ATE225782T1 - Benzopyranderivate - Google Patents

Benzopyranderivate

Info

Publication number
ATE225782T1
ATE225782T1 AT97947971T AT97947971T ATE225782T1 AT E225782 T1 ATE225782 T1 AT E225782T1 AT 97947971 T AT97947971 T AT 97947971T AT 97947971 T AT97947971 T AT 97947971T AT E225782 T1 ATE225782 T1 AT E225782T1
Authority
AT
Austria
Prior art keywords
pct
lower alkyl
denotes
integer
alkyl
Prior art date
Application number
AT97947971T
Other languages
English (en)
Inventor
Jae Chon Jo
Sung Dae Park
Hyun Suk Lim
Ju Su Kim
Sung Jin Kim
Kazumi Morikawa
Yoshitake Kanbe
Masahiro Nishimoto
Myung-Hwa Kim
Original Assignee
Chugai Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chugai Pharmaceutical Co Ltd filed Critical Chugai Pharmaceutical Co Ltd
Application granted granted Critical
Publication of ATE225782T1 publication Critical patent/ATE225782T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D335/00—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom
    • C07D335/04—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D335/06—Benzothiopyrans; Hydrogenated benzothiopyrans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/32—Antioestrogens
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
    • C07D311/26—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3
    • C07D311/34—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3 with aromatic rings attached in position 3 only
    • C07D311/38—2,3-Dihydro derivatives, e.g. isoflavanones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Endocrinology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Reproductive Health (AREA)
  • Diabetes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Pyrane Compounds (AREA)
AT97947971T 1996-12-13 1997-12-13 Benzopyranderivate ATE225782T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
KR19960065301 1996-12-13
KR19970026915 1997-06-24
PCT/KR1997/000265 WO1998025916A1 (en) 1996-12-13 1997-12-13 Novel benzopyran derivatives

Publications (1)

Publication Number Publication Date
ATE225782T1 true ATE225782T1 (de) 2002-10-15

Family

ID=26632356

Family Applications (1)

Application Number Title Priority Date Filing Date
AT97947971T ATE225782T1 (de) 1996-12-13 1997-12-13 Benzopyranderivate

Country Status (11)

Country Link
US (1) US6153768A (de)
EP (1) EP0944613B1 (de)
JP (1) JP3251946B2 (de)
KR (1) KR19980064120A (de)
CN (1) CN1120162C (de)
AT (1) ATE225782T1 (de)
AU (1) AU722089B2 (de)
CA (1) CA2275166C (de)
DE (1) DE69716292T2 (de)
ES (1) ES2185054T3 (de)
WO (1) WO1998025916A1 (de)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20010052673A (ko) * 1998-06-12 2001-06-25 이경하 에스트로겐 안타고니스트의 프로드럭
KR20000001793A (ko) * 1998-06-13 2000-01-15 이경하 신규한 벤조피란 또는 티오벤조피란 유도체
KR20010055766A (ko) * 1999-12-13 2001-07-04 이경하 3-메틸-크로만 또는 티오크로만 유도체의 금속염
EP1241167A4 (de) * 1999-12-13 2003-03-26 Chugai Pharmaceutical Co Ltd 3-ethyl, 3-propyl- oder 3-butyl-chroman und -thiochromanderivate
EP1241165A4 (de) * 1999-12-13 2003-03-19 Chugai Pharmaceutical Co Ltd Optisch aktive chroman- und thiochromanderivate
US6552069B1 (en) * 1999-12-13 2003-04-22 Chugai Seiyaku Kabushiki Kaisha 3-methyl-chroman and -thiochroman derivatives
KR20010055765A (ko) * 1999-12-13 2001-07-04 이경하 3-메틸-크로만 또는 티오크로만 유도체
AU2001267904A1 (en) 2000-06-30 2002-01-14 Chugai Seiyaku Kabushiki Kaisha Novel antiandrogenic agent
EP1281710A1 (de) * 2001-08-03 2003-02-05 CHIESI FARMACEUTICI S.p.A. 2H-1-Benzopyran derivat, Verfahren zur Herstellung und diese enthaltende pharmazeutische Zusammenstellungen
WO2002059113A1 (en) * 2001-01-24 2002-08-01 Chiesi Farmaceutici S.P.A. 2h-1-benzopyran derivatives, processes for their preparation and pharmaceutical compositions thereof
ES2236056T3 (es) * 2001-01-24 2005-07-16 Chiesi Farmaceutici S.P.A. Derivados de 2h-1-benzopirano, procedimientos para su preparacion y composiciones farmaceuticas de los mismos.
IL162295A0 (en) * 2001-12-19 2005-11-20 Ortho Mcneil Pharm Inc Tetracyclic heterocompounds as estrogen receptor modulators
US7329654B2 (en) 2001-12-19 2008-02-12 Janssen Pharmaceutica N.V. Heteroatom containing tetracyclic derivatives as selective estrogen receptor modulators
US7105679B2 (en) 2001-12-19 2006-09-12 Kanojia Ramesh M Heteroatom containing tetracyclic derivatives as selective estrogen receptor modulators
US7060850B2 (en) 2002-07-11 2006-06-13 Fluorous Technologies Incorporated Fluorous tagging and scavenging reactants and methods of synthesis and use thereof
US8080675B2 (en) 2004-09-21 2011-12-20 Marshall Edwards, Inc. Chroman derivatives, medicaments and use in therapy
EP2436680B1 (de) * 2004-09-21 2016-05-18 Marshall Edwards, Inc. Chromanderivate, Medikamente und Anwendung in der Therapie
ES2377073T3 (es) * 2004-09-21 2012-03-22 Marshall Edwards, Inc. Derivados de cromano sustituidos, medicamentos y utilización en terapia
CN101056868B (zh) 2004-09-21 2012-05-02 马休爱德华兹股份有限公司 取代的苯并二氢吡喃衍生物、药物及其在治疗中的应用
AU2006317486B9 (en) 2005-11-22 2011-08-04 Sumitomo Chemical Company, Limited Organic sulfur compounds and use thereof as arthropodicides
JP2009001551A (ja) 2007-05-18 2009-01-08 Sumitomo Chemical Co Ltd 有機硫黄化合物及びその有害節足動物防除用途
JP5298631B2 (ja) 2007-05-18 2013-09-25 住友化学株式会社 有機硫黄化合物及びその有害節足動物防除用途
TW200904329A (en) 2007-05-18 2009-02-01 Sumitomo Chemical Co Organic sulfur compound and its use for controlling harmful arthropod
DE102010030538A1 (de) 2010-06-25 2011-12-29 Bayer Schering Pharma Aktiengesellschaft 6,7-Dihydro-5H-benzo[7]annulen-Derivate, Verfahren zu ihrer Herstellung, pharmazeutische Präparate die diese enthalten, sowie deren Verwendung zur Herstellung von Arzneimitteln
WO2012061409A1 (en) 2010-11-01 2012-05-10 Marshall Edwards, Inc. Isoflavonoid compounds and methods for the treatment of cancer
CA2824521C (en) 2011-01-20 2016-06-28 Board Of Regents, The University Of Texas System Mri markers, delivery and extraction systems, and related methods
DE102011087987A1 (de) 2011-12-08 2013-06-13 Bayer Intellectual Property Gmbh 6,7-Dihydro-5H-benzo[7]annulen-Derivate, Verfahren zu ihrer Herstellung, pharmazeutische Präparate die diese enthalten, sowie deren Verwendung zur Herstellung von Arzneimitteln
PT3253208T (pt) 2015-02-02 2021-06-17 The Spanish National Cancer Res Centre Terapêuticas de combinação para utilização no tratamento do cancro da mama
CN115650863B (zh) * 2022-09-05 2024-06-25 上海博纳赛恩医药研发有限公司 制备文拉法辛盐酸盐的方法
CN118005594B (zh) * 2023-05-24 2024-10-29 内蒙古大学 3-羟基苯并二氢吡喃衍生物的合成及其抗肿瘤活性

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3374245A (en) 1964-04-01 1968-03-19 Ciba Geigy Corp Unsaturated oxacycles
GB8311678D0 (en) * 1983-04-28 1983-06-02 Ici Plc Phenol derivatives
US5395842A (en) * 1988-10-31 1995-03-07 Endorecherche Inc. Anti-estrogenic compounds and compositions
HUP9702244A3 (en) 1995-01-13 1999-12-28 Novo Nordisk As Use of 3,4-diphenyl chromans for manufacture of a pharmaceutical composition for treatment or prophylaxis of gynaecological disorders
AU4772297A (en) * 1996-10-28 1998-05-22 Novo Nordisk A/S Novel (cis)-3,4-chroman derivatives useful in the prevention or treatment of estrogen related diseases or syndromes
IL129623A0 (en) * 1996-10-28 2000-02-29 Novo Nordisk As Novel trans-3,4-chroman derivatives useful in the prevention or treatment of estrogen related diseases or syndromes
CA2269974A1 (en) * 1996-10-28 1998-05-07 Paul Stanley Bury Novel cis-3,4-chroman derivatives useful in the prevention or treatment of estrogen related diseases or syndromes

Also Published As

Publication number Publication date
CN1244863A (zh) 2000-02-16
WO1998025916A1 (en) 1998-06-18
DE69716292T2 (de) 2003-07-03
JP3251946B2 (ja) 2002-01-28
JP2000507620A (ja) 2000-06-20
KR19980064120A (ko) 1998-10-07
CN1120162C (zh) 2003-09-03
DE69716292D1 (de) 2002-11-14
EP0944613A1 (de) 1999-09-29
CA2275166A1 (en) 1998-06-18
AU5413498A (en) 1998-07-03
AU722089B2 (en) 2000-07-20
ES2185054T3 (es) 2003-04-16
CA2275166C (en) 2003-07-22
EP0944613B1 (de) 2002-10-09
US6153768A (en) 2000-11-28

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Legal Events

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