ATE219683T1 - Verfahren und zubereitungen zur verzoegerung oder vorbeugung von autoimmun krankheiten - Google Patents
Verfahren und zubereitungen zur verzoegerung oder vorbeugung von autoimmun krankheitenInfo
- Publication number
- ATE219683T1 ATE219683T1 AT94914804T AT94914804T ATE219683T1 AT E219683 T1 ATE219683 T1 AT E219683T1 AT 94914804 T AT94914804 T AT 94914804T AT 94914804 T AT94914804 T AT 94914804T AT E219683 T1 ATE219683 T1 AT E219683T1
- Authority
- AT
- Austria
- Prior art keywords
- autoimmune diseases
- delaying
- preparations
- preventing autoimmune
- methods useful
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 3
- 208000023275 Autoimmune disease Diseases 0.000 title abstract 2
- 238000002360 preparation method Methods 0.000 title 1
- 239000000203 mixture Substances 0.000 abstract 3
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 abstract 2
- 102000004877 Insulin Human genes 0.000 abstract 1
- 108090001061 Insulin Proteins 0.000 abstract 1
- 206010067584 Type 1 diabetes mellitus Diseases 0.000 abstract 1
- 239000002671 adjuvant Substances 0.000 abstract 1
- 230000000890 antigenic effect Effects 0.000 abstract 1
- 206010012601 diabetes mellitus Diseases 0.000 abstract 1
- 230000003053 immunization Effects 0.000 abstract 1
- 229940125396 insulin Drugs 0.000 abstract 1
- 238000007911 parenteral administration Methods 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/51—Lyases (4)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/26—Glucagons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/28—Insulins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Diabetes (AREA)
- Immunology (AREA)
- Endocrinology (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Zoology (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Emergency Medicine (AREA)
- Dermatology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/048,979 US5891435A (en) | 1993-04-16 | 1993-04-16 | Methods and compositions for delaying or preventing the onset of autoimmune disease |
| PCT/US1994/004179 WO1994023737A1 (en) | 1993-04-16 | 1994-04-15 | Methods and compositions for delaying or preventing the onset of autoimmune disease |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE219683T1 true ATE219683T1 (de) | 2002-07-15 |
Family
ID=21957455
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT94914804T ATE219683T1 (de) | 1993-04-16 | 1994-04-15 | Verfahren und zubereitungen zur verzoegerung oder vorbeugung von autoimmun krankheiten |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US5891435A (de) |
| EP (1) | EP0693933B1 (de) |
| JP (1) | JP3001638B2 (de) |
| AT (1) | ATE219683T1 (de) |
| CA (1) | CA2160543C (de) |
| DE (1) | DE69430868T2 (de) |
| DK (1) | DK0693933T3 (de) |
| WO (1) | WO1994023737A1 (de) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7094597B1 (en) * | 1994-05-20 | 2006-08-22 | The Regents Of The University Of California | Vaccine compositions and methods useful in inducing immune protection against arthritogenic peptides involved in the pathogenesis of rheumatoid arthritis |
| US5773570A (en) * | 1994-05-20 | 1998-06-30 | The Regents Of The University Of California | Vaccine compositions and methods useful in inducing immune protection against arthritogenic peptides involved in the pathogenesis of rheumatoid arthritis |
| ATE252913T1 (de) * | 1995-06-30 | 2003-11-15 | Novo Nordisk As | Vorbeugung einer krankheit mit diabetes charakter |
| US20020098194A1 (en) * | 1996-03-21 | 2002-07-25 | Paul V. Lehmann | Methods for inducing immunity |
| BR9906833A (pt) * | 1998-01-08 | 2001-11-27 | William Clifford Duckworth | Processos e composições para tratar ediagnosticar distúrbios relacionados à insulina |
| CA2328108A1 (en) * | 1998-05-07 | 1999-11-11 | The Regents Of The University Of California | Use of neglected target tissue antigens in modulation of immune responses |
| US7030098B2 (en) | 1999-03-12 | 2006-04-18 | The Board Of Trustees Of The Leland Stanford Junior University | DNA vaccination for treatment of autoimmune disease |
| PT1621208E (pt) | 1999-03-12 | 2010-04-07 | Univ Leland Stanford Junior | Vacinação com adn para tratamento de doença auto-imune |
| US6884785B2 (en) * | 1999-06-17 | 2005-04-26 | The Scripps Research Institute | Compositions and methods for the treatment or prevention of autoimmune diabetes |
| US20070259007A1 (en) * | 1999-10-19 | 2007-11-08 | Kruzel Marian L | Lactoferrin: an adjuvant for vaccines |
| AU1600401A (en) * | 1999-11-12 | 2001-06-06 | Chinese University Of Hong Kong, The | Malaria vaccine |
| US6989146B2 (en) * | 2000-08-09 | 2006-01-24 | The Regents Of The University Of California | Stress proteins and peptides and methods of use thereof |
| US7608683B2 (en) * | 2000-08-09 | 2009-10-27 | The Regents Of The University Of California | Stress proteins and peptides and methods of use thereof |
| EA005821B1 (ru) | 2000-11-01 | 2005-06-30 | Дзе Реджентс Оф Дзе Юниверсити Оф Калифорния | Иммуномодулирующие пептиды, полученные из белков теплового шока, и их применение |
| KR100729645B1 (ko) * | 2000-12-29 | 2007-06-18 | 주식회사 녹십자홀딩스 | 글루타민산 데카르복실라제를 코딩하는 유전자가 삽입된재조합 백시니아 바이러스 및 이를 포함하는 제 1형당뇨병 예방 백신 |
| WO2002053106A2 (en) * | 2001-01-05 | 2002-07-11 | Joslin Diabetes Center, Inc. | Autoantigen composition |
| WO2004098645A1 (en) * | 2003-05-12 | 2004-11-18 | Tolerogen, Ltd. | Immunoglobulin conjugates of autoantigens and their use in the prevention of disease |
| WO2007127787A2 (en) * | 2006-04-25 | 2007-11-08 | Joslin Diabetes Center, Inc. | Insulin autoantigen-specific regulatory cd4+ t cells |
| WO2008019139A2 (en) | 2006-08-04 | 2008-02-14 | Beth Israel Deaconess Medical Center | Inhibitors of pyruvate kinase and methods of treating disease |
| JP2011503232A (ja) | 2007-11-20 | 2011-01-27 | ザ ブリガム アンド ウィメンズ ホスピタル インコーポレイテッド | 免疫応答の調節 |
| CA2797694A1 (en) | 2010-04-29 | 2011-11-03 | The United States Of America, As Represented By The Secretary, Departmen T Of Health And Human Services | Activators of human pyruvate kinase |
| AU2013306767A1 (en) | 2012-08-22 | 2015-03-12 | Regimmune Corporation | Preparation for preventing or treating type I diabetes |
| US20160193328A1 (en) * | 2013-08-14 | 2016-07-07 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Immunoadjuvant Compositions and uses Thereof |
| EP3274053A4 (de) * | 2015-03-23 | 2018-12-05 | The Brigham and Women's Hospital, Inc. | Tolerogene nanopartikel zur behandlung von diabetes mellitus |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2051574B (en) * | 1979-05-10 | 1984-01-18 | Kyoto Pharma Ind | Adjuvant for promoting absorption of pharmacologically active substances through the rectum |
| US4464363A (en) * | 1979-12-20 | 1984-08-07 | Merck & Co., Inc. | Ajuvants for rectal delivery of drug substances |
| ZA808097B (en) * | 1980-12-29 | 1982-01-27 | Lilly Co Eli | Novel insulin formulations |
| JPS58189121A (ja) * | 1982-04-30 | 1983-11-04 | Ajinomoto Co Inc | インシユリン投与賦活剤 |
| US4789660A (en) * | 1987-09-10 | 1988-12-06 | American Home Products Corporation | Insulin administration using methyl and propyl paraben |
| SU1624511A1 (ru) * | 1989-02-14 | 1991-01-30 | Донецкий государственный медицинский институт им.М.Горького | Способ моделировани сахарного диабета |
| AU5848090A (en) * | 1989-06-19 | 1991-01-08 | Whitehead Institute For Biomedical Research | Vector-mediated genomic insertion and expression of dna in bcg |
| ES2109234T3 (es) * | 1989-07-14 | 1998-01-16 | Autoimmune Inc | Metodo de tratamiento de la uveorretinitis autoinmune en el hombre. |
| AU651097B2 (en) * | 1990-03-02 | 1994-07-14 | Autoimmune, Inc. | Enhancement of the down-regulation of autoimmune diseases by oral administration of autoantigens |
| IL97709A (en) * | 1990-03-30 | 2005-05-17 | Brigham & Womens Hospital | Use of an mbp peptide for the preparation of a medicament for the treatment of multiple sclerosis |
| US5512447A (en) * | 1990-09-07 | 1996-04-30 | The Regents Of The University Of California | Methods for the diagnosis and treatment of diabetes |
| IL99699A (en) * | 1990-10-10 | 2002-04-21 | Autoimmune Inc | Drug with the option of oral, intra-intestinal, or inhaled dosing for suppression of autoimmune response associated with type I diabetes |
| DE69334246D1 (de) * | 1992-12-03 | 2008-12-24 | Univ California | Verbesserte reagentien und methoden zur diagnose und behandlung von diabetes und stiff man syndrome |
| US5725860A (en) * | 1994-03-07 | 1998-03-10 | Auckland Uniservices Limited | Method for reducing the risk of developing diabetes |
-
1993
- 1993-04-16 US US08/048,979 patent/US5891435A/en not_active Expired - Lifetime
-
1994
- 1994-04-15 AT AT94914804T patent/ATE219683T1/de not_active IP Right Cessation
- 1994-04-15 DE DE69430868T patent/DE69430868T2/de not_active Expired - Fee Related
- 1994-04-15 EP EP94914804A patent/EP0693933B1/de not_active Expired - Lifetime
- 1994-04-15 WO PCT/US1994/004179 patent/WO1994023737A1/en not_active Ceased
- 1994-04-15 DK DK94914804T patent/DK0693933T3/da active
- 1994-04-15 JP JP6523487A patent/JP3001638B2/ja not_active Expired - Fee Related
- 1994-04-15 CA CA002160543A patent/CA2160543C/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| US5891435A (en) | 1999-04-06 |
| EP0693933B1 (de) | 2002-06-26 |
| JP3001638B2 (ja) | 2000-01-24 |
| CA2160543A1 (en) | 1994-10-27 |
| CA2160543C (en) | 2002-07-30 |
| EP0693933A1 (de) | 1996-01-31 |
| DK0693933T3 (da) | 2002-10-21 |
| DE69430868D1 (de) | 2002-08-01 |
| WO1994023737A1 (en) | 1994-10-27 |
| DE69430868T2 (de) | 2003-01-30 |
| JPH08508036A (ja) | 1996-08-27 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| REN | Ceased due to non-payment of the annual fee |