IT1284070B1 - Derivati di carbossi gem-difosfonati ad attivita' antitumorale, un processo per la loro preparazione e composizioni farmaceutiche che - Google Patents

Derivati di carbossi gem-difosfonati ad attivita' antitumorale, un processo per la loro preparazione e composizioni farmaceutiche che

Info

Publication number
IT1284070B1
IT1284070B1 IT96MI001290A ITMI961290A IT1284070B1 IT 1284070 B1 IT1284070 B1 IT 1284070B1 IT 96MI001290 A IT96MI001290 A IT 96MI001290A IT MI961290 A ITMI961290 A IT MI961290A IT 1284070 B1 IT1284070 B1 IT 1284070B1
Authority
IT
Italy
Prior art keywords
gem
carboxy
preparation
pharmaceutical compositions
cancer activity
Prior art date
Application number
IT96MI001290A
Other languages
English (en)
Inventor
Valeria Livi
Alo' Simonetta D
Silvano Spinelli
Marco Conti
Original Assignee
Boehringer Mannheim Italia
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Mannheim Italia filed Critical Boehringer Mannheim Italia
Priority to IT96MI001290A priority Critical patent/IT1284070B1/it
Publication of ITMI961290A0 publication Critical patent/ITMI961290A0/it
Priority to AU32608/97A priority patent/AU3260897A/en
Priority to PCT/EP1997/003190 priority patent/WO1997049711A1/en
Publication of ITMI961290A1 publication Critical patent/ITMI961290A1/it
Application granted granted Critical
Publication of IT1284070B1 publication Critical patent/IT1284070B1/it

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/40—Esters thereof
    • C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/4025—Esters of poly(thio)phosphonic acids
    • C07F9/4046—Esters of poly(thio)phosphonic acids containing carboxylic acid or carboxylic acid derivative substituents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
    • C07F9/3839—Polyphosphonic acids
    • C07F9/3869—Polyphosphonic acids containing carboxylic acid or carboxylic acid derivative substituents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/564—Three-membered rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
IT96MI001290A 1996-06-26 1996-06-26 Derivati di carbossi gem-difosfonati ad attivita' antitumorale, un processo per la loro preparazione e composizioni farmaceutiche che IT1284070B1 (it)

Priority Applications (3)

Application Number Priority Date Filing Date Title
IT96MI001290A IT1284070B1 (it) 1996-06-26 1996-06-26 Derivati di carbossi gem-difosfonati ad attivita' antitumorale, un processo per la loro preparazione e composizioni farmaceutiche che
AU32608/97A AU3260897A (en) 1996-06-26 1997-06-12 Derivatives of carboxy gem-bisphosphonates with antitumor activity, a process for preparing them and pharmaceutical compositions containing them
PCT/EP1997/003190 WO1997049711A1 (en) 1996-06-26 1997-06-12 Derivatives of carboxy gem-bisphosphonates with antitumor activity, a process for preparing them and pharmaceutical compositions containing them

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT96MI001290A IT1284070B1 (it) 1996-06-26 1996-06-26 Derivati di carbossi gem-difosfonati ad attivita' antitumorale, un processo per la loro preparazione e composizioni farmaceutiche che

Publications (3)

Publication Number Publication Date
ITMI961290A0 ITMI961290A0 (it) 1996-06-26
ITMI961290A1 ITMI961290A1 (it) 1997-12-26
IT1284070B1 true IT1284070B1 (it) 1998-05-08

Family

ID=11374479

Family Applications (1)

Application Number Title Priority Date Filing Date
IT96MI001290A IT1284070B1 (it) 1996-06-26 1996-06-26 Derivati di carbossi gem-difosfonati ad attivita' antitumorale, un processo per la loro preparazione e composizioni farmaceutiche che

Country Status (3)

Country Link
AU (1) AU3260897A (it)
IT (1) IT1284070B1 (it)
WO (1) WO1997049711A1 (it)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1290444B1 (it) * 1997-03-27 1998-12-03 Boehringer Mannheim Italia Coniugati di bis-fosfonati con funzionalita' alchilanti aventi attivita' antitumorale
EP1406910B1 (fr) 2001-07-16 2010-01-13 Universite Paris 13 Procedes de preparation de derives de bisphosphonates
DE102004032781A1 (de) 2004-01-23 2005-08-11 Mcs Micro Carrier Systems Gmbh Bisphosphonsäurederivate

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3425812A1 (de) * 1984-07-13 1986-01-16 Deutsches Krebsforschungszentrum, 6900 Heidelberg Neue 1-hydroxy-1,1-diphosphonsaeureverbindungen, verfahren zu ihrer herstellung und pharmakologische zubereitungen, insbesondere zur behandlung von knochentumoren
FR2611203B1 (fr) * 1987-02-20 1989-06-09 Sturtz Georges Analogues gem-diphosphoniques d'amethopterine (methotrexate) et de derives deaza-n-10 amethopterine. leur preparation et les compositions pharmaceutiques qui les contiennent
IT1241674B (it) * 1989-10-12 1994-01-27 Boehringer Biochemia Srl Acidi gem-difosfonici, un processo per la loro preparazione e composizioni farmaceutiche che li contengono.
IT1246777B (it) * 1991-04-12 1994-11-26 Boehringer Mannheim Italia Aminoacil derivati di acidi gem-difosfonici,un processo per la loro preparazione e composizioni farmaceutiche che li contengono

Also Published As

Publication number Publication date
AU3260897A (en) 1998-01-14
WO1997049711A1 (en) 1997-12-31
ITMI961290A1 (it) 1997-12-26
ITMI961290A0 (it) 1996-06-26

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