ATE222238T1 - Verfahren und zwischenprodukte zur herstellung von piperazinderivaten - Google Patents
Verfahren und zwischenprodukte zur herstellung von piperazinderivatenInfo
- Publication number
- ATE222238T1 ATE222238T1 AT95921010T AT95921010T ATE222238T1 AT E222238 T1 ATE222238 T1 AT E222238T1 AT 95921010 T AT95921010 T AT 95921010T AT 95921010 T AT95921010 T AT 95921010T AT E222238 T1 ATE222238 T1 AT E222238T1
- Authority
- AT
- Austria
- Prior art keywords
- compounds
- piperazine derivatives
- intermediate products
- formula
- producing piperazine
- Prior art date
Links
- 229940066771 systemic antihistamines piperazine derivative Drugs 0.000 title abstract 2
- GLUUGHFHXGJENI-UHFFFAOYSA-N Piperazine Chemical class C1CNCCN1 GLUUGHFHXGJENI-UHFFFAOYSA-N 0.000 title 1
- 239000013067 intermediate product Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 4
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000002947 alkylene group Chemical group 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 125000001072 heteroaryl group Chemical group 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 150000004885 piperazines Chemical class 0.000 abstract 1
- 230000008707 rearrangement Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D419/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms
- C07D419/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D419/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pyridine Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB9411108A GB9411108D0 (en) | 1994-06-03 | 1994-06-03 | Novel processes and intermediates for the preparation of piperazine derivatives |
| GBGB9510152.3A GB9510152D0 (en) | 1995-05-19 | 1995-05-19 | Process for the preparation of piperazine intermediates |
| PCT/GB1995/001256 WO1995033725A1 (en) | 1994-06-03 | 1995-06-01 | Novel processes and intermediates for the preparation of piperazine derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE222238T1 true ATE222238T1 (de) | 2002-08-15 |
Family
ID=26304996
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT95921010T ATE222238T1 (de) | 1994-06-03 | 1995-06-01 | Verfahren und zwischenprodukte zur herstellung von piperazinderivaten |
Country Status (12)
| Country | Link |
|---|---|
| US (3) | US6133449A (de) |
| EP (1) | EP0763024B1 (de) |
| JP (1) | JPH10504275A (de) |
| AT (1) | ATE222238T1 (de) |
| AU (1) | AU2622595A (de) |
| CA (1) | CA2191874C (de) |
| DE (1) | DE69527787T2 (de) |
| DK (1) | DK0763024T3 (de) |
| ES (1) | ES2180638T3 (de) |
| IL (1) | IL113966A (de) |
| PT (1) | PT763024E (de) |
| WO (1) | WO1995033725A1 (de) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH10504275A (ja) * | 1994-06-03 | 1998-04-28 | ジョン・ワイス・アンド・ブラザー・リミテッド | ピペラジン誘導体を製造するための新規な方法および中間体 |
| GB9514901D0 (en) * | 1995-07-20 | 1995-09-20 | American Home Prod | Piperazine derivatives |
| CZ8197A3 (en) | 1996-01-16 | 1997-10-15 | American Home Prod | (1h-indol-4-yl)-piperidine- or tetrahydropyridine ethyl amines and -ethyl carboxamides and pharmaceutical composition containing thereof |
| US6271234B1 (en) * | 1997-08-01 | 2001-08-07 | Recordati S.A., Chemical And Pharmaceutical Company | 1,4-disubstituted piperazines |
| US20060287335A1 (en) | 2000-11-28 | 2006-12-21 | Wyeth | Serotonergic agents for treating sexual dysfunction |
| US20060223824A1 (en) | 2000-11-28 | 2006-10-05 | Wyeth | Serotonergic agents |
| US7361773B2 (en) | 2002-03-12 | 2008-04-22 | Wyeth | Preparation of N1-(2'-pyridyl)-1,2-propanediamine sulfamic acid and its use in the synthesis of biologically active piperazines |
| ES2329122T3 (es) | 2002-03-12 | 2009-11-23 | Wyeth | Procedimiento para sintetizar n-aril piperazinas quirales. |
| JP4397693B2 (ja) * | 2002-03-12 | 2010-01-13 | ワイス | Ｎ１−（２’−ピリジル）−１，２−アルカンジアミンスルファミン酸の合成および生物学的に活性なピペラジンの合成におけるその使用 |
| BR0308347A (pt) | 2002-03-12 | 2005-01-25 | Wyeth Corp | Processo para fabricação de piperazinas 1,4-dissubstituìdas quirais |
| US7091349B2 (en) | 2002-03-12 | 2006-08-15 | Wyeth | Process for synthesizing N-aryl piperazines with chiral N′-1-[benzoyl(2-pyridyl)amino]-2-propane substitution |
| US20050209245A1 (en) * | 2004-03-19 | 2005-09-22 | Wyeth | Process for preparing N-aryl-piperazine derivatives |
| JP2010503661A (ja) * | 2006-09-12 | 2010-02-04 | ジュビラント・オルガノシス・リミテッド | ピリジンおよび／またはその誘導体の環境に優しい回収方法 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3405859A1 (de) * | 1984-02-18 | 1985-08-22 | Basf Ag, 6700 Ludwigshafen | Sulfongruppenhaltige azoverbindungen |
| DE3685840D1 (de) * | 1985-04-30 | 1992-08-06 | Dresden Arzneimittel | 3-cyan-pyridine, verfahren zu ihrer herstellung und ihre pharmazeutische verwendung. |
| GB8512163D0 (en) | 1985-05-14 | 1985-06-19 | Fujisawa Pharmaceutical Co | Oxothiazolidine compound |
| US4741831A (en) * | 1986-12-04 | 1988-05-03 | The Dow Chemical Company | Process and composition for removal of metal ions from aqueous solutions |
| EP0368169B1 (de) * | 1988-11-05 | 1995-07-19 | Sumitomo Electric Industries, Ltd. | Verfahren zur Herstellung eines organischen Kristalls |
| DE4042005A1 (de) | 1990-12-22 | 1992-06-25 | Schering Ag | D-homo-(16-en)-11(beta)-aryl-4-estrene |
| US5342953A (en) | 1991-01-31 | 1994-08-30 | Syntex (U.S.A.) Inc. | N-2-chlorobenzyl-2-oxo and N-2-chlorobenzyl-2,2-dioxo-1,2,3-oxathiazolidine derivatives, their preparation and synthesis of thieno[3,2-c]pyridine derivatives therefrom |
| MX9201991A (es) * | 1991-05-02 | 1992-11-01 | Jonh Wyeth & Brother Limited | Derivados de piperazina y procedimiento para su preparacion. |
| US5271812A (en) * | 1991-06-19 | 1993-12-21 | Sepracor, Inc. | Electrocatalytic oxidation method for the production of cyclic sulfates and sulfamidates |
| GB9314758D0 (en) * | 1993-07-16 | 1993-08-25 | Wyeth John & Brother Ltd | Heterocyclic derivatives |
| JPH10504275A (ja) * | 1994-06-03 | 1998-04-28 | ジョン・ワイス・アンド・ブラザー・リミテッド | ピペラジン誘導体を製造するための新規な方法および中間体 |
| GB9411099D0 (en) * | 1994-06-03 | 1994-07-27 | Wyeth John & Brother Ltd | Piperazine derivatives |
| US5439915A (en) * | 1994-10-20 | 1995-08-08 | American Home Products Corporation | Pyrido[3,4-B]indole carboxamide derivatives as serotonergic agents |
| US5541179A (en) * | 1995-05-02 | 1996-07-30 | American Home Products Corporation | Tropon-2-one piperazine carboxamides as serotonergic agents |
-
1995
- 1995-06-01 JP JP8500527A patent/JPH10504275A/ja active Pending
- 1995-06-01 CA CA002191874A patent/CA2191874C/en not_active Expired - Fee Related
- 1995-06-01 EP EP95921010A patent/EP0763024B1/de not_active Expired - Lifetime
- 1995-06-01 WO PCT/GB1995/001256 patent/WO1995033725A1/en not_active Ceased
- 1995-06-01 DE DE69527787T patent/DE69527787T2/de not_active Expired - Fee Related
- 1995-06-01 ES ES95921010T patent/ES2180638T3/es not_active Expired - Lifetime
- 1995-06-01 AU AU26225/95A patent/AU2622595A/en not_active Abandoned
- 1995-06-01 AT AT95921010T patent/ATE222238T1/de not_active IP Right Cessation
- 1995-06-01 IL IL11396695A patent/IL113966A/xx not_active IP Right Cessation
- 1995-06-01 PT PT95921010T patent/PT763024E/pt unknown
- 1995-06-01 DK DK95921010T patent/DK0763024T3/da active
-
1998
- 1998-01-22 US US09/012,066 patent/US6133449A/en not_active Expired - Fee Related
- 1998-01-22 US US09/010,741 patent/US6175012B1/en not_active Expired - Fee Related
-
2000
- 2000-07-12 US US09/614,792 patent/US6395902B1/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| IL113966A0 (en) | 1995-10-31 |
| IL113966A (en) | 2000-08-13 |
| AU2622595A (en) | 1996-01-04 |
| JPH10504275A (ja) | 1998-04-28 |
| WO1995033725A1 (en) | 1995-12-14 |
| CA2191874A1 (en) | 1995-12-14 |
| ES2180638T3 (es) | 2003-02-16 |
| CA2191874C (en) | 2008-05-20 |
| US6133449A (en) | 2000-10-17 |
| US6395902B1 (en) | 2002-05-28 |
| EP0763024A1 (de) | 1997-03-19 |
| DK0763024T3 (da) | 2002-12-02 |
| DE69527787D1 (de) | 2002-09-19 |
| PT763024E (pt) | 2002-11-29 |
| EP0763024B1 (de) | 2002-08-14 |
| US6175012B1 (en) | 2001-01-16 |
| DE69527787T2 (de) | 2003-01-02 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| REN | Ceased due to non-payment of the annual fee |