ATE225680T1 - Reaktor und verfahren für die festphasen-synthese von peptiden - Google Patents

Reaktor und verfahren für die festphasen-synthese von peptiden

Info

Publication number: ATE225680T1
Authority: AT; Austria
Prior art keywords: reactor; basket; solutions; pct; resin cake
Prior art date: 1997-02-11

Application number

AT98905049T

Other languages

English (en)

Inventor

Nicholas Stepaniuk

Keith Tomazi

Michael C Stapleton

Original Assignee

Mallinckrodt Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-02-11

Filing date

1998-02-10

Publication date

2002-10-15

1998-02-10 Application filed by Mallinckrodt Inc filed Critical Mallinckrodt Inc

2002-10-15 Application granted granted Critical

2002-10-15 Publication of ATE225680T1 publication Critical patent/ATE225680T1/de

Links

238000000034 method Methods 0.000 title abstract 3
108090000765 processed proteins & peptides Proteins 0.000 title abstract 2
102000004196 processed proteins & peptides Human genes 0.000 title 1
238000010532 solid phase synthesis reaction Methods 0.000 title 1
239000011347 resin Substances 0.000 abstract 4
229920005989 resin Polymers 0.000 abstract 4
239000012530 fluid Substances 0.000 abstract 2
238000010647 peptide synthesis reaction Methods 0.000 abstract 2
238000009987 spinning Methods 0.000 abstract 2
150000001413 amino acids Chemical class 0.000 abstract 1
239000007788 liquid Substances 0.000 abstract 1
239000007790 solid phase Substances 0.000 abstract 1
238000005507 spraying Methods 0.000 abstract 1

Classifications

- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J19/0046—Sequential or parallel reactions, e.g. for the synthesis of polypeptides or polynucleotides; Apparatus and devices for combinatorial chemistry or for making molecular arrays
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
- C07K1/045—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers using devices to improve synthesis, e.g. reactors, special vessels
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00277—Apparatus
- B01J2219/00279—Features relating to reactor vessels
- B01J2219/00281—Individual reactor vessels
- B01J2219/00283—Reactor vessels with top opening
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00277—Apparatus
- B01J2219/00279—Features relating to reactor vessels
- B01J2219/00281—Individual reactor vessels
- B01J2219/00295—Individual reactor vessels the reactor vessels having pervious side walls
- B01J2219/00299—Generally cylindrical reactor vessels
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00277—Apparatus
- B01J2219/00351—Means for dispensing and evacuation of reagents
- B01J2219/00353—Pumps
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00277—Apparatus
- B01J2219/00351—Means for dispensing and evacuation of reagents
- B01J2219/00421—Means for dispensing and evacuation of reagents using centrifugation
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00277—Apparatus
- B01J2219/00351—Means for dispensing and evacuation of reagents
- B01J2219/00423—Means for dispensing and evacuation of reagents using filtration, e.g. through porous frits
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00277—Apparatus
- B01J2219/00457—Dispensing or evacuation of the solid phase support
- B01J2219/00459—Beads
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00277—Apparatus
- B01J2219/00457—Dispensing or evacuation of the solid phase support
- B01J2219/00459—Beads
- B01J2219/00466—Beads in a slurry
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00277—Apparatus
- B01J2219/00479—Means for mixing reactants or products in the reaction vessels
- B01J2219/00488—Means for mixing reactants or products in the reaction vessels by rotation of the reaction vessels
- B01J2219/0049—Means for mixing reactants or products in the reaction vessels by rotation of the reaction vessels by centrifugation
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00277—Apparatus
- B01J2219/00497—Features relating to the solid phase supports
- B01J2219/005—Beads
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00583—Features relative to the processes being carried out
- B01J2219/0059—Sequential processes
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00583—Features relative to the processes being carried out
- B01J2219/00596—Solid-phase processes
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/0068—Means for controlling the apparatus of the process
- B01J2219/00686—Automatic
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/0068—Means for controlling the apparatus of the process
- B01J2219/00698—Measurement and control of process parameters
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00718—Type of compounds synthesised
- B01J2219/0072—Organic compounds
- B01J2219/00725—Peptides
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B40/00—Libraries per se, e.g. arrays, mixtures
- C40B40/04—Libraries containing only organic compounds
- C40B40/10—Libraries containing peptides or polypeptides, or derivatives thereof
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B60/00—Apparatus specially adapted for use in combinatorial chemistry or with libraries
- C40B60/14—Apparatus specially adapted for use in combinatorial chemistry or with libraries for creating libraries

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Medicinal Chemistry (AREA)
Molecular Biology (AREA)
Biochemistry (AREA)
Biophysics (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Analytical Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
Peptides Or Proteins (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Catalysts (AREA)
Physical Or Chemical Processes And Apparatus (AREA)
Devices And Processes Conducted In The Presence Of Fluids And Solid Particles (AREA)

AT98905049T 1997-02-11 1998-02-10 Reaktor und verfahren für die festphasen-synthese von peptiden ATE225680T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US3755797P	1997-02-11	1997-02-11
PCT/US1998/002634 WO1998034633A1 (en)	1997-02-11	1998-02-10	Reactor and method for solid phase peptide synthesis

Publications (1)

Publication Number	Publication Date
ATE225680T1 true ATE225680T1 (de)	2002-10-15

Family

ID=21894987

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT98905049T ATE225680T1 (de)	1997-02-11	1998-02-10	Reaktor und verfahren für die festphasen-synthese von peptiden

Country Status (16)

Country	Link
US (1)	US6028172A (de)
EP (1)	EP0909176B1 (de)
JP (1)	JP2000511934A (de)
KR (1)	KR100463630B1 (de)
CN (1)	CN1171634C (de)
AT (1)	ATE225680T1 (de)
AU (1)	AU724694B2 (de)
CA (1)	CA2250784C (de)
CZ (1)	CZ294838B6 (de)
DE (1)	DE69808579T2 (de)
DK (1)	DK0909176T3 (de)
HU (1)	HU226994B1 (de)
IL (1)	IL126456A (de)
NO (1)	NO984611L (de)
NZ (1)	NZ332174A (de)
WO (1)	WO1998034633A1 (de)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP1184649A1 (de) *	2000-09-04	2002-03-06	Eidgenössische Technische Hochschule Zürich	Kalorimeter
JP4297751B2 (ja) *	2002-07-12	2009-07-15	株式会社荏原製作所	固体反応剤
US7902488B2 (en) *	2003-06-23	2011-03-08	Cem Corporation	Microwave-assisted peptide synthesis
US7393920B2 (en)	2003-06-23	2008-07-01	Cem Corporation	Microwave-assisted peptide synthesis
CA2582769A1 (en) *	2004-10-12	2006-04-20	F. Hoffmann-La Roche Ag	Solid phase peptide sythesis
US20060105349A1 (en) *	2004-11-12	2006-05-18	Promega Corporation	Device and method for purification of biological materials
US20060105391A1 (en) *	2004-11-12	2006-05-18	Promega Corporation	Device and method for separating molecules
WO2008044890A1 (en) *	2006-10-12	2008-04-17	Dong Kook Pharm. Co., Ltd	A method for preparing peptides using by solid phase synthesis
KR101014799B1 (ko) *	2008-06-05	2011-02-15	애니젠 주식회사	펩타이드 합성 제조 장치
US8308955B2 (en) *	2009-07-20	2012-11-13	Empire Technology Development Llc	Carbon nanotube separation by reversible gelation
KR101227176B1 (ko) *	2010-02-05	2013-01-28	주식회사 부일켐텍	펩타이드 합성 제조장치
CN102702304B (zh) *	2012-05-11	2014-06-11	中南大学	多通路预活化装置、肽核酸制备系统及预活化和合成方法
EP2703073A1 (de) *	2012-08-31	2014-03-05	Biotage AB	Vorrichtung und Verfahren für die Festphasensynthese
US9695214B2 (en)	2013-03-15	2017-07-04	Massachusetts Institute Of Technology	Solid phase peptide synthesis processes and associated systems
US9169287B2 (en) *	2013-03-15	2015-10-27	Massachusetts Institute Of Technology	Solid phase peptide synthesis processes and associated systems
WO2017024407A1 (en)	2015-08-11	2017-02-16	The Royal Institution For The Advancement Of Learning/Mcgill University	Peptidic tgf-beta antagonists
JP7054922B2 (ja) *	2015-09-17	2022-04-15	マサチューセッツインスティテュートオブテクノロジー	固相ペプチド合成方法および関連するシステム
US10683325B2 (en)	2015-09-17	2020-06-16	Massachusetts Institute Of Technology	Methods and systems for solid phase peptide synthesis
WO2018057470A1 (en) *	2016-09-20	2018-03-29	C S Bio Co.	Rapid peptide synthesis at elevated temperatures
MX2019012025A (es) *	2017-04-06	2020-07-20	Mylan Inc	Inhalador de polvo de un solo uso de bajo costo.
AU2018253115B2 (en)	2017-04-12	2022-08-11	Edigene Biotechnology, Inc.	Aryl hydrocarbon receptor antagonists and uses thereof
US20190343885A1 (en)	2017-10-31	2019-11-14	Magenta Therapeutics Inc.	Compositions and methods for hematopoietic stem and progenitor cell transplant therapy
JP7412341B2 (ja)	2017-10-31	2024-01-12	エディジーンバイオテクノロジーインコーポレイテッド	造血幹細胞および前駆細胞の増幅のための組成物および方法
CN107881102B (zh) *	2017-11-23	2021-04-09	希施生物科技（上海）有限公司	一种用于核酸dna/rna生产型自动合成仪
CN111712262A (zh)	2017-12-06	2020-09-25	美真达治疗公司	用于动员造血干细胞和祖细胞的给药方案
AU2019205262A1 (en)	2018-01-03	2020-07-23	Magenta Therapeutics Inc.	Compositions and methods for the expansion of hematopoietic stem and progenitor cells and treatment of inherited metabolic disorders
CN112105628B (zh) *	2018-03-13	2025-04-04	耶路撒冷希伯来大学伊森姆研究发展有限公司	高剪切固相合成
CA3097005C (en) *	2018-05-04	2023-06-13	Polypeptide Laboratoires France	Automated synthesis reactor system with a recirculation loop
CN108752418B (zh) *	2018-08-08	2024-01-30	湖南科技学院	一种多通道多肽合成反应装置及其操作方法
CN111072749B (zh) *	2018-10-22	2023-07-07	海南建邦制药科技有限公司	多肽合成仪
JP6618133B1 (ja) *	2019-04-02	2019-12-11	ヤマト科学株式会社	固相合成装置
CN110111907A (zh) *	2019-05-10	2019-08-09	苏州市海崴生物科技有限公司	智能数字多肽合成系统
CN110283229A (zh) *	2019-07-24	2019-09-27	上海友尹化工科技有限公司	一种用于多肽药物的生产系统
WO2021087406A1 (en)	2019-11-01	2021-05-06	Magenta Therapeutics, Inc.	Dosing regimens for the mobilization of hematopoietic stem and progentor cells
SE548085C2 (en)	2020-03-17	2026-02-27	Peptisystems Ab	Peptide synthesis comprising pre-activation and recirculation of amino acids
EP4308694A1 (de)	2021-03-16	2024-01-24	Magenta Therapeutics, Inc.	Dosierschemata zur mobilisierung hämatopoetischer stammzellen für stammzelltransplantationen bei patienten mit multiplem myelom
WO2024137514A1 (en)	2022-12-22	2024-06-27	Synthego Corporation	Systems and method for automated oligonucleotide synthesis
CN115960159A (zh) *	2023-01-05	2023-04-14	希施生物科技（上海）有限公司	自动化免维护氨基酸输送路径的多肽合成仪

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE2017351C3 (de) *	1970-04-10	1974-10-10	Lkb Instrument Gmbh, 8032 Graefelfing	Verfahren und Reaktor für chemische Umsetzungen an unlöslichen Trägern mittels einer Reaktionsflüssigkeit
US4192798A (en) *	1978-11-20	1980-03-11	Bioresearch, Inc.	Rapid, large scale, automatable high pressure peptide synthesis
WO1990000932A1 (fr) *	1988-07-25	1990-02-08	Spetsialnoe Konstruktorskoe Bjuro Biologicheskogo Priborostroenia Akademii Nauk Sssr	Reacteur pour synthese en phase solide de biopolymeres
US5186824A (en) *	1991-09-04	1993-02-16	Large Scale Biology Corporation	System for solid phase reactions

1998
- 1998-02-10 US US09/155,798 patent/US6028172A/en not_active Expired - Fee Related
- 1998-02-10 CZ CZ19983178A patent/CZ294838B6/cs not_active IP Right Cessation
- 1998-02-10 IL IL12645698A patent/IL126456A/en not_active IP Right Cessation
- 1998-02-10 CN CNB988001268A patent/CN1171634C/zh not_active Expired - Fee Related
- 1998-02-10 WO PCT/US1998/002634 patent/WO1998034633A1/en not_active Ceased
- 1998-02-10 AU AU62763/98A patent/AU724694B2/en not_active Ceased
- 1998-02-10 JP JP10535043A patent/JP2000511934A/ja not_active Ceased
- 1998-02-10 HU HU9903753A patent/HU226994B1/hu not_active IP Right Cessation
- 1998-02-10 DE DE69808579T patent/DE69808579T2/de not_active Expired - Lifetime
- 1998-02-10 KR KR10-1998-0708194A patent/KR100463630B1/ko not_active Expired - Fee Related
- 1998-02-10 EP EP98905049A patent/EP0909176B1/de not_active Expired - Lifetime
- 1998-02-10 DK DK98905049T patent/DK0909176T3/da active
- 1998-02-10 AT AT98905049T patent/ATE225680T1/de not_active IP Right Cessation
- 1998-02-10 NZ NZ332174A patent/NZ332174A/xx unknown
- 1998-02-10 CA CA002250784A patent/CA2250784C/en not_active Expired - Fee Related
- 1998-10-02 NO NO984611A patent/NO984611L/no unknown

Also Published As

Publication number	Publication date
NO984611L (no)	1998-12-10
EP0909176A1 (de)	1999-04-21
IL126456A (en)	2001-05-20
EP0909176B1 (de)	2002-10-09
WO1998034633A1 (en)	1998-08-13
DE69808579D1 (de)	2002-11-14
US6028172A (en)	2000-02-22
NZ332174A (en)	1999-03-29
CN1171634C (zh)	2004-10-20
CZ317898A3 (cs)	1999-08-11
CA2250784A1 (en)	1998-08-13
AU6276398A (en)	1998-08-26
HUP9903753A2 (hu)	2000-03-28
CZ294838B6 (cs)	2005-03-16
JP2000511934A (ja)	2000-09-12
AU724694B2 (en)	2000-09-28
DE69808579T2 (de)	2003-06-26
IL126456A0 (en)	1999-08-17
KR100463630B1 (ko)	2005-05-25
KR20000064912A (ko)	2000-11-06
CN1215995A (zh)	1999-05-05
EP0909176A4 (de)	2000-04-12
HU226994B1 (en)	2010-04-28
HUP9903753A3 (en)	2000-08-28
CA2250784C (en)	2004-04-20
NO984611D0 (no)	1998-10-02
DK0909176T3 (da)	2003-02-17

Legal Events

Date	Code	Title	Description
2003-04-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
DE69808579D1 (de)	2002-11-14	Reaktor und verfahren für die festphasen-synthese von peptiden
EP0217962A4 (de)	1988-04-11	Behandlung des aktivschlamms im abwasser.
TW231340B (de)	1994-10-01
TR199800822T2 (xx)	1998-08-21	Kimyasal sava� maddelerini imha y�ntemi ve cihaz�.
JP2873578B1 (ja)	1999-03-24	無電解ニッケルめっき廃液の処理方法および装置
ES8504439A1 (es)	1985-05-01	Un metodo y un aparato para tratar material que contienen celulosa, tal como paja.
GB9422539D0 (en)	1995-01-04	Decontamination processes
RU99107570A (ru)	2001-05-20	Способ отбеливания бумажной массы
UA28061C2 (uk)	2000-10-16	Спосіб приготування свіжого мийного розчину та обробки використаного мийного розчину і пристрій для його здійснення
RU98121409A (ru)	2000-09-27	Способ обработки щелока процесса байера
DE69213352D1 (de)	1996-10-10	Verfahren, Vorrichtung sowie Zusammenstellung von Teilen zum Reinigen sowie Pumpsystems zum Einbringen von Luft oder Wasser in ein Bad
DK0510218T3 (da)	1995-05-29	Fremgangsmåde og indretning til vask og desinficering i en gennemløbsvaskemaskine
JPS55142590A (en)	1980-11-07	Treating method of water containing hydrazine
RU96102520A (ru)	1998-04-27	Способ обработки скважины
RU96107284A (ru)	1998-05-27	Способ обработки продуктивного пласта
CA2372170A1 (en)	2000-11-09	Method, apparatus and use of chelating agents for the purification of calcium sulphate
JPS57122991A (en)	1982-07-31	Treatment of waste water containing sludge and hydrazine
EP1203996A3 (de)	2002-08-28	Vorrichtung und Verfahren zur Entwicklung von photographischem Material mit Waschwasserrückgewinnung
US4632763A (en)	1986-12-30	Process for treating photographic washing waters
US3479127A (en)	1969-11-18	Process for the unhairing of skins and hides with peracids or their salts
JPS5638175A (en)	1981-04-13	Method and apparatus for removing ammoniacal nitrogen
SE9001548L (sv)	1991-10-31	Blekning av kemisk massa
RU96109752A (ru)	1998-08-27	Способ утилизации несовместимых вод
JPS5361561A (en)	1978-06-02	Treating method for removing harm from liquid ammonia
JPS5870788A (ja)	1983-04-27	故紙の再生用処理剤