ATE222921T1 - Modifizierte oligonukleotide - Google Patents

Modifizierte oligonukleotide

Info

Publication number: ATE222921T1
Authority: AT; Austria
Prior art keywords: pct; nucleotides; sec; modified oligonucleotides; date
Prior art date: 1994-01-26

Application number

AT95906958T

Other languages

English (en)

Inventor

Mesmaeker Alain De

Adrian Waldner

Jacques Lebreton

Marc-Olivier Bevierre

Catherine Lesueur

Original Assignee

Novartis Erfind Verwalt Gmbh

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-01-26

Filing date

1995-01-17

Publication date

2002-09-15

1994-01-26 Priority claimed from GB9401446A external-priority patent/GB9401446D0/en

1994-06-22 Priority claimed from GB9412526A external-priority patent/GB9412526D0/en

1995-01-17 Application filed by Novartis Erfind Verwalt Gmbh filed Critical Novartis Erfind Verwalt Gmbh

2002-09-15 Application granted granted Critical

2002-09-15 Publication of ATE222921T1 publication Critical patent/ATE222921T1/de

Links

JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Chemical class Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 title 1
239000002777 nucleoside Substances 0.000 abstract 2
239000002773 nucleotide Substances 0.000 abstract 2
125000003729 nucleotide group Chemical group 0.000 abstract 2
150000003833 nucleoside derivatives Chemical class 0.000 abstract 1
125000003835 nucleoside group Chemical group 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
Molecular Biology (AREA)
Biochemistry (AREA)
General Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Medicinal Chemistry (AREA)
Biotechnology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Animal Behavior & Ethology (AREA)
General Chemical & Material Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
Genetics & Genomics (AREA)
Pharmacology & Pharmacy (AREA)
Bioinformatics & Cheminformatics (AREA)
Virology (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Saccharide Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Compositions Of Macromolecular Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

AT95906958T 1994-01-26 1995-01-17 Modifizierte oligonukleotide ATE222921T1 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
GB9401446A GB9401446D0 (en)	1994-01-26	1994-01-26	Modified oligonucleotides
GB9412526A GB9412526D0 (en)	1994-06-22	1994-06-22	Modified oligonucleotides
PCT/EP1995/000156 WO1995020597A1 (en)	1994-01-26	1995-01-17	Modified oligonucleotides

Publications (1)

Publication Number	Publication Date
ATE222921T1 true ATE222921T1 (de)	2002-09-15

Family

ID=26304218

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT95906958T ATE222921T1 (de)	1994-01-26	1995-01-17	Modifizierte oligonukleotide

Country Status (13)

Country	Link
US (1)	US6066447A (de)
EP (1)	EP0741741B1 (de)
JP (1)	JPH09508134A (de)
AT (1)	ATE222921T1 (de)
AU (1)	AU697134B2 (de)
CA (1)	CA2180727A1 (de)
DE (1)	DE69527942T2 (de)
DK (1)	DK0741741T3 (de)
FI (1)	FI116677B (de)
HU (1)	HU220423B (de)
IL (1)	IL112424A0 (de)
NO (1)	NO316902B1 (de)
WO (1)	WO1995020597A1 (de)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
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ES2144603T5 (es) *	1993-12-13	2004-11-16	THE PROCTER & GAMBLE COMPANY	Composiciones liquidas concentradas, de viscosidad estable, de suavizante para materiales textiles.
US6166197A (en) *	1995-03-06	2000-12-26	Isis Pharmaceuticals, Inc.	Oligomeric compounds having pyrimidine nucleotide (S) with 2'and 5 substitutions
US6222025B1 (en)	1995-03-06	2001-04-24	Isis Pharmaceuticals, Inc.	Process for the synthesis of 2′-O-substituted pyrimidines and oligomeric compounds therefrom
WO1997014709A1 (en) *	1995-10-13	1997-04-24	F. Hoffmann-La Roche Ag	Antisense oligomers
US5808035A (en) *	1995-12-08	1998-09-15	Usher; David A.	Protected nucleoside and method for its synthesis
WO1998000434A1 (en) *	1996-06-28	1998-01-08	Novartis Ag	Modified oligonucleotides
PL337888A1 (en)	1997-07-03	2000-09-11	Du Pont Pharm Co	Imidazoprimidines and imidazopyridines for use in treating neurological disorders
US6686366B1 (en)	1998-06-02	2004-02-03	Osi Pharmaceuticals, Inc.	Compounds specific to adenosine A3 receptor and uses thereof
HUP0103836A3 (en)	1998-06-02	2003-05-28	Osi Pharmaceuticals Inc Uniond	Pyrrolo[2,3d]pyrimidine compositions and their use
US6878716B1 (en)	1998-06-02	2005-04-12	Osi Pharmaceuticals, Inc.	Compounds specific to adenosine A1 receptor and uses thereof
US6365589B1 (en)	1998-07-02	2002-04-02	Bristol-Myers Squibb Pharma Company	Imidazo-pyridines, -pyridazines, and -triazines as corticotropin releasing factor antagonists
US7160890B2 (en)	1999-12-02	2007-01-09	Osi Pharmaceuticals, Inc.	Compounds specific to adenosine A3 receptor and uses thereof
US6680322B2 (en)	1999-12-02	2004-01-20	Osi Pharmaceuticals, Inc.	Compounds specific to adenosine A1 receptors and uses thereof
US6664252B2 (en)	1999-12-02	2003-12-16	Osi Pharmaceuticals, Inc.	4-aminopyrrolo[2,3-d]pyrimidine compounds specific to adenosine A2a receptor and uses thereof
US6673802B2 (en)	2000-12-01	2004-01-06	Osi Pharmaceuticals, Inc.	Compounds specific to adenosine A3 receptor and uses thereof
US6680324B2 (en)	2000-12-01	2004-01-20	Osi Pharmaceuticals, Inc.	Compounds specific to adenosine A1 receptors and uses thereof
DE60234118D1 (de)	2001-11-30	2009-12-03	Osi Pharm Inc	Verbindungen, die für Adenosin A1 und A3 Rezeptoren spezifisch sind, und deren Anwendungen
US20030229067A1 (en)	2001-12-20	2003-12-11	Arlindo Castelhano	Pyrrolopyrimidine A2b selective antagonist compounds, their synthesis and use
ATE458483T1 (de)	2001-12-20	2010-03-15	Osi Pharm Inc	Selektive pyrimidin-a2b-antagonistenverbindungen, ihre synthese und verwendung
KR100649352B1 (ko) *	2005-04-30	2006-11-27	주식회사 하이닉스반도체	반도체소자의 제조 방법
US7820810B2 (en)	2007-03-19	2010-10-26	Isis Pharmaceuticals, Inc.	Process for the synthesis of 2′-O-substituted purine nulceosides
MX2011010050A (es)	2009-03-25	2011-12-14	Univ Texas	Composiciones para estimulación de resistencia inmune innata de mamiferos a patógenos.
WO2016044839A2 (en)	2014-09-19	2016-03-24	The Board Of Regents Of The University Of Texas System	Compositions and methods for treating viral infections through stimulated innate immunity in combination with antiviral compounds
JP6981961B2 (ja) *	2015-07-30	2021-12-17	ホライズンオルファンエルエルシー	フコシダーゼ阻害剤
WO2025149479A1 (en) *	2024-01-12	2025-07-17	Roche Diagnostics Gmbh	Synthesis of modified nucleoside triphosphates

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4806463A (en) *	1986-05-23	1989-02-21	Worcester Foundation For Experimental Biology	Inhibition of HTLV-III by exogenous oligonucleotides
EP0266099A3 (de) *	1986-10-28	1990-09-19	The Johns Hopkins University	Alkyl- oder Arylphosphonat-Oligonukleosid, das sich mit Nukleinesäuren vernetzen kann oder das Nukleinsäure spalten kann
WO1989008146A1 (en) *	1988-02-26	1989-09-08	Worcester Foundation For Experimental Biology	Inhibition of htlv-iii by exogenous oligonucleotides
DK0942000T3 (da) *	1989-10-24	2004-11-01	Isis Pharmaceuticals Inc	2'-modificerede oligonukleotider
US5378825A (en) *	1990-07-27	1995-01-03	Isis Pharmaceuticals, Inc.	Backbone modified oligonucleotide analogs
ATE131827T1 (de) *	1990-08-03	1996-01-15	Sterling Winthrop Inc	Verbindungen und verfahren zur unterdrückung der genexpression
EP0549686A4 (en) *	1990-09-20	1995-01-18	Gilead Sciences Inc	Modified internucleoside linkages

1995
- 1995-01-17 JP JP7519861A patent/JPH09508134A/ja active Pending
- 1995-01-17 AU AU15347/95A patent/AU697134B2/en not_active Ceased
- 1995-01-17 EP EP95906958A patent/EP0741741B1/de not_active Expired - Lifetime
- 1995-01-17 WO PCT/EP1995/000156 patent/WO1995020597A1/en not_active Ceased
- 1995-01-17 AT AT95906958T patent/ATE222921T1/de not_active IP Right Cessation
- 1995-01-17 DK DK95906958T patent/DK0741741T3/da active
- 1995-01-17 US US08/687,456 patent/US6066447A/en not_active Expired - Fee Related
- 1995-01-17 CA CA002180727A patent/CA2180727A1/en not_active Abandoned
- 1995-01-17 HU HU9602040A patent/HU220423B/hu not_active IP Right Cessation
- 1995-01-17 DE DE69527942T patent/DE69527942T2/de not_active Expired - Fee Related
- 1995-01-24 IL IL11242495A patent/IL112424A0/xx unknown
1996
- 1996-07-24 NO NO19963092A patent/NO316902B1/no unknown
- 1996-07-26 FI FI962980A patent/FI116677B/fi active IP Right Grant

Also Published As

Publication number	Publication date
HUT75704A (en)	1997-05-28
HU220423B (hu)	2002-01-28
WO1995020597A1 (en)	1995-08-03
NO963092D0 (no)	1996-07-24
EP0741741A1 (de)	1996-11-13
EP0741741B1 (de)	2002-08-28
AU1534795A (en)	1995-08-15
IL112424A0 (en)	1995-03-30
NO963092L (no)	1996-09-16
DE69527942T2 (de)	2003-03-27
FI962980A0 (fi)	1996-07-26
CA2180727A1 (en)	1995-08-03
HU9602040D0 (en)	1996-09-30
FI962980L (fi)	1996-07-26
FI116677B (fi)	2006-01-31
US6066447A (en)	2000-05-23
DK0741741T3 (da)	2002-12-23
JPH09508134A (ja)	1997-08-19
AU697134B2 (en)	1998-09-24
DE69527942D1 (de)	2002-10-02
NO316902B1 (no)	2004-06-21

Legal Events

Date	Code	Title	Description
2003-02-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
ATE222921T1 (de)	2002-09-15	Modifizierte oligonukleotide
MX9703192A (es)	1997-12-31	Nucleosidos modificados en el azucar y su uso para la sintesis de oligonucleosidos.
ES2105698T3 (es)	1997-10-16	Oligonucleotidos modificados con 7-deazapurina.
DK0712860T3 (da)	2002-03-04	Fremgangsmåde til oprensning og isolation af 2'-deoxy-2',2'-diflournukleosider
ATE373671T1 (de)	2007-10-15	Aminooxy-modifizierte oligonukleotide
DE3854297D1 (de)	1995-09-14	Nucleoside und nucleotide mit antiviraler, antitumoraler, antimetastatischer sowie immunstimulierender wirkung.
ES2061416T1 (es)	1994-12-16	Ribocimas modificadas.
FI924188A7 (fi)	1992-09-18	Yksisäikeisen DNA:n kohtaspesifinen pilkkominen
FI913236A0 (fi)	1991-07-03	9-purinylfosfonsyraderivat.
ATE53588T1 (de)	1990-06-15	Herstellung von cytosin-nukleosiden.
FI945323L (fi)	1995-05-16	5-metyyliuridiinimenetelmä 2',3'-didehydro-3'-deoksitymidiinin (d4T) laajamittaista valmistusta varten
NZ332834A (en)	2000-01-28	Glycosaminoglycan-related carbohydrate derivatives ( 5 saccharide groups ) having 4 to 6 sulphate groups
DK630589A (da)	1990-06-15	2',3'-dideoxypurinnucleosid/purinnucleosid-phosphorylase-inhibitor-sammensaetning
FR2738827B1 (fr)	1997-10-17	Detection des enterobacteries
NO962848L (no)	1996-09-06	Monohydrat av (E)-2'-deoksy-2'-(fluormetylen)cytidin
BR9801143A (pt)	2000-01-18	Copolìmeros de bloco de siloxano inovativos com espaçamento rìgidos e uso dos mesmos.
ATE175971T1 (de)	1999-02-15	Wasserlösliche retinoide
AU2739797A (en)	1997-11-26	(in situ) preparation of nucleoside phosphoramidites and their use in synthesis of oligonucleotides
DK0611373T3 (da)	1997-10-06	Oligo-2-desoxynukleotider og deres anvendelse som lægemidler med antiviral virkning.