ATE224145T1 - Reinigung von biologisch aktiven peptiden aus milch - Google Patents

Reinigung von biologisch aktiven peptiden aus milch

Info

Publication number
ATE224145T1
ATE224145T1 AT97923643T AT97923643T ATE224145T1 AT E224145 T1 ATE224145 T1 AT E224145T1 AT 97923643 T AT97923643 T AT 97923643T AT 97923643 T AT97923643 T AT 97923643T AT E224145 T1 ATE224145 T1 AT E224145T1
Authority
AT
Austria
Prior art keywords
milk
purification
biologically active
permeate
active peptides
Prior art date
Application number
AT97923643T
Other languages
German (de)
English (en)
Inventor
Joseph P Kutzko
Michael L Hayes
Lee T Sherman
Original Assignee
Genzyme Transgenics Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genzyme Transgenics Corp filed Critical Genzyme Transgenics Corp
Application granted granted Critical
Publication of ATE224145T1 publication Critical patent/ATE224145T1/de

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K1/00General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14Extraction; Separation; Purification
    • C07K1/36Extraction; Separation; Purification by a combination of two or more processes of different types
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23JPROTEIN COMPOSITIONS FOR FOODSTUFFS; WORKING-UP PROTEINS FOR FOODSTUFFS; PHOSPHATIDE COMPOSITIONS FOR FOODSTUFFS
    • A23J1/00Obtaining protein compositions for foodstuffs; Bulk opening of eggs and separation of yolks from whites
    • A23J1/20Obtaining protein compositions for foodstuffs; Bulk opening of eggs and separation of yolks from whites from milk, e.g. casein; from whey
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/827Proteins from mammals or birds
    • Y10S530/832Milk; colostrum

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Organic Chemistry (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Food Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Polymers & Plastics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AT97923643T 1996-05-13 1997-05-13 Reinigung von biologisch aktiven peptiden aus milch ATE224145T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/648,235 US6268487B1 (en) 1996-05-13 1996-05-13 Purification of biologically active peptides from milk
PCT/US1997/008044 WO1997042835A1 (en) 1996-05-13 1997-05-13 Purification of biologically active peptides from milk

Publications (1)

Publication Number Publication Date
ATE224145T1 true ATE224145T1 (de) 2002-10-15

Family

ID=24599969

Family Applications (1)

Application Number Title Priority Date Filing Date
AT97923643T ATE224145T1 (de) 1996-05-13 1997-05-13 Reinigung von biologisch aktiven peptiden aus milch

Country Status (14)

Country Link
US (1) US6268487B1 (2)
EP (1) EP0923308B1 (2)
JP (1) JP4476362B2 (2)
AT (1) ATE224145T1 (2)
AU (1) AU725993B2 (2)
CA (1) CA2254871C (2)
DE (2) DE69715641T2 (2)
DK (1) DK0923308T3 (2)
ES (1) ES2182074T3 (2)
LU (1) LU91305I2 (2)
NL (1) NL300256I2 (2)
NZ (1) NZ332916A (2)
PT (1) PT923308E (2)
WO (1) WO1997042835A1 (2)

Families Citing this family (71)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE122007000007I1 (de) 1986-04-09 2007-05-16 Genzyme Corp Genetisch transformierte Tiere, die ein gewünschtes Protein in Milch absondern
WO1999020766A2 (en) 1997-10-20 1999-04-29 Genzyme Transgenics Corporation NOVEL MODIFIED NUCLEIC ACID SEQUENCES AND METHODS FOR INCREASING mRNA LEVELS AND PROTEIN EXPRESSION IN CELL SYSTEMS
SE9802213D0 (sv) * 1998-06-18 1998-06-18 Amersham Pharm Biotech Ab A method for the removal/purification of serum albumins and means for use in the method
US20030005468A1 (en) * 1998-06-19 2003-01-02 Meade Harry M. Methods and vectors for improving nucleic acid expression
ATE328007T1 (de) * 1998-09-24 2006-06-15 Pharming Intellectual Pty Bv Reinigung von fibrinogen aus flüssigkeiten mittels ausfällung und hydrophobischer- interaktion-chromatographie
EP1148779B1 (en) * 1999-01-06 2007-12-12 Merrimack Pharmaceuticals, Inc. Expression of secreted human alpha-fetoprotein in transgenic animals
WO2001000855A1 (en) 1999-06-23 2001-01-04 Ppl Therapeutics (Scotland) Ltd. Fusion proteins incorporating lysozyme
HUP0302396A2 (hu) * 2000-05-05 2003-10-28 Gtc Biotherapeutics, Inc. Transzgénikus úton előállított dekorin
US20020077775A1 (en) * 2000-05-25 2002-06-20 Schork Nicholas J. Methods of DNA marker-based genetic analysis using estimated haplotype frequencies and uses thereof
US20030195707A1 (en) * 2000-05-25 2003-10-16 Schork Nicholas J Methods of dna marker-based genetic analysis using estimated haplotype frequencies and uses thereof
US20040226052A1 (en) * 2000-10-13 2004-11-11 Meade Harry M. Methods of producing a target molecule in a transgenic animal and purification of the target molecule
US20030036637A1 (en) * 2001-06-13 2003-02-20 Scott Fulton Purification of human serum albumin
WO2003014151A2 (en) * 2001-08-10 2003-02-20 Genset S.A. Human secreted proteins, their encoding polynucleotides, and uses thereof
US6875459B2 (en) * 2001-09-10 2005-04-05 Henry B. Kopf Method and apparatus for separation of milk, colostrum, and whey
US20060253913A1 (en) * 2001-12-21 2006-11-09 Yue-Jin Huang Production of hSA-linked butyrylcholinesterases in transgenic mammals
WO2003090545A1 (en) * 2002-04-24 2003-11-06 Dairy Development Specialists, Inc. Intermediate ingredient for dairy product manufacturing and method of making the same
EP1367065B1 (en) * 2002-05-27 2008-07-30 Nestec S.A. Acid soluble proteins from micellar casein
GB0216001D0 (en) * 2002-07-10 2002-08-21 Nat Blood Authority Process and composition
WO2004026427A2 (en) * 2002-09-17 2004-04-01 Gtc Biotherapeutics, Inc. Isolation of immunoglobulin molecules that lack inter-heavy chain disulfide bonds
BR0316643A (pt) * 2002-11-27 2005-10-11 Gtc Biotherapeutics Inc Anticorpos modificados estavelmente produzidos no leite e método de produzir os mesmos
US20040231010A1 (en) * 2003-01-09 2004-11-18 Murray James D. Lysozyme transgenic ungulates
US20040210953A1 (en) * 2003-01-09 2004-10-21 Murray James D. Lysozyme transgenic ungulates
ATE521701T1 (de) 2003-01-22 2011-09-15 Univ Duke Verbesserte konstrukte zur expression lysosomaler polypeptide
CA2516836A1 (en) * 2003-02-24 2004-09-10 Gtc Biotherapeutics, Inc. Methods of tangential flow filtration and an apparatus therefore
WO2005085287A1 (en) 2004-03-03 2005-09-15 En-N-Tech, Inc. Treatments for contaminant reduction in lactoferrin preparations and lactoferrin-containing compositions
US20050197496A1 (en) * 2004-03-04 2005-09-08 Gtc Biotherapeutics, Inc. Methods of protein fractionation using high performance tangential flow filtration
US20050245444A1 (en) * 2004-04-30 2005-11-03 Yann Echelard Method of using recombinant human antithrombin for neurocognitive disorders
US20060121004A1 (en) * 2004-12-07 2006-06-08 Yann Echelard Methods of reducing the incidence of rejection in tissue transplantation through the use of recombinant human antithrombin
US20060130159A1 (en) * 2004-12-09 2006-06-15 Nick Masiello Method of purifying recombinant MSP 1-42 derived from Plasmodium falciparum
US20080019905A9 (en) * 2005-02-18 2008-01-24 Strome Scott E Method of using an anti-CD137 antibody as an agent for radioimmunotherapy or radioimmunodetection
WO2006138647A2 (en) * 2005-06-16 2006-12-28 Gtc Biotherapeutics, Inc. Method of making recombinant human antibodies for use in biosensor technology
WO2007014244A2 (en) * 2005-07-25 2007-02-01 Gtc Biotherapeutics, Inc. Method of purifying recombinant human antithrombin to enhance the viral and prion safety profile
KR20080068089A (ko) * 2005-10-21 2008-07-22 지티씨바이오쎄라퓨틱스,인크. 항체 의존성 세포 독성 활성이 증강된 항체, 그 생산 및사용 방법
US7531632B2 (en) * 2006-02-16 2009-05-12 Gtc Biotherapeutics, Inc. Clarification of transgenic milk using depth filtration
FR2901707B1 (fr) * 2006-05-31 2017-09-29 Lab Francais Du Fractionnement Composition de facteur vii recombinant ou transgenique, chaque molecule de facteur vii possedant deux sites de n-glycosylation a motifs glycanniques definis
US20090208480A1 (en) * 2006-08-04 2009-08-20 Yue Huang Long half-life recombinant butyrylcholinesterase
FR2910786B1 (fr) * 2006-12-29 2017-08-11 Laboratoire Francais Du Fractionnement Et Des Biotechnologies (Lfb) "procede d'extraction d'une proteine presente dans du lait"
JP5208428B2 (ja) * 2007-01-30 2013-06-12 雪印メグミルク株式会社 美肌剤
FR2912310B1 (fr) 2007-02-13 2009-08-07 Kasan Sarl Nouvelles compositions cosmetiques et/ou pharmaceutiques et leurs applications.
US7919589B2 (en) 2007-07-10 2011-04-05 Glanbia Nutritionals (Ireland), Ltd. Method for removing endotoxin from proteins
EP2077273B1 (en) 2007-12-31 2011-09-14 Animal Technology Institute Taiwan Methods for separating casein from soluble proteins in a composition
TWI346666B (en) * 2007-12-31 2011-08-11 Animal Technology Inst Taiwan Method for seperating casein from casein-contained solution
CN102014656B (zh) * 2008-04-21 2014-07-23 不二制油株式会社 脱脂豆乳肽的制备方法
WO2009134389A2 (en) * 2008-05-01 2009-11-05 Gtc Biotherapeutics, Inc. An anti-cd137 antibody as an agent in the treatment of inflammatory conditions
EP2293678A4 (en) * 2008-05-14 2011-06-22 Agriculture Victoria Serv Pty ANGIOGENIC-ENRICHED MILK FRACTIONS
CN104193798A (zh) * 2009-12-18 2014-12-10 Csl有限公司 纯化多肽的方法
JP2013526840A (ja) 2009-12-21 2013-06-27 ファーマシーネ,インコーポレイテッド 組み換えブチリルコリンエステラーゼおよびその切断型
US8861162B2 (en) * 2010-03-09 2014-10-14 Honeywell International Inc. High power solid state power controller (SSPC) solution for primary power distribution applications
CN104959087B (zh) 2010-04-09 2017-08-15 帕西拉制药有限公司 用于配制大直径合成膜囊泡的方法
FR2958496A1 (fr) * 2010-04-09 2011-10-14 Bioprotein Technologies Sa Preparation de proteine plasmatique de transfert des phospholipides (pltp) humaine recombinante a partir du lait d'animaux transgeniques.
CN107190034A (zh) * 2010-10-05 2017-09-22 诺沃—诺迪斯克保健股份有限公司 生产蛋白质的方法
KR20140093603A (ko) 2010-12-30 2014-07-28 라보라토이레 프란카이즈 듀 프락티온네먼트 에트 데스 바이오테크놀로지스 병원체 불활성화제로서의 글리콜
CN105413480B (zh) 2011-04-01 2019-03-29 Emd密理博公司 含有纳米纤维的复合材料结构
KR20140054026A (ko) * 2011-07-07 2014-05-08 알에보 바이올로직스, 인코포레이티드 단백질을 안정화시키는 제제
TW201400499A (zh) 2012-03-12 2014-01-01 Revo Biolog Inc 抗凝血酶用於治療妊娠毒血症之用途
EP2687595B1 (en) 2012-07-19 2018-05-30 Laboratoire Français du Fractionnement et des Biotechnologies Method for purifying transgenic factor VII
TW201425332A (zh) 2012-08-03 2014-07-01 Revo Biolog Inc 抗凝血酶用於體外膜氧合之用途
US10034921B2 (en) 2013-02-13 2018-07-31 Laboratoire Français Du Fractionnement Et Des Biotechnologies Proteins with modified glycosylation and methods of production thereof
EP3594231A1 (en) 2013-02-13 2020-01-15 Laboratoire Français du Fractionnement et des Biotechnologies Highly galactosylated anti-tnf-alpha antibodies and uses thereof
MX384222B (es) 2013-07-05 2025-03-14 Lab Francais Du Fractionnement Matriz de cromatografia de afinidad.
US9661868B2 (en) * 2013-07-16 2017-05-30 Mead Johnson Nutrition Company Expanded bed adsorption methods for isolation of basic milk proteins including lactoferrin
AU2015270152A1 (en) * 2014-06-02 2016-12-08 Laboratoire Francais Du Fractionnement Et Des Biotechnologies Production of Fc fragments
JP6568545B2 (ja) 2014-06-26 2019-08-28 イー・エム・デイー・ミリポア・コーポレイシヨン 増強された汚れ保持容量を有するフィルタ構造
FR3034419B1 (fr) 2015-04-02 2017-12-15 Lab Francais Du Fractionnement Procede de purification d'une proteine recombinante therapeutique a partir d'un lait transgenique
EP3283202B1 (en) * 2015-04-17 2025-10-01 EMD Millipore Corporation Method of purifying a biological materia of interest in a sample using nanofiber ultrafiltration membranes operated in tangential flow filtration mode
FR3038517B1 (fr) 2015-07-06 2020-02-28 Laboratoire Francais Du Fractionnement Et Des Biotechnologies Utilisation de fragments fc modifies en immunotherapie
EP3655142B1 (en) 2017-07-21 2026-02-25 Merck Millipore Ltd Non-woven fiber membranes
KR20210016400A (ko) * 2018-05-24 2021-02-15 지앙수 헨그루이 메디슨 컴퍼니 리미티드 재조합 인간 인슐린 또는 그 유사체의 전구체를 제조하는 방법
FR3082427B1 (fr) 2018-06-14 2020-09-25 Lab Francais Du Fractionnement Combinaison de facteur vii et d'un anticorps bispecifique anti-facteurs ix et x
JP7478333B2 (ja) * 2020-07-29 2024-05-07 和弘 原 成分調整物生産装置及び成分調整物生産方法
CN113101737B (zh) * 2021-03-04 2023-09-15 京美生命科技(杭州)有限公司 一种亲和切向流过滤系统及其构建方法和外泌体提取方法及应用

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2459619B1 (fr) 1979-06-26 1983-07-29 Agronomique Inst Nat Rech Procede pour l'obtention a partir de lactoserum, d'un produit enrichi en alpha-lactalbumine et applications dudit procede
FR2487642B2 (fr) 1980-07-31 1985-10-18 Bel Fromageries Procede de preparation de fractions proteiques par ultrafiltration et chromatographie d'exclusion et d'echange d'ions
DE3432718C1 (de) 1984-09-06 1986-05-22 Biotest Pharma GmbH, 6000 Frankfurt Verfahren zur Herstellung einer Loesung von Milch- und/oder Kolostralimmunglobulinen
FR2584727B1 (fr) 1985-07-11 1988-06-17 Roussel Uclaf Procede d'extraction de proteines du lait, produits, application du procede, et compositions pharmaceutiques
JPS62298536A (ja) 1986-06-17 1987-12-25 Green Cross Corp:The 生理活性物質の自動精製方法および自動精製装置
DE3743440A1 (de) * 1987-12-21 1989-06-29 Gauri Kailash Kumar Verfahren zum trennen der geloesten und ungeloesten bestandteile von milch
US4897465A (en) 1988-10-12 1990-01-30 Abbott Laboratories Enrichment and concentration of proteins by ultrafiltration
CA2075206C (en) 1989-12-01 2006-05-23 Herbert L. Heyneker Production of recombinant polypeptides by bovine species and transgenic methods
NL9001650A (nl) 1990-07-19 1992-02-17 Ver Coop Melkind Werkwijze voor de bereiding van een melkeiwit-isolaat.
US5256294A (en) * 1990-09-17 1993-10-26 Genentech, Inc. Tangential flow filtration process and apparatus
US5175013A (en) 1990-12-31 1992-12-29 The Pillsbury Company Frozen dessert compositions and products
US5178894A (en) 1991-09-26 1993-01-12 Silvia P. Rudel High non-fat milk content bread products having improved keeping qualities
EP0652889A4 (en) 1992-06-15 1997-05-07 Gene Pharming Europ Bv PRODUCTION OF RECOMBINANT POLYPEPTIDES BY BOVINE SPECIES AND TRANSGENIC PROCESSES.
US5256437A (en) * 1992-06-19 1993-10-26 Pall Corporation Product and process of making sterile milk through dynamic microfiltration
DE69424687T2 (de) 1993-03-09 2000-09-07 Genzyme Corp., Cambridge Verfahren zur isolierung von proteinen aus milch
ATE209862T1 (de) 1994-02-16 2001-12-15 Pharming Intellectual Pty Bv Isolierung von lactoferrin aus milch
US5597486A (en) * 1995-05-01 1997-01-28 Millipore Investment Holdings Limited Membrane filtration with optimized addition of second liquid to maximize flux

Also Published As

Publication number Publication date
JP2000510701A (ja) 2000-08-22
NZ332916A (en) 2000-05-26
DE122007000008I2 (de) 2011-01-13
EP0923308A1 (en) 1999-06-23
DE122007000008I1 (de) 2009-05-20
PT923308E (pt) 2002-11-29
WO1997042835A1 (en) 1997-11-20
CA2254871C (en) 2008-03-25
EP0923308A4 (2) 1999-06-30
LU91305I2 (fr) 2007-03-12
AU2940297A (en) 1997-12-05
ES2182074T3 (es) 2003-03-01
JP4476362B2 (ja) 2010-06-09
NL300256I1 (nl) 2007-04-02
DE69715641D1 (de) 2002-10-24
DK0923308T3 (da) 2002-10-14
AU725993B2 (en) 2000-10-26
NL300256I2 (nl) 2007-09-03
US6268487B1 (en) 2001-07-31
CA2254871A1 (en) 1997-11-20
EP0923308B1 (en) 2002-09-18
DE69715641T2 (de) 2003-08-07

Similar Documents

Publication Publication Date Title
ATE224145T1 (de) Reinigung von biologisch aktiven peptiden aus milch
DK0764209T3 (da) Albuminekspression i gær
DK426386D0 (da) Fremgangsmaade til rensning og aktivering af proteiner fra uoploeselige inklusionslegemer
DE69535314D1 (de) Modifizierte pflanzenviren als vektore für heterologe peptide
ATE373010T1 (de) Gag-antigen und dessen verwendung zum nachweis von lav-infektion, sowie in immunogenen zusammensetzungen
ATE310017T1 (de) Verfahren zur reinigung und isolierung von wasserlöslichen peptiden und proteinen aus pflanzenquellen
DK0527760T3 (da) Fremgangsmåder og præparater til vaccination mod HIV
ATE146657T1 (de) Verfahren zur herstellung eines molkeprotein- hydrolysates
ATE204019T1 (de) Steigerung der transplantattoleranz durch schwein cytokine
NZ333074A (en) Milk proteins obtained from a bacteria and fat depleted product such as skim milk or whey
DK0580829T3 (da) Ekstrakt af bakterielle proteiner, fremgangsmåde til fremstilling deraf og farmaceutisk præparat indeholdende den.
NO951750L (no) Renset "nontypable" Haemophilus influenzae P5 protein som en vaksine for "nontypable" Haemophilus influenzae stamme
ATE311175T1 (de) Verfahren zur verkapselung von proteinen oder peptiden in liposomen
NO971474L (no) Anti-inflammatorisk faktor, fremgangsmåte for isolering, og anvendelse
DE3882154D1 (de) Verfahren zur herstellung des pres 1/s2/s-hepatitis-b-antigens aus hefe.
DK628188D0 (da) Protein og fremgangsmaade til fremstilling deraf
NO149454C (no) Proteinkonsentrat for tilsetning til dyrefor, fremstilling av konsentratet fra gress og andre plantevekster og anvendelse av konsentratet i dyrefor
ATE60247T1 (de) Modifizierte anorganische filtermembran zur proteintrennung.
ATE193543T1 (de) Antithrombotische peptide aus den wiederholten sequenzen des typs ii
ES8500059A1 (es) Procedimiento para la produccion de concentrado de factor antihemofilico.
MX9603369A (es) Aisalmiento de lactoferrina a partir de leche.