ATE223431T1 - Derivate von dolastatin, dreen herstellung un verwendung - Google Patents

Derivate von dolastatin, dreen herstellung un verwendung

Info

Publication number: ATE223431T1
Authority: AT; Austria
Prior art keywords: dreen; dolastatin; derivatives; preparation; dreen preparation
Prior art date: 1995-06-07

Application number

AT96918660T

Other languages

English (en)

Inventor

Andreas Haupt

Franz Emling

Cynthia A Romerdahl

Original Assignee

Abbott Gmbh & Co Kg

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-06-07

Filing date

1996-06-03

Publication date

2002-09-15

1996-06-03 Application filed by Abbott Gmbh & Co Kg filed Critical Abbott Gmbh & Co Kg

2002-09-15 Application granted granted Critical

2002-09-15 Publication of ATE223431T1 publication Critical patent/ATE223431T1/de

Links

AMRJKAQTDDKMCE-UHFFFAOYSA-N dolastatin Chemical class CC(C)C(N(C)C)C(=O)NC(C(C)C)C(=O)N(C)C(C(C)C)C(OC)CC(=O)N1CCCC1C(OC)C(C)C(=O)NC(C=1SC=CN=1)CC1=CC=CC=C1 AMRJKAQTDDKMCE-UHFFFAOYSA-N 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/08—Peptides having 5 to 11 amino acids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1002—Tetrapeptides with the first amino acid being neutral
- C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
- C07K5/101—Tetrapeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms, e.g. Val, Ile, Leu
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Biochemistry (AREA)
Biophysics (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Bioinformatics & Cheminformatics (AREA)
Epidemiology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Gastroenterology & Hepatology (AREA)
Engineering & Computer Science (AREA)
General Chemical & Material Sciences (AREA)
Immunology (AREA)
Chemical Kinetics & Catalysis (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

AT96918660T 1995-06-07 1996-06-03 Derivate von dolastatin, dreen herstellung un verwendung ATE223431T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US08/472,453 US5831002A (en)	1992-05-20	1995-06-07	Antitumor peptides
PCT/EP1996/002392 WO1996040751A1 (en)	1995-06-07	1996-06-03	Novel dolastatin derivatives, their preparation and use

Publications (1)

Publication Number	Publication Date
ATE223431T1 true ATE223431T1 (de)	2002-09-15

Family

ID=23875567

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
AT96918661T ATE224910T1 (de)	1995-06-07	1996-06-03	Derivate von dolestatin, deren herstellung und verwendung
AT96918660T ATE223431T1 (de)	1995-06-07	1996-06-03	Derivate von dolastatin, dreen herstellung un verwendung

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
AT96918661T ATE224910T1 (de)	1995-06-07	1996-06-03	Derivate von dolestatin, deren herstellung und verwendung

Country Status (33)

