ATE222909T1 - Verfahren zur herstellung von purin-derivaten - Google Patents

Verfahren zur herstellung von purin-derivaten

Info

Publication number: ATE222909T1
Authority: AT; Austria
Prior art keywords: purine derivatives; intermediates; producing purine; purin; propanediol
Prior art date: 1996-01-26

Application number

AT97901569T

Other languages

English (en)

Inventor

Humberto B Arzeno

Steven D Axt

Colin C Beard

Charles A Dvorak

Paul R Fatheree

Lawrence E Fisher

Yeun-Kwei Han

Eric R Humphreys

Jan P Lund

Sam Linh Nguyen

Douglas Leslie Wren

Original Assignee

Hoffmann La Roche

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-01-26

Filing date

1997-01-21

Publication date

2002-09-15

1997-01-21 Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche

2002-09-15 Application granted granted Critical

2002-09-15 Publication of ATE222909T1 publication Critical patent/ATE222909T1/de

Links

238000004519 manufacturing process Methods 0.000 title abstract 2
229940083251 peripheral vasodilators purine derivative Drugs 0.000 title 1
150000003212 purines Chemical class 0.000 title 1
239000000543 intermediate Substances 0.000 abstract 2
238000000034 method Methods 0.000 abstract 2
238000010521 absorption reaction Methods 0.000 abstract 1
239000003443 antiviral agent Substances 0.000 abstract 1
239000007795 chemical reaction product Substances 0.000 abstract 1
150000002148 esters Chemical class 0.000 abstract 1
IRSCQMHQWWYFCW-UHFFFAOYSA-N ganciclovir Chemical compound O=C1NC(N)=NC2=C1N=CN2COC(CO)CO IRSCQMHQWWYFCW-UHFFFAOYSA-N 0.000 abstract 1
239000012535 impurity Substances 0.000 abstract 1
239000000047 product Substances 0.000 abstract 1
238000000746 purification Methods 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
239000007858 starting material Substances 0.000 abstract 1
239000004474 valine Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/18—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 one oxygen and one nitrogen atom, e.g. guanine
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/52—Purines, e.g. adenine

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Epidemiology (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

AT97901569T 1996-01-26 1997-01-21 Verfahren zur herstellung von purin-derivaten ATE222909T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US59207996A	1996-01-26	1996-01-26
PCT/EP1997/000262 WO1997027198A1 (en)	1996-01-26	1997-01-21	Process for preparing purine derivatives

Publications (1)

Publication Number	Publication Date
ATE222909T1 true ATE222909T1 (de)	2002-09-15

Family

ID=24369197

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT97901569T ATE222909T1 (de)	1996-01-26	1997-01-21	Verfahren zur herstellung von purin-derivaten

Country Status (10)

Country	Link
JP (1)	JP4094667B2 (de)
KR (1)	KR100491941B1 (de)
CN (1)	CN1064683C (de)
AT (1)	ATE222909T1 (de)
AU (1)	AU1543797A (de)
CA (1)	CA2243650C (de)
DE (1)	DE69714971T3 (de)
ES (1)	ES2180923T5 (de)
MX (1)	MX9805935A (de)
WO (1)	WO1997027198A1 (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5869493A (en) *	1996-02-16	1999-02-09	Medivir Ab	Acyclic nucleoside derivatives
US6703394B2 (en)	1996-02-16	2004-03-09	Medivir Ab	Acyclic nucleoside derivatives
WO2005023827A1 (en) *	2003-09-11	2005-03-17	F. Hoffmann-La Roche Ag	Process for preparing antiviral nucleoside derivatives
ZA200702234B (en) *	2006-03-21	2008-07-30	Cipla Ltd	Preparation of ester of purine derivatives
CN103562207B (zh) *	2011-05-31	2016-08-17	法尔玛赞公司	用于制备缬更昔洛韦的2-氨基-9-((2-苯基-1，3-二噁烷-5-基氧基)甲基)-1h-嘌呤-6(9h)-酮化合物的制备方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4816447A (en) *	1981-08-26	1989-03-28	Merck & Co., Inc.	Anti-viral guanine compounds
NL8202626A (nl) *	1982-06-29	1984-01-16	Stichting Rega V Z W	Derivaten van 9-(2-hydroxyethoxymethyl)guanine.
AP55A (en) *	1987-08-15	1989-09-26	The Wellcome Foundation Ltd	Therapeutic Acyclic Nucleosides
CA2005815C (en) *	1988-12-19	1999-08-03	Wellcome Foundation Limited (The)	Antiviral acyclic nucleoside derivatives
JP3225545B2 (ja) *	1991-09-18	2001-11-05	味の素株式会社	非環状ヌクレオシド類の製造法
PE32296A1 (es) *	1994-07-28	1996-08-07	Hoffmann La Roche	Ester de l-monovalina derivado de 2-(2-amino-1,6-dihidro-6-oxo-purin-9-il) metoxi-1,3-propandiol y sus sales farmaceuticamente aceptables

1997
- 1997-01-21 KR KR10-1998-0705709A patent/KR100491941B1/ko not_active Expired - Lifetime
- 1997-01-21 ES ES97901569T patent/ES2180923T5/es not_active Expired - Lifetime
- 1997-01-21 CA CA002243650A patent/CA2243650C/en not_active Expired - Lifetime
- 1997-01-21 AU AU15437/97A patent/AU1543797A/en not_active Abandoned
- 1997-01-21 WO PCT/EP1997/000262 patent/WO1997027198A1/en not_active Ceased
- 1997-01-21 JP JP52651797A patent/JP4094667B2/ja not_active Expired - Lifetime
- 1997-01-21 CN CN97192606A patent/CN1064683C/zh not_active Expired - Lifetime
- 1997-01-21 AT AT97901569T patent/ATE222909T1/de active
- 1997-01-21 DE DE69714971T patent/DE69714971T3/de not_active Expired - Lifetime
1998
- 1998-07-23 MX MX9805935A patent/MX9805935A/es unknown

Also Published As

Publication number	Publication date
JP4094667B2 (ja)	2008-06-04
JP2000503977A (ja)	2000-04-04
KR100491941B1 (ko)	2005-08-05
DE69714971D1 (de)	2002-10-02
AU1543797A (en)	1997-08-20
CA2243650A1 (en)	1997-07-31
DE69714971T2 (de)	2003-05-28
CA2243650C (en)	2006-08-15
WO1997027198A1 (en)	1997-07-31
CN1064683C (zh)	2001-04-18
DE69714971T3 (de)	2005-12-15
CN1212693A (zh)	1999-03-31
KR19990081991A (ko)	1999-11-15
MX9805935A (es)	1998-11-30
ES2180923T3 (es)	2003-02-16
ES2180923T5 (es)	2005-10-16

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Legal Events

Date

Code

Title

Description

2003-01-15

UEP

Publication of translation of european patent specification

2006-09-15

UEP

Publication of translation of european patent specification

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