ATE224371T1 - N-substituierte beta-aryl und beta-heteroaryl- alpha-cyamoacrylamidderivate als tyrosine kinase inhibitoren - Google Patents
N-substituierte beta-aryl und beta-heteroaryl- alpha-cyamoacrylamidderivate als tyrosine kinase inhibitorenInfo
- Publication number
- ATE224371T1 ATE224371T1 AT95910542T AT95910542T ATE224371T1 AT E224371 T1 ATE224371 T1 AT E224371T1 AT 95910542 T AT95910542 T AT 95910542T AT 95910542 T AT95910542 T AT 95910542T AT E224371 T1 ATE224371 T1 AT E224371T1
- Authority
- AT
- Austria
- Prior art keywords
- beta
- alkyl
- pct
- hydrogen
- tyrosine kinase
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
- C07D215/24—Oxygen atoms attached in position 8
- C07D215/26—Alcohols; Ethers thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
- C07C255/32—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring
- C07C255/41—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring the carbon skeleton being further substituted by carboxyl groups, other than cyano groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/12—Radicals substituted by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/12—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
- C07D217/14—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
- C07D217/14—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals
- C07D217/16—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals substituted by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/04—One of the condensed rings being a six-membered aromatic ring
- C07C2602/10—One of the condensed rings being a six-membered aromatic ring the other ring being six-membered, e.g. tetraline
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Transplantation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Indole Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pyridine Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Quinoline Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB9406137A GB9406137D0 (en) | 1994-03-28 | 1994-03-28 | N-substituted beta-aryl- and betaheteroaryl-alpha-cyanoacrylamide derivatives and process for their preparation |
| PCT/EP1995/000758 WO1995026341A1 (en) | 1994-03-28 | 1995-03-02 | Substituted beta-aryl and beta-heteroaryl-alpha-cyanoacrylamide derivatives as tyrosine kinase inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE224371T1 true ATE224371T1 (de) | 2002-10-15 |
Family
ID=10752648
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT95910542T ATE224371T1 (de) | 1994-03-28 | 1995-03-02 | N-substituierte beta-aryl und beta-heteroaryl- alpha-cyamoacrylamidderivate als tyrosine kinase inhibitoren |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US5652250A (de) |
| EP (1) | EP0700388B1 (de) |
| JP (1) | JPH08511562A (de) |
| KR (1) | KR960702442A (de) |
| CN (1) | CN1125942A (de) |
| AT (1) | ATE224371T1 (de) |
| AU (1) | AU685599B2 (de) |
| DE (1) | DE69528229T2 (de) |
| ES (1) | ES2183866T3 (de) |
| FI (1) | FI955661L (de) |
| GB (1) | GB9406137D0 (de) |
| HU (1) | HUT73811A (de) |
| IL (1) | IL113044A0 (de) |
| MX (1) | MX9504895A (de) |
| MY (1) | MY130160A (de) |
| NO (1) | NO954692D0 (de) |
| NZ (1) | NZ281630A (de) |
| PL (1) | PL311745A1 (de) |
| TW (1) | TW347386B (de) |
| WO (1) | WO1995026341A1 (de) |
| ZA (1) | ZA952423B (de) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9613021D0 (en) * | 1996-06-21 | 1996-08-28 | Pharmacia Spa | Bicyclic 4-aralkylaminopyrimidine derivatives as tyrosine kinase inhibitors |
| AU3577997A (en) * | 1996-06-24 | 1998-01-14 | Irori | Solid phase tyrphostin library linked to matrices with memories |
| WO1999043636A2 (en) | 1998-02-27 | 1999-09-02 | The United States Of America As Represented By Thesecretary Of The Department Of Health And Human Services | Disubstituted lavendustin a analogs and pharmaceutical compositions comprising the analogs |
| HUP0000920A3 (en) * | 2000-02-28 | 2002-03-28 | Sanofi Synthelabo | Pde4 inhibitor isoquinolinylidene derivatives, process for their preparation and medicaments containing them |
| EP1752446A3 (de) * | 2000-04-13 | 2007-03-21 | HSC Research and Development Limited Partnership | Verbindungen für die Modulation der Proliferation von Zellen |
| RU2277531C9 (ru) * | 2000-04-13 | 2006-11-20 | Эйч Эс Си Рисерч Энд Дивелопмент Лимитед Партнершип | Новые соединения для модулирования клеточной пролиферации |
| EP1453500A1 (de) * | 2001-10-11 | 2004-09-08 | The Hospital For Sick Children | Styrol-acrylnitril derivate und ihre verwendung zur förderung von myelopoiesis |
| PT1701941E (pt) * | 2003-12-11 | 2012-08-03 | Univ Texas | Compostos para o tratamento de doenças proliferativas celulares |
| US7598419B2 (en) | 2004-03-26 | 2009-10-06 | Hsc Research And Development Limited Partnership | Compounds for modulating cell proliferation |
| US20100292229A1 (en) * | 2006-06-30 | 2010-11-18 | The Board Of Regents Of The University Of Texas System | Tryphostin-analogs for the treatment of cell proliferative diseases |
| JP5675606B2 (ja) | 2008-07-08 | 2015-02-25 | ボード・オブ・リージエンツ，ザ・ユニバーシテイ・オブ・テキサス・システム | シグナル伝達性転写因子（ｓｔａｔ）の増殖及び活性化の新規の抑制剤 |
| MX2012005678A (es) | 2009-11-16 | 2012-09-07 | Univ California | Enhibidores de cinasas. |
| WO2012136120A1 (zh) * | 2011-04-02 | 2012-10-11 | 中国人民解放军军事医学科学院毒物药物研究所 | 芳基丙烯酰胺化合物及其用于制备免疫抑制剂的用途 |
| HUE048834T2 (hu) * | 2011-05-17 | 2020-08-28 | Univ California | Kináz inhibitorok |
| US10214476B2 (en) * | 2011-12-30 | 2019-02-26 | Ecole Nationale Superieure De Chimie De Clermont Ferrand | Pain relief compounds |
| CA2927023C (en) * | 2013-10-10 | 2022-08-02 | The Regents Of The University Of Michigan | Deubiquitinase inhibitors and methods for use of the same |
| CN108276366B (zh) * | 2018-01-08 | 2021-09-03 | 四川大学 | 一种丙烯酰胺类衍生物及其制备方法与应用 |
| EP4104901A1 (de) * | 2021-06-15 | 2022-12-21 | Lead Discovery Center GmbH | 3-substituierte 1h-pyrrolo[2,3-b]pyridine als grk5-modulatoren |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9000950D0 (en) * | 1990-01-16 | 1990-03-14 | Erba Carlo Spa | New arylvinylamide derivatives and process for their preparation |
| GB9000939D0 (en) * | 1990-01-16 | 1990-03-14 | Erba Carlo Spa | Improvement in the total synthesis of erbstatin analogs |
| GB9004483D0 (en) * | 1990-02-28 | 1990-04-25 | Erba Carlo Spa | New aryl-and heteroarylethenylene derivatives and process for their preparation |
| US5196446A (en) * | 1990-04-16 | 1993-03-23 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Certain indole compounds which inhibit EGF receptor tyrosine kinase |
| EP0527181A4 (en) * | 1990-04-16 | 1993-04-07 | Rorer International (Holdings) | Heterocyclicethenediyl compounds which inhibit egf receptor tyrosine kinase |
| GB9115160D0 (en) * | 1991-07-12 | 1991-08-28 | Erba Carlo Spa | Methylen-oxindole derivatives and process for their preparation |
| CA2080554A1 (en) * | 1991-10-15 | 1993-04-16 | Mitsubishi Chemical Corporation | Styrene derivatives |
| GB9204945D0 (en) * | 1992-03-06 | 1992-04-22 | Erba Carlo Spa | 3-aryl-glycidic ester derivatives and process for their preparation |
| GB9226855D0 (en) * | 1992-12-23 | 1993-02-17 | Erba Carlo Spa | Vinylene-azaindole derivatives and process for their preparation |
-
1994
- 1994-03-28 GB GB9406137A patent/GB9406137D0/en active Pending
-
1995
- 1995-03-02 US US08/537,947 patent/US5652250A/en not_active Expired - Fee Related
- 1995-03-02 JP JP7524920A patent/JPH08511562A/ja not_active Ceased
- 1995-03-02 FI FI955661A patent/FI955661L/fi not_active Application Discontinuation
- 1995-03-02 AT AT95910542T patent/ATE224371T1/de not_active IP Right Cessation
- 1995-03-02 ES ES95910542T patent/ES2183866T3/es not_active Expired - Lifetime
- 1995-03-02 DE DE69528229T patent/DE69528229T2/de not_active Expired - Fee Related
- 1995-03-02 AU AU18498/95A patent/AU685599B2/en not_active Expired - Fee Related
- 1995-03-02 CN CN95190227A patent/CN1125942A/zh active Pending
- 1995-03-02 EP EP95910542A patent/EP0700388B1/de not_active Expired - Lifetime
- 1995-03-02 WO PCT/EP1995/000758 patent/WO1995026341A1/en not_active Ceased
- 1995-03-02 HU HU9503714A patent/HUT73811A/hu unknown
- 1995-03-02 NZ NZ281630A patent/NZ281630A/en unknown
- 1995-03-02 MX MX9504895A patent/MX9504895A/es unknown
- 1995-03-02 PL PL95311745A patent/PL311745A1/xx unknown
- 1995-03-02 KR KR1019950705290A patent/KR960702442A/ko not_active Withdrawn
- 1995-03-15 MY MYPI95000645A patent/MY130160A/en unknown
- 1995-03-20 IL IL11304495A patent/IL113044A0/xx unknown
- 1995-03-23 TW TW084102825A patent/TW347386B/zh active
- 1995-03-24 ZA ZA952423A patent/ZA952423B/xx unknown
- 1995-11-20 NO NO954692A patent/NO954692D0/no unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP0700388A1 (de) | 1996-03-13 |
| FI955661A7 (fi) | 1996-01-19 |
| AU685599B2 (en) | 1998-01-22 |
| US5652250A (en) | 1997-07-29 |
| GB9406137D0 (en) | 1994-05-18 |
| FI955661L (fi) | 1996-01-19 |
| HUT73811A (en) | 1996-09-30 |
| EP0700388B1 (de) | 2002-09-18 |
| ES2183866T3 (es) | 2003-04-01 |
| ZA952423B (en) | 1995-12-19 |
| MX9504895A (es) | 1998-03-31 |
| HU9503714D0 (en) | 1996-02-28 |
| NZ281630A (en) | 1998-02-26 |
| KR960702442A (ko) | 1996-04-27 |
| AU1849895A (en) | 1995-10-17 |
| NO954692L (no) | 1995-11-20 |
| IL113044A0 (en) | 1995-06-29 |
| WO1995026341A1 (en) | 1995-10-05 |
| JPH08511562A (ja) | 1996-12-03 |
| DE69528229T2 (de) | 2003-08-14 |
| MY130160A (en) | 2007-06-29 |
| NO954692D0 (no) | 1995-11-20 |
| DE69528229D1 (en) | 2002-10-24 |
| FI955661A0 (fi) | 1995-11-24 |
| CN1125942A (zh) | 1996-07-03 |
| TW347386B (en) | 1998-12-11 |
| PL311745A1 (en) | 1996-03-18 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DE69528229D1 (en) | N-substituierte beta-aryl und beta-heteroaryl-alpha-cyamoacrylamidderivate als tyrosine kinase inhibitoren | |
| NO953146L (no) | Biologisk aktive 3-substituerte oksindolderivater som er nyttige som antiangiogeniske midler | |
| CA2053253A1 (en) | New aryl-and heteroarylethenylene derivatives and process for their preparation | |
| NO986055D0 (no) | Nye heterocykliske forbindelser, deres fremstilling, farmas÷ytiske preparat | |
| CA2160444A1 (en) | Aroyl-piperdine derivatives | |
| DK0641328T3 (da) | Broforbundne, azabicykliske derivater som substans P-antagonister | |
| ATE206420T1 (de) | Methylenoxindolderivate und verfahren zu ihrer herstellung | |
| DK0677046T3 (da) | Piperazinderivater som 5-HT-antagonister. | |
| EA199800170A1 (ru) | Производные 2-(4-замещенного)бензиламино-2-метилпропанамида | |
| CA2135783A1 (en) | Substituted (arylalkoxybenzyl) amino-propanamide derivatives and process for their preparation | |
| GB9306899D0 (en) | Substituted (arylalkylaminobenzyl) aminopropionamide derivatives and process for their preparation | |
| YU78100A (sh) | 4,5,6 i 7-indol i indolin derivati, njihova izrada i upotreba | |
| CA2163115A1 (en) | N-substituted beta-aryl- and beta-heteroaryl-alpha-cyanoacrylamide derivatives and process for their preparation | |
| ATE505463T1 (de) | Benzodiazepin-derivate, verwendbar als cck- rezeptor antagonisten | |
| ES2056025A1 (es) | Nuevos derivados de indol. | |
| HK1018456A1 (en) | Process for the preparation of n-[2-(dimethylamino)ethyl]acridine-4-carboxamide used as anti cancer compounds |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |