ATE220680T1 - Taxane derivate, ihre herstellung und zusammensetzungen die sie enthalten - Google Patents

Taxane derivate, ihre herstellung und zusammensetzungen die sie enthalten

Info

Publication number: ATE220680T1
Authority: AT; Austria
Prior art keywords: pct; deacetyl; derivatives; preparation; sec
Prior art date: 1996-05-10

Application number

AT97922918T

Other languages

English (en)

Inventor

Ezio Bombardelli

Original Assignee

Indena Spa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-05-10

Filing date

1997-04-29

Publication date

2002-08-15

1997-04-29 Application filed by Indena Spa filed Critical Indena Spa

2002-08-15 Application granted granted Critical

2002-08-15 Publication of ATE220680T1 publication Critical patent/ATE220680T1/de

Links

DKPFODGZWDEEBT-QFIAKTPHSA-N taxane Chemical class C([C@]1(C)CCC[C@@H](C)[C@H]1C1)C[C@H]2[C@H](C)CC[C@@H]1C2(C)C DKPFODGZWDEEBT-QFIAKTPHSA-N 0.000 title abstract 2
239000000203 mixture Substances 0.000 title 1
OAKJQQAXSVQMHS-UHFFFAOYSA-N Hydrazine Chemical compound NN OAKJQQAXSVQMHS-UHFFFAOYSA-N 0.000 abstract 2
150000002148 esters Chemical class 0.000 abstract 2
BMYNFMYTOJXKLE-UHFFFAOYSA-N 3-azaniumyl-2-hydroxypropanoate Chemical group NCC(O)C(O)=O BMYNFMYTOJXKLE-UHFFFAOYSA-N 0.000 abstract 1
YWLXLRUDGLRYDR-ZHPRIASZSA-N 5beta,20-epoxy-1,7beta,10beta,13alpha-tetrahydroxy-9-oxotax-11-ene-2alpha,4alpha-diyl 4-acetate 2-benzoate Chemical compound O([C@H]1[C@H]2[C@@](C([C@H](O)C3=C(C)[C@@H](O)C[C@]1(O)C3(C)C)=O)(C)[C@@H](O)C[C@H]1OC[C@]12OC(=O)C)C(=O)C1=CC=CC=C1 YWLXLRUDGLRYDR-ZHPRIASZSA-N 0.000 abstract 1
AVXURJPOCDRRFD-UHFFFAOYSA-N Hydroxylamine Chemical compound ON AVXURJPOCDRRFD-UHFFFAOYSA-N 0.000 abstract 1
230000000259 anti-tumor effect Effects 0.000 abstract 1
230000006907 apoptotic process Effects 0.000 abstract 1
239000012736 aqueous medium Substances 0.000 abstract 1
230000004663 cell proliferation Effects 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
230000001939 inductive effect Effects 0.000 abstract 1
230000002401 inhibitory effect Effects 0.000 abstract 1
125000002755 pyrazolinyl group Chemical group 0.000 abstract 1
239000004094 surface-active agent Substances 0.000 abstract 1
231100000331 toxic Toxicity 0.000 abstract 1
230000002588 toxic effect Effects 0.000 abstract 1
210000004881 tumor cell Anatomy 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/08—Bridged systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
- C07D491/18—Bridged systems

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Oncology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Epoxy Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

AT97922918T 1996-05-10 1997-04-29 Taxane derivate, ihre herstellung und zusammensetzungen die sie enthalten ATE220680T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
IT96MI000942A IT1283633B1 (it)	1996-05-10	1996-05-10	Derivati tassanici loro sintesi e formulazioni che li contengono
PCT/EP1997/002198 WO1997043291A1 (en)	1996-05-10	1997-04-29	Taxane derivatives, the preparation thereof and formulations containing them

Publications (1)

Publication Number	Publication Date
ATE220680T1 true ATE220680T1 (de)	2002-08-15

Family

ID=11374240

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT97922918T ATE220680T1 (de)	1996-05-10	1997-04-29	Taxane derivate, ihre herstellung und zusammensetzungen die sie enthalten

Country Status (20)

Country	Link
US (1)	US5955489A (de)
EP (1)	EP0901492B1 (de)
JP (1)	JP3423002B2 (de)
KR (1)	KR100314382B1 (de)
CN (1)	CN1097055C (de)
AT (1)	ATE220680T1 (de)
AU (1)	AU715748B2 (de)
CA (1)	CA2253912C (de)
CZ (1)	CZ287489B6 (de)
DE (1)	DE69714040T2 (de)
DK (1)	DK0901492T3 (de)
ES (1)	ES2180985T3 (de)
HU (1)	HU224965B1 (de)
IT (1)	IT1283633B1 (de)
NO (1)	NO322266B1 (de)
PL (1)	PL185778B1 (de)
PT (1)	PT901492E (de)
RU (1)	RU2168513C2 (de)
SK (1)	SK282471B6 (de)
WO (1)	WO1997043291A1 (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP2003026673A (ja) *	1999-03-05	2003-01-29	Asahi Kasei Corp	骨形成促進剤
HK1049787B (en)	1999-10-01	2014-07-25	Immunogen, Inc.	Compositions and methods for treating cancer using immunoconjugates and chemotherapeutic agents
ITMI20012186A1 (it)	2001-10-19	2003-04-19	Indena Spa	Procedimento per la preparazione della 14-beta-idrossi-baccatina iii-1,14-carbonato
ITMI20012185A1 (it)	2001-10-19	2003-04-19	Indena Spa	Procedimento per la preparazione della 14beta-idrossi-baccatina iii-1,14-carbonato
EP1883627B1 (de)	2005-05-18	2018-04-18	Pharmascience Inc.	An die bir-domäne bindende verbindungen
WO2007131366A1 (en)	2006-05-16	2007-11-22	Aegera Therapeutics Inc.	Iap bir domain binding compounds
DK2080764T3 (da)	2008-01-18	2012-09-24	Indena Spa	Faste former af ortataxel
SG182724A1 (en)	2010-02-12	2012-08-30	Pharmascience Inc	Iap bir domain binding compounds
CN113603660B (zh) *	2021-09-02	2024-01-05	无锡紫杉药业有限公司	一种10-羰基多西他赛的制备方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2601785B1 (fr) *	1986-07-15	1989-07-28	Telecommunications Sa	Dispositif de reserve pour cable a fibre optique et le procede de mise en oeuvre
FR2601675B1 (fr) *	1986-07-17	1988-09-23	Rhone Poulenc Sante	Derives du taxol, leur preparation et les compositions pharmaceutiques qui les contiennent
US5059699A (en) *	1990-08-28	1991-10-22	Virginia Tech Intellectual Properties, Inc.	Water soluble derivatives of taxol
US5393886A (en) *	1993-05-05	1995-02-28	The Du Pont Merck Pharmaceutical Company	Intermediates for the synthesis of anthrapyrazolone anticancer agents
IT1275936B1 (it) *	1995-03-17	1997-10-24	Indena Spa	Derivati della 10-deacetilbaccatina iii e della 10-deacetil-14b- idrossibaccatina iii loro metodo di preparazione e formulazioni
IT1275435B (it) *	1995-05-19	1997-08-07	Indena Spa	Derivati della 10-desacetil-14beta-idrossibaccatina iii,loro metodo di preparazione e formulazioni che li contengono

1996
- 1996-05-10 IT IT96MI000942A patent/IT1283633B1/it active IP Right Grant
1997
- 1997-04-29 KR KR1019980709041A patent/KR100314382B1/ko not_active Expired - Fee Related
- 1997-04-29 AU AU28886/97A patent/AU715748B2/en not_active Ceased
- 1997-04-29 CZ CZ19983619A patent/CZ287489B6/cs not_active IP Right Cessation
- 1997-04-29 CN CN97194491A patent/CN1097055C/zh not_active Expired - Fee Related
- 1997-04-29 DK DK97922918T patent/DK0901492T3/da active
- 1997-04-29 DE DE69714040T patent/DE69714040T2/de not_active Expired - Lifetime
- 1997-04-29 SK SK1539-98A patent/SK282471B6/sk not_active IP Right Cessation
- 1997-04-29 US US09/155,959 patent/US5955489A/en not_active Expired - Lifetime
- 1997-04-29 CA CA002253912A patent/CA2253912C/en not_active Expired - Fee Related
- 1997-04-29 EP EP97922918A patent/EP0901492B1/de not_active Expired - Lifetime
- 1997-04-29 WO PCT/EP1997/002198 patent/WO1997043291A1/en not_active Ceased
- 1997-04-29 RU RU98122311/04A patent/RU2168513C2/ru not_active IP Right Cessation
- 1997-04-29 JP JP54044497A patent/JP3423002B2/ja not_active Expired - Fee Related
- 1997-04-29 AT AT97922918T patent/ATE220680T1/de active
- 1997-04-29 PT PT97922918T patent/PT901492E/pt unknown
- 1997-04-29 HU HU9903649A patent/HU224965B1/hu not_active IP Right Cessation
- 1997-04-29 ES ES97922918T patent/ES2180985T3/es not_active Expired - Lifetime
- 1997-04-29 PL PL97329768A patent/PL185778B1/pl not_active IP Right Cessation
1998
- 1998-11-06 NO NO19985187A patent/NO322266B1/no not_active IP Right Cessation

Also Published As

Publication number	Publication date
HU224965B1 (en)	2006-04-28
CA2253912A1 (en)	1997-11-20
EP0901492B1 (de)	2002-07-17
CZ361998A3 (cs)	1999-06-16
JP3423002B2 (ja)	2003-07-07
HUP9903649A2 (hu)	2001-05-28
SK282471B6 (sk)	2002-02-05
KR20000010894A (ko)	2000-02-25
ITMI960942A1 (it)	1997-11-10
WO1997043291A1 (en)	1997-11-20
ES2180985T3 (es)	2003-02-16
NO985187L (no)	1998-11-06
DE69714040D1 (de)	2002-08-22
NO322266B1 (no)	2006-09-04
IT1283633B1 (it)	1998-04-23
PL185778B1 (pl)	2003-07-31
NO985187D0 (no)	1998-11-06
PT901492E (pt)	2002-10-31
SK153998A3 (en)	1999-04-13
CZ287489B6 (en)	2000-12-13
PL329768A1 (en)	1999-04-12
CN1097055C (zh)	2002-12-25
AU715748B2 (en)	2000-02-10
HK1019603A1 (en)	2000-02-18
ITMI960942A0 (de)	1996-05-10
CA2253912C (en)	2006-03-28
KR100314382B1 (ko)	2002-02-28
DK0901492T3 (da)	2002-09-02
JP2000513716A (ja)	2000-10-17
AU2888697A (en)	1997-12-05
DE69714040T2 (de)	2003-03-13
HUP9903649A3 (en)	2001-06-28
US5955489A (en)	1999-09-21
CN1218475A (zh)	1999-06-02
RU2168513C2 (ru)	2001-06-10
EP0901492A1 (de)	1999-03-17

Publication	Publication Date	Title
IL102208A0 (en)	1993-01-14	Azanorbornane derivatives
HU9500836D0 (en)	1995-05-29	Fluoroalkoxybenzyl derivatives of nitrogen containing heterocycles
FI932229A0 (fi)	1993-05-17	Azabicykliska bryggderivat
IL108769A0 (en)	1994-06-24	Spirocyclic piperidine derivatives
ATE163007T1 (de)	1998-02-15	Neue vitamin d derivate
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ATE190845T1 (de)	2000-04-15	Rektale flunisolid-zubereitung zur behandlung entzündlicher darmerkrankungen
MY110894A (en)	1999-06-30	New pyrazolylpryrazoles, processes for their preparation, as well as intermediates, and thier use as herbicides