ES2182074T3 - Purificacion de peptidos de la leche, activos biologicamente. - Google Patents

Purificacion de peptidos de la leche, activos biologicamente.

Info

Publication number
ES2182074T3
ES2182074T3 ES97923643T ES97923643T ES2182074T3 ES 2182074 T3 ES2182074 T3 ES 2182074T3 ES 97923643 T ES97923643 T ES 97923643T ES 97923643 T ES97923643 T ES 97923643T ES 2182074 T3 ES2182074 T3 ES 2182074T3
Authority
ES
Spain
Prior art keywords
milk
procedure
purification
retentive
soluble
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES97923643T
Other languages
English (en)
Inventor
Joseph P Kutzko
Michael L Hayes
Lee T Sherman
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
rEVO Biologics Inc
Original Assignee
Genzyme Transgenics Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genzyme Transgenics Corp filed Critical Genzyme Transgenics Corp
Application granted granted Critical
Publication of ES2182074T3 publication Critical patent/ES2182074T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/36—Extraction; Separation; Purification by a combination of two or more processes of different types
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23J—PROTEIN COMPOSITIONS FOR FOODSTUFFS; WORKING-UP PROTEINS FOR FOODSTUFFS; PHOSPHATIDE COMPOSITIONS FOR FOODSTUFFS
    • A23J1/00—Obtaining protein compositions for foodstuffs; Bulk opening of eggs and separation of yolks from whites
    • A23J1/20—Obtaining protein compositions for foodstuffs; Bulk opening of eggs and separation of yolks from whites from milk, e.g. casein; from whey
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/827—Proteins from mammals or birds
    • Y10S530/832—Milk; colostrum

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Organic Chemistry (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Food Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Polymers & Plastics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

SE DESCRIBE UN PROCEDIMIENTO PARA SEPARAR UN COMPONENTE LACTEO SOLUBLE DE LA LECHE (POR EJEMPLO, EN UN SISTEMA DE EXTRACCION CONTINUA EN CIRCUITO CERRADO). EL PROCEDIMIENTO COMPRENDE LA UTILIZACION DE FILTRACION DE FLUJO TANGENCIAL A TRAVES DE UNA MEMBRANA PARA FORMAR UN RETENTIVO Y UN PERMEATO, SOMETIENDO EL PERMEATO A UN DISPOSITIVO CAPTOR PARA EXTRAER BASICAMENTE EL COMPONENTE LACTEO SOLUBLE, COMBINANDO EL EFLUENTE DEL DISPOSITIVO CAPTOR CON LA MUESTRA DE LECHE ORIGINAL (RETENTIVO) Y CONTINUAR ESTE PROCEDIMIENTO HASTA QUE LA LECHE SE HA PURIFICADO SUFICIENTEMENTE. PREFERIBLEMENTE, LA LECHE SE COMBINA CON UN AGENTE QUELANTE, TAL COMO EDTA, PARA MEJORAR LA EFICIENCIA DE LA PURIFICACION. ESTE PROCEDIMIENTO ES UTILIZADO VENTAJOSAMENTE CON LA LECHE PROCEDENTE DE ANIMALES TRANSGENICOS QUE HAN SIDO GENETICAMENTE ALTERADOS PARA EXPRESAR PROTEINAS EXOGENAS, TALES COMO PROTEINAS TERAPEUTICAS, EN SU LECHE.
ES97923643T 1996-05-13 1997-05-13 Purificacion de peptidos de la leche, activos biologicamente. Expired - Lifetime ES2182074T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/648,235 US6268487B1 (en) 1996-05-13 1996-05-13 Purification of biologically active peptides from milk

Publications (1)

Publication Number Publication Date
ES2182074T3 true ES2182074T3 (es) 2003-03-01

Family

ID=24599969

Family Applications (1)

Application Number Title Priority Date Filing Date
ES97923643T Expired - Lifetime ES2182074T3 (es) 1996-05-13 1997-05-13 Purificacion de peptidos de la leche, activos biologicamente.

Country Status (14)

Country Link
US (1) US6268487B1 (es)
EP (1) EP0923308B1 (es)
JP (1) JP4476362B2 (es)
AT (1) ATE224145T1 (es)
AU (1) AU725993B2 (es)
CA (1) CA2254871C (es)
DE (2) DE69715641T2 (es)
DK (1) DK0923308T3 (es)
ES (1) ES2182074T3 (es)
LU (1) LU91305I2 (es)
NL (1) NL300256I2 (es)
NZ (1) NZ332916A (es)
PT (1) PT923308E (es)
WO (1) WO1997042835A1 (es)

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Also Published As

Publication number Publication date
JP2000510701A (ja) 2000-08-22
NZ332916A (en) 2000-05-26
DE122007000008I2 (de) 2011-01-13
EP0923308A1 (en) 1999-06-23
DE122007000008I1 (de) 2009-05-20
PT923308E (pt) 2002-11-29
WO1997042835A1 (en) 1997-11-20
CA2254871C (en) 2008-03-25
EP0923308A4 (es) 1999-06-30
LU91305I2 (fr) 2007-03-12
AU2940297A (en) 1997-12-05
JP4476362B2 (ja) 2010-06-09
NL300256I1 (nl) 2007-04-02
DE69715641D1 (de) 2002-10-24
DK0923308T3 (da) 2002-10-14
AU725993B2 (en) 2000-10-26
NL300256I2 (nl) 2007-09-03
US6268487B1 (en) 2001-07-31
CA2254871A1 (en) 1997-11-20
EP0923308B1 (en) 2002-09-18
ATE224145T1 (de) 2002-10-15
DE69715641T2 (de) 2003-08-07

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