DK0901492T3 - Taxanderivater, fremstillingen deraf og formuleringer indeholdende dem - Google Patents

Taxanderivater, fremstillingen deraf og formuleringer indeholdende dem

Info

Publication number: DK0901492T3
Authority: DK; Denmark
Prior art keywords: pct; deacetyl; derivatives; preparation; sec
Prior art date: 1996-05-10

Application number

DK97922918T

Other languages

English (en)

Inventor

Ezio Bombardelli

Original Assignee

Indena Spa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-05-10

Filing date

1997-04-29

Publication date

2002-09-02

1997-04-29 Application filed by Indena Spa filed Critical Indena Spa

2002-09-02 Application granted granted Critical

2002-09-02 Publication of DK0901492T3 publication Critical patent/DK0901492T3/da

Links

DKPFODGZWDEEBT-QFIAKTPHSA-N taxane Chemical class C([C@]1(C)CCC[C@@H](C)[C@H]1C1)C[C@H]2[C@H](C)CC[C@@H]1C2(C)C DKPFODGZWDEEBT-QFIAKTPHSA-N 0.000 title abstract 2
238000009472 formulation Methods 0.000 title 1
239000000203 mixture Substances 0.000 title 1
OAKJQQAXSVQMHS-UHFFFAOYSA-N Hydrazine Chemical compound NN OAKJQQAXSVQMHS-UHFFFAOYSA-N 0.000 abstract 2
150000002148 esters Chemical class 0.000 abstract 2
BMYNFMYTOJXKLE-UHFFFAOYSA-N 3-azaniumyl-2-hydroxypropanoate Chemical group NCC(O)C(O)=O BMYNFMYTOJXKLE-UHFFFAOYSA-N 0.000 abstract 1
YWLXLRUDGLRYDR-ZHPRIASZSA-N 5beta,20-epoxy-1,7beta,10beta,13alpha-tetrahydroxy-9-oxotax-11-ene-2alpha,4alpha-diyl 4-acetate 2-benzoate Chemical compound O([C@H]1[C@H]2[C@@](C([C@H](O)C3=C(C)[C@@H](O)C[C@]1(O)C3(C)C)=O)(C)[C@@H](O)C[C@H]1OC[C@]12OC(=O)C)C(=O)C1=CC=CC=C1 YWLXLRUDGLRYDR-ZHPRIASZSA-N 0.000 abstract 1
AVXURJPOCDRRFD-UHFFFAOYSA-N Hydroxylamine Chemical compound ON AVXURJPOCDRRFD-UHFFFAOYSA-N 0.000 abstract 1
230000000259 anti-tumor effect Effects 0.000 abstract 1
230000006907 apoptotic process Effects 0.000 abstract 1
239000012736 aqueous medium Substances 0.000 abstract 1
230000004663 cell proliferation Effects 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
230000001939 inductive effect Effects 0.000 abstract 1
230000002401 inhibitory effect Effects 0.000 abstract 1
125000002755 pyrazolinyl group Chemical group 0.000 abstract 1
239000004094 surface-active agent Substances 0.000 abstract 1
231100000331 toxic Toxicity 0.000 abstract 1
230000002588 toxic effect Effects 0.000 abstract 1
210000004881 tumor cell Anatomy 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/08—Bridged systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
- C07D491/18—Bridged systems

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
General Health & Medical Sciences (AREA)
General Chemical & Material Sciences (AREA)
Oncology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Epoxy Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Plural Heterocyclic Compounds (AREA)

DK97922918T 1996-05-10 1997-04-29 Taxanderivater, fremstillingen deraf og formuleringer indeholdende dem DK0901492T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
IT96MI000942A IT1283633B1 (it)	1996-05-10	1996-05-10	Derivati tassanici loro sintesi e formulazioni che li contengono
PCT/EP1997/002198 WO1997043291A1 (en)	1996-05-10	1997-04-29	Taxane derivatives, the preparation thereof and formulations containing them

Publications (1)

Publication Number	Publication Date
DK0901492T3 true DK0901492T3 (da)	2002-09-02

Family

ID=11374240

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK97922918T DK0901492T3 (da)	1996-05-10	1997-04-29	Taxanderivater, fremstillingen deraf og formuleringer indeholdende dem

Country Status (20)

Country	Link
US (1)	US5955489A (da)
EP (1)	EP0901492B1 (da)
JP (1)	JP3423002B2 (da)
KR (1)	KR100314382B1 (da)
CN (1)	CN1097055C (da)
AT (1)	ATE220680T1 (da)
AU (1)	AU715748B2 (da)
CA (1)	CA2253912C (da)
CZ (1)	CZ287489B6 (da)
DE (1)	DE69714040T2 (da)
DK (1)	DK0901492T3 (da)
ES (1)	ES2180985T3 (da)
HU (1)	HU224965B1 (da)
IT (1)	IT1283633B1 (da)
NO (1)	NO322266B1 (da)
PL (1)	PL185778B1 (da)
PT (1)	PT901492E (da)
RU (1)	RU2168513C2 (da)
SK (1)	SK282471B6 (da)
WO (1)	WO1997043291A1 (da)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP2003026673A (ja) *	1999-03-05	2003-01-29	Asahi Kasei Corp	骨形成促進剤
JP4776843B2 (ja)	1999-10-01	2011-09-21	イムノゲンインコーポレーティッド	免疫複合体及び化学療法剤を用いる癌治療用組成物及び方法
ITMI20012185A1 (it)	2001-10-19	2003-04-19	Indena Spa	Procedimento per la preparazione della 14beta-idrossi-baccatina iii-1,14-carbonato
ITMI20012186A1 (it)	2001-10-19	2003-04-19	Indena Spa	Procedimento per la preparazione della 14-beta-idrossi-baccatina iii-1,14-carbonato
WO2006122408A1 (en)	2005-05-18	2006-11-23	Aegera Therapeutics Inc.	Bir domain binding compounds
BRPI0711591A2 (pt)	2006-05-16	2011-11-16	Aegera Therapeutics, Inc.	composto de ligação de domìnio bir da iap
EP2080764B1 (en)	2008-01-18	2012-08-22	INDENA S.p.A.	Solid forms of ortataxel
NZ602368A (en)	2010-02-12	2014-10-31	Pharmascience Inc	Iap bir domain binding compounds
CN113603660B (zh) *	2021-09-02	2024-01-05	无锡紫杉药业有限公司	一种10-羰基多西他赛的制备方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2601785B1 (fr) *	1986-07-15	1989-07-28	Telecommunications Sa	Dispositif de reserve pour cable a fibre optique et le procede de mise en oeuvre
FR2601675B1 (fr) *	1986-07-17	1988-09-23	Rhone Poulenc Sante	Derives du taxol, leur preparation et les compositions pharmaceutiques qui les contiennent
US5059699A (en) *	1990-08-28	1991-10-22	Virginia Tech Intellectual Properties, Inc.	Water soluble derivatives of taxol
US5393886A (en) *	1993-05-05	1995-02-28	The Du Pont Merck Pharmaceutical Company	Intermediates for the synthesis of anthrapyrazolone anticancer agents
IT1275936B1 (it) *	1995-03-17	1997-10-24	Indena Spa	Derivati della 10-deacetilbaccatina iii e della 10-deacetil-14b- idrossibaccatina iii loro metodo di preparazione e formulazioni
IT1275435B (it) *	1995-05-19	1997-08-07	Indena Spa	Derivati della 10-desacetil-14beta-idrossibaccatina iii,loro metodo di preparazione e formulazioni che li contengono

1996
- 1996-05-10 IT IT96MI000942A patent/IT1283633B1/it active IP Right Grant
1997
- 1997-04-29 CA CA002253912A patent/CA2253912C/en not_active Expired - Fee Related
- 1997-04-29 KR KR1019980709041A patent/KR100314382B1/ko not_active Expired - Fee Related
- 1997-04-29 DE DE69714040T patent/DE69714040T2/de not_active Expired - Lifetime
- 1997-04-29 US US09/155,959 patent/US5955489A/en not_active Expired - Lifetime
- 1997-04-29 JP JP54044497A patent/JP3423002B2/ja not_active Expired - Fee Related
- 1997-04-29 PT PT97922918T patent/PT901492E/pt unknown
- 1997-04-29 PL PL97329768A patent/PL185778B1/pl not_active IP Right Cessation
- 1997-04-29 CN CN97194491A patent/CN1097055C/zh not_active Expired - Fee Related
- 1997-04-29 WO PCT/EP1997/002198 patent/WO1997043291A1/en not_active Ceased
- 1997-04-29 CZ CZ19983619A patent/CZ287489B6/cs not_active IP Right Cessation
- 1997-04-29 ES ES97922918T patent/ES2180985T3/es not_active Expired - Lifetime
- 1997-04-29 RU RU98122311/04A patent/RU2168513C2/ru not_active IP Right Cessation
- 1997-04-29 DK DK97922918T patent/DK0901492T3/da active
- 1997-04-29 HU HU9903649A patent/HU224965B1/hu not_active IP Right Cessation
- 1997-04-29 AU AU28886/97A patent/AU715748B2/en not_active Ceased
- 1997-04-29 AT AT97922918T patent/ATE220680T1/de active
- 1997-04-29 EP EP97922918A patent/EP0901492B1/en not_active Expired - Lifetime
- 1997-04-29 SK SK1539-98A patent/SK282471B6/sk not_active IP Right Cessation
1998
- 1998-11-06 NO NO19985187A patent/NO322266B1/no not_active IP Right Cessation

Also Published As

Publication number	Publication date
ATE220680T1 (de)	2002-08-15
NO322266B1 (no)	2006-09-04
PL185778B1 (pl)	2003-07-31
AU715748B2 (en)	2000-02-10
EP0901492B1 (en)	2002-07-17
SK153998A3 (en)	1999-04-13
WO1997043291A1 (en)	1997-11-20
CA2253912C (en)	2006-03-28
IT1283633B1 (it)	1998-04-23
CN1097055C (zh)	2002-12-25
HK1019603A1 (en)	2000-02-18
CA2253912A1 (en)	1997-11-20
ITMI960942A0 (da)	1996-05-10
NO985187L (no)	1998-11-06
CZ287489B6 (en)	2000-12-13
EP0901492A1 (en)	1999-03-17
PT901492E (pt)	2002-10-31
JP3423002B2 (ja)	2003-07-07
CZ361998A3 (cs)	1999-06-16
RU2168513C2 (ru)	2001-06-10
NO985187D0 (no)	1998-11-06
JP2000513716A (ja)	2000-10-17
PL329768A1 (en)	1999-04-12
ES2180985T3 (es)	2003-02-16
US5955489A (en)	1999-09-21
CN1218475A (zh)	1999-06-02
ITMI960942A1 (it)	1997-11-10
SK282471B6 (sk)	2002-02-05
HU224965B1 (en)	2006-04-28
DE69714040D1 (de)	2002-08-22
HUP9903649A3 (en)	2001-06-28
KR100314382B1 (ko)	2002-02-28
AU2888697A (en)	1997-12-05
DE69714040T2 (de)	2003-03-13
HUP9903649A2 (hu)	2001-05-28
KR20000010894A (ko)	2000-02-25

Publication	Publication Date	Title
ZA924527B (en)	1993-12-20	Azanorbornane derivatives
GR3021411T3 (en)	1997-01-31	Fluoroalkoxybenzylamino derivatives of nitrogen containing heterocycles.
IL108769A0 (en)	1994-06-24	Spirocyclic piperidine derivatives
SG55184A1 (en)	1998-12-21	New imidazopyridines
ES2136037B1 (es)	2000-11-16	Inhibidores de sulfamida-metaloproteasa
NO985187D0 (no)	1998-11-06	Taxanderivater, deres fremstilling og formuleringer som inneholder dem
PL314181A1 (en)	1996-08-19	Phenylindole compounds
NO923226L (no)	1992-08-18	Nytt beta-fenylisoserinderivat, dets fremstilling og anvendelse
HUT73231A (en)	1996-07-29	Pharmaceutical compositions with 17-beta-monosubstituted-carbamoyl-4-aza-5-alpha-androst-1-en-3-ones for treatment of chronic prostatitis
DK0675895T3 (da)	1998-02-23	Etoposidderivater, fremgangsmåde til fremstilling deraf, anvendelse deraf som lægemiddel og anvendelse deraf til fremstilling af et lægemiddel til anticancerbehandling
DK0918754T3 (da)	2008-03-31	Anthranilsyrediamidderivater, fremstilling og farmaceutisk anvendelse deraf som antigastrinmidler
IL117734A0 (en)	1996-07-23	Beta-carbolines and pharmaceutical compositions containing them