ATE223902T1 - Chinolinderivate als gnrh antagonisten - Google Patents

Chinolinderivate als gnrh antagonisten

Info

Publication number: ATE223902T1
Authority: AT; Austria
Prior art keywords: agent; cancer; controlling agent; animals; agents
Prior art date: 1995-10-19

Application number

AT96935360T

Other languages

English (en)

Inventor

Shuichi Furuya

Nobuo Choh

Satoshi Sasaki

Original Assignee

Takeda Chemical Industries Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-10-19

Filing date

1996-10-18

Publication date

2002-09-15

1996-10-18 Application filed by Takeda Chemical Industries Ltd filed Critical Takeda Chemical Industries Ltd

2002-09-15 Application granted granted Critical

2002-09-15 Publication of ATE223902T1 publication Critical patent/ATE223902T1/de

Links

229940027991 antiseptic and disinfectant quinoline derivative Drugs 0.000 title abstract 2
SMWDFEZZVXVKRB-UHFFFAOYSA-N Quinoline Chemical class N1=CC=CC2=CC=CC=C21 SMWDFEZZVXVKRB-UHFFFAOYSA-N 0.000 title 1
229940121381 gonadotrophin releasing hormone (gnrh) antagonists Drugs 0.000 title 1
239000003795 chemical substances by application Substances 0.000 abstract 7
241001465754 Metazoa Species 0.000 abstract 3
230000001419 dependent effect Effects 0.000 abstract 2
230000027758 ovulation cycle Effects 0.000 abstract 2
230000001737 promoting effect Effects 0.000 abstract 2
208000002874 Acne Vulgaris Diseases 0.000 abstract 1
241000251468 Actinopterygii Species 0.000 abstract 1
201000000736 Amenorrhea Diseases 0.000 abstract 1
206010001928 Amenorrhoea Diseases 0.000 abstract 1
206010061692 Benign muscle neoplasm Diseases 0.000 abstract 1
206010004446 Benign prostatic hyperplasia Diseases 0.000 abstract 1
206010006187 Breast cancer Diseases 0.000 abstract 1
208000026310 Breast neoplasm Diseases 0.000 abstract 1
206010008342 Cervix carcinoma Diseases 0.000 abstract 1
201000009273 Endometriosis Diseases 0.000 abstract 1
239000000579 Gonadotropin-Releasing Hormone Substances 0.000 abstract 1
201000004458 Myoma Diseases 0.000 abstract 1
206010028980 Neoplasm Diseases 0.000 abstract 1
208000007913 Pituitary Neoplasms Diseases 0.000 abstract 1
201000005746 Pituitary adenoma Diseases 0.000 abstract 1
206010061538 Pituitary tumour benign Diseases 0.000 abstract 1
206010036618 Premenstrual syndrome Diseases 0.000 abstract 1
206010060862 Prostate cancer Diseases 0.000 abstract 1
208000004403 Prostatic Hyperplasia Diseases 0.000 abstract 1
208000000236 Prostatic Neoplasms Diseases 0.000 abstract 1
101000857870 Squalus acanthias Gonadoliberin Proteins 0.000 abstract 1
208000006105 Uterine Cervical Neoplasms Diseases 0.000 abstract 1
208000002495 Uterine Neoplasms Diseases 0.000 abstract 1
206010000496 acne Diseases 0.000 abstract 1
231100000540 amenorrhea Toxicity 0.000 abstract 1
230000003042 antagnostic effect Effects 0.000 abstract 1
201000011510 cancer Diseases 0.000 abstract 1
201000010881 cervical cancer Diseases 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
201000010099 disease Diseases 0.000 abstract 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
239000003814 drug Substances 0.000 abstract 1
229940124566 female contraceptive agent Drugs 0.000 abstract 1
230000035558 fertility Effects 0.000 abstract 1
239000003163 gonadal steroid hormone Substances 0.000 abstract 1
XLXSAKCOAKORKW-AQJXLSMYSA-N gonadorelin Chemical compound C([C@@H](C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1[C@@H](CCC1)C(=O)NCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H]1NC(=O)CC1)C1=CC=C(O)C=C1 XLXSAKCOAKORKW-AQJXLSMYSA-N 0.000 abstract 1
229940035638 gonadotropin-releasing hormone Drugs 0.000 abstract 1
239000005556 hormone Substances 0.000 abstract 1
229940088597 hormone Drugs 0.000 abstract 1
230000001939 inductive effect Effects 0.000 abstract 1
230000036512 infertility Effects 0.000 abstract 1
208000000509 infertility Diseases 0.000 abstract 1
231100000535 infertility Toxicity 0.000 abstract 1
239000000543 intermediate Substances 0.000 abstract 1
235000013372 meat Nutrition 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1
230000016087 ovulation Effects 0.000 abstract 1
208000021310 pituitary gland adenoma Diseases 0.000 abstract 1
201000010065 polycystic ovary syndrome Diseases 0.000 abstract 1
208000006155 precocious puberty Diseases 0.000 abstract 1
230000035935 pregnancy Effects 0.000 abstract 1
230000002265 prevention Effects 0.000 abstract 1
125000002943 quinolinyl group Chemical class N1=C(C=CC2=CC=CC=C12)* 0.000 abstract 1
230000001739 rebound effect Effects 0.000 abstract 1
229940124597 therapeutic agent Drugs 0.000 abstract 1
206010046766 uterine cancer Diseases 0.000 abstract 1
210000004291 uterus Anatomy 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
- C07D215/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Steroid Compounds (AREA)
Plural Heterocyclic Compounds (AREA)

