ATE223395T1 - Synthese von optisch reiner 4-aryl-2- hydroxytetronic - Google Patents

Synthese von optisch reiner 4-aryl-2- hydroxytetronic

Info

Publication number: ATE223395T1
Authority: AT; Austria
Prior art keywords: optically pure; aryl; synthesis; treatment; hydroxytetronic
Prior art date: 1994-02-25

Application number

AT95911075T

Other languages

English (en)

Inventor

Allen T Hopper

Donald T Witiak

Original Assignee

Univ Ohio State Res Found

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-02-25

Filing date

1995-02-22

Publication date

2002-09-15

1994-02-25 Priority claimed from US08/201,775 external-priority patent/US5399721A/en

1995-02-22 Application filed by Univ Ohio State Res Found filed Critical Univ Ohio State Res Found

2002-09-15 Application granted granted Critical

2002-09-15 Publication of ATE223395T1 publication Critical patent/ATE223395T1/de

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D339/00—Heterocyclic compounds containing rings having two sulfur atoms as the only ring hetero atoms
- C07D339/08—Six-membered rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/62—Three oxygen atoms, e.g. ascorbic acid

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Medicinal Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Chemical Kinetics & Catalysis (AREA)
Engineering & Computer Science (AREA)
Epidemiology (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Vascular Medicine (AREA)
Diabetes (AREA)
Hematology (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Urology & Nephrology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Furan Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

AT95911075T 1994-02-25 1995-02-22 Synthese von optisch reiner 4-aryl-2- hydroxytetronic ATE223395T1 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US08/201,775 US5399721A (en)	1990-01-12	1994-02-25	Synthesis of optically pure 4-aryl-2-hydroxytetronic acids
US08/350,205 US5504108A (en)	1990-01-12	1994-12-05	Optically pure 4-aryl-2-hydroxytetronic acids
PCT/US1995/002183 WO1995023139A1 (en)	1994-02-25	1995-02-22	Optically pure 4-aryl-2-hydroxytetronic acids

Publications (1)

Publication Number	Publication Date
ATE223395T1 true ATE223395T1 (de)	2002-09-15

Family

ID=26897085

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT95911075T ATE223395T1 (de)	1994-02-25	1995-02-22	Synthese von optisch reiner 4-aryl-2- hydroxytetronic

Country Status (10)

Country	Link
US (1)	US5504108A (de)
EP (1)	EP0746551B1 (de)
JP (1)	JP3241735B2 (de)
AT (1)	ATE223395T1 (de)
CA (1)	CA2184068A1 (de)
DE (1)	DE69528044T2 (de)
DK (1)	DK0746551T3 (de)
ES (1)	ES2182890T3 (de)
PT (1)	PT746551E (de)
WO (1)	WO1995023139A1 (de)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6005000A (en) *	1996-08-22	1999-12-21	Oxis International, Inc.	5,5-Disubstituted-3, 4-dihydroxy-2(5H)-furanones and methods of use therefor
AU1676300A (en) *	1999-12-29	2001-07-16	Oxis Isle Of Man, Limited	Methods for resolving racemic mixtures of 5-substituted 4-hydroxy-2-furanones
NZ524252A (en)	2000-07-20	2004-03-26	Lauras As	Cox-2 inhibitors for treating HIV and AIDS
US20040242693A1 (en) *	2001-11-30	2004-12-02	Norimasa Okuda	Optically active mandelic acid and its derivative, and method for crystallization thereof
CZ2004718A3 (cs) *	2001-12-21	2004-12-15	Ortho-Mc-Neil Pharmaceutical, Inc.	Způsob přípravy 2-(substituovaný fenyl)-2-hydroxyethylkarbamátů
EA007741B1 (ru) *	2001-12-21	2006-12-29	Орто-Макнейл Фармасьютикал, Инк.	Способ получения 2-(замещенный фенил)-2-гидроксиэтилкарбаматов
NZ720946A (en)	2009-04-29	2017-09-29	Amarin Pharmaceuticals Ie Ltd	Pharmaceutical compositions comprising epa and a cardiovascular agent and methods of using the same
GB2512863A (en) *	2013-04-09	2014-10-15	Pornthip Lattmann	Medicinal applications of arylated hydroxy-tetronic acids

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP2830268B2 (ja) *	1989-01-21	1998-12-02	武田薬品工業株式会社	アスコルビン酸誘導体の製造法
US5095126A (en) *	1990-01-12	1992-03-10	Ohio State University Research Foundation	Efficient synthesis for optically pure stereogenically labile 4-substituted-2-hydroxytetronic acids
US5071872A (en) *	1990-08-14	1991-12-10	The Ohio State University Research Foundation	Method for improving interleukin-2 activity using aci-reductone compounds

1994
- 1994-12-05 US US08/350,205 patent/US5504108A/en not_active Expired - Fee Related
1995
- 1995-02-22 WO PCT/US1995/002183 patent/WO1995023139A1/en not_active Ceased
- 1995-02-22 JP JP52242295A patent/JP3241735B2/ja not_active Expired - Fee Related
- 1995-02-22 EP EP95911075A patent/EP0746551B1/de not_active Expired - Lifetime
- 1995-02-22 ES ES95911075T patent/ES2182890T3/es not_active Expired - Lifetime
- 1995-02-22 DE DE69528044T patent/DE69528044T2/de not_active Expired - Fee Related
- 1995-02-22 PT PT95911075T patent/PT746551E/pt unknown
- 1995-02-22 AT AT95911075T patent/ATE223395T1/de not_active IP Right Cessation
- 1995-02-22 CA CA002184068A patent/CA2184068A1/en not_active Abandoned
- 1995-02-22 DK DK95911075T patent/DK0746551T3/da active

Also Published As

Publication number	Publication date
EP0746551A1 (de)	1996-12-11
ES2182890T3 (es)	2003-03-16
DE69528044T2 (de)	2003-04-17
US5504108A (en)	1996-04-02
DE69528044D1 (de)	2002-10-10
EP0746551B1 (de)	2002-09-04
CA2184068A1 (en)	1995-08-31
DK0746551T3 (da)	2003-01-06
JP3241735B2 (ja)	2001-12-25
PT746551E (pt)	2003-01-31
WO1995023139A1 (en)	1995-08-31
JPH10500663A (ja)	1998-01-20

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Legal Events

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2003-02-15

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Publication of translation of european patent specification

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Country of ref document: EP

2004-11-15

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