ATE223406T1 - 1,4-disubstitutierte cyclohexanderivate zur behandlung von depression - Google Patents

1,4-disubstitutierte cyclohexanderivate zur behandlung von depression

Info

Publication number: ATE223406T1
Authority: AT; Austria
Prior art keywords: hydrogen; treatment; depression; halogen; alkyl
Prior art date: 1999-01-07

Application number

AT00903156T

Other languages

English (en)

Inventor

Richard Eric Mewshaw

Reinhardt Bernhard Baudy

Original Assignee

Wyeth Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-01-07

Filing date

2000-01-06

Publication date

2002-09-15

2000-01-06 Application filed by Wyeth Corp filed Critical Wyeth Corp

2002-09-15 Application granted granted Critical

2002-09-15 Publication of ATE223406T1 publication Critical patent/ATE223406T1/de

Links

-1 1,4-DISUBSTITUTED CYCLOHEXANE Chemical class 0.000 title 1
208000020401 Depressive disease Diseases 0.000 title 1
229910052739 hydrogen Inorganic materials 0.000 abstract 4
239000001257 hydrogen Substances 0.000 abstract 4
150000002431 hydrogen Chemical class 0.000 abstract 4
125000000217 alkyl group Chemical group 0.000 abstract 3
229910052736 halogen Inorganic materials 0.000 abstract 3
150000002367 halogens Chemical class 0.000 abstract 3
IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical group N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 2
XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 abstract 2
125000003545 alkoxy group Chemical group 0.000 abstract 2
125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 2
OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 1
125000002877 alkyl aryl group Chemical group 0.000 abstract 1
125000003118 aryl group Chemical group 0.000 abstract 1
239000004202 carbamide Substances 0.000 abstract 1
235000013877 carbamide Nutrition 0.000 abstract 1
229910052799 carbon Inorganic materials 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
208000035475 disorder Diseases 0.000 abstract 1
230000000926 neurological effect Effects 0.000 abstract 1
229910052757 nitrogen Chemical group 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Life Sciences & Earth Sciences (AREA)
Neurology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pain & Pain Management (AREA)
Psychiatry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Liquid Crystal Substances (AREA)
Plural Heterocyclic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

AT00903156T 1999-01-07 2000-01-06 1,4-disubstitutierte cyclohexanderivate zur behandlung von depression ATE223406T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US22655299A	1999-01-07	1999-01-07
PCT/US2000/000348 WO2000040579A1 (en)	1999-01-07	2000-01-06	New 1,4-disubstituted cyclohexane derivatives for the treatment of depression

Publications (1)

Publication Number	Publication Date
ATE223406T1 true ATE223406T1 (de)	2002-09-15

Family

ID=22849378

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT00903156T ATE223406T1 (de)	1999-01-07	2000-01-06	1,4-disubstitutierte cyclohexanderivate zur behandlung von depression

Country Status (11)

Country	Link
EP (1)	EP1140919B1 (de)
JP (1)	JP2002534426A (de)
CN (1)	CN1335844A (de)
AT (1)	ATE223406T1 (de)
AU (1)	AU2494400A (de)
CA (1)	CA2355361A1 (de)
DE (1)	DE60000405T2 (de)
DK (1)	DK1140919T3 (de)
ES (1)	ES2182775T3 (de)
PT (1)	PT1140919E (de)
WO (1)	WO2000040579A1 (de)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP2004531506A (ja)	2001-03-29	2004-10-14	ブリストル−マイヤーズ　スクイブ　カンパニー	選択的なセロトニン再取り込みインヒビターとしてのシクロプロピルインドール誘導体
CN100391974C (zh) *	2006-01-09	2008-06-04	浙江理工大学	一种重组胶原蛋白及其合成和表达纯化方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3907974A1 (de) *	1989-03-11	1990-09-13	Merck Patent Gmbh	Indolderivate
US4975445A (en) *	1989-12-06	1990-12-04	Warner-Lambert Company	Substituted cyclohexenes as central nervous system agents
DK158590D0 (da) *	1990-07-02	1990-07-02	Lundbeck & Co As H	Indolderivater
US5322851A (en) *	1990-07-02	1994-06-21	H. Lundbeck A/S	Indole derivatives
US5124332A (en) *	1991-01-28	1992-06-23	Warner-Lambert Company	Substituted indoles as central nervous system agents
US5314896A (en) *	1991-11-20	1994-05-24	Warner-Lambert Company	1,3-substituted cycloalkenes and cycloalkanes as central nervous system agents
GB9300194D0 (en) *	1993-01-06	1993-03-03	Wyeth John & Brother Ltd	Piperazine derivatives
US5468767A (en) *	1994-01-06	1995-11-21	Bristol-Myers Squibb Company	Antidepressant 3-(aminocycloalkenyl)-indole-5-nitrile derivatives
CN1184425A (zh) *	1995-03-20	1998-06-10	伊莱利利公司	5－取代－3－(1,2,3,6－四氢吡啶－4－基)－和3－(哌啶－4－基)－1h－吲哚:新型5－ht1f激动剂
TW530054B (en) *	1997-09-24	2003-05-01	Duphar Int Res	New piperazine and piperidine compounds

2000
- 2000-01-06 ES ES00903156T patent/ES2182775T3/es not_active Expired - Lifetime
- 2000-01-06 JP JP2000592287A patent/JP2002534426A/ja active Pending
- 2000-01-06 CA CA002355361A patent/CA2355361A1/en not_active Abandoned
- 2000-01-06 AU AU24944/00A patent/AU2494400A/en not_active Abandoned
- 2000-01-06 CN CN00802511A patent/CN1335844A/zh active Pending
- 2000-01-06 DE DE60000405T patent/DE60000405T2/de not_active Expired - Fee Related
- 2000-01-06 PT PT00903156T patent/PT1140919E/pt unknown
- 2000-01-06 DK DK00903156T patent/DK1140919T3/da active
- 2000-01-06 AT AT00903156T patent/ATE223406T1/de not_active IP Right Cessation
- 2000-01-06 WO PCT/US2000/000348 patent/WO2000040579A1/en not_active Ceased
- 2000-01-06 EP EP00903156A patent/EP1140919B1/de not_active Expired - Lifetime

Also Published As

Publication number	Publication date
CN1335844A (zh)	2002-02-13
ES2182775T3 (es)	2003-03-16
AU2494400A (en)	2000-07-24
DE60000405D1 (de)	2002-10-10
DK1140919T3 (da)	2002-12-30
CA2355361A1 (en)	2000-07-13
EP1140919B1 (de)	2002-09-04
DE60000405T2 (de)	2003-08-07
EP1140919A1 (de)	2001-10-10
WO2000040579A1 (en)	2000-07-13
JP2002534426A (ja)	2002-10-15
PT1140919E (pt)	2002-12-31

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Legal Events

Date	Code	Title	Description
2003-01-15	UEP	Publication of translation of european patent specification
2004-04-15	REN	Ceased due to non-payment of the annual fee