ATE222901T1 - Carboxylsubstituierte chromanderivate zur verwendung als beta 3 adrenorezeptor-agonisten - Google Patents

Carboxylsubstituierte chromanderivate zur verwendung als beta 3 adrenorezeptor-agonisten

Info

Publication number
ATE222901T1
ATE222901T1 AT98963240T AT98963240T ATE222901T1 AT E222901 T1 ATE222901 T1 AT E222901T1 AT 98963240 T AT98963240 T AT 98963240T AT 98963240 T AT98963240 T AT 98963240T AT E222901 T1 ATE222901 T1 AT E222901T1
Authority
AT
Austria
Prior art keywords
beta
derivatives
chromeder
carboxyl substituted
adrenoreceptor agonists
Prior art date
Application number
AT98963240T
Other languages
English (en)
Inventor
Richard D Connell
Timothy G Lease
Jeremy Baryza
Original Assignee
Bayer Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Ag filed Critical Bayer Ag
Application granted granted Critical
Publication of ATE222901T1 publication Critical patent/ATE222901T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Emergency Medicine (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Child & Adolescent Psychology (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Detergent Compositions (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Pyrrole Compounds (AREA)
AT98963240T 1997-12-19 1998-12-16 Carboxylsubstituierte chromanderivate zur verwendung als beta 3 adrenorezeptor-agonisten ATE222901T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US99462097A 1997-12-19 1997-12-19
PCT/US1998/026735 WO1999032476A1 (en) 1997-12-19 1998-12-16 Carboxyl substituted chroman derivatives useful as beta 3 adrenoreceptor agonists

Publications (1)

Publication Number Publication Date
ATE222901T1 true ATE222901T1 (de) 2002-09-15

Family

ID=25540853

Family Applications (1)

Application Number Title Priority Date Filing Date
AT98963240T ATE222901T1 (de) 1997-12-19 1998-12-16 Carboxylsubstituierte chromanderivate zur verwendung als beta 3 adrenorezeptor-agonisten

Country Status (24)

Country Link
EP (1) EP1040106B1 (de)
JP (1) JP2001526282A (de)
KR (1) KR20010033188A (de)
CN (1) CN1284952A (de)
AT (1) ATE222901T1 (de)
AU (1) AU749097B2 (de)
BG (1) BG104593A (de)
BR (1) BR9814302A (de)
CA (1) CA2316971A1 (de)
DE (1) DE69807523T2 (de)
DK (1) DK1040106T3 (de)
ES (1) ES2183434T3 (de)
HU (1) HUP0004565A3 (de)
ID (1) ID26524A (de)
IL (1) IL136689A0 (de)
NO (1) NO20003083L (de)
NZ (1) NZ505200A (de)
PL (1) PL341229A1 (de)
PT (1) PT1040106E (de)
RU (1) RU2223269C2 (de)
SK (1) SK9362000A3 (de)
TR (1) TR200001927T2 (de)
UA (1) UA62993C2 (de)
WO (1) WO1999032476A1 (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR035605A1 (es) * 2000-12-11 2004-06-16 Bayer Corp Derivados de aminometil cromano di-sustituidos, un metodo para su preparacion, composiciones farmaceuticas y el uso de dichos derivados para la manufactura de medicamentos utiles como agonistas beta-3-adreno-receptores
AR035858A1 (es) * 2001-04-23 2004-07-21 Bayer Corp Derivados de cromano 2,6-sustituidos,composiciones farmaceuticas,uso de dichos derivados para la manufactura de medicamentos utiles como agonistas adrenorreceptores beta-3
JPWO2003033468A1 (ja) * 2001-10-17 2005-02-03 株式会社カネカ （Ｓ）−α−ハロメチルピリジンメタノール誘導体の製造方法
MY147767A (en) * 2004-06-16 2013-01-31 Janssen Pharmaceutica Nv Novel sulfamate and sulfamide derivatives useful for the treatment of epilepsy and related disorders
CN101120002A (zh) 2005-02-17 2008-02-06 惠氏公司 环烷基稠合的吲哚、苯并噻吩、苯并呋喃和茚衍生物
RU2392277C2 (ru) * 2005-12-28 2010-06-20 Асино Фарма Аг Способ получения рацемического небиволола
US7560575B2 (en) * 2005-12-28 2009-07-14 Acino Pharma Ag Process for preparation of racemic Nebivolol
EP1803716B1 (de) * 2005-12-28 2012-07-25 Acino Pharma AG Ein Verfahren zur Herstellung von racemischem Nebivolol
ES2534318B1 (es) * 2013-10-18 2016-01-28 Artax Biopharma Inc. Derivados de cromeno sustituidos por alcóxido como inhibidores de la interacción TCR-Nck
ES2534336B1 (es) * 2013-10-18 2016-01-28 Artax Biopharma Inc. Derivados de cromeno como inhibidores de la interacción TCR-Nck

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1337429C (en) * 1983-12-05 1995-10-24 Guy Rosalia Eugene Van Lommen Derivatives of 2,2'-iminobisethanol
GB8801306D0 (en) * 1988-01-21 1988-02-17 Ici Plc Chemical compounds
UA35545C2 (uk) * 1991-04-08 2001-04-16 Джон Вайс Енд Бразер Лімітед Спосіб одержання похідних 4-оксохіноліну або хромону
US5451677A (en) * 1993-02-09 1995-09-19 Merck & Co., Inc. Substituted phenyl sulfonamides as selective β 3 agonists for the treatment of diabetes and obesity
US5767133A (en) * 1993-06-14 1998-06-16 Pfizer Inc. Secondary amines as antidiabetic and antiobesity agents
GB9405019D0 (en) * 1994-03-15 1994-04-27 Smithkline Beecham Plc Novel compounds
US5561142A (en) * 1994-04-26 1996-10-01 Merck & Co., Inc. Substituted sulfonamides as selective β3 agonists for the treatment of diabetes and obesity
EP0801060A1 (de) * 1996-04-09 1997-10-15 Pfizer Inc. Heterocyclische Beta-3 adrenergische Angonisten

Also Published As

Publication number Publication date
DE69807523D1 (de) 2002-10-02
PT1040106E (pt) 2002-11-29
NO20003083D0 (no) 2000-06-15
CN1284952A (zh) 2001-02-21
HUP0004565A3 (en) 2002-12-28
IL136689A0 (en) 2001-06-14
AU749097B2 (en) 2002-06-20
EP1040106A1 (de) 2000-10-04
NZ505200A (en) 2002-09-27
ES2183434T3 (es) 2003-03-16
TR200001927T2 (tr) 2001-06-21
BR9814302A (pt) 2000-10-10
CA2316971A1 (en) 1999-07-01
WO1999032476A1 (en) 1999-07-01
PL341229A1 (en) 2001-03-26
KR20010033188A (ko) 2001-04-25
DE69807523T2 (de) 2003-01-09
HUP0004565A2 (hu) 2001-08-28
AU1830099A (en) 1999-07-12
ID26524A (id) 2001-01-11
BG104593A (en) 2001-09-28
SK9362000A3 (en) 2001-09-11
NO20003083L (no) 2000-08-15
DK1040106T3 (da) 2002-12-02
EP1040106B1 (de) 2002-08-28
JP2001526282A (ja) 2001-12-18
UA62993C2 (en) 2004-01-15
RU2223269C2 (ru) 2004-02-10

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Legal Events

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UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee