ATE221079T1 - Zusammensetzungen und verfahrenen zur synthese von organophosphorus derivaten - Google Patents

Zusammensetzungen und verfahrenen zur synthese von organophosphorus derivaten

Info

Publication number
ATE221079T1
ATE221079T1 AT96927149T AT96927149T ATE221079T1 AT E221079 T1 ATE221079 T1 AT E221079T1 AT 96927149 T AT96927149 T AT 96927149T AT 96927149 T AT96927149 T AT 96927149T AT E221079 T1 ATE221079 T1 AT E221079T1
Authority
AT
Austria
Prior art keywords
methods
synthesis
compositions
nucleoside
chirality
Prior art date
Application number
AT96927149T
Other languages
English (en)
Inventor
Wojciech J Stec
Lucyna Wozniak
Original Assignee
Polska Akad Nauk Centrum
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PL31024895A external-priority patent/PL181746B1/pl
Priority claimed from PL96312934A external-priority patent/PL184377B1/pl
Priority claimed from US08/653,204 external-priority patent/US5936080A/en
Application filed by Polska Akad Nauk Centrum filed Critical Polska Akad Nauk Centrum
Application granted granted Critical
Publication of ATE221079T1 publication Critical patent/ATE221079T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Saccharide Compounds (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
AT96927149T 1995-09-01 1996-08-29 Zusammensetzungen und verfahrenen zur synthese von organophosphorus derivaten ATE221079T1 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
PL31024895A PL181746B1 (pl) 1995-09-01 1995-09-01 Sposób wytwarzania modyfikowanych P-chiralnych analogów nukleotydów
PL96312934A PL184377B1 (pl) 1996-02-26 1996-02-26 Nowe pochodne fosforoorganiczne i sposób ich wytwarzania
US08/653,204 US5936080A (en) 1996-05-24 1996-05-24 Compositions and methods for the synthesis of organophosphorus derivatives
PCT/IB1996/000867 WO1997009340A1 (en) 1995-09-01 1996-08-29 Compositions and methods for the synthesis of organophosphorus derivatives

Publications (1)

Publication Number Publication Date
ATE221079T1 true ATE221079T1 (de) 2002-08-15

Family

ID=27354079

Family Applications (1)

Application Number Title Priority Date Filing Date
AT96927149T ATE221079T1 (de) 1995-09-01 1996-08-29 Zusammensetzungen und verfahrenen zur synthese von organophosphorus derivaten

Country Status (8)

Country Link
EP (1) EP0850248B1 (de)
AT (1) ATE221079T1 (de)
AU (1) AU707093B2 (de)
CA (1) CA2233460A1 (de)
DE (1) DE69622571T2 (de)
DK (1) DK0850248T3 (de)
NZ (1) NZ315384A (de)
WO (1) WO1997009340A1 (de)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5852188A (en) 1990-01-11 1998-12-22 Isis Pharmaceuticals, Inc. Oligonucleotides having chiral phosphorus linkages
ATE221127T1 (de) 1991-10-15 2002-08-15 Isis Pharmaceuticals Inc Über chirale phosphoratome gebundene oligonukleotide
DK0828749T3 (da) * 1995-05-26 2003-10-27 Genta Inc Fremgangsmåder til syntese af organophosphorderivater
US6211354B1 (en) * 1998-05-06 2001-04-03 Tosch Corporation Optically active DNA probe having phosphonic diester linkage

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU6603690A (en) * 1989-10-05 1991-04-28 University Patents Inc. Nucleoside and polynucleotide thiophosphoramidite and phosphorodithioate compounds and processes
US5703223A (en) * 1994-09-02 1997-12-30 Thomas Jefferson University Solid phase synthesis of oligonucleotides with stereospecific substituted phosphonate linkages by pentavalent grignard coupling

Also Published As

Publication number Publication date
EP0850248B1 (de) 2002-07-24
CA2233460A1 (en) 1997-03-13
NZ315384A (en) 1999-04-29
EP0850248A1 (de) 1998-07-01
DK0850248T3 (da) 2002-11-04
AU707093B2 (en) 1999-07-01
DE69622571D1 (de) 2002-08-29
DE69622571T2 (de) 2003-03-27
WO1997009340A1 (en) 1997-03-13
AU6707996A (en) 1997-03-27

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