ATE224957T1 - Neue nukleinsaure-polymer komplexe, verfahren zur deren herstellung und verwendung zur transfektion von zellen - Google Patents
Neue nukleinsaure-polymer komplexe, verfahren zur deren herstellung und verwendung zur transfektion von zellenInfo
- Publication number
- ATE224957T1 ATE224957T1 AT95918049T AT95918049T ATE224957T1 AT E224957 T1 ATE224957 T1 AT E224957T1 AT 95918049 T AT95918049 T AT 95918049T AT 95918049 T AT95918049 T AT 95918049T AT E224957 T1 ATE224957 T1 AT E224957T1
- Authority
- AT
- Austria
- Prior art keywords
- polymeric conjugate
- functions
- free
- nucleic acid
- residues
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
- A61K47/645—Polycationic or polyanionic oligopeptides, polypeptides or polyamino acids, e.g. polylysine, polyarginine, polyglutamic acid or peptide TAT
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Biochemistry (AREA)
- Public Health (AREA)
- Plant Pathology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Microbiology (AREA)
- Veterinary Medicine (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
- Medicinal Preparation (AREA)
- Saccharide Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR9405174A FR2719316B1 (fr) | 1994-04-28 | 1994-04-28 | Nouveaux complexes d'acide nucléique et de polymère, leur procédé de préparation et leur utilisation pour la transfection de cellules. |
| PCT/FR1995/000535 WO1995030020A1 (fr) | 1994-04-28 | 1995-04-24 | Nouveaux complexes d'acide nucleique et de polymere, leur procede de preparation et leur utilisation pour la transfection de cellules |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE224957T1 true ATE224957T1 (de) | 2002-10-15 |
Family
ID=9462633
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT95918049T ATE224957T1 (de) | 1994-04-28 | 1995-04-24 | Neue nukleinsaure-polymer komplexe, verfahren zur deren herstellung und verwendung zur transfektion von zellen |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US5595897A (de) |
| EP (1) | EP0753070B1 (de) |
| AT (1) | ATE224957T1 (de) |
| AU (1) | AU695056B2 (de) |
| CA (1) | CA2187629C (de) |
| DE (1) | DE69528363T2 (de) |
| ES (1) | ES2181775T3 (de) |
| FR (1) | FR2719316B1 (de) |
| WO (1) | WO1995030020A1 (de) |
Families Citing this family (45)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5674908A (en) | 1993-12-20 | 1997-10-07 | Life Technologies, Inc. | Highly packed polycationic ammonium, sulfonium and phosphonium lipids |
| US6989434B1 (en) * | 1994-02-11 | 2006-01-24 | Invitrogen Corporation | Reagents for intracellular delivery of macromolecules |
| US5733762A (en) * | 1994-04-28 | 1998-03-31 | I.D.M. Immuno-Designed Molecules | Complexes of nucleic acid and polymer, their process of preparation and their use for the transfection of cells |
| US5795587A (en) * | 1995-01-23 | 1998-08-18 | University Of Pittsburgh | Stable lipid-comprising drug delivery complexes and methods for their production |
| US20030069173A1 (en) * | 1998-03-16 | 2003-04-10 | Life Technologies, Inc. | Peptide-enhanced transfections |
| US5780448A (en) * | 1995-11-07 | 1998-07-14 | Ottawa Civic Hospital Loeb Research | DNA-based vaccination of fish |
| EP0775751A3 (de) * | 1995-11-22 | 1998-06-10 | F. Hoffmann-La Roche Ag | Zelltransfektion |
| WO1997045069A1 (en) * | 1996-05-29 | 1997-12-04 | Cell Genesys, Inc. | Cationic polymer/lipid nucleic acid delivery vehicles |
| US5948681A (en) * | 1996-08-14 | 1999-09-07 | Children's Hospital Of Philadelphia | Non-viral vehicles for use in gene transfer |
| DE69736163T2 (de) * | 1996-11-04 | 2007-05-03 | Ottawa Health Research Institute, Ottawa | Verfahren zur Expression von Polypeptide in Fischen durch eintauchen in eine plasmid DNA enthaltende Lösung |
| FR2755976B1 (fr) * | 1996-11-15 | 1999-01-15 | Idm Immuno Designed Molecules | Nouveaux complexes d'acides nucleiques et de polymere substitue par des residus entrainant la destabilisation des membranes cellulaires |
| US6919076B1 (en) | 1998-01-20 | 2005-07-19 | Pericor Science, Inc. | Conjugates of agents and transglutaminase substrate linking molecules |
| US6958148B1 (en) | 1998-01-20 | 2005-10-25 | Pericor Science, Inc. | Linkage of agents to body tissue using microparticles and transglutaminase |
| WO1999040771A2 (en) * | 1998-02-13 | 1999-08-19 | Selective Genetics, Inc. | Concurrent flow mixing for preparing compositions comprising gene therapy vectors |
| NZ512244A (en) | 1998-11-12 | 2003-12-19 | Invitrogen Corp | Polycationic transfection reagents for introducing anions into a cell |
| US6358697B2 (en) | 1999-04-21 | 2002-03-19 | Children's Hospital Medical Center | Intracellular pharmaceutical targeting |
| FR2797402B1 (fr) | 1999-07-15 | 2004-03-12 | Biomerieux Stelhys | Utilisation d'un polypeptide pour detecter, prevenir ou traiter un etat pathologique associe a une maladie degenerative, neurologique ou autoimmune |
| IL131074A0 (en) | 1999-07-23 | 2001-03-19 | Polygene Ltd | A biodegradable polycation composition for delivery of an anionic macromolecule |
| US7713739B1 (en) * | 2000-11-17 | 2010-05-11 | Novartis Vaccines And Diagnostics, Inc. | Microparticle-based transfection and activation of dendritic cells |
| EP1235900B1 (de) * | 1999-11-19 | 2006-07-05 | Chiron Corporation | Transfektion and aktivierung von dendritischen zellen durch mikropartikel |
| EP1156832A1 (de) | 1999-12-28 | 2001-11-28 | Transgene S.A. | Die verwendung von lithium (li+) zur präparation einer zusammensetzung für die transformation eines polynukleotides in eine zelle und zusammensetzungen für die gentherapie |
| WO2001060415A1 (en) * | 2000-02-18 | 2001-08-23 | The Immune Response Corporation | Methods and compositions for gene delivery |
| MXPA02008637A (es) | 2000-03-02 | 2004-09-06 | Ml Lab Plc | Elemento de respuesta a factor de celulas t. |
| JP2004508023A (ja) * | 2000-09-08 | 2004-03-18 | インビトロジェン コーポレイション | 核酸合成の感度および特異性を増強するための化合物および方法 |
| RU2005102604A (ru) * | 2002-07-03 | 2005-09-10 | Перикор Сайенс, Инк. (Us) | Композиция гиалуроновой кислоты и способы применения |
| CA2513072A1 (en) * | 2003-01-09 | 2004-07-29 | Invitrogen Corporation | Cellular delivery and activation polypeptide-nucleic acid complexes |
| AU2004260935A1 (en) * | 2003-06-30 | 2005-02-10 | Canji, Inc. | Polymer encapsulation of adenoviruses |
| WO2008036929A2 (en) * | 2006-09-21 | 2008-03-27 | Alnylam Pharmaceuticals, Inc. | Complex for transferring an anionic substance into a cell |
| KR20100071985A (ko) * | 2007-09-11 | 2010-06-29 | 몬도바이오테크 래보래토리즈 아게 | 치료제로서의 데펜신 펩티드의 용도 |
| GB0724253D0 (en) * | 2007-12-12 | 2008-01-30 | Fermentas Uab | Transfection reagent |
| FR2928373B1 (fr) * | 2008-03-05 | 2010-12-31 | Centre Nat Rech Scient | Polymere derive de la polyethylenimine lineaire pour le transfert de gene. |
| US9856456B2 (en) | 2009-10-12 | 2018-01-02 | Thermo Fisher Scientific Baltics Uab | Delivery agent |
| ES2640906T3 (es) | 2010-03-24 | 2017-11-07 | Institut National De La Sante Et De La Recherche Medicale | Modelo primate de la familia de los cercopitécidos infectado por una cepa del VHB de genotipo humano |
| EP3169310A1 (de) | 2014-07-15 | 2017-05-24 | Life Technologies Corporation | Zusammensetzungen mit lipidaggregaten und verfahren zur effizienten bereitstellung von molekülen an zellen |
| US11826423B2 (en) | 2016-11-16 | 2023-11-28 | Immunomic Therapeutics, Inc. | Nucleic acids for treatment of allergies |
| IL270024B2 (en) | 2017-04-22 | 2025-04-01 | Immunomic Therapeutics Inc | LAMP structures and their use in vaccination |
| KR20200016224A (ko) | 2017-05-02 | 2020-02-14 | 이뮤노믹 쎄라퓨틱스, 인크. | 암 항원을 포함하는 lamp (리소솜 연관 막 단백질) 구축물 |
| EP3793595A1 (de) | 2018-05-15 | 2021-03-24 | Immunomic Therapeutics, Inc. | Verbesserte lamp-konstrukte mit allergenen |
| TWI852977B (zh) | 2019-01-10 | 2024-08-21 | 美商健生生物科技公司 | 前列腺新抗原及其用途 |
| JP2022551732A (ja) | 2019-10-18 | 2022-12-13 | イミュノミック セラピューティックス， インコーポレイテッド | がん抗原を含む改良ｌａｍｐ構築物 |
| CR20220220A (es) | 2019-11-18 | 2022-09-20 | Janssen Biotech Inc | Vacunas basadas en calr y jak2 mutantes y sus usos |
| US20230024133A1 (en) | 2020-07-06 | 2023-01-26 | Janssen Biotech, Inc. | Prostate Neoantigens And Their Uses |
| US20230035403A1 (en) | 2020-07-06 | 2023-02-02 | Janssen Biotech, Inc. | Method For Determining Responsiveness To Prostate Cancer Treatment |
| EP4175664A2 (de) | 2020-07-06 | 2023-05-10 | Janssen Biotech, Inc. | Prostata-neoantigene und ihre verwendungen |
| EP4508071A1 (de) | 2022-04-10 | 2025-02-19 | Immunomic Therapeutics, Inc. | Bicistronische lampenkonstrukte mit immunreaktionserhöhenden genen und verfahren zur verwendung davon |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4104186A1 (de) * | 1991-02-12 | 1992-08-13 | Genentech Inc | Neue, ueber endozytose in hoehere eukaryotische zellen aufnehmbare, nukleinsaeure enthaltende komplexe |
-
1994
- 1994-04-28 FR FR9405174A patent/FR2719316B1/fr not_active Expired - Fee Related
- 1994-08-10 US US08/288,681 patent/US5595897A/en not_active Expired - Fee Related
-
1995
- 1995-04-24 CA CA002187629A patent/CA2187629C/fr not_active Expired - Fee Related
- 1995-04-24 AT AT95918049T patent/ATE224957T1/de not_active IP Right Cessation
- 1995-04-24 ES ES95918049T patent/ES2181775T3/es not_active Expired - Lifetime
- 1995-04-24 DE DE69528363T patent/DE69528363T2/de not_active Expired - Fee Related
- 1995-04-24 EP EP95918049A patent/EP0753070B1/de not_active Expired - Lifetime
- 1995-04-24 WO PCT/FR1995/000535 patent/WO1995030020A1/fr not_active Ceased
- 1995-04-24 AU AU24128/95A patent/AU695056B2/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| DE69528363T2 (de) | 2003-05-15 |
| US5595897A (en) | 1997-01-21 |
| EP0753070B1 (de) | 2002-09-25 |
| FR2719316A1 (fr) | 1995-11-03 |
| CA2187629C (fr) | 2004-09-21 |
| ES2181775T3 (es) | 2003-03-01 |
| DE69528363D1 (de) | 2002-10-31 |
| AU2412895A (en) | 1995-11-29 |
| WO1995030020A1 (fr) | 1995-11-09 |
| EP0753070A1 (de) | 1997-01-15 |
| FR2719316B1 (fr) | 1996-05-31 |
| CA2187629A1 (fr) | 1995-11-09 |
| AU695056B2 (en) | 1998-08-06 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |