ATE223436T1 - Synthetische pulmonäre oberflächenaktive peptide - Google Patents

Synthetische pulmonäre oberflächenaktive peptide

Info

Publication number
ATE223436T1
ATE223436T1 AT92912964T AT92912964T ATE223436T1 AT E223436 T1 ATE223436 T1 AT E223436T1 AT 92912964 T AT92912964 T AT 92912964T AT 92912964 T AT92912964 T AT 92912964T AT E223436 T1 ATE223436 T1 AT E223436T1
Authority
AT
Austria
Prior art keywords
amino acid
synthetic pulmonary
active peptides
acid residues
acid residue
Prior art date
Application number
AT92912964T
Other languages
English (en)
Inventor
Charles G Cochrane
Susan D Revak
Original Assignee
Scripps Research Inst
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Scripps Research Inst filed Critical Scripps Research Inst
Application granted granted Critical
Publication of ATE223436T1 publication Critical patent/ATE223436T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/785—Alveolar surfactant peptides; Pulmonary surfactant peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pulmonology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Toxicology (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
AT92912964T 1991-06-14 1992-06-01 Synthetische pulmonäre oberflächenaktive peptide ATE223436T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/715,397 US5260273A (en) 1988-01-06 1991-06-14 Pulmonary surfactant protein and related polypeptide
PCT/US1992/004537 WO1992022315A1 (en) 1991-06-14 1992-06-01 Synthetic pulmonary surfactant peptides

Publications (1)

Publication Number Publication Date
ATE223436T1 true ATE223436T1 (de) 2002-09-15

Family

ID=24873864

Family Applications (1)

Application Number Title Priority Date Filing Date
AT92912964T ATE223436T1 (de) 1991-06-14 1992-06-01 Synthetische pulmonäre oberflächenaktive peptide

Country Status (11)

Country Link
US (3) US5260273A (de)
EP (1) EP0590006B1 (de)
JP (1) JP3459248B2 (de)
AT (1) ATE223436T1 (de)
AU (1) AU666857B2 (de)
CA (1) CA2111342A1 (de)
DE (1) DE69232760T2 (de)
DK (1) DK0590006T3 (de)
ES (1) ES2182821T3 (de)
IE (2) IE921897A1 (de)
WO (1) WO1992022315A1 (de)

Families Citing this family (63)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6613734B2 (en) * 1988-01-06 2003-09-02 The Scripps Research Institute Peptides-containing liposomal surfactants
US5260273A (en) * 1988-01-06 1993-11-09 The Scripps Research Institute Pulmonary surfactant protein and related polypeptide
US6013619A (en) * 1988-01-06 2000-01-11 The Scripps Research Institute Pulmonary surfactants and therapeutic uses, including pulmonary lavage
CA2118939A1 (en) * 1991-09-13 1993-04-01 W. Lee Maloy Biologically active amphiphilic peptide compositions and uses thereof
DK0733645T3 (da) * 1993-12-08 2003-07-14 Mitsubishi Pharma Corp Syntetisk peptid, lungeoverfladeaktivt stof indeholdende dette og præparat mod respiratory distress syndrome
DE4418936A1 (de) * 1994-05-31 1996-02-08 Byk Gulden Lomberg Chem Fab Polypeptid
US5750370A (en) * 1995-06-06 1998-05-12 Human Genome Sciences, Inc. Nucleic acid encoding human endothlein-bombesin receptor and method of producing the receptor
DE69620801T2 (de) * 1995-11-20 2002-10-10 Ortho Mcneil Pharm Inc Verfahren zur solubisierung des pulmonnären oberflächeraktiven peptides
PT877602E (pt) 1996-01-24 2002-07-31 Byk Gulden Lomberg Chem Fab Processo para o fabrico de composicoes de surfactantes pulmonares em po
WO1997029738A1 (en) * 1996-02-16 1997-08-21 The Administrators Of The Tulane Educational Fund Methods and compositions for treating eustachian tube dysfunction by inhalation
US6120795A (en) * 1996-03-27 2000-09-19 Ortho Pharmaceutical Corp. Manufacture of liposomes and lipid-protein complexes by ethanolic injection and thin film evaporation
AU2322097A (en) * 1996-03-27 1997-10-17 Ortho Pharmaceutical Corporation Lyophilized pulmonary surfactant peptide compositions
US6013764A (en) 1996-07-17 2000-01-11 Ortho Pharmaceutical Corp. Liquid phase peptide synthesis of KL-4 pulmonary surfactant
GB9916316D0 (en) * 1999-07-12 1999-09-15 Quadrant Holdings Cambridge Dry powder compositions
US6676930B2 (en) 1999-11-28 2004-01-13 Scientific Development And Research, Inc. Composition and method for treatment of otitis media
US6156294A (en) 1999-11-28 2000-12-05 Scientific Development And Research, Inc. Composition and method for treatment of otitis media
AU2002338882B2 (en) 2001-10-11 2008-04-03 Fraunhofer-Gesellschaft Zur Foerderung Der Angewandten Forschung E.V. Novel use of pulmonary surfactant
AU2002357168A1 (en) 2001-12-12 2003-07-09 Penn State Research Foundation Surfactant prevention of lung complications from cancer chemotherapy
AU2003223718B2 (en) * 2002-04-25 2007-08-16 The Scripps Research Institute Treatment and prevention of pulmonary conditions
EP1481665A1 (de) * 2003-05-30 2004-12-01 CHIESI FARMACEUTICI S.p.A. Neue Lipidmischungen für synthetische Tenside
EP1694314A4 (de) * 2003-12-04 2009-07-01 Scripps Research Inst Behandlung und prävention von asthma
WO2005115520A1 (en) * 2004-05-20 2005-12-08 Discovery Laboratories, Inc. Methods , systems and devices for noninvasive pulmonary delivery
CA2575513C (en) 2004-08-06 2014-09-16 Altana Pharma Ag Composition comprising a pulmonary surfactant and a tnf-derived peptide
US7464012B2 (en) * 2004-12-10 2008-12-09 L'air Liquide, Societe Anonyme A Directoire Et Conseil De Surveillance Pour L'etude Et L'exploitation Des Procedes Georges Claude Simplified process simulator
US7582312B2 (en) * 2004-11-15 2009-09-01 Discovery Laboratories, Inc. Methods to produce lung surfactant formulations via lyophilization and formulations and uses thereof
US8337815B2 (en) * 2004-12-23 2012-12-25 Discovery Laboratories, Inc. Pulmonary surfactant formulations
SI1841458T1 (sl) 2005-01-06 2012-04-30 Discovery Lab Inc Zdravljenje s predpisanim odmerjanjem surfaktanta za zdravljenje ali preprečevanje bronhopulmonalne displazije
US8028697B2 (en) 2005-04-28 2011-10-04 Trudell Medical International Ventilator circuit and method for the use thereof
US7741450B2 (en) 2006-02-08 2010-06-22 Morphotek Inc. Antibodies to GM-CSF
EP2063903A1 (de) * 2006-09-19 2009-06-03 Discovery Laboratories, Inc. Lungentensidformulierungen und verfahren zur förderung von schleimbeseitigung
US7951781B2 (en) 2006-11-02 2011-05-31 University Of Iowa Research Foundation Methods and compositions related to PLUNC surfactant polypeptides
EP1997502A1 (de) 2007-06-01 2008-12-03 CHIESI FARMACEUTICI S.p.A. Rekonstituierte Tenside mit verbesserten Eigenschaften
AU2008259768B2 (en) * 2007-06-05 2013-08-29 Paka Pulmonary Pharmaceuticals, Inc. Compositions for delivering medicaments into the lungs, uses thereof
US8048043B2 (en) 2007-06-08 2011-11-01 Chiesi Farmaceutici S. P. A. Method of administration of a pulmonary surfactant
ES2565219T3 (es) 2008-03-17 2016-04-01 Discovery Laboratories, Inc. Adaptador de circuito de ventilación y sistema proximal de administración de aerosol
EP2626098B1 (de) 2008-10-22 2020-08-19 Trudell Medical International Modulares Aerosolabgabesystem
WO2010068754A2 (en) 2008-12-10 2010-06-17 Paka Pulmonary Pharmaceuticals, Inc. Methods and compositions for delivery of medicaments to the lungs
CA2773490A1 (en) 2009-09-08 2011-03-17 Chiesi Farmaceutici S.P.A. A therapeutic combination comprising a pulmonary surfactant and antioxidant enzymes
WO2011035140A1 (en) 2009-09-18 2011-03-24 Paka Pulmonary Pharmaceuticals, Inc. Methods and compositions for delivery of contrast moieties to the lungs
GB201115910D0 (en) 2011-09-14 2011-10-26 Univ Manchester Peptides
WO2013067164A1 (en) 2011-11-04 2013-05-10 Discovery Laboratories, Inc. Ventilation circuit adaptor and proximal aerosol delivery system
MX359654B (es) 2012-03-28 2018-10-05 Discovery Lab Inc Liofilizacion de agente tensioactivo pulmonar liposomico sintetico.
WO2013188016A2 (en) 2012-05-04 2013-12-19 Discovery Laboratories, Inc. Surfactant therapy for exposure to ionizing radiation
WO2015061412A1 (en) * 2013-10-22 2015-04-30 The Scripps Research Institute Methods and compositions for promoting bronchioli dilatation
EP3106090A1 (de) 2015-06-15 2016-12-21 CHIESI FARMACEUTICI S.p.A. System zur effektiven und atemsynchronisierten abgabe eines medikaments in die lungen
EP3285645B1 (de) 2015-04-22 2020-08-12 Chiesi Farmaceutici S.p.A. System zur effektiven und atemsynchronisierten abgabe eines medikaments in die lungen
US11311691B2 (en) 2015-04-28 2022-04-26 Chiesi Farmaceutici S.P.A Device for facilitating the administration of a medicament to the lung by a catheter
CN107979996A (zh) 2015-04-30 2018-05-01 不莱梅大学 新的皮肤医疗和美容护理产品
CN104817631B (zh) * 2015-05-26 2018-04-13 成都圣诺生物科技股份有限公司 一种合成西那普肽的方法
US11207475B2 (en) 2016-07-28 2021-12-28 Chiesi Farmaceutici S.P.A Method and system for delivery of an aerosolized medicament
KR102395835B1 (ko) 2016-08-24 2022-05-10 키에시 파르마슈티시 엣스. 피. 에이. 재구성된 폐 계면활성제 조성물을 포함하는 안정한 약제학적 제제
AU2017349790A1 (en) 2016-10-26 2019-05-02 Chiesi Farmaceutici S.P.A. Device for facilitating the administration of a medicament to the lung by a catheter
CA3043792A1 (en) 2016-12-22 2018-06-28 Chiesi Farmaceutici S.P.A. A therapeutic combination comprising a pulmonary surfactant and a steroid for the treatment of evolving bpd
WO2019115771A1 (en) 2017-12-15 2019-06-20 Pari Pharma Gmbh Nebuliser system, holding system, combination comprising nebuliser system and holding system, and aerosol administration method
TW201927286A (zh) 2017-12-15 2019-07-16 義大利商凱西製藥公司 用於噴霧投藥之包含肺表面張力素的藥學調配物
KR102781186B1 (ko) 2018-04-23 2025-03-17 키에시 파르마슈티시 엣스. 피. 에이. Bpd의 예방을 위한 폐 계면활성제 및 스테로이드를 포함하는 치료학적 조합물
EP3666315A1 (de) 2018-12-14 2020-06-17 PARI Pharma GmbH Aerosolabgabevorrichtung und verfahren zum betrieb der aerosolabgabevorrichtung
EP3666316A1 (de) 2018-12-14 2020-06-17 PARI Pharma GmbH Aerosolabgabevorrichtung und verfahren zum betrieb der aerosolabgabevorrichtung
EP3843105A1 (de) 2019-12-23 2021-06-30 PARI Pharma GmbH Steuerungsvorrichtung für aerosolzerstäubersystem
US12606609B2 (en) 2020-01-28 2026-04-21 Chiesi Farmaceutici S.P.A. Polypeptides having improved properties
EP4411745A1 (de) 2023-02-01 2024-08-07 Pari Medical Holding GmbH Medizinisches beurteilungsverfahren, aerosolzerstäuber und medizinisches beurteilungssystem
EP4464236A1 (de) 2023-05-15 2024-11-20 Pari Medical Holding GmbH Verfahren zum betreiben einer inhalationsvorrichtung, inhalationsvorrichtung und inhalationsvorrichtungssystem zur bereitstellung von inhalationsverfahrensrückmeldung
EP4464354A1 (de) 2023-05-15 2024-11-20 Pari Medical Holding GmbH Verfahren zum betreiben einer inhalationsvorrichtung, inhalationsvorrichtung und inhalationsvorrichtungssystem zur bereitstellung eines inhalationsverfahrens/ einer atemführung

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4643988A (en) * 1984-05-15 1987-02-17 Research Corporation Amphipathic peptides
US4562003A (en) * 1984-10-26 1985-12-31 California Biotechnology, Inc. Monoclonal antibodies against alveolar surfactant protein
US4659805A (en) * 1984-12-11 1987-04-21 California Biotechnology, Inc. Recombinant alveolar surfactant protein
US4933280A (en) * 1984-12-11 1990-06-12 California Biotechnology Inc. Recombinant DNA sequence encoding Alveolar Surfactant Protein
WO1988003170A1 (en) * 1986-10-24 1988-05-05 Whitsett Jeffrey A Pulmonary hydrophobic surfactant-associated proteins
US5164369A (en) * 1988-01-06 1992-11-17 The Scripps Research Institute Pulmonary surfactant protein and related polypeptide
US5260273A (en) * 1988-01-06 1993-11-09 The Scripps Research Institute Pulmonary surfactant protein and related polypeptide
US4861756A (en) * 1988-03-08 1989-08-29 Merrell Dow Pharmaceuticals Inc. Synthetic pulmonary surfactant
AR245141A1 (es) * 1988-07-01 1993-12-30 Merrell Dow Pharma Procedimiento de sintesis secuencial o de bloques en fase solida para preparar polipeptidos de estructura helicoidal.

Also Published As

Publication number Publication date
CA2111342A1 (en) 1992-12-23
AU666857B2 (en) 1996-02-29
US5789381A (en) 1998-08-04
US5260273A (en) 1993-11-09
AU2177792A (en) 1993-01-12
JP3459248B2 (ja) 2003-10-20
ES2182821T3 (es) 2003-03-16
WO1992022315A1 (en) 1992-12-23
EP0590006B1 (de) 2002-09-04
DK0590006T3 (da) 2003-01-06
DE69232760D1 (de) 2002-10-10
DE69232760T2 (de) 2003-02-06
IE921897A1 (en) 1992-12-16
EP0590006A4 (en) 1994-07-13
JPH06508619A (ja) 1994-09-29
EP0590006A1 (de) 1994-04-06
IE20040101A1 (en) 2004-04-07
US5407914A (en) 1995-04-18

Similar Documents

Publication Publication Date Title
ATE223436T1 (de) Synthetische pulmonäre oberflächenaktive peptide
EP0350506A4 (en) Pulmonary surfactant protein and related polypeptide
ATE368053T1 (de) Antimikrobielle peptide
CA2025598A1 (en) Chimaeric hepadnavirus core antigen proteins
EA200100447A1 (ru) Гибридные белки на основе бета-интерферона и их применение
IL113617A0 (en) Soluble polypeptide fraction
EP0334244A3 (de) Peptide-Antagonisten von Bradykinin
WO1996028470A3 (en) Peptide analogues of human myelin basic protein useful in treating multiple sclerosis
RU94046091A (ru) Полипептидные антагонисты бомбезина, фармацевтическая композиция и способ лечения
WO1993019178A3 (en) Peptides useful for inducing tolerance
GB9606040D0 (en) Active peptide
CA2020663A1 (en) Substitution analogues of magainin peptides
DE3261304D1 (en) Retro-inverso analogues of c-terminal penta and hexapeptides of substance p.
EP1006126A3 (de) Peptide mit osteogener Aktivität
DE69313647D1 (de) Synthetische peptide als lungensurfactants mit kovalent gebundenen antioxidantien
MY103251A (en) Biologically active molecules
MX9304540A (es) Tensioactivos pulmonares peptidicos y combinaciones terapeuticas.
JPS6468308A (en) Trichogenous and hair-tonic agent
EP0490383A3 (en) Peptides of the hiv-gag protein, their preparation and use
DE69408299D1 (de) Phospholipase c inhibitierendes peptid
RU95116353A (ru) Способ получения нонапептидэтиламида
CA2088478A1 (en) Cloning and expression of a rhoptry associated protein of p. falciparum
SE8703855L (sv) Vasoaktiva peptider
ITMI931627A0 (it) Analoghi di un polipeptide anti-trombinico e procedimento per la loro preparazione
WO1994004565A3 (en) Ipnv vaccine

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification