ATE219674T1 - Zusammensetzung enthaltend capsaicin oder seine analogen und lokalanästhetika - Google Patents
Zusammensetzung enthaltend capsaicin oder seine analogen und lokalanästhetikaInfo
- Publication number
- ATE219674T1 ATE219674T1 AT98911614T AT98911614T ATE219674T1 AT E219674 T1 ATE219674 T1 AT E219674T1 AT 98911614 T AT98911614 T AT 98911614T AT 98911614 T AT98911614 T AT 98911614T AT E219674 T1 ATE219674 T1 AT E219674T1
- Authority
- AT
- Austria
- Prior art keywords
- capsaicin
- site
- analogues
- anesthesia
- pain
- Prior art date
Links
- YKPUWZUDDOIDPM-SOFGYWHQSA-N capsaicin Chemical compound COC1=CC(CNC(=O)CCCC\C=C\C(C)C)=CC=C1O YKPUWZUDDOIDPM-SOFGYWHQSA-N 0.000 title abstract 16
- 229960002504 capsaicin Drugs 0.000 title abstract 8
- 235000017663 capsaicin Nutrition 0.000 title abstract 8
- 239000000203 mixture Substances 0.000 title abstract 2
- 230000036407 pain Effects 0.000 abstract 5
- 206010002091 Anaesthesia Diseases 0.000 abstract 3
- 230000037005 anaesthesia Effects 0.000 abstract 3
- 238000000034 method Methods 0.000 abstract 2
- 210000004872 soft tissue Anatomy 0.000 abstract 2
- 230000003444 anaesthetic effect Effects 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 210000001503 joint Anatomy 0.000 abstract 1
- 238000000554 physical therapy Methods 0.000 abstract 1
- 230000002035 prolonged effect Effects 0.000 abstract 1
- 238000002694 regional anesthesia Methods 0.000 abstract 1
- 230000002459 sustained effect Effects 0.000 abstract 1
- 210000002435 tendon Anatomy 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/235—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
- A61K31/24—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group having an amino or nitro group
- A61K31/245—Amino benzoic acid types, e.g. procaine, novocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P23/00—Anaesthetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P23/00—Anaesthetics
- A61P23/02—Local anaesthetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Anesthesiology (AREA)
- Neurology (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Emergency Medicine (AREA)
- Pain & Pain Management (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Immunology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US4069797P | 1997-03-13 | 1997-03-13 | |
| PCT/US1998/004912 WO1998040070A1 (en) | 1997-03-13 | 1998-03-12 | Compositions containing capsaicin or capsaicin analogues and a local anesthetic |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE219674T1 true ATE219674T1 (de) | 2002-07-15 |
Family
ID=21912426
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT98911614T ATE219674T1 (de) | 1997-03-13 | 1998-03-12 | Zusammensetzung enthaltend capsaicin oder seine analogen und lokalanästhetika |
| AT01204692T ATE481970T1 (de) | 1997-03-13 | 1998-03-12 | Zusammensetzungen enthaltend capsaicin oder capsaicin analoge und ein anästhetikum |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT01204692T ATE481970T1 (de) | 1997-03-13 | 1998-03-12 | Zusammensetzungen enthaltend capsaicin oder capsaicin analoge und ein anästhetikum |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US5962532A (de) |
| EP (2) | EP0998288B2 (de) |
| JP (1) | JP2001515492A (de) |
| AT (2) | ATE219674T1 (de) |
| AU (1) | AU720859B2 (de) |
| CA (1) | CA2285203C (de) |
| DE (2) | DE69806246T3 (de) |
| DK (2) | DK1201241T3 (de) |
| ES (2) | ES2179473T5 (de) |
| PT (2) | PT1201241E (de) |
| WO (1) | WO1998040070A1 (de) |
Families Citing this family (75)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6248788B1 (en) | 1996-11-06 | 2001-06-19 | The Regents Of The University Of California | Therapeutic method with capsaicin and capasicin analogs |
| US6239180B1 (en) * | 1995-11-08 | 2001-05-29 | The Regents Of The University Of California | Transdermal therapeutic device and method with capsaicin and capsaicin analogs |
| EP2198854B1 (de) | 1997-09-18 | 2011-11-30 | Pacira Pharmaceuticals, Inc. | Retardierte Freisetzung Liposomaler Anesthetischer Zusammensetzungen |
| EP1030652B1 (de) | 1997-11-14 | 2012-04-25 | Pacira Pharmaceuticals, Inc. | Herstellung von multivesikulären liposomen |
| SE9800139D0 (sv) | 1998-01-21 | 1998-01-21 | Astra Ab | New use |
| US6790207B2 (en) | 1998-06-04 | 2004-09-14 | Curon Medical, Inc. | Systems and methods for applying a selected treatment agent into contact with tissue to treat disorders of the gastrointestinal tract |
| US6802841B2 (en) | 1998-06-04 | 2004-10-12 | Curon Medical, Inc. | Systems and methods for applying a selected treatment agent into contact with tissue to treat sphincter dysfunction |
| AU752225B2 (en) | 1998-07-17 | 2002-09-12 | Pacira Pharmaceuticals, Inc. | Biodegradable compositions for the controlled release of encapsulated substances |
| JP2004525071A (ja) * | 2000-07-20 | 2004-08-19 | ニューロジェン コーポレイション | カプサイシン受容体リガンド |
| US20040146590A1 (en) | 2001-03-22 | 2004-07-29 | Iadarola Michael J | Molecular neurochirurgie for pain control administering locally capsaicin or resinferatoxin |
| US20030096000A1 (en) * | 2001-05-31 | 2003-05-22 | Solis Rosa Maria | Encapsulation of nanosuspensions in liposomes and microspheres |
| US20030105159A1 (en) * | 2001-08-10 | 2003-06-05 | Mccleary Joel | Kavalactone compositions and methods of use |
| EP1450824A4 (de) * | 2001-11-02 | 2005-09-28 | Elan Corp Plc | Pharmazeutische zusammensetzung |
| CN1627944A (zh) * | 2002-01-17 | 2005-06-15 | 神经能质公司 | 取代的喹唑啉-4-基胺类似物作为辣椒辣素调节剂 |
| DK1539124T3 (en) * | 2002-09-05 | 2018-10-08 | Vanderbilt Royalty Sub L P | : COMPOSITIONS AND KITS FOR REMOVAL OF BODY SURFACES |
| CA2499994C (en) * | 2002-09-23 | 2012-07-10 | Verion, Inc. | Abuse-resistant pharmaceutical compositions |
| US20040156931A1 (en) | 2002-12-18 | 2004-08-12 | Algorx | Administration of capsaicinoids |
| PT1605956E (pt) * | 2002-12-18 | 2016-03-09 | Centrexion Therapeutics Corp | Administração de capsaicinóides para o tratamento da osteoartrite |
| US7943166B2 (en) | 2003-04-10 | 2011-05-17 | Neurogesx, Inc. | Methods and compositions for administration of TRPV1 agonists |
| JP5148271B2 (ja) * | 2004-06-02 | 2013-02-20 | ニューロジズエックス,インコーポレーテッド | 疼痛処置のためのカプサイシノイド、局所麻酔薬および/または鎮痒薬を含有する処方物 |
| DE502004011941D1 (de) | 2004-12-22 | 2011-01-05 | Mestex Ag | Mischung eines vanilloidrezeptoragonisten mit einer nervenregenerationshemmenden substanz, ihre verwendung für die herstellung eines schmerzmittels und verfahren zur applikation dieses mittels |
| EP1830835B1 (de) * | 2004-12-28 | 2012-03-14 | Mestex AG | Verwendung eines vanilloidrezeptoragonisten zusammen mit einem glycosaminoglycan oder proteoglycan f]r die herstellung eines mittels zur behandlung von gelenkschmerzen und verfahren zur applikation dieses mittels |
| ES2533256T3 (es) | 2004-12-28 | 2015-04-08 | Mestex Ag | Uso de resiniferatoxina (RTX) para la fabricación de un medicamento para el tratamiento del dolor |
| EP1858495A2 (de) * | 2005-02-14 | 2007-11-28 | Neurogesx, Inc. | Vorrichtung zur abgabe von trpv1-agonisten |
| EP1865933B1 (de) * | 2005-03-30 | 2015-11-04 | Vanderbilt Royalty Sub L.P. | Capsaicin-pflaster mit geringer konzentration und verfahren zur behandlung von neuropathischem schmerz |
| EP1865941B8 (de) * | 2005-04-01 | 2010-12-22 | Neurogesx, Inc. | Öle von capsaicinoiden und verfahren zu ihrer herstellung und verwendung |
| US8916611B2 (en) * | 2006-04-28 | 2014-12-23 | Warsaw Orthopedic, Inc. | Pharmaceutical removal of neuronal extensions from a degenerating disc |
| US7943666B2 (en) * | 2006-07-24 | 2011-05-17 | Trinity Laboratories, Inc. | Esters of capsaicin for treating pain |
| US7645767B2 (en) * | 2006-08-31 | 2010-01-12 | Trinity Laboratories, Inc. | Pharmaceutical compositions for treating chronic pain and pain associated with neuropathy |
| WO2009145842A2 (en) | 2008-04-04 | 2009-12-03 | Forsight Labs, Llc | Therapeutic device for pain management and vision |
| US8158682B2 (en) * | 2008-09-12 | 2012-04-17 | Vallinex, Inc. | Instillation administration of capsaicinoids for the treatment of pain |
| US8987328B2 (en) * | 2008-10-30 | 2015-03-24 | Trinity Laboratories, Inc. | Esters of capsaicinoids as dietary supplements |
| EP2427056A4 (de) * | 2009-05-07 | 2012-08-22 | Univ Cincinnati | Verfahren zur verhinderung von ischämie während einer peripheren schmerzrezeptionsstimulation |
| WO2011044381A1 (en) * | 2009-10-07 | 2011-04-14 | Inflasoothe, Inc. | Pain relief composition, system and method |
| US9498385B2 (en) | 2009-10-23 | 2016-11-22 | Nexisvision, Inc. | Conformable therapeutic shield for vision and pain |
| WO2011050327A1 (en) | 2009-10-23 | 2011-04-28 | Forsight Labs Llc | Corneal denervation for treatment of ocular pain |
| US8591025B1 (en) | 2012-09-11 | 2013-11-26 | Nexisvision, Inc. | Eye covering and refractive correction methods for LASIK and other applications |
| WO2012015882A1 (en) | 2010-07-27 | 2012-02-02 | Bean Bruce P | Methods and compositions for preventing and relieving muscle cramps and for recovery from neuromuscular irritability and fatigue following exercise |
| JP2013544132A (ja) | 2010-10-25 | 2013-12-12 | ネクシスビジョン, インコーポレイテッド | 視力のための眼被覆物を特定するための方法および装置 |
| CN103328038A (zh) | 2010-12-01 | 2013-09-25 | 史拜诺莫度雷森公司 | 向神经解剖结构直接递送药剂 |
| US8678584B2 (en) | 2012-04-20 | 2014-03-25 | Nexisvision, Inc. | Contact lenses for refractive correction |
| US12044905B2 (en) | 2011-04-28 | 2024-07-23 | Journey1 Inc | Contact lenses for refractive correction |
| EP2701644B1 (de) | 2011-04-28 | 2018-05-30 | Nexisvision, Inc. | Augenabdeckung mit verbessertem tränenfluss und komfort und/oder verbesserter anwendbarkeit |
| EP3388057B1 (de) | 2011-09-09 | 2022-03-09 | Propella Therapeutics, Inc. | Schmerzlindernde zusammensetzung mit einem trpv1-selektiven agonisten sowie herstellung und anwendungen davon |
| US9211274B2 (en) * | 2012-02-01 | 2015-12-15 | Warsaw Orthopedic, Inc. | TRPV1 compounds in a biodegradable polymer carrier |
| US9465233B2 (en) | 2012-04-20 | 2016-10-11 | Nexisvision, Inc. | Bimodular contact lenses |
| CA2871027A1 (en) | 2012-04-20 | 2013-12-12 | Nexisvision, Inc. | Contact lenses for refractive correction |
| AU2013341380B2 (en) | 2012-11-12 | 2018-04-26 | Propella Therapeutics, Inc. | Aqueous based capsaicinoid formulations, and treatment in combination with a corticosteroid |
| CA2916885A1 (en) | 2013-06-26 | 2014-12-31 | Nexisvision, Inc. | Contact lenses for refractive correction |
| US9956166B2 (en) | 2013-09-18 | 2018-05-01 | Sorrento Therapeutics, Inc. | Methods for administration and methods for treating cardiovascular diseases with resiniferatoxin |
| US20150133561A1 (en) | 2013-11-12 | 2015-05-14 | Vizuri Health Sciences Llc | Aqueous based capsaicinoid formulations and methods of manufacture and use |
| US9341864B2 (en) | 2013-11-15 | 2016-05-17 | Nexisvision, Inc. | Contact lenses having a reinforcing scaffold |
| WO2015116559A1 (en) | 2014-01-29 | 2015-08-06 | Nexisvision, Inc. | Multifocal bimodulus contact lenses |
| MX377377B (es) | 2014-04-15 | 2025-03-10 | Propella Therapeutics Inc | Composiciones tópicas para el alivio del dolor, manufactura y uso. |
| US11634384B2 (en) | 2014-11-25 | 2023-04-25 | Concentric Analgesics, Inc. | Prodrugs of phenolic TRPV1 agonists |
| US9359316B1 (en) | 2014-11-25 | 2016-06-07 | Concentric Analgesics, Inc. | Prodrugs of phenolic TRPV1 agonists |
| EP3463576A4 (de) | 2016-05-25 | 2020-01-15 | Concentric Analgesics, Inc. | Prodrugs von phenolischen trpv1-agonisten in kombination mit lokalanästhetika und vasokonstriktoren für verbesserte lokalanästhesie |
| KR102657458B1 (ko) | 2016-11-02 | 2024-04-12 | 센트렉시온 테라퓨틱스 코포레이션 | 안정한 수성의 캡사이신 주사 가능한 제형 및 이의 의학적 용도 |
| WO2018136943A1 (en) | 2017-01-23 | 2018-07-26 | Flex Pharma, Inc. | Compositions and methods affecting exercise performance |
| WO2019018769A1 (en) | 2017-07-20 | 2019-01-24 | Centrexion Therapeutics Corporation | METHODS AND COMPOSITIONS FOR THE TREATMENT OF PAIN USING CAPSAICINE |
| US20210283098A1 (en) * | 2018-07-05 | 2021-09-16 | Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. | Methods and Compositions for Treating Pain and Itch |
| US10717712B2 (en) | 2018-07-27 | 2020-07-21 | Concentric Analgesics, Inc. | Pegylated prodrugs of phenolic TRPV1 agonists |
| EP3840739B1 (de) | 2018-08-24 | 2025-11-12 | Centrexion Therapeutics Corporation | Verfahren zur sequenziellen dosierung von capsaicin zur behandlung von kniegelenkschmerzen |
| US11447444B1 (en) | 2019-01-18 | 2022-09-20 | Centrexion Therapeutics Corporation | Capsaicinoid prodrug compounds and their use in treating medical conditions |
| US11254659B1 (en) | 2019-01-18 | 2022-02-22 | Centrexion Therapeutics Corporation | Capsaicinoid prodrug compounds and their use in treating medical conditions |
| WO2022099284A1 (en) * | 2020-11-05 | 2022-05-12 | Young Biopharma, Llc | Novel capsaicin analogs and uses thereof |
| US11278494B1 (en) | 2021-01-22 | 2022-03-22 | Pacira Pharmaceuticals, Inc. | Manufacturing of bupivacaine multivesicular liposomes |
| US12151024B2 (en) | 2021-01-22 | 2024-11-26 | Pacira Pharmaceuticals, Inc. | Manufacturing of bupivacaine multivesicular liposomes |
| US11357727B1 (en) | 2021-01-22 | 2022-06-14 | Pacira Pharmaceuticals, Inc. | Manufacturing of bupivacaine multivesicular liposomes |
| US11033495B1 (en) | 2021-01-22 | 2021-06-15 | Pacira Pharmaceuticals, Inc. | Manufacturing of bupivacaine multivesicular liposomes |
| GB2627096A (en) | 2021-10-14 | 2024-08-14 | Pacira Pharmaceuticals Inc | Bupivacaine multivesicular liposome formulations and uses thereof |
| CN117883414B (zh) * | 2024-03-18 | 2024-06-21 | 山东第二医科大学 | 一种长效缓释辣椒素微球及其制备方法和应用 |
| US12246092B1 (en) | 2024-05-20 | 2025-03-11 | Pacira Pharmaceuticals, Inc. | Manufacturing of bupivacaine multivesicular liposomes |
| US12251472B1 (en) | 2024-05-20 | 2025-03-18 | Pacira Pharmaceuticals, Inc. | Manufacturing of bupivacaine multivesicular liposomes |
