ATE219942T1 - Therapeutische pulverformulierung zur pulmonaren anwendung, welche kristallines insulin enthält - Google Patents

Therapeutische pulverformulierung zur pulmonaren anwendung, welche kristallines insulin enthält

Info

Publication number: ATE219942T1
Authority: AT; Austria
Prior art keywords: powder formulation; drying; containing crystalline; use containing; crystalline insulin
Prior art date: 1997-03-20

Application number

AT98907915T

Other languages

English (en)

Inventor

Steen Jensen

Philip Hansen

Original Assignee

Novo Nordisk As

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-03-20

Filing date

1998-03-20

Publication date

2002-07-15

1998-03-20 Application filed by Novo Nordisk As filed Critical Novo Nordisk As

2002-07-15 Application granted granted Critical

2002-07-15 Publication of ATE219942T1 publication Critical patent/ATE219942T1/de

Links

NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 title abstract 4
239000000203 mixture Substances 0.000 title abstract 4
239000000843 powder Substances 0.000 title abstract 4
238000009472 formulation Methods 0.000 title abstract 3
102000004877 Insulin Human genes 0.000 title abstract 2
108090001061 Insulin Proteins 0.000 title abstract 2
229940125396 insulin Drugs 0.000 title abstract 2
230000002685 pulmonary effect Effects 0.000 title abstract 2
230000001225 therapeutic effect Effects 0.000 title abstract 2
101000976075 Homo sapiens Insulin Proteins 0.000 abstract 1
238000010521 absorption reaction Methods 0.000 abstract 1
238000001035 drying Methods 0.000 abstract 1
239000003623 enhancer Substances 0.000 abstract 1
238000004108 freeze drying Methods 0.000 abstract 1
PBGKTOXHQIOBKM-FHFVDXKLSA-N insulin (human) Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@H]1CSSC[C@H]2C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@H](C(=O)N[C@H](C(N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC=3C=CC(O)=CC=3)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=3C=CC(O)=CC=3)C(=O)N[C@@H](CSSC[C@H](NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=3C=CC(O)=CC=3)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=3NC=NC=3)NC(=O)[C@H](CO)NC(=O)CNC1=O)C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)O)C(O)=O)C(=O)N[C@@H](CC(N)=O)C(O)=O)=O)CSSC[C@@H](C(N2)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)CN)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](NC(=O)[C@@H](N)CC=1C=CC=CC=1)C(C)C)C1=CN=CN1 PBGKTOXHQIOBKM-FHFVDXKLSA-N 0.000 abstract 1
239000002245 particle Substances 0.000 abstract 1
210000002345 respiratory system Anatomy 0.000 abstract 1
238000001694 spray drying Methods 0.000 abstract 1
238000001291 vacuum drying Methods 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/28—Insulins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Diabetes (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Endocrinology (AREA)
Epidemiology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Gastroenterology & Hepatology (AREA)
Otolaryngology (AREA)
Hematology (AREA)
Obesity (AREA)
Chemical Kinetics & Catalysis (AREA)
Emergency Medicine (AREA)
Organic Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Zoology (AREA)
Pulmonology (AREA)
Immunology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicinal Preparation (AREA)

AT98907915T 1997-03-20 1998-03-20 Therapeutische pulverformulierung zur pulmonaren anwendung, welche kristallines insulin enthält ATE219942T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DK31997		1997-03-20
PCT/DK1998/000108 WO1998042368A1 (en)	1997-03-20	1998-03-20	Therapeutic powder formulation for pulmonary administration, containing crystalline insulin

Publications (1)

Publication Number	Publication Date
ATE219942T1 true ATE219942T1 (de)	2002-07-15

Family

ID=8092222

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT98907915T ATE219942T1 (de)	1997-03-20	1998-03-20	Therapeutische pulverformulierung zur pulmonaren anwendung, welche kristallines insulin enthält

Country Status (6)

Country	Link
EP (1)	EP0971729B1 (de)
JP (1)	JP2001518916A (de)
AT (1)	ATE219942T1 (de)
AU (1)	AU6611998A (de)
DE (1)	DE69806362T2 (de)
WO (1)	WO1998042368A1 (de)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO1999055310A1 (en)	1998-04-27	1999-11-04	Altus Biologics Inc.	Stabilized protein crystals, formulations containing them and methods of making them
AU758146B2 (en) *	1998-10-16	2003-03-13	Novo Nordisk A/S	Stable concentrated insulin preparations for pulmonary delivery
HUP0103606A3 (en) *	1998-10-16	2002-05-28	Novo Nordisk As	Insulin preparations for pulmonary delivery containing menthol
US6211144B1 (en)	1998-10-16	2001-04-03	Novo Nordisk A/S	Stable concentrated insulin preparations for pulmonary delivery
US6635617B1 (en)	1998-10-16	2003-10-21	Novo Nordisk A/S	Insulin preparations for pulmonary delivery containing menthol
US6350432B1 (en) *	1999-03-19	2002-02-26	Generex Pharmaceuticals Incorporated	Pressurized container having an aerosolized pharmaceutical composition
AU4450700A (en) *	1999-04-27	2000-11-10	Eli Lilly And Company	Insulin crystals for pulmonary administration
WO2001000675A1 (en) *	1999-06-29	2001-01-04	Eli Lilly And Company	Protamine-free insoluble acylated insulin compositions
WO2001000674A1 (en) *	1999-06-29	2001-01-04	Eli Lilly And Company	Insulin crystals for pulmonary administration
US20040265238A1 (en) *	2003-06-27	2004-12-30	Imtiaz Chaudry	Inhalable formulations for treating pulmonary hypertension and methods of using same
JP4463814B2 (ja)	2003-08-05	2010-05-19	ノボノルディスクアクティーゼルスカブ	新規のインスリン誘導体
JP2006199589A (ja) *	2003-09-03	2006-08-03	Ltt Bio-Pharma Co Ltd	生理活性タンパク質またはペプチドを含有するナノ粒子およびその製造方法、ならびに当該ナノ粒子からなる外用剤
EP1711220A1 (de)	2004-01-16	2006-10-18	Biodel, Inc.	Sublinguale arzneimittelabgabevorrichtung
US20080090753A1 (en)	2004-03-12	2008-04-17	Biodel, Inc.	Rapid Acting Injectable Insulin Compositions
EP1969004B1 (de)	2005-12-28	2011-08-10	Novo Nordisk A/S	Ein acyliertes insulin und zink enthaltende zusammensetzungen und verfahren zur herstellung dieser zusammensetzungen
US9034818B2 (en)	2007-06-13	2015-05-19	Novo Nordisk A/S	Pharmaceutical formulations comprising an insulin derivative
ES2607003T3 (es)	2008-10-30	2017-03-28	Novo Nordisk A/S	Tratamiento de diabetes mellitus utilizando inyecciones de insulina con una frecuencia de inyección inferior a la diaria
US9060927B2 (en)	2009-03-03	2015-06-23	Biodel Inc.	Insulin formulations for rapid uptake
DK2632478T3 (da)	2010-10-27	2019-10-07	Novo Nordisk As	Behandling af diabetes melitus under anvendelse af insulinindsprøjtninger indgivet med varierende indsprøjtningsintervaller
JP2016519127A (ja)	2013-04-30	2016-06-30	ノヴォノルディスクアー／エス	新規投与レジメン
US10335464B1 (en)	2018-06-26	2019-07-02	Novo Nordisk A/S	Device for titrating basal insulin
JP7518149B2 (ja)	2019-07-12	2024-07-17	ノヴォノルディスクアー／エス	高濃度インスリン製剤

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE2933946A1 (de) *	1979-08-22	1981-03-12	Hoechst Ag, 6000 Frankfurt	Insulinkristallsuspension und verfahren zu ihrer herstellung.
IS1796B (is) *	1993-06-24	2001-12-31	Ab Astra	Fjölpeptíð lyfjablanda til innöndunar sem einnig inniheldur eykjaefnasamband
US5597893A (en) *	1994-10-31	1997-01-28	Eli Lilly And Company	Preparation of stable insulin analog crystals
SE9404468D0 (sv) *	1994-12-22	1994-12-22	Astra Ab	Powder formulations

1998
- 1998-03-20 AT AT98907915T patent/ATE219942T1/de not_active IP Right Cessation
- 1998-03-20 EP EP98907915A patent/EP0971729B1/de not_active Expired - Lifetime
- 1998-03-20 AU AU66119/98A patent/AU6611998A/en not_active Abandoned
- 1998-03-20 JP JP54474698A patent/JP2001518916A/ja active Pending
- 1998-03-20 DE DE69806362T patent/DE69806362T2/de not_active Expired - Fee Related
- 1998-03-20 WO PCT/DK1998/000108 patent/WO1998042368A1/en not_active Ceased

Also Published As

Publication number	Publication date
DE69806362T2 (de)	2003-01-30
WO1998042368A1 (en)	1998-10-01
JP2001518916A (ja)	2001-10-16
DE69806362D1 (de)	2002-08-08
AU6611998A (en)	1998-10-20
EP0971729B1 (de)	2002-07-03
EP0971729A1 (de)	2000-01-19

Legal Events

Date	Code	Title	Description
2003-01-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
ATE219942T1 (de)	2002-07-15	Therapeutische pulverformulierung zur pulmonaren anwendung, welche kristallines insulin enthält
AU6611898A (en)	1998-10-20	Method for preparation of a therapeutic powder through coprecipitation of insulin and absorption enhancer
DE69100792D1 (de)	1994-01-27	Aerosolträger.
YU59092A (sh)	1994-12-28	Formulacije aerosola koji ne sadrže hlorofluorougljenična jedinjenja
CA2346791A1 (en)	2000-04-20	Flow resistance modulated aerosolized active agent delivery
KR970703366A (ko)	1997-07-03	인터페론의 건조 분말 제형물을 제조하기 위한 방법 및 조성물(methods and compositions for the dry powder formulation of interferons)
YU59192A (sh)	1994-12-28	Formulacija aerosola koje ne sadrže hlorofluorougljenična jedinjenja
IS1768B (is)	2001-05-02	Lyfjablanda til innöndunar sem inniheldur insúlín
IS4179A (is)	1994-12-25	Fjölpeptíð lyfjablanda til innöndunar sem einnig inniheldur eykjaefnasamband
TW329387B (en)	1998-04-11	Pharmaceutical composition for treating airway passage and lung diseases comprising mometasone furoate
TR200002692T2 (tr)	2001-02-21	Aerosol haline getirilen aktif maddenin verilmesi.
LT2001021A (en)	2001-11-26	Dry powder active agent pulmonary delivery
NO20024708D0 (no)	2002-10-01	Behandling av respiratoriske sykdommer
BG102689A (bg)	1999-02-26	Фармацевтичен аерозолен състав за използване при лечение на респираторни смущения
CA2226657A1 (en)	1997-02-06	Improvements in and relating to powders for use in dry powder inhalers
DE69205177D1 (de)	1995-11-02	Pharmazeutische Aerosolformulierung.
NO974618L (no)	1998-04-08	Farmasöytiske preparater for intranasal administrasjon
BR9709845B1 (pt)	2008-11-18	preparaÇço aquosa de insulina, formulaÇço farmacÊutica parenteral, e, processso para aumentar a estabilidade quÍmica de uma preparaÇço de insulina.
ATE137958T1 (de)	1996-06-15	Pharmazeutische aerosolzubereitung sowie deren verwendung zur behandlung und prophylaxe viraler erkrankungen
ATE202481T1 (de)	2001-07-15	Reines, biologisch aktives colistin, seine bestandteile und eine colistin-zubereitung zur behandlung von entzündungen der atemwege
ATE114244T1 (de)	1994-12-15	Pharmazeutische zusammensetzungen enthaltend fluticasonpropionat und oxikonazol oder dessen salz zur lokalen anwendung.
ATE417599T1 (de)	2009-01-15	Pharmazeutische zubereitung zur intranasalen applikation von proteinen, enthaltend chitosan oder eines seiner derivate
ATE284696T1 (de)	2005-01-15	Pharmazeutische zusammensetzung enthaltend salmeterol und budesonid zur behandlung von atemkrankheiten
WO2005041852A3 (en)	2006-05-18	Keratin gel and the types 2, 4 and 6 of collagens of frog protein