ATE223920T1 - Antitumorale bisphosphonate mit alkylierenden einheiten - Google Patents

Antitumorale bisphosphonate mit alkylierenden einheiten

Info

Publication number
ATE223920T1
ATE223920T1 AT98917062T AT98917062T ATE223920T1 AT E223920 T1 ATE223920 T1 AT E223920T1 AT 98917062 T AT98917062 T AT 98917062T AT 98917062 T AT98917062 T AT 98917062T AT E223920 T1 ATE223920 T1 AT E223920T1
Authority
AT
Austria
Prior art keywords
antitumoral
bisphosphonates
alkylating
units
relates
Prior art date
Application number
AT98917062T
Other languages
English (en)
Inventor
Valeria Livi
Silvano Spinelli
Marco Conti
Alo' Simonetta D
Ernesto Menta
Original Assignee
Novuspharma Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novuspharma Spa filed Critical Novuspharma Spa
Application granted granted Critical
Publication of ATE223920T1 publication Critical patent/ATE223920T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
    • C07F9/3839—Polyphosphonic acids
    • C07F9/3869—Polyphosphonic acids containing carboxylic acid or carboxylic acid derivative substituents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/40—Esters thereof
    • C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/4025—Esters of poly(thio)phosphonic acids
    • C07F9/4046—Esters of poly(thio)phosphonic acids containing carboxylic acid or carboxylic acid derivative substituents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AT98917062T 1997-03-27 1998-03-24 Antitumorale bisphosphonate mit alkylierenden einheiten ATE223920T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT97MI000730A IT1290444B1 (it) 1997-03-27 1997-03-27 Coniugati di bis-fosfonati con funzionalita' alchilanti aventi attivita' antitumorale
PCT/EP1998/001707 WO1998043987A1 (en) 1997-03-27 1998-03-24 Bis-phosphonate confugates with alkylating moieties having antitumor activity

Publications (1)

Publication Number Publication Date
ATE223920T1 true ATE223920T1 (de) 2002-09-15

Family

ID=11376675

Family Applications (1)

Application Number Title Priority Date Filing Date
AT98917062T ATE223920T1 (de) 1997-03-27 1998-03-24 Antitumorale bisphosphonate mit alkylierenden einheiten

Country Status (9)

Country Link
US (1) US6207655B1 (de)
EP (1) EP0971939B1 (de)
AT (1) ATE223920T1 (de)
AU (1) AU7040398A (de)
CA (1) CA2284704A1 (de)
DE (1) DE69807857T2 (de)
ES (1) ES2183346T3 (de)
IT (1) IT1290444B1 (de)
WO (1) WO1998043987A1 (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1202828C (zh) * 1999-05-21 2005-05-25 诺瓦提斯公司 二膦酸在制备抑制或逆转血管发生的药物中的用途
GB9911926D0 (en) * 1999-05-21 1999-07-21 Okuno Tetsuji Organic compounds
US7354923B2 (en) * 2001-08-10 2008-04-08 Palatin Technologies, Inc. Piperazine melanocortin-specific compounds
EP2270021A1 (de) 2009-06-18 2011-01-05 Centre National de la Recherche Scientifique Phosphonatsynthone zur Synthese von Phosphonat-Derivaten mit besserer Bioverfügbarkeit
CA3189858A1 (en) 2020-09-05 2022-03-10 William W. Metcalf Phosphonate products and methods
CN116529254A (zh) * 2020-09-05 2023-08-01 伊利诺伊大学董事会 膦酸盐产品和方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3425812A1 (de) * 1984-07-13 1986-01-16 Deutsches Krebsforschungszentrum, 6900 Heidelberg Neue 1-hydroxy-1,1-diphosphonsaeureverbindungen, verfahren zu ihrer herstellung und pharmakologische zubereitungen, insbesondere zur behandlung von knochentumoren
FR2611203B1 (fr) * 1987-02-20 1989-06-09 Sturtz Georges Analogues gem-diphosphoniques d'amethopterine (methotrexate) et de derives deaza-n-10 amethopterine. leur preparation et les compositions pharmaceutiques qui les contiennent
DE3804686A1 (de) * 1988-02-15 1989-08-24 Henkel Kgaa Arzneimittel mit einer kombination von cytostatika bzw. hormontherapeutika und phosphonoderivaten
IT1241674B (it) * 1989-10-12 1994-01-27 Boehringer Biochemia Srl Acidi gem-difosfonici, un processo per la loro preparazione e composizioni farmaceutiche che li contengono.
IT1246777B (it) * 1991-04-12 1994-11-26 Boehringer Mannheim Italia Aminoacil derivati di acidi gem-difosfonici,un processo per la loro preparazione e composizioni farmaceutiche che li contengono
IT1284070B1 (it) * 1996-06-26 1998-05-08 Boehringer Mannheim Italia Derivati di carbossi gem-difosfonati ad attivita' antitumorale, un processo per la loro preparazione e composizioni farmaceutiche che

Also Published As

Publication number Publication date
EP0971939A1 (de) 2000-01-19
EP0971939B1 (de) 2002-09-11
WO1998043987A1 (en) 1998-10-08
ITMI970730A1 (it) 1998-09-27
AU7040398A (en) 1998-10-22
ES2183346T3 (es) 2003-03-16
DE69807857T2 (de) 2003-05-22
IT1290444B1 (it) 1998-12-03
US6207655B1 (en) 2001-03-27
CA2284704A1 (en) 1998-10-08
DE69807857D1 (de) 2002-10-17

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee