NO953146L - Biologisk aktive 3-substituerte oksindolderivater som er nyttige som antiangiogeniske midler - Google Patents

Biologisk aktive 3-substituerte oksindolderivater som er nyttige som antiangiogeniske midler

Info

Publication number
NO953146L
NO953146L NO953146A NO953146A NO953146L NO 953146 L NO953146 L NO 953146L NO 953146 A NO953146 A NO 953146A NO 953146 A NO953146 A NO 953146A NO 953146 L NO953146 L NO 953146L
Authority
NO
Norway
Prior art keywords
hydrogen
alkyl
halogen
tetralin
isoquinoline
Prior art date
Application number
NO953146A
Other languages
English (en)
Other versions
NO953146D0 (no
Inventor
Franco Buzzetti
Antonio Longo
Maria Gabriella Brasca
Fabrizio Orzi
Angelo Crugnola
Dario Ballinari
Mariangela Mariani
Original Assignee
Pharmacia Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia Spa filed Critical Pharmacia Spa
Publication of NO953146D0 publication Critical patent/NO953146D0/no
Publication of NO953146L publication Critical patent/NO953146L/no

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A61K31/405—Indole-alkanecarboxylic acids; Derivatives thereof, e.g. tryptophan, indomethacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/475—Quinolines; Isoquinolines having an indole ring, e.g. yohimbine, reserpine, strychnine, vinblastine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Indole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Ny anvendelse av en forbindelse av formelen: CH (D hvor Y er en bicyklisk ring valgt fra naftalen, tetralin, kinolin, isokinolin og indol; n er O eller et helt tall fra l til 3; R! er hydrogen, CpCg alkyl eller C2-C6 alkanoyl; R2 er hydrogen, halogen, Cj-Cg alkyl. cyano, karboksy, nitro eller NHR, hvor R er hydrogen eller GI-Cg alkyl: R3 er hydrogen eller Cj-Cg alkyl; R4 er hydrogen, hydroksy, Ci-Cg alkoksy, C2-Cg alkanoyloksy. karboksy, nitro eller NHR, hvor R er som definert ovenfor; R5 er hydrogen, GI-Cg alkyl eller halogen; eller et farmasøytisk akseptabelt salt derav; og hvor, når Y er naftalen. så er n O eller eller et helt tall fra l til 3, mens når Y er tetralin, kinolin, isokinolin eller indol så er n O, l eller 2; og hvor, når den bicykliske ringen Y er naftalen, kinolin, isokinolin eller indol, så kan hver av substituemene ORj, R2 og oksindolyliden uavhengig være på hvilken som helst av aryl- eller heteroarylgruppedelene i den bicykliske ringen, mens bare henzengruppedelen er substituert når Y er tetralin; og hvor, når Y er naftalen, tetralin, kinolin eller isokinolin, så er R2 hydrogen, halogen, cyano eller Cj-Cg alkyl og R3, R4 og Rf er hydrogen; mens når Y er indol så er R2 hydrogen, halogen, Cj-Cg alkyl, cyano, karboksy, nitro, eller - NHR, hvor R er som definert ovenfor, R3 er hydrogen eller Ci-Cg alkyl. R$ er hydrogen, hydroksy, Cj-Cg alkoksy, C2-Cg alkanoyloksy, karboksy, nitro eller -NHR, hvor R er som definert ovenfor, og RS er hydrogen, halogen eller Cj- Cg alkyl; som antiangiogenisk middel.
NO953146A 1993-12-22 1995-08-10 Biologisk aktive 3-substituerte oksindolderivater som er nyttige som antiangiogeniske midler NO953146L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB939326136A GB9326136D0 (en) 1993-12-22 1993-12-22 Biologically active 3-substituted oxindole derivatives useful as anti-angiogenic agents
PCT/EP1994/003664 WO1995017181A1 (en) 1993-12-22 1994-11-08 Biologically active 3-substituted oxindole derivatives useful as anti-angiogenic agents

Publications (2)

Publication Number Publication Date
NO953146D0 NO953146D0 (no) 1995-08-10
NO953146L true NO953146L (no) 1995-08-10

Family

ID=10746990

Family Applications (1)

Application Number Title Priority Date Filing Date
NO953146A NO953146L (no) 1993-12-22 1995-08-10 Biologisk aktive 3-substituerte oksindolderivater som er nyttige som antiangiogeniske midler

Country Status (17)

Country Link
US (1) US5576330A (no)
EP (1) EP0684820B1 (no)
JP (1) JPH08507089A (no)
KR (1) KR960700707A (no)
AT (1) ATE204168T1 (no)
AU (1) AU676958B2 (no)
CA (1) CA2155098A1 (no)
DE (1) DE69427962T2 (no)
ES (1) ES2162871T3 (no)
GB (1) GB9326136D0 (no)
HU (1) HUT73176A (no)
IL (1) IL112010A (no)
NO (1) NO953146L (no)
PL (1) PL310379A1 (no)
TW (1) TW273510B (no)
WO (1) WO1995017181A1 (no)
ZA (1) ZA9410204B (no)

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Also Published As

Publication number Publication date
ZA9410204B (en) 1995-11-10
TW273510B (no) 1996-04-01
ES2162871T3 (es) 2002-01-16
NO953146D0 (no) 1995-08-10
HUT73176A (en) 1996-06-28
DE69427962T2 (de) 2002-04-04
JPH08507089A (ja) 1996-07-30
KR960700707A (ko) 1996-02-24
EP0684820A1 (en) 1995-12-06
IL112010A (en) 1998-10-30
EP0684820B1 (en) 2001-08-16
PL310379A1 (en) 1995-12-11
DE69427962D1 (de) 2001-09-20
AU676958B2 (en) 1997-03-27
CA2155098A1 (en) 1995-06-29
US5576330A (en) 1996-11-19
HU9502761D0 (en) 1995-11-28
IL112010A0 (en) 1995-03-15
GB9326136D0 (en) 1994-02-23
WO1995017181A1 (en) 1995-06-29
AU8061294A (en) 1995-07-10
ATE204168T1 (de) 2001-09-15

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