ES2182890T3 - Sintesis de acidos 4-arilo-2-hidroxitetronicos opticamente puros. - Google Patents

Sintesis de acidos 4-arilo-2-hidroxitetronicos opticamente puros.

Info

Publication number
ES2182890T3
ES2182890T3 ES95911075T ES95911075T ES2182890T3 ES 2182890 T3 ES2182890 T3 ES 2182890T3 ES 95911075 T ES95911075 T ES 95911075T ES 95911075 T ES95911075 T ES 95911075T ES 2182890 T3 ES2182890 T3 ES 2182890T3
Authority
ES
Spain
Prior art keywords
optically pure
hydroxythetronic
synthesis
acids
treatment
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES95911075T
Other languages
English (en)
Inventor
Allen T Hopper
Donald T Witiak
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ohio State University Research Foundation
Original Assignee
Ohio State University Research Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/201,775 external-priority patent/US5399721A/en
Application filed by Ohio State University Research Foundation filed Critical Ohio State University Research Foundation
Application granted granted Critical
Publication of ES2182890T3 publication Critical patent/ES2182890T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D339/00—Heterocyclic compounds containing rings having two sulfur atoms as the only ring hetero atoms
    • C07D339/08—Six-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/62—Three oxygen atoms, e.g. ascorbic acid

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Diabetes (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Furan Compounds (AREA)

Abstract

LA PRESENTE INVENCION SE REFIERE A UN METODO PARA LA SINTESIS DE ACIDOS 4-ARIL-2-HIDROXITETRONICOS, LABILES ESTEREOGENICAMENTE OPTICAMENTE PUROS DE UN ALDEHIDO OPTICAMENTE PURO. LA INVENCION ADEMAS SE REFIERE AL USO DE TALES COMPUESTOS OPTICAMENTE PUROS COMO POTENTES INHIBIDORES DE AGREGACION DE PLAQUETAS TRABAJANDO AL NIVEL DE LA CICLOOXIGENASA, Y ADICIONALMENTE COMO INHIBIDORES DE CICLOOXIGENASA Y 5-LIPOXIGENASA. LA INVENCION ADEMAS SE REFIERE AL USO FARMACEUTICO DE TALES COMPUESTOS EN EL TRATAMIENTO DE ENFERMEDADES ARTERIALES CORONARIAS, ESPECIALMENTE EN EL TRATAMIENTO Y/O PREVENCION DE ATEROSCLEROSIS, Y EN EL TRATAMIENTO DE DIVERSAS PATOLOGIAS INFLAMATORIAS, ESPECIALMENTE ARTRITIS.
ES95911075T 1994-02-25 1995-02-22 Sintesis de acidos 4-arilo-2-hidroxitetronicos opticamente puros. Expired - Lifetime ES2182890T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/201,775 US5399721A (en) 1990-01-12 1994-02-25 Synthesis of optically pure 4-aryl-2-hydroxytetronic acids
US08/350,205 US5504108A (en) 1990-01-12 1994-12-05 Optically pure 4-aryl-2-hydroxytetronic acids

Publications (1)

Publication Number Publication Date
ES2182890T3 true ES2182890T3 (es) 2003-03-16

Family

ID=26897085

Family Applications (1)

Application Number Title Priority Date Filing Date
ES95911075T Expired - Lifetime ES2182890T3 (es) 1994-02-25 1995-02-22 Sintesis de acidos 4-arilo-2-hidroxitetronicos opticamente puros.

Country Status (10)

Country Link
US (1) US5504108A (es)
EP (1) EP0746551B1 (es)
JP (1) JP3241735B2 (es)
AT (1) ATE223395T1 (es)
CA (1) CA2184068A1 (es)
DE (1) DE69528044T2 (es)
DK (1) DK0746551T3 (es)
ES (1) ES2182890T3 (es)
PT (1) PT746551E (es)
WO (1) WO1995023139A1 (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6005000A (en) 1996-08-22 1999-12-21 Oxis International, Inc. 5,5-Disubstituted-3, 4-dihydroxy-2(5H)-furanones and methods of use therefor
DE69913390D1 (de) * 1999-12-29 2004-01-15 Oxis Isle Of Man Ltd Methode zur trennung von racemischen mischungen von 5-substituierten 4-hydroxy-2-furanonen
NZ524252A (en) 2000-07-20 2004-03-26 Lauras As Cox-2 inhibitors for treating HIV and AIDS
US20040242693A1 (en) * 2001-11-30 2004-12-02 Norimasa Okuda Optically active mandelic acid and its derivative, and method for crystallization thereof
WO2003053916A1 (en) * 2001-12-21 2003-07-03 Ortho-Mcneil Pharmaceutical, Inc. Process for preparing 2-(substituted phenyl) - 2 - hydroxy-ethyl carbamates
KR20100134082A (ko) * 2001-12-21 2010-12-22 오르토-맥네일 파마슈티칼, 인코퍼레이티드 2-(치환된 페닐)-2-하이드록시-에틸 카바메이트의 제조방법
CN107233337A (zh) 2009-04-29 2017-10-10 阿马里纳药物爱尔兰有限公司 含有epa和心血管剂的药物组合物以及使用其的方法
GB2512863A (en) * 2013-04-09 2014-10-15 Pornthip Lattmann Medicinal applications of arylated hydroxy-tetronic acids

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2830268B2 (ja) * 1989-01-21 1998-12-02 武田薬品工業株式会社 アスコルビン酸誘導体の製造法
US5095126A (en) * 1990-01-12 1992-03-10 Ohio State University Research Foundation Efficient synthesis for optically pure stereogenically labile 4-substituted-2-hydroxytetronic acids
US5071872A (en) * 1990-08-14 1991-12-10 The Ohio State University Research Foundation Method for improving interleukin-2 activity using aci-reductone compounds

Also Published As

Publication number Publication date
EP0746551A1 (en) 1996-12-11
JP3241735B2 (ja) 2001-12-25
DE69528044D1 (de) 2002-10-10
PT746551E (pt) 2003-01-31
DE69528044T2 (de) 2003-04-17
EP0746551B1 (en) 2002-09-04
US5504108A (en) 1996-04-02
WO1995023139A1 (en) 1995-08-31
DK0746551T3 (da) 2003-01-06
ATE223395T1 (de) 2002-09-15
CA2184068A1 (en) 1995-08-31
JPH10500663A (ja) 1998-01-20

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