ATE226596T1 - Monoklonale antikörper zur diagnose und behandlung von kolorektalkrebs - Google Patents

Monoklonale antikörper zur diagnose und behandlung von kolorektalkrebs

Info

Publication number
ATE226596T1
ATE226596T1 AT94923816T AT94923816T ATE226596T1 AT E226596 T1 ATE226596 T1 AT E226596T1 AT 94923816 T AT94923816 T AT 94923816T AT 94923816 T AT94923816 T AT 94923816T AT E226596 T1 ATE226596 T1 AT E226596T1
Authority
AT
Austria
Prior art keywords
pct
chain
sequence
human
residues
Prior art date
Application number
AT94923816T
Other languages
English (en)
Inventor
Walter Fred Bodmer
Helga Durbin
David Snary
Lorna Mary Stewart
Susan Young
Paul Alan Bates
Original Assignee
Imp Cancer Res Tech
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Imp Cancer Res Tech filed Critical Imp Cancer Res Tech
Application granted granted Critical
Publication of ATE226596T1 publication Critical patent/ATE226596T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3046—Stomach, Intestines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3007—Carcino-embryonic Antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • Oncology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
AT94923816T 1993-08-21 1994-08-19 Monoklonale antikörper zur diagnose und behandlung von kolorektalkrebs ATE226596T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB939317423A GB9317423D0 (en) 1993-08-21 1993-08-21 Monoclonal antibodies
PCT/GB1994/001816 WO1995006067A1 (en) 1993-08-21 1994-08-19 Monoclonal antibodies for use in diagnosis and treatment of colorectal cancer

Publications (1)

Publication Number Publication Date
ATE226596T1 true ATE226596T1 (de) 2002-11-15

Family

ID=10740834

Family Applications (1)

Application Number Title Priority Date Filing Date
AT94923816T ATE226596T1 (de) 1993-08-21 1994-08-19 Monoklonale antikörper zur diagnose und behandlung von kolorektalkrebs

Country Status (12)

Country Link
US (1) US5965710A (de)
EP (1) EP0721470B1 (de)
JP (1) JP3492373B2 (de)
AT (1) ATE226596T1 (de)
AU (1) AU7390694A (de)
CA (1) CA2168440C (de)
DE (1) DE69431602T2 (de)
DK (1) DK0721470T3 (de)
ES (1) ES2187529T3 (de)
GB (1) GB9317423D0 (de)
PT (1) PT721470E (de)
WO (1) WO1995006067A1 (de)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5872215A (en) * 1991-12-02 1999-02-16 Medical Research Council Specific binding members, materials and methods
GB9621295D0 (en) * 1995-12-07 1996-11-27 Cambridge Antibody Tech Specific binding members,materials and methods
US6417337B1 (en) * 1996-10-31 2002-07-09 The Dow Chemical Company High affinity humanized anti-CEA monoclonal antibodies
WO1999006834A2 (en) * 1997-08-04 1999-02-11 Ixsys, Incorporated Methods for identifying ligand specific binding molecules
DE19739685A1 (de) * 1997-09-10 1999-03-11 Eichel Streiber Christoph Von Monoklonale Antikörper zur Therapie und Prophylaxe von Erkrankungen durch Clostridium difficile
AU6940700A (en) * 1999-08-26 2001-03-19 Amy P. N Skubitz Peptides capable of modulating the function of cd66 (ceacam) family members
US6835549B2 (en) * 2000-02-24 2004-12-28 University Of Medicine & Dentistry Of New Jersey Immunoassay method for the diagnosis of gastric intestinal metaplasia associated with gastric carcinoma
US6774209B1 (en) 2000-04-03 2004-08-10 Dyax Corp. Binding peptides for carcinoembryonic antigen (CEA)
EP1472276A4 (de) * 2001-02-28 2007-05-09 Keith M Skubitz Kleine, zur modulation der funktion von mitgliedern der cd66 (ceacam)-familie fähige peptide
CA2439402A1 (en) * 2001-03-02 2002-09-12 University Of Pittsburgh Of The Commonwealth System Of Higher Education Pcr method
PT2000545E (pt) * 2001-06-20 2011-12-21 Genentech Inc Composições e métodos para o diagnóstico e tratamento do tumor pulmonar
US20040229215A1 (en) * 2003-03-04 2004-11-18 Auburn University Methods of forming monolayers of phage-derived products and uses thereof
WO2005114444A1 (en) * 2004-04-30 2005-12-01 America Online, Inc. Network configuration management
US8187595B2 (en) 2004-05-07 2012-05-29 The University Of North Carolina At Chapel Hill Monoclonal antibodies for enhancing or inhibiting insulin-like growth factor-I
AU2005286876A1 (en) * 2004-09-20 2006-03-30 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Multiple mode multiplex reaction quenching method
KR101527334B1 (ko) 2005-08-11 2015-06-09 알피 마토씨안-로저스 자가면역 질병의 치료 및 진단용 ｔｃｒ-ｖ-베타 관련 펩티드
EP1940355B1 (de) 2005-09-30 2012-12-19 Auburn University Nanoträger zur gezielten Freisetzung eines Wirkstoffs - enthaltend Ansammlungen von auf ein Ziel ausgerichteten Landschaftsphagenproteinen
US8119352B2 (en) * 2006-06-20 2012-02-21 Cepheld Multi-stage amplification reactions by control of sequence replication times
AU2008351621B2 (en) * 2008-02-29 2013-05-09 Signalomics Gmbh Optimized adhesin fragments and corresponding nanoparticles
KR101528013B1 (ko) * 2009-08-31 2015-06-16 로슈 글리카트 아게 친화성-성숙된 인간화된 항-ｃｅａ 단일클론 항체
CA2773515C (en) * 2009-09-29 2015-04-28 Roche Glycart Ag Bispecific death receptor agonistic antibodies
WO2011109769A1 (en) 2010-03-04 2011-09-09 Ventana Medical Systems, Inc. Processing system for processing specimens using acoustic energy
US10539487B2 (en) 2010-03-04 2020-01-21 Ventana Medical Systems, Inc. Systems and methods for monitoring tissue sample processing
US10126216B2 (en) 2011-02-17 2018-11-13 Ventana Medical Systems, Inc. Method for tissue sample fixation
PE20141017A1 (es) * 2011-03-02 2014-08-25 Roche Glycart Ag Anticuerpos del cea
EA201892619A1 (ru) 2011-04-29 2019-04-30 Роше Гликарт Аг Иммуноконъюгаты, содержащие мутантные полипептиды интерлейкина-2
CA2882757A1 (en) * 2012-08-31 2014-03-06 The University Of North Carolina At Chapel Hill Monoclonal antibodies for enhancing or inhibiting insulin-like growth factor 1 (igf-1)
UA118028C2 (uk) 2013-04-03 2018-11-12 Рош Глікарт Аг Біспецифічне антитіло, специфічне щодо fap і dr5, антитіло, специфічне щодо dr5, і спосіб їх застосування
US9753036B2 (en) 2014-04-29 2017-09-05 Edp Biotech Corporation Methods and compositions for screening and detecting biomarkers
KR20250024741A (ko) 2022-03-23 2025-02-19 시나픽스 비.브이. 암배아성 항원을 발현하는 종양을 표적화하기 위한 항체-컨쥬게이트

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU625613B2 (en) * 1988-01-05 1992-07-16 Novartis Ag Novel chimeric antibodies

Also Published As

Publication number Publication date
WO1995006067A1 (en) 1995-03-02
DK0721470T3 (da) 2003-02-24
DE69431602T2 (de) 2003-06-26
DE69431602D1 (de) 2002-11-28
AU7390694A (en) 1995-03-21
EP0721470B1 (de) 2002-10-23
JPH09501571A (ja) 1997-02-18
PT721470E (pt) 2003-03-31
EP0721470A1 (de) 1996-07-17
ES2187529T3 (es) 2003-06-16
CA2168440A1 (en) 1995-03-02
JP3492373B2 (ja) 2004-02-03
GB9317423D0 (en) 1993-10-06
US5965710A (en) 1999-10-12
CA2168440C (en) 2002-07-23

Similar Documents

Publication Publication Date Title
DE69431602D1 (de) Monoklonale antikörper zur diagnose und behandlung von kolorektalkrebs
PT699237E (pt) Fvs de cadeia anti-egfr e anticorpos anti-egfr
Natvig et al. IgG antigens of the Cγ2 and Cγ3 homology regions interacting with rheumatoid factors
EA200301098A1 (ru) Ассоциированные с ганглиозидами рекомбинантные антитела и их применение в диагностике и лечении опухолей
HRP20020693B1 (hr) HUMANIZIRANA PROTUTIJELA KOJA SADRŽE PEPTID Aß
DE69527975D1 (de) Humanisierte antikörper gegen cd38
RU2006107453A (ru) Полипептидные композиции, связывающие cd20
ATE350478T1 (de) Monoklonaler antikoerper gegen cea, konjugate die dieses antikoerper enthalten und deren therapeutische verwendung in einem adept-system
GB2246781A (en) CD3 specific recombinant antibody
DE69636748D1 (de) Bispezifischer antikörper zur effektiven behandlung von b-zell lymphomen und zellinien
NO2006008I2 (no) Natalizumab, anti alfa-4 integrin humanized monoclonal antibody
NZ614727A (en) Human antibodies that bind human tnfa
Terness et al. The natural human IgG anti-F (ab') 2 antibody recognizes a conformational IgG1 hinge epitope.
GB2278357B (en) Humanised antibodies directed against A33 antigen
KR940006602A (ko) 면역글로불린 이소타입에 대한 재조형 모노클로날 항체
Poljak et al. Studies on the three-dimensional structure of immunoglobulins
DE69311796D1 (de) Peptide von dem caseinomacropeptid, antikorper dagegen und ihre andwendungen
DE3775182D1 (de) Monoklonale antikoerper gegen menschliche ige-rezeptoren auf lymphocyten, diese antikoerper produzierende hybridomas und reaktionsansaetze zum gebrauch dieser antikoerper.
Guillien et al. Specificity of antibodies in single cells after immunization with antigens bearing several antigenic determinants: Study with a new paired staining technique
Wines et al. The Fab/c fragment of IgG produced by cleavage at cyanocysteine residues
Hopper et al. Shared N-terminal sequences in monoclonal IgMκ and IgGκ proteins from a patient with a complex multiple paraprotein disorder
Borden et al. An immunochemical analysis of precipitating and non-precipitating idiotype-anti-idiotype reactions
Strosberg et al. Cross-idiotypic specificity among immunoglobulins in subacute sclerosing panencephalitis and multiple sclerosis
Oriol et al. Common Antigenic Determinants in Fd Fragments of Guinea Pig γ1, γ2 and γM Immunoglobulins
Steward General structure of immunoglobulins

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification

Ref document number: 0721470

Country of ref document: EP

EEIH Change in the person of patent owner