ATE221072T1 - Herstellungsverfahren des 4'- methylepipodophyllotoxin aus podophyllotoxin - Google Patents

Herstellungsverfahren des 4'- methylepipodophyllotoxin aus podophyllotoxin

Info

Publication number: ATE221072T1
Authority: AT; Austria
Prior art keywords: pct; podophyllotoxin; methylepipodophyllotoxin; production process; date jun
Prior art date: 1995-12-14

Application number

AT96942404T

Other languages

English (en)

Inventor

Thierry Imbert

Yves Guminski

Original Assignee

Pf Medicament

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-12-14

Filing date

1996-12-13

Publication date

2002-08-15

1996-12-13 Application filed by Pf Medicament filed Critical Pf Medicament

2002-08-15 Application granted granted Critical

2002-08-15 Publication of ATE221072T1 publication Critical patent/ATE221072T1/de

Links

YJGVMLPVUAXIQN-UHFFFAOYSA-N epipodophyllotoxin Natural products COC1=C(OC)C(OC)=CC(C2C3=CC=4OCOC=4C=C3C(O)C3C2C(OC3)=O)=C1 YJGVMLPVUAXIQN-UHFFFAOYSA-N 0.000 title abstract 2
YJGVMLPVUAXIQN-XVVDYKMHSA-N podophyllotoxin Chemical compound COC1=C(OC)C(OC)=CC([C@@H]2C3=CC=4OCOC=4C=C3[C@H](O)[C@@H]3[C@@H]2C(OC3)=O)=C1 YJGVMLPVUAXIQN-XVVDYKMHSA-N 0.000 title abstract 2
229960001237 podophyllotoxin Drugs 0.000 title abstract 2
YVCVYCSAAZQOJI-UHFFFAOYSA-N podophyllotoxin Natural products COC1=C(O)C(OC)=CC(C2C3=CC=4OCOC=4C=C3C(O)C3C2C(OC3)=O)=C1 YVCVYCSAAZQOJI-UHFFFAOYSA-N 0.000 title abstract 2
238000004519 manufacturing process Methods 0.000 title 1
FOVRGQUEGRCWPD-UHFFFAOYSA-N (5aR)-9t-beta-D-Glucopyranosyloxy-5t-(4-hydroxy-3,5-dimethoxy-phenyl)-(5ar,8at)-5,8,8a,9-tetrahydro-5aH-furo[3',4';6,7]naphtho[2,3-d][1,3]dioxol-6-on Natural products COC1=C(O)C(OC)=CC(C2C3=CC=4OCOC=4C=C3C(OC3C(C(O)C(O)C(CO)O3)O)C3C2C(OC3)=O)=C1 FOVRGQUEGRCWPD-UHFFFAOYSA-N 0.000 abstract 1
YVCVYCSAAZQOJI-JHQYFNNDSA-N 4'-demethylepipodophyllotoxin Chemical compound COC1=C(O)C(OC)=CC([C@@H]2C3=CC=4OCOC=4C=C3[C@@H](O)[C@@H]3[C@@H]2C(OC3)=O)=C1 YVCVYCSAAZQOJI-JHQYFNNDSA-N 0.000 abstract 1
UCKMPCXJQFINFW-UHFFFAOYSA-N Sulphide Chemical compound [S-2] UCKMPCXJQFINFW-UHFFFAOYSA-N 0.000 abstract 1
239000002253 acid Substances 0.000 abstract 1
125000001931 aliphatic group Chemical group 0.000 abstract 1
125000003118 aryl group Chemical group 0.000 abstract 1
239000003153 chemical reaction reagent Substances 0.000 abstract 1
150000007522 mineralic acids Chemical class 0.000 abstract 1
150000007524 organic acids Chemical class 0.000 abstract 1
239000003960 organic solvent Substances 0.000 abstract 1
230000002194 synthesizing effect Effects 0.000 abstract 1
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/04—Ortho-condensed systems

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

AT96942404T 1995-12-14 1996-12-13 Herstellungsverfahren des 4'- methylepipodophyllotoxin aus podophyllotoxin ATE221072T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
FR9514875A FR2742439B1 (fr)	1995-12-14	1995-12-14	Procede de preparation de la 4'-demethylepipodophyllotoxine a partir de la podophyllotoxine
PCT/FR1996/002000 WO1997021713A1 (fr)	1995-12-14	1996-12-13	Procede de preparation de la 4'-demethylepipodophyllotoxine a partir de la podophyllotoxine

Publications (1)

Publication Number	Publication Date
ATE221072T1 true ATE221072T1 (de)	2002-08-15

Family

ID=9485535

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT96942404T ATE221072T1 (de)	1995-12-14	1996-12-13	Herstellungsverfahren des 4'- methylepipodophyllotoxin aus podophyllotoxin

Country Status (10)

Country	Link
US (1)	US6008382A (de)
EP (1)	EP0876374B1 (de)
JP (1)	JP2000501726A (de)
AT (1)	ATE221072T1 (de)
AU (1)	AU1179497A (de)
DE (1)	DE69622589D1 (de)
ES (1)	ES2179959T3 (de)
FR (1)	FR2742439B1 (de)
PT (1)	PT876374E (de)
WO (1)	WO1997021713A1 (de)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2869035B1 (fr)	2004-04-16	2006-07-14	Pierre Fabre Medicament Sa	Derives (poly)aminoalkylaminoacetamide d'epipodophyllotoxine leur procede de preparation et leurs applications en therapeutique comme agent anticancereux
FR2921368B1 (fr)	2007-09-25	2012-10-12	Pf Medicament	Nouveau procede de synthese de derives anticancereux de (poly) aminoalkylaminoacetamide d'epipodophyllotoxine.
FR2935143B1 (fr)	2008-08-19	2010-12-03	Pf Medicament	Nouveaus derives (poly)aminoalkylaminoalkylamides, alkyl-urees, ou alkyl-sulfonamides d'epipodophyllotoxine, leur procede de preparation et leur application en therapeuthique comme agent cancereux

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU632796B2 (en) *	1989-02-23	1993-01-14	University Of North Carolina At Chapel Hill, The	Etoposide analogues

1995
- 1995-12-14 FR FR9514875A patent/FR2742439B1/fr not_active Expired - Fee Related
1996
- 1996-12-13 JP JP09521813A patent/JP2000501726A/ja active Pending
- 1996-12-13 EP EP96942404A patent/EP0876374B1/de not_active Expired - Lifetime
- 1996-12-13 ES ES96942404T patent/ES2179959T3/es not_active Expired - Lifetime
- 1996-12-13 AU AU11794/97A patent/AU1179497A/en not_active Abandoned
- 1996-12-13 WO PCT/FR1996/002000 patent/WO1997021713A1/fr not_active Ceased
- 1996-12-13 DE DE69622589T patent/DE69622589D1/de not_active Expired - Lifetime
- 1996-12-13 US US09/077,303 patent/US6008382A/en not_active Expired - Fee Related
- 1996-12-13 AT AT96942404T patent/ATE221072T1/de not_active IP Right Cessation
- 1996-12-13 PT PT96942404T patent/PT876374E/pt unknown

Also Published As

Publication number	Publication date
WO1997021713A1 (fr)	1997-06-19
ES2179959T3 (es)	2003-02-01
EP0876374A1 (de)	1998-11-11
AU1179497A (en)	1997-07-03
DE69622589D1 (de)	2002-08-29
JP2000501726A (ja)	2000-02-15
EP0876374B1 (de)	2002-07-24
FR2742439B1 (fr)	1998-03-06
PT876374E (pt)	2002-12-31
US6008382A (en)	1999-12-28
FR2742439A1 (fr)	1997-06-20

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Legal Events

Date	Code	Title	Description
2003-01-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties