AU722089B2 - Novel benzopyran derivatives - Google Patents

Novel benzopyran derivatives Download PDF

Info

Publication number
AU722089B2
AU722089B2 AU54134/98A AU5413498A AU722089B2 AU 722089 B2 AU722089 B2 AU 722089B2 AU 54134/98 A AU54134/98 A AU 54134/98A AU 5413498 A AU5413498 A AU 5413498A AU 722089 B2 AU722089 B2 AU 722089B2
Authority
AU
Australia
Prior art keywords
formula
compound
hydroxy
methyl
hydroxyphenyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU54134/98A
Other languages
English (en)
Other versions
AU5413498A (en
Inventor
Jae Chon Jo
Yoshitake Kanbe
Ju Su Kim
Myung-Hwa Kim
Sung-Jin Kim
Hyun Suk Lim
Kazumi Morikawa
Masahiro Nishimoto
Sung Dae Park
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Chugai Pharmaceutical Co Ltd
Original Assignee
C&C Research Laboratories
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by C&C Research Laboratories filed Critical C&C Research Laboratories
Publication of AU5413498A publication Critical patent/AU5413498A/en
Application granted granted Critical
Publication of AU722089B2 publication Critical patent/AU722089B2/en
Assigned to CHUGAI SEIYAKU KABUSHIKI KAISHA reassignment CHUGAI SEIYAKU KABUSHIKI KAISHA Alteration of Name(s) in Register under S187 Assignors: C & C RESEARCH LABORATORIES
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D335/00—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom
    • C07D335/04—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D335/06—Benzothiopyrans; Hydrogenated benzothiopyrans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/32—Antioestrogens
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
    • C07D311/26—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3
    • C07D311/34—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3 with aromatic rings attached in position 3 only
    • C07D311/38—2,3-Dihydro derivatives, e.g. isoflavanones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Endocrinology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Diabetes (AREA)
  • Reproductive Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Pyrane Compounds (AREA)
  • Saccharide Compounds (AREA)
AU54134/98A 1996-12-13 1997-12-13 Novel benzopyran derivatives Ceased AU722089B2 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
KR19960065301 1996-12-13
KR9665301 1996-12-13
KR19970026915 1997-06-24
KR9726915 1997-06-24
PCT/KR1997/000265 WO1998025916A1 (en) 1996-12-13 1997-12-13 Novel benzopyran derivatives

Publications (2)

Publication Number Publication Date
AU5413498A AU5413498A (en) 1998-07-03
AU722089B2 true AU722089B2 (en) 2000-07-20

Family

ID=26632356

Family Applications (1)

Application Number Title Priority Date Filing Date
AU54134/98A Ceased AU722089B2 (en) 1996-12-13 1997-12-13 Novel benzopyran derivatives

Country Status (11)

Country Link
US (1) US6153768A (de)
EP (1) EP0944613B1 (de)
JP (1) JP3251946B2 (de)
KR (1) KR19980064120A (de)
CN (1) CN1120162C (de)
AT (1) ATE225782T1 (de)
AU (1) AU722089B2 (de)
CA (1) CA2275166C (de)
DE (1) DE69716292T2 (de)
ES (1) ES2185054T3 (de)
WO (1) WO1998025916A1 (de)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU4165299A (en) * 1998-06-12 1999-12-30 C & C Research Laboratories Prodrugs of estrogen antagonist
KR20000001793A (ko) * 1998-06-13 2000-01-15 이경하 신규한 벤조피란 또는 티오벤조피란 유도체
AU1888001A (en) * 1999-12-13 2001-06-18 Chugai Seiyaku Kabushiki Kaisha Optically active chroman and thiochroman derivatives
KR20010055766A (ko) * 1999-12-13 2001-07-04 이경하 3-메틸-크로만 또는 티오크로만 유도체의 금속염
WO2001042235A1 (en) * 1999-12-13 2001-06-14 Chugai Seiyaku Kabushiki Kaisha 3-ethyl-, 3-propyl- or 3-butyl-chroman and -thiochroman derivatives
WO2001042234A1 (en) * 1999-12-13 2001-06-14 Chugai Seiyaku Kabushiki Kaisha 3-methyl-chroman and -thiochroman derivatives
KR20010055765A (ko) * 1999-12-13 2001-07-04 이경하 3-메틸-크로만 또는 티오크로만 유도체
AU2001267904A1 (en) 2000-06-30 2002-01-14 Chugai Seiyaku Kabushiki Kaisha Novel antiandrogenic agent
ES2236056T3 (es) * 2001-01-24 2005-07-16 Chiesi Farmaceutici S.P.A. Derivados de 2h-1-benzopirano, procedimientos para su preparacion y composiciones farmaceuticas de los mismos.
IL157065A0 (en) * 2001-01-24 2004-02-08 Chiesi Farma Spa 2h-1-benzopyran derivatives, processes for their preparation and pharmaceutical compositions thereof
EP1281710A1 (de) * 2001-08-03 2003-02-05 CHIESI FARMACEUTICI S.p.A. 2H-1-Benzopyran derivat, Verfahren zur Herstellung und diese enthaltende pharmazeutische Zusammenstellungen
US7105679B2 (en) 2001-12-19 2006-09-12 Kanojia Ramesh M Heteroatom containing tetracyclic derivatives as selective estrogen receptor modulators
US7329654B2 (en) 2001-12-19 2008-02-12 Janssen Pharmaceutica N.V. Heteroatom containing tetracyclic derivatives as selective estrogen receptor modulators
ATE321764T1 (de) * 2001-12-19 2006-04-15 Ortho Mcneil Pharm Inc Tetracyclische heteroverbindungen als modulatoren des östrogenrezeptors
WO2004007407A2 (en) 2002-07-11 2004-01-22 Fluorous Technologies Incorporated Fluorous tagging and scavenging reactants and methods of synthesis and use thereof
US8080675B2 (en) 2004-09-21 2011-12-20 Marshall Edwards, Inc. Chroman derivatives, medicaments and use in therapy
ATE532777T1 (de) * 2004-09-21 2011-11-15 Marshall Edwards Inc Substituierte chromanderivate, medikamente und anwendungen in der therapie
ES2516067T3 (es) * 2004-09-21 2014-10-30 Mei Pharma, Inc. Derivados de cromano sustituidos, medicamentos y utilización en terapia
WO2006032086A1 (en) * 2004-09-21 2006-03-30 Novogen Research Pty Ltd Chroman derivatives, medicaments and use in therapy
CN101312944B (zh) 2005-11-22 2013-03-06 住友化学株式会社 有机硫化合物及其作为节肢动物杀灭剂的应用
JP2009001551A (ja) 2007-05-18 2009-01-08 Sumitomo Chemical Co Ltd 有機硫黄化合物及びその有害節足動物防除用途
JP5298631B2 (ja) 2007-05-18 2013-09-25 住友化学株式会社 有機硫黄化合物及びその有害節足動物防除用途
TW200904329A (en) 2007-05-18 2009-02-01 Sumitomo Chemical Co Organic sulfur compound and its use for controlling harmful arthropod
DE102010030538A1 (de) 2010-06-25 2011-12-29 Bayer Schering Pharma Aktiengesellschaft 6,7-Dihydro-5H-benzo[7]annulen-Derivate, Verfahren zu ihrer Herstellung, pharmazeutische Präparate die diese enthalten, sowie deren Verwendung zur Herstellung von Arzneimitteln
CA2816322A1 (en) 2010-11-01 2012-05-10 Marshall Edwards, Inc. Isoflavonoid compositions and methods for the treatment of cancer
BR112013018534B1 (pt) 2011-01-20 2021-04-06 Board Of Regents, The University Of Texas System Agente de contraste, seus métodos de preparação, e produto de combinação
DE102011087987A1 (de) 2011-12-08 2013-06-13 Bayer Intellectual Property Gmbh 6,7-Dihydro-5H-benzo[7]annulen-Derivate, Verfahren zu ihrer Herstellung, pharmazeutische Präparate die diese enthalten, sowie deren Verwendung zur Herstellung von Arzneimitteln
CN107427003B (zh) 2015-02-02 2023-01-31 梅制药公司 联合治疗
CN115650863B (zh) * 2022-09-05 2024-06-25 上海博纳赛恩医药研发有限公司 制备文拉法辛盐酸盐的方法
CN118005594B (zh) * 2023-05-24 2024-10-29 内蒙古大学 3-羟基苯并二氢吡喃衍生物的合成及其抗肿瘤活性

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3374245A (en) 1964-04-01 1968-03-19 Ciba Geigy Corp Unsaturated oxacycles
GB8311678D0 (en) * 1983-04-28 1983-06-02 Ici Plc Phenol derivatives
US5395842A (en) * 1988-10-31 1995-03-07 Endorecherche Inc. Anti-estrogenic compounds and compositions
HUP9702244A3 (en) 1995-01-13 1999-12-28 Novo Nordisk As Use of 3,4-diphenyl chromans for manufacture of a pharmaceutical composition for treatment or prophylaxis of gynaecological disorders
EP0937059A1 (de) * 1996-10-28 1999-08-25 Novo Nordisk A/S $i(TRANS)-3,4-CHROMANDERIVATE ZUR VORBEUGUNG ODER BEHANDLUNGVON OESTROGENBEZOGENEN KRANKHEITEN ODER SYNDROMEN
IL129618A0 (en) * 1996-10-28 2000-02-29 Novo Nordisk As Novel CIS-3,4-chroman derivatives useful in the prevention or treatment of estrogen related diseases or syndromes
JP2001502708A (ja) * 1996-10-28 2001-02-27 ノボ ノルディスク アクティーゼルスカブ エストロゲン関連の疾患または症候群の予防または治療に有用な新規なシス―３，４―クロマン誘導体

Also Published As

Publication number Publication date
JP3251946B2 (ja) 2002-01-28
CN1244863A (zh) 2000-02-16
CA2275166C (en) 2003-07-22
EP0944613A1 (de) 1999-09-29
CN1120162C (zh) 2003-09-03
WO1998025916A1 (en) 1998-06-18
ES2185054T3 (es) 2003-04-16
DE69716292D1 (de) 2002-11-14
US6153768A (en) 2000-11-28
DE69716292T2 (de) 2003-07-03
CA2275166A1 (en) 1998-06-18
KR19980064120A (ko) 1998-10-07
JP2000507620A (ja) 2000-06-20
AU5413498A (en) 1998-07-03
ATE225782T1 (de) 2002-10-15
EP0944613B1 (de) 2002-10-09

Similar Documents

Publication Publication Date Title
CA2275166C (en) Novel benzopyran derivatives
US6645951B1 (en) Benzopyran or thiobenzopyran derivatives
AU703637B2 (en) Amino(thio)ether derivatives
US5474994A (en) Bicyclic heterocyclic derivatives having α1 -adrenergic and 5HT1A
EA004182B1 (ru) Бензоциклогептены, содержащие их фармацевтические препараты и их применение для получения лекарственных средств
CZ205994A3 (en) Heterobicyclic compounds
EA002322B1 (ru) Трициклические соединения
CA2192097A1 (en) 2-amino-3-aroyl-benzo¬.beta.|thiophenes and method of making the same
PL156250B1 (pl) Sposób wytwarzania nowych 1-/1H-imidazolilo-4/alkilobenzamidów PL PL PL PL PL PL PL PL PL
US5143924A (en) Oxodihydropyridyl chroman derivatives
US20100029782A1 (en) Calcilytic Compounds
HUT58329A (en) Process for producing 5,11-dihydro-dibenzo(b,e)(1,4)-thiazepine derivatives and pharmaceutical compositions containing them
CN101133037A (zh) 六元杂环化合物及其用途
EP0402232A1 (de) Pyridobenzoindolderivate, ihre Herstellung und sie enthaltende Zubereitungen
JPH08509491A (ja) 胃腸疾患の治療に有用なエタノールアミン誘導体
EP0365093B1 (de) Muscarin-Rezeptor-Antagonisten
CA2126719A1 (en) Piperidines and piperazines
HUP0003187A2 (hu) Szubsztituált benzotiofének és eljárás előállításukra
IE902313A1 (en) 2-amino-1,2,3,4-tetrahydronaphthalene derivatives with¹cardiovascular activity, process for their preparation and¹pharmaceutical compositions containing them
FR2692578A1 (fr) Dérivés d'indolizines, procédé de préparation et utilisation pour la préparation de composés aminoalkoxybenzènesulfonyl-indolizines à activité pharmaceutique.
KR950007592B1 (ko) 디벤즈[b,e]옥세핀 유도체 및 그것을 유효성분으로 하는 의약
WO1999003835A1 (en) Aromatic ketone derivatives and uses thereof
HK1025953A (en) Novel benzopyran derivatives
US20040044226A1 (en) Estrogen receptor modulators
JPH02202857A (ja) アミノアルコキシベンゼン誘導体

Legal Events

Date Code Title Description
FGA Letters patent sealed or granted (standard patent)
PC Assignment registered

Owner name: CHUGAI SEIYAKU KABUSHIKI KAISHA

Free format text: FORMER OWNER WAS: C AND C RESEARCH LABORATORIES

MK14 Patent ceased section 143(a) (annual fees not paid) or expired