AT96935360T 1995-10-19 1996-10-18 Chinolinderivate als gnrh antagonisten ATE223902T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
JP27164095		1995-10-19
PCT/JP1996/003019 WO1997014682A1 (en)	1995-10-19	1996-10-18	Quinoline derivatives as gnrh antagonists

Publications (1)

Publication Number	Publication Date
ATE223902T1 true ATE223902T1 (de)	2002-09-15

Family

ID=17502876

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT96935360T ATE223902T1 (de)	1995-10-19	1996-10-18	Chinolinderivate als gnrh antagonisten

Country Status (8)

Country	Link
US (2)	US5807869A (de)
EP (1)	EP0876349B1 (de)
CN (1)	CN1200114A (de)
AT (1)	ATE223902T1 (de)
AU (1)	AU7333496A (de)
CA (1)	CA2229201A1 (de)
DE (1)	DE69623655T2 (de)
WO (1)	WO1997014682A1 (de)

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US6194419B1 (en)	1997-12-26	2001-02-27	Takeda Chemical Industries, Ltd.	Nitrogen-containing heterocyclic compounds, their production and use
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EP1067930A4 (de) *	1998-04-02	2002-09-18	Merck & Co Inc	Antagonisten des gonadoliberins
WO1999051234A1 (en) *	1998-04-02	1999-10-14	Merck & Co., Inc.	Antagonists of gonadotropin releasing hormone
AU3210799A (en) *	1998-04-02	1999-10-25	Merck & Co., Inc.	Antagonists of gonadotropin releasing hormone
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US6248736B1 (en)	1999-01-08	2001-06-19	Pharmacia & Upjohn Company	4-oxo-1,4-dihydro-3-quinolinecarboxamides as antiviral agents
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US6537998B1 (en)	1999-10-15	2003-03-25	Neurocrine Biosciences, Inc.	Gonadotropin-releasing hormone receptor antagonists and methods relating thereto
US6608197B2 (en)	2000-01-25	2003-08-19	Neurocrine Biosciences, Inc.	Gonadotropin-releasing hormone receptor antagonists and methods relating thereto
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EP1414808A1 (de)	2001-08-02	2004-05-06	Neurocrine Biosciences, Inc.	1,2,4-triazin-3,5-dione als antagonisten des gonadotropin freisetzenden hormons
JP2005504034A (ja)	2001-08-02	2005-02-10	ニューロクラインバイオサイエンシーズ，インコーポレイテッド	ゴナドトロピン放出性ホルモンレセプターアンタゴニストとしてのピリジノン誘導体およびピリダジノン誘導体
AU2002324586B2 (en)	2001-08-02	2008-04-24	Neurocrine Biosciences, Inc.	1,3,5-triazine-2,4,6-triones, preparation and use as gonadotropin-releasing hormone receptor antagonists
JP2005505525A (ja)	2001-08-02	2005-02-24	ニューロクラインバイオサイエンシーズ，インコーポレイテッド	性腺刺激ホルモン放出ホルモンレセプターアンタゴニストおよびそれに関連する方法
EP1412363A1 (de)	2001-08-02	2004-04-28	Neurocrine Biosciences, Inc.	Rezeptor antagonisten für gonadotropin-freisetzende hormone
EP1479684A4 (de)	2002-01-30	2006-01-04	Takeda Pharmaceutical	Thienopyrimidine, verfahren zu deren herstellung und deren verwendung
WO2003086464A1 (en) *	2002-04-12	2003-10-23	Takeda Pharmaceutical Company Limited.	Preventives/remedies for hotflash
BRPI0412327A (pt)	2003-07-07	2006-09-05	Neurocrine Biosciences Inc	derivados de pirimidina-2,4-diona como antagonistas de receptor de hormÈnio liberador de gonadotropina
JP4673847B2 (ja)	2003-07-07	2011-04-20	ニューロクラインバイオサイエンシーズ，インコーポレイテッド	性腺刺激ホルモン放出ホルモンレセプターアンタゴニストおよびそれに関連する方法
EP1646389B1 (de)	2003-07-07	2008-09-10	Neurocrine Biosciences, Inc.	Pyrimidin-2,4-dion-derivate als gonadotropin freisetzende hormon-rezeptor-antagonisten
MXPA06014131A (es) *	2004-06-04	2007-03-07	Astellas Pharma Inc	Derivado de propano-1,3-diona o su sal.
US8354427B2 (en) *	2004-06-24	2013-01-15	Vertex Pharmaceutical Incorporated	Modulators of ATP-binding cassette transporters
CA2881078C (en)	2004-06-24	2018-10-02	Vertex Pharmaceuticals Incorporated	Modulators of atp-binding cassette transporters
WO2006001499A2 (en)	2004-06-25	2006-01-05	Takeda Pharmaceutical Company Limited	Metastin derivatives and use thereof
DE102004033902A1 (de)	2004-07-14	2006-02-16	Zentaris Gmbh	Neue Tetrahydrocarbazolderivate mit verbesserter biologischer Wirkung und verbesserter Löslichkeit als Liganden für G-Protein gekoppelte Rezeptoren (GPCR's)
SI1864976T1 (sl) *	2005-03-31	2012-12-31	Astellas Pharma Inc.	Propan-1,3-dionski derivat ali njegova sol
UA92007C2 (ru) *	2005-05-04	2010-09-27	Н.В. Органон	Производные 4-фенил-5-оксо-1,4,5,6,7,8-гексагидрохинолина для лечения бесплодности
UA92009C2 (ru) *	2005-05-04	2010-09-27	Н.В. Органон	Производные 4-фенил-5-оксо-1,4,5,6,7,8-гексагидрохинолина для лечения бесплодия
UA92008C2 (en) *	2005-05-04	2010-09-27	Н.В. Органон	4-PHENYL-5-OXO-l,4,5,6,7,8-HEXAHYDROQUINOLINE DERIVATIVES AS MEDICAMENTS FOR THE TREATMENT OF INFERTILITY
CN101171234B (zh) *	2005-05-04	2011-11-16	欧加农股份有限公司	二氢吡啶衍生物
US8404643B2 (en)	2005-12-22	2013-03-26	Takeda Pharmaceutical Company Limited	Metastin derivatives and use thereof
AR058584A1 (es)	2005-12-22	2008-02-13	Takeda Pharmaceutical	Derivados de metastina y uso de los mismos
WO2007075901A2 (en) *	2005-12-24	2007-07-05	Vertex Pharmaceuticals Incorporated	Quinolin- 4 - one derivatives as modulators of abc transporters
LT1993360T (lt)	2005-12-28	2017-06-12	Vertex Pharmaceuticals Incorporated	N-[2,4-bis(1,1-dimetiletil)-5-hidroksifenil]-1,4-dihidro-4-oksochinolin-3-karboksamido kieta forma
JO3048B1 (ar)	2006-10-25	2016-09-05	Takeda Pharmaceuticals Co	مشتقات متاستين واستخدامها
EP2095818A1 (de)	2008-02-29	2009-09-02	AEterna Zentaris GmbH	Verwendung von LHRH-Antagonisten in nicht-kastrierenden Dosen
US20100074949A1 (en)	2008-08-13	2010-03-25	William Rowe	Pharmaceutical composition and administration thereof
US12458635B2 (en)	2008-08-13	2025-11-04	Vertex Pharmaceuticals Incorporated	Pharmaceutical composition and administrations thereof
SI3330255T1 (sl)	2009-03-20	2021-03-31	Vertex Pharmaceuticals Incorporated	Postopek izdelave regulatorja transmembranske prevodnosti pri cistični fibrozi
TW201130854A (en)	2009-12-22	2011-09-16	Bayer Schering Pharma Ag	Pyridinone derivatives and pharmaceutical compositions thereof
US8802700B2 (en)	2010-12-10	2014-08-12	Vertex Pharmaceuticals Incorporated	Modulators of ATP-Binding Cassette transporters
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EP2819670B1 (de)	2012-02-27	2026-05-20	Vertex Pharmaceuticals Incorporated	Pharmazeutische zubereitung und deren verabreichungen
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TW449600B (en) *	1994-04-19	2001-08-11	Takeda Chemical Industries Ltd	Condensed-ring thiophene derivatives, their production and use

1996
- 1996-10-18 CA CA002229201A patent/CA2229201A1/en not_active Abandoned
- 1996-10-18 AT AT96935360T patent/ATE223902T1/de not_active IP Right Cessation
- 1996-10-18 WO PCT/JP1996/003019 patent/WO1997014682A1/en not_active Ceased
- 1996-10-18 EP EP96935360A patent/EP0876349B1/de not_active Expired - Lifetime
- 1996-10-18 CN CN96197676.4A patent/CN1200114A/zh active Pending
- 1996-10-18 DE DE69623655T patent/DE69623655T2/de not_active Expired - Fee Related
- 1996-10-18 AU AU73334/96A patent/AU7333496A/en not_active Abandoned
1997
- 1997-01-07 US US08/779,609 patent/US5807869A/en not_active Expired - Fee Related
1998
- 1998-09-14 US US09/152,514 patent/US6087503A/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
US5807869A (en)	1998-09-15
EP0876349B1 (de)	2002-09-11
WO1997014682A1 (en)	1997-04-24
AU7333496A (en)	1997-05-07
US6087503A (en)	2000-07-11
DE69623655D1 (de)	2002-10-17
CA2229201A1 (en)	1997-04-24
DE69623655T2 (de)	2003-04-24
EP0876349A1 (de)	1998-11-11
CN1200114A (zh)	1998-11-25

Legal Events

Date	Code	Title	Description
2003-03-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
DE69623655D1 (de)	2002-10-17	Chinolinderivate als gnrh antagonisten
ATE255113T1 (de)	2003-12-15	Bizyklische thiophen-derivate und verwendung als gonadotropinreleasing hormonantagonisten
ATE249464T1 (de)	2003-09-15	Thienopyrimidinderivate, ihre herstellung und verwendung
Drost	2007	Bubaline versus bovine reproduction
Asher et al.	1993	Oestrous synchronization, semen collection and artificial insemination of farmed red deer (Cervus elaphus) and fallow deer (Dama dama)
EP0593491B1 (de)	1996-10-23	LHRH-Antagonisten
Olson et al.	1993	New developments in small animal population control
Ulguim et al.	2018	Ovulation and fertility responses for sows receiving once daily boar exposure after weaning and OvuGel® followed by a single fixed time post cervical artificial insemination
Ulguim et al.	2016	Single fixed-time artificial insemination in gilts and weaned sows using pLH at estrus onset administered through vulvar submucosal route
ATE252910T1 (de)	2003-11-15	Methode zur behandlung von fruchtbarkeitsstörungen
Atabay et al.	2020	Enhancing prostaglandin-based estrus synchronization protocol for artificial insemination in water buffaloes
Oosthuizen et al.	2020	Presynchronization with prostaglandin F2α and prolonged exposure to exogenous progesterone impacts estrus expression and fertility in beef heifers
MX9604808A (es)	1998-02-28	Derivados de tiofeno de anillos condensados, su produccion y uso.
MY117985A (en)	2004-08-30	Condensed-ring thiophene derivatives, their production and use.
Gangwar et al.	2023	Success of artificial insemination in goats: An overview
Alifakiotis	1986	Increasing ovulation rate and lambing percentage by active immunization against androstenedione in dairy sheep breeds
Sharma et al.	1977	Indomethacin in low concentration potentiates the actions of some spasmogens on the isolated oestrous rat uterus
EP0199302A2 (de)	1986-10-29	Kontrazeption für Hunde mit Luteinisierungshormon freimachenden Hormon-Antagonisten
Markandeya et al.	2003	Studies on hormonal therapies for the induction of postpartum oestrus in buffaloes.
Ruginosu et al.	2018	Preliminary results regarding estrus synchronization in postpartum dairy cows with GnRH analogue, PRID-intravaginal device and PGF2 α, followed by artificial insemination at estrus detection.
Lymberopoulos et al.	1999	Laparoscopic intrauterine insemination in superovulated Chios breed ewes
Knight	1985	Pheromones in farm animals
KR100210472B1 (ko)	1999-07-15	황체형성 호르몬 분비 호르몬 길항 펩티드
Singh et al.	2004	Induction of oestrus in post-partum anoestrus cows with GnRH and short-term steroid treatment.
Shukla	2006	Management of sub estrus in Murrah buffaloes in sub Himalayan terrains of India by Dinoprost therapy through intra vulvo submucosal route