ATE223400T1 - Verfahren und zwischenprodukte zur herstellung von 4-trifluoromethylbiphenyl-2-carbonsaüre,(2- (2h-(1,2,4) triazol-3-ylmethyl)-1,2,3,4- tetrahydro-isoquinolin-6-yl)-amide - Google Patents

Verfahren und zwischenprodukte zur herstellung von 4-trifluoromethylbiphenyl-2-carbonsaüre,(2- (2h-(1,2,4) triazol-3-ylmethyl)-1,2,3,4- tetrahydro-isoquinolin-6-yl)-amide

Info

Publication number
ATE223400T1
ATE223400T1 AT97905354T AT97905354T ATE223400T1 AT E223400 T1 ATE223400 T1 AT E223400T1 AT 97905354 T AT97905354 T AT 97905354T AT 97905354 T AT97905354 T AT 97905354T AT E223400 T1 ATE223400 T1 AT E223400T1
Authority
AT
Austria
Prior art keywords
carbonoxic
trifluoromethylbiphenyl
isoquinoline
ylmethyl
triazole
Prior art date
Application number
AT97905354T
Other languages
English (en)
Inventor
Frank John Urban
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Application granted granted Critical
Publication of ATE223400T1 publication Critical patent/ATE223400T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
AT97905354T 1996-04-30 1997-03-13 Verfahren und zwischenprodukte zur herstellung von 4-trifluoromethylbiphenyl-2-carbonsaüre,(2- (2h-(1,2,4) triazol-3-ylmethyl)-1,2,3,4- tetrahydro-isoquinolin-6-yl)-amide ATE223400T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US1649596P 1996-04-30 1996-04-30
PCT/IB1997/000254 WO1997041111A1 (en) 1996-04-30 1997-03-13 Processes and intermediates for preparing 4'-trifluoromethylbiphenyl-2-carboxylic acid [2-(2h-[1,2,4]triazol-3-ylmethyl)-1,2,3,4-tetrahydro-isoquinolin-6-yl]-amide

Publications (1)

Publication Number Publication Date
ATE223400T1 true ATE223400T1 (de) 2002-09-15

Family

ID=21777423

Family Applications (1)

Application Number Title Priority Date Filing Date
AT97905354T ATE223400T1 (de) 1996-04-30 1997-03-13 Verfahren und zwischenprodukte zur herstellung von 4-trifluoromethylbiphenyl-2-carbonsaüre,(2- (2h-(1,2,4) triazol-3-ylmethyl)-1,2,3,4- tetrahydro-isoquinolin-6-yl)-amide

Country Status (23)

Country Link
US (1) US5998623A (de)
EP (1) EP0902785B1 (de)
JP (1) JPH11507959A (de)
KR (1) KR20000065152A (de)
CN (1) CN1216988A (de)
AR (1) AR006876A1 (de)
AT (1) ATE223400T1 (de)
AU (1) AU711279B2 (de)
BR (1) BR9709137A (de)
CA (1) CA2252621C (de)
CZ (1) CZ346498A3 (de)
DE (1) DE69715188T2 (de)
DK (1) DK0902785T3 (de)
ES (1) ES2180935T3 (de)
HU (1) HUP9902157A3 (de)
ID (1) ID17294A (de)
IL (1) IL126202A0 (de)
PL (1) PL329739A1 (de)
PT (1) PT902785E (de)
TR (1) TR199802163T2 (de)
WO (1) WO1997041111A1 (de)
YU (1) YU16297A (de)
ZA (1) ZA973696B (de)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6197798B1 (en) 1998-07-21 2001-03-06 Novartis Ag Amino-benzocycloalkane derivatives
CO5271688A1 (es) * 1999-11-10 2003-04-30 Pfizer Prod Inc Uso de inhibidor de secrecion de apoliproteinas b y/o de proteina de transferencia de trigliceridos microsmales
CA2324801A1 (en) * 1999-11-10 2001-05-10 Andrew Gordon Swick Use of apo b secretion/mtp inhibitors and anti-obesity agents
CA2324800A1 (en) * 1999-11-10 2001-05-10 Mary Anne Hickman Use of apo b secretion/mtp inhibitors
IL139450A0 (en) * 1999-11-10 2001-11-25 Pfizer Prod Inc Methods of administering apo b-secretion/mtp inhibitors
US6878707B2 (en) * 2000-01-18 2005-04-12 Novartis Ag Carboxamides useful as inhibitors of microsomal triglyceride transfer protein and of apolipoprotein b secretion
AU2001277727A1 (en) * 2000-08-10 2002-02-25 Tanabe Seiyaku Co., Ltd. Benzoylaminoisoindoline compounds, processes for the preparation of the same andintermediates for the synthesis thereof
AU2001277728A1 (en) * 2000-08-10 2002-02-25 Tanabe Seiyaku Co., Ltd. Biphenylcarboxamidoisoindoline compounds, processes for the preparation of the same and intermediates for the synthesis thereof
NZ549721A (en) 2004-03-05 2010-08-27 Univ Pennsylvania Methods for treating disorders or diseases associated with hyperlipidemia and hypercholesterolemia while minimizing side-effects
WO2008075949A1 (en) * 2006-12-20 2008-06-26 Friesland Brands B.V. Modulation of human microsomal triglyceride transfer protein (mtp or mttp) gene expression by food-grade/ingested dietary microorganisms
EP4188372A1 (de) 2020-07-29 2023-06-07 Amryt Pharmaceuticals Inc. Lomitapid zur verwendung in verfahren zur behandlung von hyperlipidämie und hypercholesterinämie bei pädiatrischen patienten

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5595872A (en) * 1992-03-06 1997-01-21 Bristol-Myers Squibb Company Nucleic acids encoding microsomal trigyceride transfer protein
ZA931601B (en) * 1992-03-06 1993-10-05 Squibb & Sons Inc Microsomal triglyceride transfer protein
IL110172A (en) * 1993-07-22 2001-10-31 Lilly Co Eli Bicyclic compounds and pharmaceutical compositions containing them
DK0832069T3 (da) * 1995-06-07 2003-04-22 Pfizer Biphenyl-2-carboxylsyre-tetrahydroisoquinolin-6-ylamidderivater, deres fremstilling og deres anvendelse som inhibitorer af sekretion af mikrosomalt triglyceridoverførselsprotein og/eller apolipoprotein B (Apo B)
WO1996040640A1 (en) * 1995-06-07 1996-12-19 Pfizer Inc. BIPHENYL-2-CARBOXYLIC ACID-TETRAHYDRO-ISOQUINOLIN-6-YL AMIDE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS INHIBITORS OF MICROSOMAL TRIGLYCERIDE TRANSFER PROTEIN AND/OR APOLIPOPROTEIN B (Apo B) SECRETION

Also Published As

Publication number Publication date
IL126202A0 (en) 1999-05-09
DE69715188D1 (de) 2002-10-10
CA2252621A1 (en) 1997-11-06
AU2226697A (en) 1997-11-19
WO1997041111A1 (en) 1997-11-06
DK0902785T3 (da) 2002-10-07
AU711279B2 (en) 1999-10-07
HUP9902157A2 (hu) 2000-04-28
HUP9902157A3 (en) 2000-07-28
CA2252621C (en) 2002-09-03
CN1216988A (zh) 1999-05-19
JPH11507959A (ja) 1999-07-13
BR9709137A (pt) 1999-08-03
TR199802163T2 (xx) 1999-02-22
YU16297A (sh) 1999-09-27
KR20000065152A (ko) 2000-11-06
DE69715188T2 (de) 2003-01-02
ZA973696B (en) 1998-10-29
ID17294A (id) 1997-12-18
AR006876A1 (es) 1999-09-29
US5998623A (en) 1999-12-07
EP0902785B1 (de) 2002-09-04
PT902785E (pt) 2002-12-31
EP0902785A1 (de) 1999-03-24
CZ346498A3 (cs) 1999-09-15
ES2180935T3 (es) 2003-02-16
PL329739A1 (en) 1999-04-12

Similar Documents

Publication Publication Date Title
DE69626710D1 (de) Verfahren zur Herstellung von Polysiloxanpolycarbonatblockcopolymeren
DE69632293D1 (de) Verfahren zur Herstellung von Polysiloxan-Polycarbonat-Blockcopolymeren
DE69529768D1 (de) Verfahren und herstellung zur hydroverwirrung von vliesstoffen
EP0875074A4 (de) Halbleiterbauelemente und verfahren zur herstellung
DE59400298D1 (de) Verfahren zur Herstellung von Polydimethylsiloxanen
DE69707537D1 (de) Verfahren zur Herstellung von 5-substituierten Tetrazolen
DE69522399D1 (de) Verfahren zur Herstellung von 1,2-Benzisothiazol-3-onen
DE69407624D1 (de) Verfahren zur herstellung von sialon-verbundwerkstoffen
DE69841108D1 (de) Verfahren zur herstellung von siliziumkarbideinkristallen
DE69727303D1 (de) Verfahren zur herstellung von halbleiterscheiben grosser abmessungen
DE69839723D1 (de) Verfahren und Vorrichtung zur Herstellung von Halbleiterkristallen
DE59707046D1 (de) Kontinuierliches Verfahren zur Herstellung von 4-Aminopiperidinen
DE69715188D1 (de) Verfahren und zwischenprodukte zur herstellung von 4-trifluoromethylbiphenyl-2-carbonsaüre,(2-(2h-(1,2,4) triazol-3-ylmethyl)-1,2,3,4-tetrahydro-isoquinolin-6-yl)-amide
DE69102275D1 (de) Alumina enthaltende säureadsorbentien und verfahren zur herstellung derselben.
DE69515697D1 (de) Blockcopolymere und verfahren zur herstellung
DE69806832D1 (de) Verfahren zur Herstellung von Octaphenylcyclotetrasiloxan und Sym-Tetramethyltetraphenylcyclotetrasiloxan
DE69408919D1 (de) Verfahren zur Herstellung von Polydimethylsiloxanen
DE69834613D1 (de) Halbleiterbauelement und verfahren zur dessen herstellung
DE59604829D1 (de) Kontinuierliches Verfahren zur Herstellung von 4-Amino-2,2,6,6-tetramethylpiperidin
DE59510180D1 (de) Verfahren zur Herstellung von 4-Amino-2,2,6,6-tetramethyl-piperidin
DE69936449D1 (de) Verfahren zur herstellung von 1,3-disubstituierten-4-oxocyclischen harnstoffen
EP0726715A4 (de) Psyllium enthaltendes stabforzeiges konfekt; verfahren zur herstellung desselben und verwendung desselben
DE69701822D1 (de) Verfahren zur Herstellung von Polyalkoholen
DE69702327D1 (de) Verfahren zur Herstellung von Siliziumsulfid
DE59800130D1 (de) Verfahren zur Herstellung von Organosilazanen

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee