ATE222264T1 - Multimerische mehrzweckwirkstoffe gegen thrombose - Google Patents

Multimerische mehrzweckwirkstoffe gegen thrombose

Info

Publication number
ATE222264T1
ATE222264T1 AT93924287T AT93924287T ATE222264T1 AT E222264 T1 ATE222264 T1 AT E222264T1 AT 93924287 T AT93924287 T AT 93924287T AT 93924287 T AT93924287 T AT 93924287T AT E222264 T1 ATE222264 T1 AT E222264T1
Authority
AT
Austria
Prior art keywords
multimeric
multipurpose
cyclic peptides
including linear
antithrombotic agents
Prior art date
Application number
AT93924287T
Other languages
English (en)
Inventor
Richard T Dean
John Lister-James
Original Assignee
Diatide Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Diatide Inc filed Critical Diatide Inc
Application granted granted Critical
Publication of ATE222264T1 publication Critical patent/ATE222264T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/75—Fibrinogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2123/00—Preparations for testing in vivo
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Hematology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Genetics & Genomics (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Materials For Medical Uses (AREA)
  • Hydrogenated Pyridines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
AT93924287T 1992-10-02 1993-10-01 Multimerische mehrzweckwirkstoffe gegen thrombose ATE222264T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US95546692A 1992-10-02 1992-10-02
PCT/US1993/009387 WO1994007918A1 (en) 1992-10-02 1993-10-01 Multimeric polyvalent antithrombotic agents

Publications (1)

Publication Number Publication Date
ATE222264T1 true ATE222264T1 (de) 2002-08-15

Family

ID=25496861

Family Applications (1)

Application Number Title Priority Date Filing Date
AT93924287T ATE222264T1 (de) 1992-10-02 1993-10-01 Multimerische mehrzweckwirkstoffe gegen thrombose

Country Status (11)

Country Link
US (2) US5977064A (de)
EP (1) EP0665853B1 (de)
JP (1) JPH08502261A (de)
AT (1) ATE222264T1 (de)
AU (1) AU696206B2 (de)
CA (1) CA2145847A1 (de)
DE (1) DE69332203T2 (de)
DK (1) DK0665853T3 (de)
ES (1) ES2182833T3 (de)
WO (1) WO1994007918A1 (de)
ZA (1) ZA937300B (de)

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US5849261A (en) * 1991-02-08 1998-12-15 Diatide, Inc. Radiolabeled vasoactive intestinal peptides for diagnosis and therapy
US6019958A (en) * 1991-02-08 2000-02-01 Diatide, Inc. Technetium-99m labeled peptides for imaging inflammation
US5830856A (en) * 1991-02-08 1998-11-03 Diatide, Inc. Radiolabeled compounds for thrombus imaging
US5508020A (en) * 1992-06-05 1996-04-16 Diatech, Inc. Technetium-99M labeled peptides for imaging
AU709306B2 (en) * 1992-04-30 1999-08-26 Cis Bio International Radiolabeled compounds for thrombus imaging
US5620675A (en) 1992-06-23 1997-04-15 Diatech, Inc. Radioactive peptides
AU696206B2 (en) * 1992-10-02 1998-09-03 Cis Bio International Multimeric polyvalent antithrombotic agents
US6051206A (en) * 1994-06-03 2000-04-18 Diatide, Inc Radiolabeled somatostatin-derived peptides for imaging and therapeutic uses
US6254852B1 (en) 1999-07-16 2001-07-03 Dupont Pharmaceuticals Company Porous inorganic targeted ultrasound contrast agents
EP1210124A2 (de) * 1999-07-29 2002-06-05 Epix Medical, Inc. Zielrichtung von multimere bilderzeugung mitteln durch multilocus bindung
TWI221406B (en) * 2001-07-30 2004-10-01 Epix Medical Inc Systems and methods for targeted magnetic resonance imaging of the vascular system
AR047692A1 (es) * 2003-07-10 2006-02-08 Epix Medical Inc Imagenes de blancos estacionarios
US20080267882A1 (en) * 2007-04-27 2008-10-30 Stanford University Imaging compounds, methods of making imaging compounds, methods of imaging, therapeutic compounds, methods of making therapeutic compounds, and methods of therapy
AU2009246397B2 (en) 2008-05-13 2013-01-17 University Of Kansas Metal abstraction peptide (MAP) tag and associated methods
US20120076283A1 (en) 2010-09-23 2012-03-29 Ajmera Dinesh Predictive Customer Service Environment
US11080721B2 (en) 2012-04-20 2021-08-03 7.ai, Inc. Method and apparatus for an intuitive customer experience
WO2013181461A2 (en) 2012-06-01 2013-12-05 University Of Kansas Metal abstraction peptide with superoxide dismutase activity
TWI568747B (zh) 2012-09-05 2017-02-01 上海晟順生物科技有限公司 同時具溶血栓、清除自由基和血栓靶向功能的新穎化合物及其製備方法和用途
DK3993876T3 (en) 2019-07-01 2024-12-02 Tonix Pharma Ltd Anti-cd154 antibodies and uses thereof
AU2022205313A1 (en) 2021-01-06 2023-07-20 Tonix Pharma Limited Methods of inducing immune tolerance with modified anti-cd154 antibodies
WO2025248134A1 (en) 2024-05-31 2025-12-04 Tonix Pharma Limited Treatment methods comprising administration of modified cd154 antibodies

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US4614517A (en) * 1982-08-04 1986-09-30 La Jolla Cancer Research Foundation Tetrapeptide
US4792525A (en) * 1982-08-04 1988-12-20 La Jolla Cancer Research Foundation Tetrapeptide
US4578079A (en) * 1982-08-04 1986-03-25 La Jolla Cancer Research Foundation Tetrapeptide
EP0274868A1 (de) * 1986-12-13 1988-07-20 A.s. Clausen, Kaldager & Co. Messgerät
US4843647A (en) * 1987-08-31 1989-07-04 Burlington Industries, Inc. Cold weather system
AU639409B2 (en) * 1987-12-10 1993-07-29 La Jolla Cancer Research Foundation Conformationally stabilized cell adhesion peptides
WO1989010135A1 (en) * 1988-04-29 1989-11-02 New England Deaconess Hospital Corporation Hybrid peptides and methods of their use
JP2859343B2 (ja) * 1988-10-14 1999-02-17 ビーエーエスエフ、コーポレーション 油を含んで成る自由流動性噴霧乾燥食用粉末の製造法
FR2639232A1 (fr) * 1988-10-21 1990-05-25 Sanofi Sa Medicaments contenant une interleukine-2 glycosylee
ATE135584T1 (de) * 1988-12-20 1996-04-15 Jolla Cancer Res Found Polypeptid-polymer-konjugate mit wundheilender wirkung
US5196510A (en) * 1988-12-29 1993-03-23 Cytogen Corporation Molecular recognition units
US5384309A (en) * 1989-07-17 1995-01-24 Genentech, Inc. Cyclized peptides and their use as platelet aggregation inhibitors
EP0410537A1 (de) * 1989-07-28 1991-01-30 Merck & Co. Inc. Fibrinogen-Rezeptor-Antagonisten
CA2021952A1 (en) * 1989-07-28 1991-01-29 Ruth F. Nutt Fibrinogen receptor antagonists
EP0410541A1 (de) * 1989-07-28 1991-01-30 Merck & Co. Inc. Fibrinogenrezeptorantagonisten
CA2021951A1 (en) * 1989-07-28 1991-01-29 Ruth F. Nutt Fibrinogen receptor antagonists
DE3925962A1 (de) * 1989-08-05 1991-02-07 Thomson Brandt Gmbh Videorecorder mit bandstandsanzeige
US5196404B1 (en) * 1989-08-18 1996-09-10 Biogen Inc Inhibitors of thrombin
FR2651077B1 (fr) * 1989-08-18 1994-06-10 Letourneur Gregoire Dispositif de traitement d'echo notamment acoustique dans une ligne telephonique
US4952562A (en) * 1989-09-29 1990-08-28 Rorer Pharmaceutical Corporation Anti-thrombotic peptides and pseudopeptides
NZ235563A (en) * 1989-10-13 1993-04-28 Merck & Co Inc Fibrinogen receptor antagonist and pharmaceutical composition
NZ235564A (en) * 1989-10-13 1993-10-26 Merck & Co Inc Fibrinogen receptor antagonist and pharmaceutical compositions
CA2027936C (en) * 1989-10-23 2001-07-24 Smithkline Beecham Corporation Cyclic anti-aggregatory peptides
US5091542A (en) * 1990-03-09 1992-02-25 Hybritech Incorporated Tris-maleimido compounds as intermediates in trifunctional antibody synthesis
ATE155482T1 (de) * 1990-04-06 1997-08-15 Jolla Cancer Res Found Verfahren und verbindung zur behandlung von thrombose
US5185433A (en) * 1990-04-09 1993-02-09 Centocor, Inc. Cross-linking protein compositions having two or more identical binding sites
US5298488A (en) * 1990-10-26 1994-03-29 Fuji Photo Film Co., Ltd. CM-chitin derivatives and use thereof
JP2745351B2 (ja) * 1991-02-14 1998-04-28 富士写真フイルム株式会社 ペプチド誘導体及びその用途
DK0578728T3 (da) * 1991-04-05 1999-04-12 Genentech Inc Inhibitorer for aggregering af blodplader, hvilke inhibitorer har høj specificitet for GP IIbIIIa
US5508020A (en) * 1992-06-05 1996-04-16 Diatech, Inc. Technetium-99M labeled peptides for imaging
US5338725A (en) * 1992-06-30 1994-08-16 The Research Foundation Of The State University Of New York Anti-aggregatory agents for platelets
AU696206B2 (en) * 1992-10-02 1998-09-03 Cis Bio International Multimeric polyvalent antithrombotic agents
AU7763194A (en) * 1994-06-16 1996-01-04 Nassif Haddad Building block

Also Published As

Publication number Publication date
AU5402694A (en) 1994-04-26
EP0665853B1 (de) 2002-08-14
ES2182833T3 (es) 2003-03-16
DE69332203T2 (de) 2003-05-28
CA2145847A1 (en) 1994-04-14
US6150329A (en) 2000-11-21
WO1994007918A1 (en) 1994-04-14
JPH08502261A (ja) 1996-03-12
AU696206B2 (en) 1998-09-03
US5977064A (en) 1999-11-02
ZA937300B (en) 1995-03-30
DK0665853T3 (da) 2002-11-04
EP0665853A1 (de) 1995-08-09
DE69332203D1 (de) 2002-09-19

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee