ES2180985T3 - Derivados de taxano, su preparacion y formulaciones que los contienen. - Google Patents

Derivados de taxano, su preparacion y formulaciones que los contienen.

Info

Publication number
ES2180985T3
ES2180985T3 ES97922918T ES97922918T ES2180985T3 ES 2180985 T3 ES2180985 T3 ES 2180985T3 ES 97922918 T ES97922918 T ES 97922918T ES 97922918 T ES97922918 T ES 97922918T ES 2180985 T3 ES2180985 T3 ES 2180985T3
Authority
ES
Spain
Prior art keywords
derivatives
preparation
deacetil
hidroxi
esters
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES97922918T
Other languages
English (en)
Inventor
Ezio Bombardelli
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Indena SpA
Original Assignee
Indena SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Indena SpA filed Critical Indena SpA
Application granted granted Critical
Publication of ES2180985T3 publication Critical patent/ES2180985T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/08—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
    • C07D491/18—Bridged systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Epoxy Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

LA PRESENTE INVENCION SE REFIERE A LA PREPARACION DE DERIVADOS DEL TAXANO, COMENZANDO POR LA 14 - HIDROXI - 10 - DEACETIL BACCATINA III, 19 - HIDROXI - 10 - DEACETIL - BACCATINA III Y SUS ESTERES EN C 13 , HACIENDO REACCIONAR LOS RESPECTIVOS DERIVADOS 10 - DEHIDRO CON HIDRAZINA, HIDROXILAMINA Y SUS DERIVADOS. LOS NUEVOS COMPUESTOS CONTIENEN UN GRUPO PIRAZOLINA QUE INCLUYE LOS CARBONOS C 7 Y C 9 . LOS ESTERES C 13 DE DICHAS MOLECULAS, CON CADENAS DE ISOSERINA SUSTITUIDAS EJERCEN ACTIVIDAD ANTITUMORAL, INHIBIENDO LA PROLIFERACION CELULAR DE LINEAS DE CELULAS TUMORALES NORMALES Y RESISTENTES E INDUCIENDO APOPTOSIS. DEBIDO A SU CARACTER BASICO, ESTAS MOLECULAS PUEDEN SER ADMINISTRADAS PREVIA SALIFICACION EN MEDIO ACUOSO SIN EXIGIR EL USO DE SURFACTANTES TOXICOS.
ES97922918T 1996-05-10 1997-04-29 Derivados de taxano, su preparacion y formulaciones que los contienen. Expired - Lifetime ES2180985T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT96MI000942A IT1283633B1 (it) 1996-05-10 1996-05-10 Derivati tassanici loro sintesi e formulazioni che li contengono

Publications (1)

Publication Number Publication Date
ES2180985T3 true ES2180985T3 (es) 2003-02-16

Family

ID=11374240

Family Applications (1)

Application Number Title Priority Date Filing Date
ES97922918T Expired - Lifetime ES2180985T3 (es) 1996-05-10 1997-04-29 Derivados de taxano, su preparacion y formulaciones que los contienen.

Country Status (20)

Country Link
US (1) US5955489A (es)
EP (1) EP0901492B1 (es)
JP (1) JP3423002B2 (es)
KR (1) KR100314382B1 (es)
CN (1) CN1097055C (es)
AT (1) ATE220680T1 (es)
AU (1) AU715748B2 (es)
CA (1) CA2253912C (es)
CZ (1) CZ287489B6 (es)
DE (1) DE69714040T2 (es)
DK (1) DK0901492T3 (es)
ES (1) ES2180985T3 (es)
HU (1) HU224965B1 (es)
IT (1) IT1283633B1 (es)
NO (1) NO322266B1 (es)
PL (1) PL185778B1 (es)
PT (1) PT901492E (es)
RU (1) RU2168513C2 (es)
SK (1) SK282471B6 (es)
WO (1) WO1997043291A1 (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2003026673A (ja) * 1999-03-05 2003-01-29 Asahi Kasei Corp 骨形成促進剤
JP4776843B2 (ja) 1999-10-01 2011-09-21 イムノゲン インコーポレーティッド 免疫複合体及び化学療法剤を用いる癌治療用組成物及び方法
ITMI20012185A1 (it) 2001-10-19 2003-04-19 Indena Spa Procedimento per la preparazione della 14beta-idrossi-baccatina iii-1,14-carbonato
ITMI20012186A1 (it) 2001-10-19 2003-04-19 Indena Spa Procedimento per la preparazione della 14-beta-idrossi-baccatina iii-1,14-carbonato
WO2006122408A1 (en) 2005-05-18 2006-11-23 Aegera Therapeutics Inc. Bir domain binding compounds
BRPI0711591A2 (pt) 2006-05-16 2011-11-16 Aegera Therapeutics, Inc. composto de ligação de domìnio bir da iap
EP2080764B1 (en) 2008-01-18 2012-08-22 INDENA S.p.A. Solid forms of ortataxel
NZ602368A (en) 2010-02-12 2014-10-31 Pharmascience Inc Iap bir domain binding compounds
CN113603660B (zh) * 2021-09-02 2024-01-05 无锡紫杉药业有限公司 一种10-羰基多西他赛的制备方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2601785B1 (fr) * 1986-07-15 1989-07-28 Telecommunications Sa Dispositif de reserve pour cable a fibre optique et le procede de mise en oeuvre
FR2601675B1 (fr) * 1986-07-17 1988-09-23 Rhone Poulenc Sante Derives du taxol, leur preparation et les compositions pharmaceutiques qui les contiennent
US5059699A (en) * 1990-08-28 1991-10-22 Virginia Tech Intellectual Properties, Inc. Water soluble derivatives of taxol
US5393886A (en) * 1993-05-05 1995-02-28 The Du Pont Merck Pharmaceutical Company Intermediates for the synthesis of anthrapyrazolone anticancer agents
IT1275936B1 (it) * 1995-03-17 1997-10-24 Indena Spa Derivati della 10-deacetilbaccatina iii e della 10-deacetil-14b- idrossibaccatina iii loro metodo di preparazione e formulazioni
IT1275435B (it) * 1995-05-19 1997-08-07 Indena Spa Derivati della 10-desacetil-14beta-idrossibaccatina iii,loro metodo di preparazione e formulazioni che li contengono

Also Published As

Publication number Publication date
ATE220680T1 (de) 2002-08-15
NO322266B1 (no) 2006-09-04
PL185778B1 (pl) 2003-07-31
AU715748B2 (en) 2000-02-10
EP0901492B1 (en) 2002-07-17
SK153998A3 (en) 1999-04-13
DK0901492T3 (da) 2002-09-02
WO1997043291A1 (en) 1997-11-20
CA2253912C (en) 2006-03-28
IT1283633B1 (it) 1998-04-23
CN1097055C (zh) 2002-12-25
HK1019603A1 (en) 2000-02-18
CA2253912A1 (en) 1997-11-20
ITMI960942A0 (es) 1996-05-10
NO985187L (no) 1998-11-06
CZ287489B6 (en) 2000-12-13
EP0901492A1 (en) 1999-03-17
PT901492E (pt) 2002-10-31
JP3423002B2 (ja) 2003-07-07
CZ361998A3 (cs) 1999-06-16
RU2168513C2 (ru) 2001-06-10
NO985187D0 (no) 1998-11-06
JP2000513716A (ja) 2000-10-17
PL329768A1 (en) 1999-04-12
US5955489A (en) 1999-09-21
CN1218475A (zh) 1999-06-02
ITMI960942A1 (it) 1997-11-10
SK282471B6 (sk) 2002-02-05
HU224965B1 (en) 2006-04-28
DE69714040D1 (de) 2002-08-22
HUP9903649A3 (en) 2001-06-28
KR100314382B1 (ko) 2002-02-28
AU2888697A (en) 1997-12-05
DE69714040T2 (de) 2003-03-13
HUP9903649A2 (hu) 2001-05-28
KR20000010894A (ko) 2000-02-25

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