ATE222252T1 - Substitierte oxime, hydrazone und olefine als neurokinin antagonisten - Google Patents

Substitierte oxime, hydrazone und olefine als neurokinin antagonisten

Info

Publication number: ATE222252T1
Authority: AT; Austria
Prior art keywords: heteroaryl; alkyl; cycloalkyl; substited; hydrazones
Prior art date: 1996-11-01

Application number

AT97913743T

Other languages

English (en)

Inventor

Neng-Yang Shih

Gregory A Reichard

Robert G Aslanian

Original Assignee

Schering Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-11-01

Filing date

1997-10-30

Publication date

2002-08-15

1997-10-30 Application filed by Schering Corp filed Critical Schering Corp

2002-08-15 Application granted granted Critical

2002-08-15 Publication of ATE222252T1 publication Critical patent/ATE222252T1/de

Links

150000001336 alkenes Chemical class 0.000 title abstract 2
150000007857 hydrazones Chemical class 0.000 title abstract 2
150000002923 oximes Chemical class 0.000 title abstract 2
239000005557 antagonist Substances 0.000 title 1
125000000753 cycloalkyl group Chemical group 0.000 abstract 4
150000001875 compounds Chemical class 0.000 abstract 3
125000001072 heteroaryl group Chemical group 0.000 abstract 3
125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 2
125000003118 aryl group Chemical group 0.000 abstract 2
125000000592 heterocycloalkyl group Chemical group 0.000 abstract 2
125000002768 hydroxyalkyl group Chemical group 0.000 abstract 2
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
208000009079 Bronchial Spasm Diseases 0.000 abstract 1
208000014181 Bronchial disease Diseases 0.000 abstract 1
206010006482 Bronchospasm Diseases 0.000 abstract 1
206010011224 Cough Diseases 0.000 abstract 1
208000018522 Gastrointestinal disease Diseases 0.000 abstract 1
125000000217 alkyl group Chemical group 0.000 abstract 1
208000006673 asthma Diseases 0.000 abstract 1
125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
208000027866 inflammatory disease Diseases 0.000 abstract 1
125000001624 naphthyl group Chemical group 0.000 abstract 1
229910052757 nitrogen Inorganic materials 0.000 abstract 1
IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 1
QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 abstract 1
JRZJOMJEPLMPRA-UHFFFAOYSA-N olefin Chemical class CCCCCCCC=C JRZJOMJEPLMPRA-UHFFFAOYSA-N 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
125000005545 phthalimidyl group Chemical group 0.000 abstract 1
125000004193 piperazinyl group Chemical group 0.000 abstract 1
125000003386 piperidinyl group Chemical class 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/14—Antitussive agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Bioinformatics & Cheminformatics (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Pulmonology (AREA)
Pain & Pain Management (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Orthopedic Medicine & Surgery (AREA)
Immunology (AREA)
Rheumatology (AREA)
Physical Education & Sports Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Plural Heterocyclic Compounds (AREA)

AT97913743T 1996-11-01 1997-10-30 Substitierte oxime, hydrazone und olefine als neurokinin antagonisten ATE222252T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US74253896A	1996-11-01	1996-11-01
PCT/US1997/019164 WO1998020010A1 (en)	1996-11-01	1997-10-30	Substituted oximes, hydrazones and olefins as neurokinin antagonists

Publications (1)

Publication Number	Publication Date
ATE222252T1 true ATE222252T1 (de)	2002-08-15

Family

ID=24985225

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT97913743T ATE222252T1 (de)	1996-11-01	1997-10-30	Substitierte oxime, hydrazone und olefine als neurokinin antagonisten

Country Status (8)

Country	Link
EP (1)	EP0937076B1 (de)
JP (1)	JP2001510455A (de)
AT (1)	ATE222252T1 (de)
AU (1)	AU5086298A (de)
CA (1)	CA2269858A1 (de)
DE (1)	DE69714758T2 (de)
ES (1)	ES2180956T3 (de)
WO (1)	WO1998020010A1 (de)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ID29137A (id) *	1998-07-27	2001-08-02	Schering Corp	Ligan-ligan afinitas tinggi untuk reseptor nosiseptin orl-1
EP2117538A1 (de)	2007-01-24	2009-11-18	Glaxo Group Limited	Pharmazeutische zusammensetzungen mit 2-methoxy-5- (5-trifluoromethyl-tetrazol-i-yl-benzyl) - (2s-phenyl-piperidin-3s-yl-)

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5434158A (en) *	1994-04-26	1995-07-18	Merck & Co., Inc.	Spiro-substituted azacycles as neurokinin-3 antagonists

1997
- 1997-10-30 CA CA002269858A patent/CA2269858A1/en not_active Abandoned
- 1997-10-30 JP JP52147298A patent/JP2001510455A/ja active Pending
- 1997-10-30 DE DE69714758T patent/DE69714758T2/de not_active Expired - Fee Related
- 1997-10-30 EP EP97913743A patent/EP0937076B1/de not_active Expired - Lifetime
- 1997-10-30 AU AU50862/98A patent/AU5086298A/en not_active Abandoned
- 1997-10-30 WO PCT/US1997/019164 patent/WO1998020010A1/en not_active Ceased
- 1997-10-30 ES ES97913743T patent/ES2180956T3/es not_active Expired - Lifetime
- 1997-10-30 AT AT97913743T patent/ATE222252T1/de not_active IP Right Cessation

Also Published As

Publication number	Publication date
AU5086298A (en)	1998-05-29
EP0937076A1 (de)	1999-08-25
DE69714758D1 (de)	2002-09-19
CA2269858A1 (en)	1998-05-14
ES2180956T3 (es)	2003-02-16
DE69714758T2 (de)	2003-01-02
WO1998020010A1 (en)	1998-05-14
EP0937076B1 (de)	2002-08-14
JP2001510455A (ja)	2001-07-31

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Legal Events

Date	Code	Title	Description
2003-02-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties