ATE220926T1 - Radiomarkierte verbindungen zur thrombus- bilderzeugung - Google Patents

Radiomarkierte verbindungen zur thrombus- bilderzeugung

Info

Publication number: ATE220926T1
Authority: AT; Austria
Prior art keywords: pct; methods; compounds; tagted; radiom
Prior art date: 1993-04-08

Application number

AT94921885T

Other languages

English (en)

Inventor

Richard T Dean

John Lister-James

Edward R Civitello

William Mcbride

Original Assignee

Diatide Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-04-08

Filing date

1994-04-08

Publication date

2002-08-15

1994-04-08 Application filed by Diatide Inc filed Critical Diatide Inc

2002-08-15 Application granted granted Critical

2002-08-15 Publication of ATE220926T1 publication Critical patent/ATE220926T1/de

Links

208000007536 Thrombosis Diseases 0.000 title 1
238000003384 imaging method Methods 0.000 title 1
150000001875 compounds Chemical class 0.000 abstract 3
238000000034 method Methods 0.000 abstract 3
102000005962 receptors Human genes 0.000 abstract 2
108020003175 receptors Proteins 0.000 abstract 2
102100025306 Integrin alpha-IIb Human genes 0.000 abstract 1
101710149643 Integrin alpha-IIb Proteins 0.000 abstract 1
GKLVYJBZJHMRIY-OUBTZVSYSA-N Technetium-99 Chemical compound [99Tc] GKLVYJBZJHMRIY-OUBTZVSYSA-N 0.000 abstract 1
230000027455 binding Effects 0.000 abstract 1
239000003153 chemical reaction reagent Substances 0.000 abstract 1
239000003795 chemical substances by application Substances 0.000 abstract 1
239000012216 imaging agent Substances 0.000 abstract 1
-1 peptides Chemical class 0.000 abstract 1
102000004196 processed proteins & peptides Human genes 0.000 abstract 1
108090000765 processed proteins & peptides Proteins 0.000 abstract 1
230000009870 specific binding Effects 0.000 abstract 1
229940056501 technetium 99m Drugs 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/088—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins conjugates with carriers being peptides, polyamino acids or proteins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/082—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins the peptide being a RGD-containing peptide
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2123/00—Preparations for testing in vivo

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Proteomics, Peptides & Aminoacids (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Optics & Photonics (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Animal Behavior & Ethology (AREA)
Physics & Mathematics (AREA)
Public Health (AREA)
Chemical & Material Sciences (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Peptides Or Proteins (AREA)
Investigating Or Analysing Biological Materials (AREA)
Ultra Sonic Daignosis Equipment (AREA)
Surgical Instruments (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Measurement Of Radiation (AREA)

AT94921885T 1993-04-08 1994-04-08 Radiomarkierte verbindungen zur thrombus- bilderzeugung ATE220926T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US4482593A	1993-04-08	1993-04-08
PCT/US1994/003878 WO1994023758A1 (en)	1993-04-08	1994-04-08	Radiolabeled compounds for thrombus imaging

Publications (1)

Publication Number	Publication Date
ATE220926T1 true ATE220926T1 (de)	2002-08-15

Family

ID=21934541

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT94921885T ATE220926T1 (de)	1993-04-08	1994-04-08	Radiomarkierte verbindungen zur thrombus- bilderzeugung

Country Status (13)

Country	Link
US (1)	US6056940A (de)
EP (1)	EP0693941B1 (de)
JP (1)	JP2954355B2 (de)
AT (1)	ATE220926T1 (de)
AU (1)	AU687080B2 (de)
BR (1)	BR1100946A (de)
CA (2)	CA2160120A1 (de)
DE (1)	DE69431052T2 (de)
DK (1)	DK0693941T3 (de)
ES (1)	ES2179076T3 (de)
SG (1)	SG49788A1 (de)
WO (1)	WO1994023758A1 (de)
ZA (1)	ZA942439B (de)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
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US5997844A (en) *	1991-02-08	1999-12-07	Diatide, Inc.	Technetium-99m labeled peptides for imaging
US7238340B1 (en) *	1991-11-27	2007-07-03	Cis Bio International	Monoamine, diamide, thiol-containing metal chelating agents
US6019958A (en) *	1991-02-08	2000-02-01	Diatide, Inc.	Technetium-99m labeled peptides for imaging inflammation
US5830856A (en) *	1991-02-08	1998-11-03	Diatide, Inc.	Radiolabeled compounds for thrombus imaging
US5443815A (en) *	1991-11-27	1995-08-22	Diatech, Inc.	Technetium-99m labeled peptides for imaging
US5645815A (en)	1991-02-08	1997-07-08	Diatide, Inc.	Radiolabled compounds for thrombus imaging
US5965107A (en) *	1992-03-13	1999-10-12	Diatide, Inc.	Technetium-99m labeled peptides for imaging
US5849261A (en) *	1991-02-08	1998-12-15	Diatide, Inc.	Radiolabeled vasoactive intestinal peptides for diagnosis and therapy
US5736122A (en) *	1991-02-08	1998-04-07	Diatide, Inc.	Technetium-99m labeled peptides for thrombus imaging
ATE188387T1 (de) *	1991-02-08	2000-01-15	Diatide Inc	Technetium-99m markierte polypeptide zur bildformung
US5989519A (en) *	1992-03-13	1999-11-23	Diatide, Inc.	Technetium-99m labeled peptides for imaging inflammation
US5508020A (en) *	1992-06-05	1996-04-16	Diatech, Inc.	Technetium-99M labeled peptides for imaging
US5968476A (en) *	1992-05-21	1999-10-19	Diatide, Inc.	Technetium-99m labeled peptides for thrombus imaging
EP0772459B1 (de) *	1994-05-02	2003-03-19	Diatide, Inc.	Technetium-99m markierte bildformungsmittel
US5753206A (en) *	1995-06-07	1998-05-19	Immunomedics, Inc.	Radiometal-binding analogues of luteinizing hormone releasing hormone
EP0975374B1 (de)	1996-07-12	2007-12-05	Immunomedics, Inc.	Radiometall-bindende peptide analoge
US5951981A (en) *	1996-12-02	1999-09-14	Diatide, Inc.	Thrombolytic agents with antithrombotic activity
US5886142A (en) *	1997-05-20	1999-03-23	Thomas Jefferson University	Radiolabeled thrombus imaging agents
DE10005631A1 (de) *	2000-02-09	2001-08-23	Max Planck Gesellschaft	Arginin-Mimetika als Faktor X¶a¶-Inhibitoren
AU2004226464A1 (en) *	2003-03-26	2004-10-14	Cardiomind, Inc.	Implant delivery technologies

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US4578079A (en) *	1982-08-04	1986-03-25	La Jolla Cancer Research Foundation	Tetrapeptide
US4792525A (en) *	1982-08-04	1988-12-20	La Jolla Cancer Research Foundation	Tetrapeptide
US5225181A (en) *	1985-06-07	1993-07-06	The Research Foundation Of State University Of New York	Radiolabeled antiplatelet monoclonal antibody for imaging in-vivo thrombi
US4877868A (en) *	1986-03-12	1989-10-31	Neorx Corporation	Radionuclide antibody coupling
CA1335725C (en) *	1987-09-25	1995-05-30	Stephen W. Hadley	Method of diagnosing blood clots using fibrin-binding proteins
AU639409B2 (en) *	1987-12-10	1993-07-29	La Jolla Cancer Research Foundation	Conformationally stabilized cell adhesion peptides
WO1989010759A1 (en) *	1988-04-29	1989-11-16	Mallinckrodt, Inc.	Diaminedithiol chelating agents for radiopharmaceuticals
US5196510A (en) *	1988-12-29	1993-03-23	Cytogen Corporation	Molecular recognition units
US4986979A (en) *	1989-03-14	1991-01-22	Neorx Corporation	Imaging tissue sites of inflammation
GB8914020D0 (en) *	1989-06-19	1989-08-09	Antisoma Ltd	Synthetic peptides for use in thrombus detection
US5384309A (en) *	1989-07-17	1995-01-24	Genentech, Inc.	Cyclized peptides and their use as platelet aggregation inhibitors
CA2021950A1 (en) *	1989-07-28	1991-01-29	Ruth F. Nutt	Fibrinogen receptor antagonists
CA2021952A1 (en) *	1989-07-28	1991-01-29	Ruth F. Nutt	Fibrinogen receptor antagonists
EP0410540A1 (de) *	1989-07-28	1991-01-30	Merck & Co. Inc.	Fibrinogenrezeptorantagonisten
EP0410537A1 (de) *	1989-07-28	1991-01-30	Merck & Co. Inc.	Fibrinogen-Rezeptor-Antagonisten
US5443816A (en) *	1990-08-08	1995-08-22	Rhomed Incorporated	Peptide-metal ion pharmaceutical preparation and method
US4952562A (en) *	1989-09-29	1990-08-28	Rorer Pharmaceutical Corporation	Anti-thrombotic peptides and pseudopeptides
NZ235563A (en) *	1989-10-13	1993-04-28	Merck & Co Inc	Fibrinogen receptor antagonist and pharmaceutical composition
NZ235564A (en) *	1989-10-13	1993-10-26	Merck & Co Inc	Fibrinogen receptor antagonist and pharmaceutical compositions
AU6470590A (en) *	1989-10-23	1991-04-26	Smithkline Beecham Corporation	Cyclic anti-aggregatory peptides
US5086069A (en) *	1990-02-05	1992-02-04	Rorer Pharmaceutical Corporation	Anti-thrombotic peptide and pseudopeptide derivatives
IL97459A0 (en) *	1990-03-09	1992-06-21	Hybritech Inc	Trifunctional antibody-like compounds as a combined diagnostic and therapeutic agent
DE69126871T2 (de) *	1990-04-06	1998-03-12	Jolla Cancer Res Found	Verfahren und verbindung zur behandlung von thrombose
US5105327A (en) *	1990-05-10	1992-04-14	Uses, Inc.	Ac power conditioning circuit
IL99537A (en) *	1990-09-27	1995-11-27	Merck & Co Inc	Fibrinogen receptor antagonists and pharmaceutical compositions containing them
US5645815A (en) *	1991-02-08	1997-07-08	Diatide, Inc.	Radiolabled compounds for thrombus imaging
ATE188387T1 (de) *	1991-02-08	2000-01-15	Diatide Inc	Technetium-99m markierte polypeptide zur bildformung
US5965107A (en) *	1992-03-13	1999-10-12	Diatide, Inc.	Technetium-99m labeled peptides for imaging
EP0574545B1 (de) *	1991-03-06	1994-11-30	G.D. Searle & Co.	Phenylamidinderivate als plättchenaggregationsinhibitoren
CA2106314A1 (en) *	1991-04-05	1992-10-06	John P. Burnier	Platelet aggregation inhibitors having high specification for gpiibiiia
US5321034A (en) *	1991-05-07	1994-06-14	Merck & Co., Inc.	Fibrinogen receptor antagonists
US5220050A (en) *	1991-05-17	1993-06-15	G. D. Searle & Co.	Peptide mimetic compounds useful as platelet aggregation inhibitors
AU666318B2 (en) *	1991-06-28	1996-02-08	Smithkline Beecham Corporation	Bicyclic fibrinogen antagonists
US5250679A (en) *	1991-10-18	1993-10-05	Genentech, Inc.	Nonpeptidyl platelet aggregation inhibitors having specificity for the GPIIb III.sub. receptor
US5508020A (en) *	1992-06-05	1996-04-16	Diatech, Inc.	Technetium-99M labeled peptides for imaging
DE69334033D1 (de) *	1992-05-21	2006-07-27	Diatide Inc	Technetium-99M markierte Peptide zur Bilderzeugung von Thrombus
US5744120A (en) *	1993-03-30	1998-04-28	The Dupont Merick Pharmaceutical Company	Ternary radiopharmaceutical complexes
US5879657A (en) *	1993-03-30	1999-03-09	The Dupont Merck Pharmaceutical Company	Radiolabeled platelet GPIIb/IIIa receptor antagonists as imaging agents for the diagnosis of thromboembolic disorders

1994
- 1994-04-08 ZA ZA942439A patent/ZA942439B/xx unknown
- 1994-04-08 JP JP6523329A patent/JP2954355B2/ja not_active Expired - Fee Related
- 1994-04-08 SG SG1996006000A patent/SG49788A1/en unknown
- 1994-04-08 AT AT94921885T patent/ATE220926T1/de not_active IP Right Cessation
- 1994-04-08 ES ES94921885T patent/ES2179076T3/es not_active Expired - Lifetime
- 1994-04-08 CA CA002160120A patent/CA2160120A1/en not_active Abandoned
- 1994-04-08 EP EP94921885A patent/EP0693941B1/de not_active Expired - Lifetime
- 1994-04-08 CA CA002363780A patent/CA2363780C/en not_active Expired - Fee Related
- 1994-04-08 WO PCT/US1994/003878 patent/WO1994023758A1/en not_active Ceased
- 1994-04-08 DE DE69431052T patent/DE69431052T2/de not_active Expired - Fee Related
- 1994-04-08 US US08/535,170 patent/US6056940A/en not_active Expired - Fee Related
- 1994-04-08 DK DK94921885T patent/DK0693941T3/da active
- 1994-04-08 AU AU72413/94A patent/AU687080B2/en not_active Ceased
1997
- 1997-05-14 BR BR1100946-2A patent/BR1100946A/pt active IP Right Grant

Also Published As

Publication number	Publication date
BR1100946A (pt)	2000-08-08
ZA942439B (en)	1996-01-08
WO1994023758A1 (en)	1994-10-27
EP0693941A1 (de)	1996-01-31
EP0693941B1 (de)	2002-07-24
DK0693941T3 (da)	2002-10-14
JPH08508999A (ja)	1996-09-24
AU7241394A (en)	1994-11-08
AU687080B2 (en)	1998-02-19
DE69431052T2 (de)	2003-03-13
JP2954355B2 (ja)	1999-09-27
US6056940A (en)	2000-05-02
ES2179076T3 (es)	2003-01-16
DE69431052D1 (de)	2002-08-29
SG49788A1 (en)	1998-06-15
CA2363780C (en)	2003-01-07
CA2160120A1 (en)	1994-10-27
CA2363780A1 (en)	1994-10-27

Legal Events

Date	Code	Title	Description
2003-01-15	UEP	Publication of translation of european patent specification
2008-01-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
DE69431052D1 (de)	2002-08-29	Radiomarkierte verbindungen zur thrombus-bilderzeugung
ATE184203T1 (de)	1999-09-15	Technetium-99m-markierte peptide zur bilderzeugung
ATE152918T1 (de)	1997-05-15	Technetium-99m-markierte peptide zur bilderzeugung
DE69329382D1 (de)	2000-10-12	Technetium-99m markierte peptide zur bilderzeugung von thrombus
ATE340594T1 (de)	2006-10-15	Somatostatin bindende peptide-metallchelat konjugate
PL311037A1 (en)	1996-01-22	Radioisotope labelled antagonists of the platelet receptor gpiib/iiia as visualising agents in diagnosing thrombotic/embolic diseases
ATE325625T1 (de)	2006-06-15	Technetium-99m markierte peptide zur diagnostischen bilderzeugung von entzündungen
DK0630265T3 (da)	2003-06-30	Technetium-99m mærkede peptider til afbildning af inflammation
DE69534943D1 (de)	2006-05-24	Technetium-99m markierte peptide zur bildformung
DK0804481T3 (da)	2003-07-28	Somatostatin-derivater og deres radioaktivt mærkede produkter
ES2194908T3 (es)	2003-12-01	Agentes de produccion de imagenes marcados con tecnecio-99m.
ZA952206B (en)	1995-12-12	Scintigraphic imaging agents
FR2663748B1 (fr)	1992-10-09	Anticorps specifiques de la liaison isopeptidique induite par les transglutaminases, antigenes constitues par des isopeptides glu-lys reconnus par lesdits anticorps, agents de diagnostic et compositions therapeutiques les contenant.
CA2190108A1 (en)	1995-11-23	Somatostatin binding peptide-metal chelate conjugates