Country	Link
US (1)	US5831002A (de)
EP (2)	EP0871656B1 (de)
JP (2)	JP4221062B2 (de)
KR (2)	KR100437985B1 (de)
CN (2)	CN1182154C (de)
AR (2)	AR003136A1 (de)
AT (2)	ATE224910T1 (de)
AU (2)	AU725164B2 (de)
BG (2)	BG102125A (de)
BR (2)	BR9609423A (de)
CA (2)	CA2219819C (de)
CO (2)	CO4700527A1 (de)
CZ (2)	CZ293682B6 (de)
DE (2)	DE69623472T2 (de)
DK (2)	DK0871656T3 (de)
ES (2)	ES2188759T3 (de)
HR (2)	HRP960257A2 (de)
HU (2)	HU228071B1 (de)
IL (2)	IL122215A (de)
MX (2)	MX9709146A (de)
MY (2)	MY119042A (de)
NO (2)	NO318384B1 (de)
NZ (2)	NZ310443A (de)
PL (2)	PL185762B1 (de)
PT (2)	PT832104E (de)
RO (2)	RO118953B1 (de)
SI (2)	SI0871656T1 (de)
SK (1)	SK282466B6 (de)
TR (2)	TR199701545T1 (de)
TW (2)	TW508357B (de)
UA (2)	UA46776C2 (de)
WO (2)	WO1996040751A1 (de)
ZA (2)	ZA964711B (de)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5807984A (en) *	1995-11-09	1998-09-15	Basf Aktienegesellschaft	Oligopeptides, the preparation and use thereof
TW474946B (en) *	1995-12-15	2002-02-01	Basf Ag	Novel compounds, the preparation and use thereof
US20010009901A1 (en) *	1996-12-11	2001-07-26	Basf Aktiengesellschaft Germany	Antineoplastic peptides
US5965537A (en) *	1997-03-10	1999-10-12	Basf Aktiengesellschaft	Dolastatin 15 derivatives with carbonyl and heterocyclic functionalities at the C-terminus
US6103698A (en)	1997-03-13	2000-08-15	Basf Aktiengesellschaft	Dolastatin-15 derivatives in combination with taxanes
US6143721A (en) *	1997-07-18	2000-11-07	Basf Aktiengesellschaft	Dolastatin 15 derivatives
US6015790A (en) *	1997-10-06	2000-01-18	Basf Aktiengesellschaft	Methods and compositions for treating rheumatoid arthritis
US5985837A (en) *	1998-07-08	1999-11-16	Basf Aktiengesellschaft	Dolastatin 15 derivatives
WO2000051998A1 (en)	1999-03-02	2000-09-08	Boehringer Ingelheim Pharmaceuticals, Inc.	Compounds useful as reversible inhibitors of cathepsin s
US6420364B1 (en)	1999-09-13	2002-07-16	Boehringer Ingelheim Pharmaceuticals, Inc.	Compound useful as reversible inhibitors of cysteine proteases
CA2385528C (en)	1999-10-01	2013-12-10	Immunogen, Inc.	Compositions and methods for treating cancer using immunoconjugates and chemotherapeutic agents
WO2002088298A1 (en)	2001-04-27	2002-11-07	The Procter & Gamble Company	Compounds, compositions, and methods for controlling biofilms
AU2002359792A1 (en) *	2001-12-18	2003-06-30	Proteologics, Inc.	Methods and compositions for the inhibition of viral release
AU2003224644A1 (en) *	2002-02-27	2003-09-09	The Government Of The United States Of America, Represented By The Secretary, Department Of Healtan	Conjugates of ligand, linker and cytotoxic agent and related compositions and methods of use
WO2006013552A2 (en)	2004-08-02	2006-02-09	Ramot At Tel Aviv University Ltd.	Articles of peptide nanostructures and method of forming the same
JP4954983B2 (ja)	2005-05-18	2012-06-20	ファーマサイエンス・インコーポレイテッド	Ｂｉｒドメイン結合化合物
CA2619568A1 (en) *	2005-08-19	2007-03-01	Government Of The United States Of America, Represented By The Secretary , Department Of Health And Human Services	Topical formulations of histone deacetylase inhibitors and methods of using the same
EP1973928A2 (de) *	2005-10-11	2008-10-01	Ramot at Tel-Aviv University Ltd.	Selbstzusammengebaute fmoc-ff-hydrogele
SG10201407457UA (en)	2006-05-16	2014-12-30	Pharmascience Inc	Iap bir domain binding compounds
JP5452223B2 (ja) *	2006-07-24	2014-03-26	テトラロジックファーマシューティカルズコーポレーション	Ｉａｐ阻害剤
CA2683098C (en) *	2007-04-12	2014-03-18	Scinopharm Taiwan Ltd.	Process for making galantamine
UY32099A (es)	2008-09-11	2010-04-30	Enanta Pharm Inc	Inhibidores macrocíclicos de serina proteasas de hepatitis c
US8283372B2 (en)	2009-07-02	2012-10-09	Tetralogic Pharmaceuticals Corp.	2-(1H-indol-3-ylmethyl)-pyrrolidine dimer as a SMAC mimetic
MX340870B (es)	2010-02-12	2016-07-27	Pharmascience Inc	Compuestos de unión del dominio de repetición de inhibidores de proteínas de apoptosis de baculovirus.
WO2012092411A2 (en)	2010-12-30	2012-07-05	Enanta Pharmaceuticals, Inc.	Phenanthridine macrocyclic hepatitis c serine protease inhibitors
CN103534256B (zh)	2010-12-30	2016-08-10	益安药业	大环丙型肝炎丝氨酸蛋白酶抑制剂
US10201584B1 (en)	2011-05-17	2019-02-12	Abbvie Inc.	Compositions and methods for treating HCV
CN103717595A (zh)	2011-05-27	2014-04-09	Ambrx公司	含有非天然氨基酸连接的海兔毒素衍生物的组合物、涉及该海兔毒素衍生物的方法及其用途
WO2015103490A1 (en)	2014-01-03	2015-07-09	Abbvie, Inc.	Solid antiviral dosage forms
EP4400121A1 (de)	2021-09-03	2024-07-17	Toray Industries, Inc.	Pharmazeutische zusammensetzung zur behandlung und/oder prävention von krebs

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4816444A (en) *	1987-07-10	1989-03-28	Arizona Board Of Regents, Arizona State University	Cell growth inhibitory substance
US4879278A (en) *	1989-05-16	1989-11-07	Arizona Board Of Regents	Isolation and structural elucidation of the cytostatic linear depsipeptide dolastatin 15
SG87056A1 (en) *	1991-08-09	2002-03-19	Teikoku Hormone Mfg Co Ltd	Novel tetrapeptide derivative
DE69320339T2 (de) *	1992-05-20	1998-12-17	Basf Ag, 67063 Ludwigshafen	Derivate des Dolastatin
US5504191A (en) *	1994-08-01	1996-04-02	Arizona Board Of Regents Acting On Behalf Of Arizona State University	Human cancer inhibitory pentapeptide methyl esters
US5530097A (en) *	1994-08-01	1996-06-25	Arizona Board Of Regents Acting On Behalf Of Arizona State University	Human cancer inhibitory peptide amides

1995
- 1995-06-07 US US08/472,453 patent/US5831002A/en not_active Expired - Lifetime
1996
- 1996-06-03 TR TR97/01545T patent/TR199701545T1/xx unknown
- 1996-06-03 WO PCT/EP1996/002392 patent/WO1996040751A1/en not_active Ceased
- 1996-06-03 PL PL96323723A patent/PL185762B1/pl unknown
- 1996-06-03 DE DE69623472T patent/DE69623472T2/de not_active Expired - Lifetime
- 1996-06-03 SI SI9630550T patent/SI0871656T1/xx unknown
- 1996-06-03 MX MX9709146A patent/MX9709146A/es unknown
- 1996-06-03 SI SI9630539T patent/SI0832104T1/xx unknown
- 1996-06-03 ES ES96918661T patent/ES2188759T3/es not_active Expired - Lifetime
- 1996-06-03 HU HU9801910A patent/HU228071B1/hu not_active IP Right Cessation
- 1996-06-03 PT PT96918660T patent/PT832104E/pt unknown
- 1996-06-03 CN CNB961944676A patent/CN1182154C/zh not_active Expired - Fee Related
- 1996-06-03 CA CA002219819A patent/CA2219819C/en not_active Expired - Fee Related
- 1996-06-03 EP EP96918661A patent/EP0871656B1/de not_active Expired - Lifetime
- 1996-06-03 EP EP96918660A patent/EP0832104B1/de not_active Expired - Lifetime
- 1996-06-03 TR TR97/01544T patent/TR199701544T1/xx unknown
- 1996-06-03 NZ NZ310443A patent/NZ310443A/en not_active IP Right Cessation
- 1996-06-03 KR KR1019970709063A patent/KR100437985B1/ko not_active Expired - Fee Related
- 1996-06-03 SK SK1653-97A patent/SK282466B6/sk not_active IP Right Cessation
- 1996-06-03 MX MX9709147A patent/MX9709147A/es unknown
- 1996-06-03 KR KR1019970709064A patent/KR100437986B1/ko not_active Expired - Fee Related
- 1996-06-03 RO RO97-02264A patent/RO118953B1/ro unknown
- 1996-06-03 CZ CZ19973763A patent/CZ293682B6/cs not_active IP Right Cessation
- 1996-06-03 AU AU61241/96A patent/AU725164B2/en not_active Ceased
- 1996-06-03 CA CA002219818A patent/CA2219818C/en not_active Expired - Fee Related
- 1996-06-03 RO RO97-02254A patent/RO119783B1/ro unknown
- 1996-06-03 MY MYPI96002155A patent/MY119042A/en unknown
- 1996-06-03 AT AT96918661T patent/ATE224910T1/de active
- 1996-06-03 AT AT96918660T patent/ATE223431T1/de active
- 1996-06-03 DE DE69623992T patent/DE69623992T2/de not_active Expired - Lifetime
- 1996-06-03 UA UA98010070A patent/UA46776C2/uk unknown
- 1996-06-03 JP JP50013297A patent/JP4221062B2/ja not_active Expired - Fee Related
- 1996-06-03 AU AU61242/96A patent/AU725170B2/en not_active Ceased
- 1996-06-03 WO PCT/EP1996/002393 patent/WO1996040752A1/en not_active Ceased
- 1996-06-03 PL PL96323726A patent/PL185763B1/pl unknown
- 1996-06-03 CZ CZ19973765A patent/CZ293683B6/cs not_active IP Right Cessation
- 1996-06-03 DK DK96918661T patent/DK0871656T3/da active
- 1996-06-03 BR BR9609423A patent/BR9609423A/pt not_active Application Discontinuation
- 1996-06-03 PT PT96918661T patent/PT871656E/pt unknown
- 1996-06-03 DK DK96918660T patent/DK0832104T3/da active
- 1996-06-03 JP JP50013197A patent/JP3957751B2/ja not_active Expired - Fee Related
- 1996-06-03 IL IL12221596A patent/IL122215A/xx not_active IP Right Cessation
- 1996-06-03 HU HU9801817A patent/HU228073B1/hu not_active IP Right Cessation
- 1996-06-03 CN CNB961944684A patent/CN1182153C/zh not_active Expired - Fee Related
- 1996-06-03 BR BR9609424-9A patent/BR9609424A/pt not_active Application Discontinuation
- 1996-06-03 ES ES96918660T patent/ES2186783T3/es not_active Expired - Lifetime
- 1996-06-03 NZ NZ310444A patent/NZ310444A/xx not_active IP Right Cessation
- 1996-06-03 IL IL12221696A patent/IL122216A/en not_active IP Right Cessation
- 1996-06-03 UA UA98010069A patent/UA46775C2/uk unknown
- 1996-06-04 MY MYPI96002170A patent/MY124487A/en unknown
- 1996-06-06 HR HR08/472,453A patent/HRP960257A2/hr not_active Application Discontinuation
- 1996-06-06 ZA ZA9604711A patent/ZA964711B/xx unknown
- 1996-06-06 ZA ZA9604710A patent/ZA964710B/xx unknown
- 1996-06-06 HR HR08/472,453A patent/HRP960277A2/hr not_active Application Discontinuation
- 1996-06-06 AR ARP960102980A patent/AR003136A1/es active IP Right Grant
- 1996-06-06 AR ARP960102981A patent/AR003427A1/es active IP Right Grant
- 1996-06-07 CO CO96029751A patent/CO4700527A1/es unknown
- 1996-06-07 TW TW085106866A patent/TW508357B/zh not_active IP Right Cessation
- 1996-06-07 CO CO96029749A patent/CO4700526A1/es unknown
- 1996-10-02 TW TW085106867A patent/TW424096B/zh not_active IP Right Cessation
1997
- 1997-12-05 NO NO19975710A patent/NO318384B1/no not_active IP Right Cessation
- 1997-12-05 NO NO19975711A patent/NO317670B1/no not_active IP Right Cessation
- 1997-12-18 BG BG102125A patent/BG102125A/xx unknown
- 1997-12-29 BG BG102152A patent/BG102152A/xx unknown

Also Published As

Publication number	Publication date
SK282466B6 (sk)	2002-02-05
HUP9801817A2 (hu)	1998-11-30
BG102152A (en)	1998-09-30
HU228073B1 (hu)	2012-09-28
IL122216A0 (en)	1998-04-05
CA2219819A1 (en)	1996-12-19
KR100437985B1 (ko)	2004-09-18
BR9609424A (pt)	2000-03-28
BR9609423A (pt)	1999-06-29
HUP9801910A2 (hu)	1999-01-28
CN1187198A (zh)	1998-07-08
DE69623472T2 (de)	2003-08-21
SI0871656T1 (en)	2003-08-31
MX9709147A (es)	1998-03-31
HUP9801910A3 (en)	1999-06-28
IL122216A (en)	2002-02-10
SI0832104T1 (en)	2003-08-31
DE69623992T2 (de)	2003-05-22
HRP960257A2 (en)	1998-02-28
HUP9801817A3 (en)	1999-06-28
JPH11504653A (ja)	1999-04-27
MX9709146A (es)	1998-03-31
ATE224910T1 (de)	2002-10-15
CA2219818A1 (en)	1996-12-19
IL122215A (en)	2001-08-26
RO119783B1 (ro)	2005-03-30
KR100437986B1 (ko)	2004-09-18
JP3957751B2 (ja)	2007-08-15
JP4221062B2 (ja)	2009-02-12
AU6124296A (en)	1996-12-30
TR199701544T1 (xx)	1998-03-21
CZ376397A3 (cs)	1998-06-17
PL323726A1 (en)	1998-04-14
CZ293683B6 (cs)	2004-07-14
PL185763B1 (pl)	2003-07-31
CA2219818C (en)	2008-05-20
DE69623472D1 (de)	2002-10-10
NO975710L (no)	1998-02-02
CN1182154C (zh)	2004-12-29
UA46775C2 (uk)	2002-06-17
PL185762B1 (pl)	2003-07-31
SK165397A3 (en)	1998-10-07
UA46776C2 (uk)	2002-06-17
MY119042A (en)	2005-03-31
WO1996040751A1 (en)	1996-12-19
WO1996040752A1 (en)	1996-12-19
NO318384B1 (no)	2005-03-14
HU228071B1 (hu)	2012-09-28
EP0871656B1 (de)	2002-09-25
CA2219819C (en)	2008-05-20
EP0871656A1 (de)	1998-10-21
TR199701545T1 (xx)	1998-04-21
CZ293682B6 (cs)	2004-07-14
DK0832104T3 (da)	2003-01-06
ZA964711B (en)	1997-12-08
AR003427A1 (es)	1998-08-05
CO4700527A1 (es)	1998-12-29
AU6124196A (en)	1996-12-30
ES2188759T3 (es)	2003-07-01
AU725164B2 (en)	2000-10-05
CN1187199A (zh)	1998-07-08
NZ310444A (en)	1999-11-29
AU725170B2 (en)	2000-10-05
NO317670B1 (no)	2004-11-29
TW508357B (en)	2002-11-01
US5831002A (en)	1998-11-03
ES2186783T3 (es)	2003-05-16
AR003136A1 (es)	1998-07-08
KR19990022582A (ko)	1999-03-25
DE69623992D1 (de)	2002-10-31
NO975710D0 (no)	1997-12-05
PL323723A1 (en)	1998-04-14
KR19990022583A (ko)	1999-03-25
TW424096B (en)	2001-03-01
JPH11504652A (ja)	1999-04-27
HRP960277A2 (en)	1997-10-31
IL122215A0 (en)	1998-04-05
BG102125A (en)	1998-09-30
CZ376597A3 (cs)	1998-06-17
PT871656E (pt)	2002-12-31
RO118953B1 (ro)	2004-01-30
CN1182153C (zh)	2004-12-29
NZ310443A (en)	1999-10-28
PT832104E (pt)	2002-12-31
MY124487A (en)	2006-06-30
NO975711D0 (no)	1997-12-05
EP0832104A1 (de)	1998-04-01
DK0871656T3 (da)	2003-01-27
EP0832104B1 (de)	2002-09-04
CO4700526A1 (es)	1998-12-29
ZA964710B (en)	1997-12-08
NO975711L (no)	1998-01-30

Legal Events

Date

Code

Title

Description

2003-02-15

UEP

Publication of translation of european patent specification

Ref document number: 0832104

Country of ref document: EP

Publication	Publication Date	Title
DE69623472D1 (de)	2002-10-10	Derivate von dolastatin, dreen herstellung un verwendung
ATE258549T1 (de)	2004-02-15	Oxazolidindion-derivate, ihre herstellung und verwendung
DE69622148D1 (de)	2002-08-08	Chinazozin derivate und deren verwendung
DE69719603D1 (de)	2003-04-17	Kosmetisches Haarwaschmittel und dessen Verwendung
DE69600048D1 (de)	1997-09-11	Kosmetisches Haarwaschmittel und dessen Verwendung
DE69505657D1 (de)	1998-12-03	Fluorcarbonetherhybriden enthaltende physiologich akzeptabele emulsionen und verwendungsverfahren
DE69715482D1 (de)	2002-10-24	Herstellung von 1,1,1,3,3-Pentachlorbutan und von 1,1,1,3,3-Pentafluorbutan
ATE238342T1 (de)	2003-05-15	Neue thrombin-inhibitoren, deren herstellung und verwendung
DE59710701D1 (de)	2003-10-09	Kosmetische zubereitungen
ATE259357T1 (de)	2004-02-15	Derivate von acyl-piperazinil-pyrimidinen, ihre herstellung und verwendung als medikament
ATE186447T1 (de)	1999-11-15	Zusammensetzung und verwendung
DE69625857D1 (de)	2003-02-27	Siliconderivate, ihre Herstellung und Verwendung
DE59709718D1 (de)	2003-05-08	Kosmetische zubereitungen
DE69628195D1 (de)	2003-06-18	Verwendung von xyloglucanendotransglycosylase
DE69522630D1 (de)	2001-10-18	Herstellung von geschmiedeten Bauteilen
DE59912915D1 (de)	2006-01-19	Herstellung von 4,4'-Diketo-carotinoiden
ATE184005T1 (de)	1999-09-15	Oxazolidinone derivate, ihre herstellung und ihre therapeutische verwendung
FI952297L (fi)	1995-11-13	Fluoridia vapauttava hammaspohjustekoostumus ja menetelmä sen käyttämiseksi
KR960030598U (ko)	1996-10-22	이,미용원용가습장치
ATE198192T1 (de)	2001-01-15	Benzolsulfonamidderivate, ihre herstellung und ihre therapeutische verwendung
DE59501950D1 (de)	1998-05-28	Isolongifolanol-Derivate, ihre Herstellung und ihre Verwendung
DE19781649T1 (de)	1999-04-29	Herstellung von länglichen Elementen
DE69733607D1 (de)	2005-07-28	Herstellung von cycloalkyldiarylphosphinen
DE69834057D1 (de)	2006-05-18	Echinocandinderivate, deren herstellung und deren verwendung zur bekämpfung von pilzen
DE69710305D1 (de)	2002-03-21	Derivate von 4-Vinyl-4'-alpha-hydroxyethyl-biphenyl