
FR2714381B1 (fr) *	1993-12-29	1996-02-02	Pharmascience Lab	Dérivés de la benzoxazine, leurs procédés d'obtention et leur utilisation en tant que médicaments .

1995
- 1995-11-07 US US08/553,188 patent/US5696117A/en not_active Expired - Lifetime
1996
- 1996-10-17 WO PCT/US1996/016669 patent/WO1997017333A1/en not_active Ceased
- 1996-10-17 AT AT96936648T patent/ATE229944T1/de not_active IP Right Cessation
- 1996-10-17 IL IL12433796A patent/IL124337A/en not_active IP Right Cessation
- 1996-10-17 DE DE69625515T patent/DE69625515T2/de not_active Expired - Fee Related
- 1996-10-17 JP JP9518188A patent/JP2000500134A/ja not_active Ceased
- 1996-10-17 SK SK597-98A patent/SK283888B6/sk not_active IP Right Cessation
- 1996-10-17 NZ NZ321251A patent/NZ321251A/en unknown
- 1996-10-17 HU HU9901184A patent/HUP9901184A3/hu unknown
- 1996-10-17 ES ES96936648T patent/ES2188795T3/es not_active Expired - Lifetime
- 1996-10-17 KR KR10-1998-0703405A patent/KR100503910B1/ko not_active Expired - Fee Related
- 1996-10-17 BR BR9611400-2A patent/BR9611400A/pt not_active IP Right Cessation
- 1996-10-17 RU RU98110572/04A patent/RU2191179C2/ru not_active IP Right Cessation
- 1996-10-17 CZ CZ981379A patent/CZ137998A3/cs unknown
- 1996-10-17 DK DK96936648T patent/DK0869949T3/da active
- 1996-10-17 EP EP96936648A patent/EP0869949B1/de not_active Expired - Lifetime
- 1996-10-17 PL PL96326704A patent/PL189987B1/pl not_active IP Right Cessation
- 1996-10-17 SK SK1033-2002A patent/SK285388B6/sk not_active IP Right Cessation
- 1996-10-17 AU AU74519/96A patent/AU720743B2/en not_active Ceased
- 1996-11-06 AR ARP960105075A patent/AR004706A1/es active IP Right Grant
- 1996-11-06 ZA ZA9609326A patent/ZA969326B/xx unknown
- 1996-11-07 MY MYPI96004648A patent/MY128650A/en unknown
- 1996-11-25 TW TW085114485A patent/TW536537B/zh not_active IP Right Cessation
1997
- 1997-07-23 US US08/899,235 patent/US5854242A/en not_active Expired - Lifetime
1998
- 1998-05-06 NO NO19982071A patent/NO311026B1/no not_active IP Right Cessation
- 1998-05-07 MX MX9803650A patent/MX9803650A/es not_active IP Right Cessation

Also Published As

Publication number	Publication date
US5854242A (en)	1998-12-29
WO1997017333A1 (en)	1997-05-15
DE69625515T2 (de)	2003-05-15
SK59798A3 (en)	1999-09-10
RU2191179C2 (ru)	2002-10-20
EP0869949B1 (de)	2002-12-18
JP2000500134A (ja)	2000-01-11
IL124337A (en)	2001-08-08
IL124337A0 (en)	1998-12-06
DE69625515D1 (de)	2003-01-30
NO982071L (no)	1998-06-05
NZ321251A (en)	1999-10-28
PL326704A1 (en)	1998-10-26
EP0869949A1 (de)	1998-10-14
HUP9901184A2 (hu)	1999-10-28
ZA969326B (en)	1998-05-06
MY128650A (en)	2007-02-28
AU7451996A (en)	1997-05-29
DK0869949T3 (da)	2003-03-31
AR004706A1 (es)	1999-03-10
PL189987B1 (pl)	2005-10-31
CZ137998A3 (cs)	1998-10-14
ES2188795T3 (es)	2003-07-01
BR9611400A (pt)	1999-08-31
KR19990067395A (ko)	1999-08-16
MX9803650A (es)	1998-11-30
NO311026B1 (no)	2001-10-01
US5696117A (en)	1997-12-09
AU720743B2 (en)	2000-06-08
HUP9901184A3 (en)	2001-11-28
TW536537B (en)	2003-06-11
KR100503910B1 (ko)	2005-12-29
NO982071D0 (no)	1998-05-06
SK283888B6 (sk)	2004-04-06
SK285388B6 (sk)	2006-12-07

Legal Events

Date

Code

Title

Description

2003-03-15

UEP

Publication of translation of european patent specification

Ref document number: 0869949

Country of ref document: EP

2010-07-15

REN

Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
DE69625515D1 (de)	2003-01-30	Benzooxazine als antimikrobielle mittel
DE69509464D1 (de)	1999-06-10	Antimikrobielles Mittel
DE59608798D1 (de)	2002-04-04	Endoparasitizide mittel
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ATE174340T1 (de)	1998-12-15	Antiparasitäre mittel
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NO981133D0 (no)	1998-03-13	Ikke-reseptormedierte kontrastmidler
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EP0778847A4 (de)	1998-01-07	Immunstimulierende mittel
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DE69629811D1 (de)	2003-10-09	Antivirale mittel
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