| US12251468B1 (en) | 2024-05-20 | 2025-03-18 | Pacira Pharmaceuticals, Inc. | Manufacturing of bupivacaine multivesicular liposomes |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4313958A (en) † | 1980-10-24 | 1982-02-02 | The Procter & Gamble Company | Method of producing analgesia |
| US4424205A (en) * | 1982-03-18 | 1984-01-03 | The Procter & Gamble Company | Hydroxyphenylacetamides having analgesic and anti-irritant activity |
| US4681897A (en) * | 1984-01-16 | 1987-07-21 | The Procter & Gamble Company | Pharmaceutical products providing enhanced analgesia |
| US4939149A (en) * | 1988-10-24 | 1990-07-03 | The United States Of America As Represented By The Department Of Health And Human Services | Resiniferatoxin and analogues thereof to cause sensory afferent C-fiber and thermoregulatory desensitization |
| US5008289A (en) * | 1988-12-02 | 1991-04-16 | Galenpharma, Inc. | Composition for treating nasal disorders and headaches |
| US4997853A (en) * | 1988-12-02 | 1991-03-05 | Galenpharma, Inc. | Method and compositions utilizing capsaicin as an external analgesic |
| US5188837A (en) * | 1989-11-13 | 1993-02-23 | Nova Pharmaceutical Corporation | Lipsopheres for controlled delivery of substances |
| US5762963A (en) * | 1995-06-07 | 1998-06-09 | Emory University | Method and compositions for controlling oral and pharyngeal pain using capsaicinoids |
-
1998
- 1998-03-12 AT AT98911614T patent/ATE219674T1/de active
- 1998-03-12 ES ES98911614T patent/ES2179473T5/es not_active Expired - Lifetime
- 1998-03-12 DK DK01204692.6T patent/DK1201241T3/da active
- 1998-03-12 EP EP98911614A patent/EP0998288B2/de not_active Expired - Lifetime
- 1998-03-12 DE DE69806246T patent/DE69806246T3/de not_active Expired - Lifetime
- 1998-03-12 WO PCT/US1998/004912 patent/WO1998040070A1/en not_active Ceased
- 1998-03-12 US US09/041,294 patent/US5962532A/en not_active Expired - Lifetime
- 1998-03-12 AT AT01204692T patent/ATE481970T1/de active
- 1998-03-12 JP JP53982298A patent/JP2001515492A/ja active Pending
- 1998-03-12 AU AU65532/98A patent/AU720859B2/en not_active Expired
- 1998-03-12 DK DK98911614T patent/DK0998288T4/da active
- 1998-03-12 PT PT01204692T patent/PT1201241E/pt unknown
- 1998-03-12 CA CA002285203A patent/CA2285203C/en not_active Expired - Lifetime
- 1998-03-12 DE DE69841907T patent/DE69841907D1/de not_active Expired - Lifetime
- 1998-03-12 EP EP01204692A patent/EP1201241B8/de not_active Expired - Lifetime
- 1998-03-12 ES ES01204692T patent/ES2350755T3/es not_active Expired - Lifetime
- 1998-03-12 PT PT98911614T patent/PT998288E/pt unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ES2350755T3 (es) | 2011-01-26 |
| CA2285203C (en) | 2005-07-26 |
| ES2179473T3 (es) | 2003-01-16 |
| JP2001515492A (ja) | 2001-09-18 |
| EP1201241B8 (de) | 2010-10-27 |
| ES2179473T5 (es) | 2006-03-01 |
| EP1201241A2 (de) | 2002-05-02 |
| EP0998288B2 (de) | 2005-08-03 |
| EP0998288B1 (de) | 2002-06-26 |
| AU720859B2 (en) | 2000-06-15 |
| DK0998288T3 (da) | 2002-10-14 |
| HK1027759A1 (en) | 2001-01-23 |
| DE69841907D1 (de) | 2010-11-04 |
| DE69806246T2 (de) | 2003-02-06 |
| CA2285203A1 (en) | 1998-09-17 |
| DK0998288T4 (da) | 2005-08-22 |
| AU6553298A (en) | 1998-09-29 |
| PT998288E (pt) | 2002-11-29 |
| ATE481970T1 (de) | 2010-10-15 |
| US5962532A (en) | 1999-10-05 |
| WO1998040070A1 (en) | 1998-09-17 |
| DK1201241T3 (da) | 2010-12-13 |
| EP1201241A3 (de) | 2004-01-02 |
| EP1201241B1 (de) | 2010-09-22 |
| PT1201241E (pt) | 2010-12-02 |
| EP0998288A1 (de) | 2000-05-10 |
| DE69806246T3 (de) | 2006-05-18 |
| DE69806246D1 (de) | 2002-08-01 |
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